AU2005247467B2 - Compounds, formulations, and methods for treating or preventing inflammatory skin disorders - Google Patents
Compounds, formulations, and methods for treating or preventing inflammatory skin disorders Download PDFInfo
- Publication number
- AU2005247467B2 AU2005247467B2 AU2005247467A AU2005247467A AU2005247467B2 AU 2005247467 B2 AU2005247467 B2 AU 2005247467B2 AU 2005247467 A AU2005247467 A AU 2005247467A AU 2005247467 A AU2005247467 A AU 2005247467A AU 2005247467 B2 AU2005247467 B2 AU 2005247467B2
- Authority
- AU
- Australia
- Prior art keywords
- alkyl
- compounds
- independently hydrogen
- pharmaceutically acceptable
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57414204P | 2004-05-25 | 2004-05-25 | |
| US10/853,585 US7439241B2 (en) | 2003-05-27 | 2004-05-25 | Compounds, formulations, and methods for treating or preventing rosacea |
| US10/853,585 | 2004-05-25 | ||
| US60/574,142 | 2004-05-25 | ||
| PCT/US2005/018288 WO2005115395A2 (en) | 2004-05-25 | 2005-05-25 | Compounds, formulations, and methods for treating or preventing inflammatory skin disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2005247467A1 AU2005247467A1 (en) | 2005-12-08 |
| AU2005247467B2 true AU2005247467B2 (en) | 2010-12-02 |
Family
ID=35451386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2005247467A Ceased AU2005247467B2 (en) | 2004-05-25 | 2005-05-25 | Compounds, formulations, and methods for treating or preventing inflammatory skin disorders |
Country Status (15)
| Country | Link |
|---|---|
| EP (2) | EP1761266B1 (enExample) |
| JP (2) | JP4955543B2 (enExample) |
| KR (1) | KR101257046B1 (enExample) |
| CN (2) | CN101426502A (enExample) |
| AU (1) | AU2005247467B2 (enExample) |
| BR (1) | BRPI0511519A (enExample) |
| CA (2) | CA2824612C (enExample) |
| DK (1) | DK1761266T3 (enExample) |
| ES (2) | ES2647618T3 (enExample) |
| MX (1) | MXPA06013649A (enExample) |
| NZ (1) | NZ552325A (enExample) |
| PL (1) | PL1761266T3 (enExample) |
| PT (1) | PT1761266E (enExample) |
| SI (1) | SI1761266T1 (enExample) |
| WO (1) | WO2005115395A2 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040266776A1 (en) | 2003-06-25 | 2004-12-30 | Gil Daniel W. | Methods of preventing and reducing the severity of stress-associated conditions |
| US7439241B2 (en) * | 2003-05-27 | 2008-10-21 | Galderma Laboratories, Inc. | Compounds, formulations, and methods for treating or preventing rosacea |
| US8410102B2 (en) | 2003-05-27 | 2013-04-02 | Galderma Laboratories Inc. | Methods and compositions for treating or preventing erythema |
| US20050020600A1 (en) * | 2003-07-23 | 2005-01-27 | Scherer Warren J. | Methods of treating cutaneous flushing using selective alpha-2-adrenergic receptor agonists |
| GB0611241D0 (en) * | 2006-06-07 | 2006-07-19 | Daniolabs Ltd | The treatment of increased sebum production |
| CA2779063A1 (en) * | 2009-10-26 | 2011-05-05 | Galderma Pharma S.A. | Methods of treating or preventing acute erythema |
| EP2329849B1 (en) | 2009-11-18 | 2015-04-29 | Galderma Research & Development | Combination of alpha-2 adrenergic receptor agonist and non-steroidal anti-inflammatory agent for treating or preventing an inflammatory skin disorder |
| US8394800B2 (en) * | 2009-11-19 | 2013-03-12 | Galderma Laboratories, L.P. | Method for treating psoriasis |
| KR20150058551A (ko) | 2010-03-26 | 2015-05-28 | 갈데르마 리써어치 앤드 디벨로프먼트 | 모세혈관 확장증의 안전하고 유효한 치료를 위한 개선된 방법 및 조성물 |
| US8513247B2 (en) * | 2010-03-26 | 2013-08-20 | Galderma Laboratories, L.P. | Methods and compositions for safe and effective treatment of erythema |
| US8501796B2 (en) * | 2010-09-16 | 2013-08-06 | Allergan, Inc. | Ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol for lowering intraocular pressure |
| US20120076738A1 (en) * | 2010-09-28 | 2012-03-29 | Michael Graeber | Combination treatment for dermatological conditions |
| US20120082625A1 (en) * | 2010-09-28 | 2012-04-05 | Michael Graeber | Combination treatment for rosacea |
| EP2605753A2 (en) * | 2010-10-21 | 2013-06-26 | Galderma S.A. | Topical gel composition |
| PH12013500738A1 (en) | 2010-10-21 | 2016-08-05 | Galderma Sa | Brimonidine gel compositions and methods of use |
| CN101972272B (zh) * | 2010-10-31 | 2012-07-04 | 无锡龙腾画材有限公司 | 一种二氧化氯皮肤凝胶及其制备方法 |
| KR20210080591A (ko) * | 2010-11-16 | 2021-06-30 | 알러간, 인코포레이티드 | (3-(1-(1h-이미다졸-4-일)에틸)-2-메틸페닐)메탄올을 포함하는 약제학적 조성물 |
| KR102058756B1 (ko) * | 2011-02-15 | 2020-01-22 | 어클라리스 쎄라퓨틱스, 인코포레이티드 | 주사비 징후들의 치료용 옥시메타졸린의 약학 크림 조성물들 |
| FR2977493B1 (fr) * | 2011-07-05 | 2014-02-14 | Galderma Res & Dev | Nouvelle composition anesthesique stable pour la reduction des reactions cutanees |
| MX2014004383A (es) * | 2011-10-19 | 2014-11-12 | Galderma Sa | Metodo para reducir el enrojecimiento facial asociado con el uso sistemico de inhibidores de fosfodiesterasa tipo 5. |
| US9283217B2 (en) | 2011-11-10 | 2016-03-15 | Allergan, Inc. | Pharmaceutical compositions comprising 7-(1 H-imidazol-4-ylmethyl)-5,6,7,8-tetrahydro-quinoline for treating skin diseases and conditions |
| UA109359C2 (xx) * | 2011-11-10 | 2015-08-10 | Лікування захворювань і станів шкіри 7-(1h-імідазол-4-ілметил)-5,6,7,8-тетрагідрохіноліном | |
| WO2013078151A1 (en) | 2011-11-21 | 2013-05-30 | Allergan, Inc. | Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3h-imidazole derivatives for treating retinal diseases |
| RU2015148910A (ru) * | 2013-05-06 | 2017-06-13 | Аллерган, Инк. | Альфа-адренергические агонисты для лечения повреждения тканей |
| JP2016525553A (ja) * | 2013-07-26 | 2016-08-25 | ガルデルマ・リサーチ・アンド・デヴェロップメント | 皮膚肥厚の治療法 |
| TWI709417B (zh) | 2013-10-07 | 2020-11-11 | 美商帝國製藥美國股份有限公司 | 使用右美托咪啶經皮組成物用於治療注意力不足過動症、焦慮及失眠的方法及組成物 |
| RU2648449C2 (ru) | 2013-10-07 | 2018-03-26 | ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. | Способы и композиции для трансдермальной доставки неседативного количества дексмедетомидина |
| RU2018105761A (ru) | 2013-10-07 | 2019-02-26 | ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. | Устройства для трансдермальной доставки дексмедетомидина и способы их применения |
| US9937117B2 (en) * | 2015-07-09 | 2018-04-10 | Galderma S.A. | Method of reducing hair loss associated with chemotherapy |
| JP2017052723A (ja) * | 2015-09-10 | 2017-03-16 | 株式会社Lttバイオファーマ | ドライアイ改善剤 |
| KR20210113439A (ko) | 2016-10-31 | 2021-09-15 | 테이코쿠 팔마 유에스에이, 인코포레이티드 | 덱스메데토미딘 경피 전달 장치를 이용한 통증을 관리하는 방법 |
| CN106727462B (zh) * | 2016-11-14 | 2019-04-09 | 四川省人民医院 | 一种治疗面部皮炎的药物及其应用 |
| JP2022516796A (ja) * | 2019-01-12 | 2022-03-02 | セリックス バイオ プライヴェート リミテッド | 選択的αアドレナリン受容体作用薬又は抗コリン作動薬及びリポ酸の組合せ物並びにその使用 |
| US20220218590A1 (en) * | 2019-05-14 | 2022-07-14 | Abend Fritz Ventures Llc | Compositions and methods for removal of skin adhesive patches, products, and residual adhesives |
| EP4203958A4 (en) * | 2020-08-26 | 2024-10-09 | Oticara, Inc. | COMPOSITIONS, DEVICES AND METHODS FOR TREATING NOSE, EAR AND OTHER TISSUE INFECTIONS AND/OR INFECTIONS |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4164570A (en) * | 1973-09-24 | 1979-08-14 | David Clough | Stabilized aqueous catecholamine solutions |
| US5442053A (en) * | 1982-09-28 | 1995-08-15 | Fidia, S.P.A. | Salts and mixtures of hyaluronic acid with pharmaceutically active substances, pharmaceutical compositions containing the same and methods for administration of such compositions |
| US5720962A (en) * | 1995-10-04 | 1998-02-24 | Au Pharmaceuticals, Inc. | Analgesic lotion for hemorrhoids and method of making such lotion |
| US6284765B1 (en) * | 2000-04-27 | 2001-09-04 | The University Of North Texas Health Science Center At Fort Worth | (+) naloxone and epinephrine combination therapy |
| US6441047B2 (en) * | 1995-11-17 | 2002-08-27 | Alcon Manufacturing Ltd.. | Combination therapy for treating glaucoma |
| US20020197300A1 (en) * | 1999-02-22 | 2002-12-26 | Schultz Clyde L. | Drug delivery system for anti-glaucomatous medication |
| WO2005010025A2 (en) * | 2003-07-23 | 2005-02-03 | Scherer Warren J | Methods of treating cutaneous flushing using selective alpha-2-adrenergic receptor agonists |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3278447A (en) | 1963-12-02 | 1966-10-11 | Cloro Bac Products Inc | Process for stabilizing chlorine dioxide solution |
| US4029792A (en) | 1972-02-29 | 1977-06-14 | Pfizer Inc. | (2-Imidazolin-2-ylamino) substituted -quinoxalines and -quinazolines as antihypertensive agents |
| BE795970A (fr) | 1972-02-29 | 1973-08-27 | Pfizer | Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant |
| US4285967A (en) * | 1978-06-30 | 1981-08-25 | Estee Lauder Inc. | Cosmetic preparation for reducing redness of blemishes |
| US4256763A (en) * | 1978-09-19 | 1981-03-17 | Mchugh John E | Treatment of herpes simplex infections and acne |
| US4908387A (en) * | 1988-06-06 | 1990-03-13 | The Regents Of The University Of California | Use of beta2 antagonists in the treatment of inflammatory diseases, in particular, rheumatoid arthritis |
| IL92351A (en) | 1988-11-29 | 1994-02-27 | Allergan Inc Irvine | Aqueous opthalmic solutions containing stabilized chlorine dioxide and an inorganic salt |
| IT1252692B (it) * | 1991-11-27 | 1995-06-23 | Zambon Spa | Composizione farmaceutica per uso oftalmico contenente un antiinfiammatorio non steroideo ed un decongestionante come principi attivi |
| US5736165A (en) | 1993-05-25 | 1998-04-07 | Allergan | In-the-eye use of chlorine dioxide-containing compositions |
| US6194415B1 (en) | 1995-06-28 | 2001-02-27 | Allergan Sales, Inc. | Method of using (2-imidazolin-2-ylamino) quinoxoalines in treating neural injury |
| US5910312A (en) * | 1996-10-09 | 1999-06-08 | Ideal Ideas, Inc. | Acne treatment composition with vasoconstrictor |
| US5916574A (en) * | 1996-10-09 | 1999-06-29 | Ideal Ideas, Inc. | Method of treating natural poison skin conditions |
| JPH1129482A (ja) * | 1997-05-14 | 1999-02-02 | Taisho Pharmaceut Co Ltd | 医薬組成物 |
| KR20010032435A (ko) * | 1997-11-24 | 2001-04-25 | 데이비드 엠 모이어 | 5-(2-이미다졸리닐아미노)벤즈이미다졸 유도체, 그의 제조및 대사 안정성이 개선된 알파-아드레날린수용체아고니스트로서의 그의 용도 |
| US6159944A (en) * | 1998-02-27 | 2000-12-12 | Synchroneuron, Llc | Method for treating painful conditions of the anal region and compositions therefor |
| IN185228B (enExample) | 1999-02-03 | 2000-12-09 | Bakulesh Mafatlal Dr Khamar | |
| US6468989B1 (en) | 2000-07-13 | 2002-10-22 | Dow Pharmaceutical Sciences | Gel compositions containing metronidazole |
| JP4927298B2 (ja) * | 2000-07-14 | 2012-05-09 | アラーガン、インコーポレイテッド | α−2−アドレナリンアゴニスト成分を含有する組成物 |
| US6387383B1 (en) | 2000-08-03 | 2002-05-14 | Dow Pharmaceutical Sciences | Topical low-viscosity gel composition |
| JP3520076B2 (ja) * | 2001-10-02 | 2004-04-19 | 憲司 中村 | 皮膚外用剤 |
| US20040266776A1 (en) | 2003-06-25 | 2004-12-30 | Gil Daniel W. | Methods of preventing and reducing the severity of stress-associated conditions |
| US7439241B2 (en) * | 2003-05-27 | 2008-10-21 | Galderma Laboratories, Inc. | Compounds, formulations, and methods for treating or preventing rosacea |
-
2005
- 2005-05-25 CN CNA2005800223827A patent/CN101426502A/zh active Pending
- 2005-05-25 KR KR1020067027124A patent/KR101257046B1/ko not_active Expired - Fee Related
- 2005-05-25 DK DK05754754.9T patent/DK1761266T3/da active
- 2005-05-25 ES ES12165557.5T patent/ES2647618T3/es not_active Expired - Lifetime
- 2005-05-25 AU AU2005247467A patent/AU2005247467B2/en not_active Ceased
- 2005-05-25 CA CA2824612A patent/CA2824612C/en not_active Expired - Fee Related
- 2005-05-25 CN CN201410590016.2A patent/CN104490884A/zh active Pending
- 2005-05-25 WO PCT/US2005/018288 patent/WO2005115395A2/en not_active Ceased
- 2005-05-25 BR BRPI0511519-1A patent/BRPI0511519A/pt not_active Application Discontinuation
- 2005-05-25 NZ NZ552325A patent/NZ552325A/en not_active IP Right Cessation
- 2005-05-25 PL PL05754754T patent/PL1761266T3/pl unknown
- 2005-05-25 EP EP05754754.9A patent/EP1761266B1/en not_active Expired - Lifetime
- 2005-05-25 ES ES05754754T patent/ES2424644T3/es not_active Expired - Lifetime
- 2005-05-25 CA CA2567401A patent/CA2567401C/en not_active Expired - Fee Related
- 2005-05-25 MX MXPA06013649A patent/MXPA06013649A/es not_active Application Discontinuation
- 2005-05-25 PT PT57547549T patent/PT1761266E/pt unknown
- 2005-05-25 JP JP2007515279A patent/JP4955543B2/ja not_active Expired - Fee Related
- 2005-05-25 EP EP12165557.5A patent/EP2481412B1/en not_active Expired - Lifetime
- 2005-05-25 SI SI200531745T patent/SI1761266T1/sl unknown
-
2011
- 2011-12-01 JP JP2011263425A patent/JP5547705B2/ja not_active Expired - Fee Related
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4164570A (en) * | 1973-09-24 | 1979-08-14 | David Clough | Stabilized aqueous catecholamine solutions |
| US5442053A (en) * | 1982-09-28 | 1995-08-15 | Fidia, S.P.A. | Salts and mixtures of hyaluronic acid with pharmaceutically active substances, pharmaceutical compositions containing the same and methods for administration of such compositions |
| US5720962A (en) * | 1995-10-04 | 1998-02-24 | Au Pharmaceuticals, Inc. | Analgesic lotion for hemorrhoids and method of making such lotion |
| US6441047B2 (en) * | 1995-11-17 | 2002-08-27 | Alcon Manufacturing Ltd.. | Combination therapy for treating glaucoma |
| US20020197300A1 (en) * | 1999-02-22 | 2002-12-26 | Schultz Clyde L. | Drug delivery system for anti-glaucomatous medication |
| US6284765B1 (en) * | 2000-04-27 | 2001-09-04 | The University Of North Texas Health Science Center At Fort Worth | (+) naloxone and epinephrine combination therapy |
| WO2005010025A2 (en) * | 2003-07-23 | 2005-02-03 | Scherer Warren J | Methods of treating cutaneous flushing using selective alpha-2-adrenergic receptor agonists |
Also Published As
| Publication number | Publication date |
|---|---|
| NZ552325A (en) | 2010-11-26 |
| CN101426502A (zh) | 2009-05-06 |
| WO2005115395A3 (en) | 2009-04-09 |
| CA2567401A1 (en) | 2005-12-08 |
| JP5547705B2 (ja) | 2014-07-16 |
| EP1761266A2 (en) | 2007-03-14 |
| PL1761266T3 (pl) | 2013-09-30 |
| DK1761266T3 (da) | 2013-08-05 |
| KR101257046B1 (ko) | 2013-04-22 |
| CA2567401C (en) | 2013-11-12 |
| JP2008500356A (ja) | 2008-01-10 |
| JP4955543B2 (ja) | 2012-06-20 |
| BRPI0511519A (pt) | 2007-12-26 |
| SI1761266T1 (sl) | 2013-08-30 |
| EP1761266B1 (en) | 2013-05-08 |
| MXPA06013649A (es) | 2007-07-09 |
| ES2424644T3 (es) | 2013-10-07 |
| WO2005115395A2 (en) | 2005-12-08 |
| EP2481412A1 (en) | 2012-08-01 |
| KR20070032716A (ko) | 2007-03-22 |
| AU2005247467A1 (en) | 2005-12-08 |
| PT1761266E (pt) | 2013-06-04 |
| EP2481412B1 (en) | 2017-09-27 |
| CN104490884A (zh) | 2015-04-08 |
| JP2012072176A (ja) | 2012-04-12 |
| EP1761266A4 (en) | 2009-11-11 |
| CA2824612A1 (en) | 2005-12-08 |
| CA2824612C (en) | 2016-08-16 |
| ES2647618T3 (es) | 2017-12-22 |
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