AU2004238139B2 - Immunostimulating Agents - Google Patents
Immunostimulating Agents Download PDFInfo
- Publication number
- AU2004238139B2 AU2004238139B2 AU2004238139A AU2004238139A AU2004238139B2 AU 2004238139 B2 AU2004238139 B2 AU 2004238139B2 AU 2004238139 A AU2004238139 A AU 2004238139A AU 2004238139 A AU2004238139 A AU 2004238139A AU 2004238139 B2 AU2004238139 B2 AU 2004238139B2
- Authority
- AU
- Australia
- Prior art keywords
- schizophyllan
- immunostimulating
- cpg dna
- cpg
- complex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
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- 239000003022 immunostimulating agent Substances 0.000 title claims description 40
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
Landscapes
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Inorganic Chemistry (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
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| JP2003136876 | 2003-05-15 | ||
| JP2003-136876 | 2003-05-15 | ||
| PCT/JP2004/006793 WO2004100965A1 (fr) | 2003-05-15 | 2004-05-13 | Immunostimulant |
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| JP (1) | JP4850512B2 (fr) |
| KR (1) | KR100872472B1 (fr) |
| CN (1) | CN1798563A (fr) |
| AU (1) | AU2004238139B2 (fr) |
| CA (1) | CA2527756C (fr) |
| WO (1) | WO2004100965A1 (fr) |
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| NO20014256D0 (no) | 2001-09-03 | 2001-09-03 | Bjoern Kristiansen | Fremstilling av immunstimulerende forbindelse |
| AU2004238139B2 (en) * | 2003-05-15 | 2009-12-03 | Mitsui Dm Sugar Co.,Ltd. | Immunostimulating Agents |
| EP1896600A2 (fr) | 2005-06-15 | 2008-03-12 | Medimush A/S | Polythérapie contre le cancer et kit de composants associé |
| PT2227248E (pt) * | 2007-11-26 | 2014-08-27 | Novartis Ag | Glucanos com adjuvante |
| WO2009068996A2 (fr) | 2007-11-26 | 2009-06-04 | Novartis Ag | Glucanes à liaison bêta-1,3 conjuguée |
| GB201003922D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Conjugation process |
| JPWO2012008465A1 (ja) * | 2010-07-16 | 2013-09-09 | ナパジェン ファーマ, インコーポレテッドNapaJen Pharma, Inc. | 核酸多糖複合体 |
| MX2016003668A (es) | 2013-09-20 | 2016-06-24 | Nat Inst Of Biomedical Innovation Health And Nutrition | Complejo que contiene oligonucleotido que tiene actividad potenciadora inmune, y uso del mismo. |
| CN105940012B (zh) * | 2014-02-06 | 2024-06-11 | 独立行政法人科学技术振兴机构 | 肽/β－1，3－葡聚糖复合体及其制造方法以及含有它的医药组合物 |
| JP6501247B2 (ja) * | 2014-12-16 | 2019-04-17 | 公立大学法人北九州市立大学 | 免疫賦活用ポリヌクレオチド／シゾフィラン複合体及びそれを含む医薬組成物 |
| CN106148266A (zh) * | 2015-04-20 | 2016-11-23 | 烟台赛泽生物技术有限公司 | 一种免疫细胞用培养基及该培养基的添加剂 |
| CN105462922A (zh) * | 2015-12-31 | 2016-04-06 | 广州赛莱拉干细胞科技股份有限公司 | 一种增加免疫细胞得率的方法 |
| WO2018174140A1 (fr) | 2017-03-23 | 2018-09-27 | ナパジェン ファーマ，インコーポレテッド | Inhibiteur d'activité d'adhésion de cellules cancéreuses |
| CN107126558B (zh) * | 2017-04-26 | 2020-06-23 | 广州渔跃生物技术有限公司 | 鸡传染性法氏囊病灭活疫苗及其制备方法 |
| CN108295049B (zh) * | 2018-02-12 | 2020-07-14 | 中山大学 | 一种负载抗原的水溶性胺化β-1,3-D-葡聚糖纳米粒子及其制备方法和应用 |
| CN108553479A (zh) * | 2018-04-03 | 2018-09-21 | 南京大学 | 阳离子修饰的琼脂糖和核酸药物组合物及制备方法和应用 |
| EP4025204A4 (fr) * | 2019-09-04 | 2023-10-11 | Axelia Oncology Pty Ltd | Immunothérapie anticancéreuse |
| WO2022102694A1 (fr) | 2020-11-12 | 2022-05-19 | 第一三共株式会社 | Complexe de bêta-glucane et d'acide nucléique ayant une taille de particule contrôlée |
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| WO1995004548A1 (fr) * | 1993-08-11 | 1995-02-16 | Jenner Technologies | Vaccins contre le cancer de la prostate |
| WO1996014873A2 (fr) * | 1994-11-16 | 1996-05-23 | Sri International | CONJUGUES DE β-GLUCANES LIES PAR COVALENCE UTILISES POUR UNE ADMINISTRATION CIBLEE |
| WO1998016247A1 (fr) * | 1996-10-11 | 1998-04-23 | The Regents Of The University Of California | Conjugues polynucleotide immunostimulateur/molecule immunomodulatrice |
| WO2001034207A1 (fr) * | 1999-11-10 | 2001-05-17 | Japan Science And Technology Corporation | Supports de genes |
| WO2002072152A1 (fr) * | 2001-03-13 | 2002-09-19 | Japan Science And Technology Corporation | Supports de gene mettant en oeuvre un polysaccharide et leur procede de production |
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| JPH04352724A (ja) * | 1990-07-27 | 1992-12-07 | Mitsui Toatsu Chem Inc | 免疫調節型治療剤 |
| EP0468520A3 (en) * | 1990-07-27 | 1992-07-01 | Mitsui Toatsu Chemicals, Inc. | Immunostimulatory remedies containing palindromic dna sequences |
| IL107150A0 (en) | 1992-09-29 | 1993-12-28 | Isis Pharmaceuticals Inc | Oligonucleotides having a conserved g4 core sequence |
| US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6239116B1 (en) * | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| WO1996002555A1 (fr) | 1994-07-15 | 1996-02-01 | The University Of Iowa Research Foundation | Oligonucleotides immunomodulateurs |
| US5780448A (en) | 1995-11-07 | 1998-07-14 | Ottawa Civic Hospital Loeb Research | DNA-based vaccination of fish |
| DK0914440T3 (da) * | 1996-04-19 | 2007-05-21 | Merial Ltd | Nukleinsyrevaccination mod parvovirusinfektioner |
| PL334197A1 (en) * | 1996-12-27 | 2000-02-14 | Icn Pharmaceuticals | Oligonucleotidic aptamers of high g content and methods of modulating immunilogical response |
| EP0855184A1 (fr) * | 1997-01-23 | 1998-07-29 | Grayson B. Dr. Lipford | Composition pharmaceutique comprenant un polynucléotide et un antigène notamment pour la vaccination |
| JP2001513776A (ja) * | 1997-02-28 | 2001-09-04 | ユニバーシティ オブ アイオワ リサーチ ファウンデーション | ＬＰＳ関連障害の処置における非メチル化ＣｐＧジヌクレオチドを含む核酸の使用 |
| US6406705B1 (en) * | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
| CA2291483C (fr) * | 1997-06-06 | 2012-09-18 | Dynavax Technologies Corporation | Oligonucleotides immunostimulateurs, compositions correspondantes et leurs procedes d'utilisation |
| US6589940B1 (en) * | 1997-06-06 | 2003-07-08 | Dynavax Technologies Corporation | Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof |
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| ES2284247T3 (es) * | 1998-04-03 | 2007-11-01 | University Of Iowa Research Foundation | Metodos y productos para estimular el sistema inmunitario usando oligonucleotidos y citoquinas inmunoterapeuticos. |
| AU3884199A (en) * | 1998-05-06 | 1999-11-23 | Ottawa Health Research Institute | Methods for the prevention and treatment of parasitic infections and related diseases using cpg oligonucleotides |
| JP2002514397A (ja) * | 1998-05-14 | 2002-05-21 | コーリー ファーマシューティカル ゲーエムベーハー | ＣｐＧオリゴヌクレオチドを用いる造血調節の方法 |
| US20010034330A1 (en) * | 1998-08-10 | 2001-10-25 | Charlotte Kensil | Innate immunity-stimulating compositions of CpG and saponin and methods thereof |
| US5962636A (en) * | 1998-08-12 | 1999-10-05 | Amgen Canada Inc. | Peptides capable of modulating inflammatory heart disease |
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- 2004-05-13 AU AU2004238139A patent/AU2004238139B2/en not_active Expired
- 2004-05-13 WO PCT/JP2004/006793 patent/WO2004100965A1/fr active Application Filing
- 2004-05-13 CN CNA2004800132950A patent/CN1798563A/zh active Pending
- 2004-05-13 CA CA2527756A patent/CA2527756C/fr not_active Expired - Fee Related
- 2004-05-13 EP EP04732786A patent/EP1625850B1/fr not_active Expired - Lifetime
- 2004-05-13 KR KR1020057021797A patent/KR100872472B1/ko active IP Right Grant
- 2004-05-13 JP JP2005506241A patent/JP4850512B2/ja not_active Expired - Lifetime
- 2004-05-13 US US10/557,108 patent/US7790189B2/en active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| KR20060012005A (ko) | 2006-02-06 |
| EP1625850A4 (fr) | 2008-12-24 |
| CA2527756A1 (fr) | 2004-11-25 |
| US20080262210A1 (en) | 2008-10-23 |
| JP4850512B2 (ja) | 2012-01-11 |
| CA2527756C (fr) | 2014-05-06 |
| EP1625850A1 (fr) | 2006-02-15 |
| WO2004100965A1 (fr) | 2004-11-25 |
| JPWO2004100965A1 (ja) | 2006-07-13 |
| KR100872472B1 (ko) | 2008-12-05 |
| EP1625850B1 (fr) | 2012-02-29 |
| CN1798563A (zh) | 2006-07-05 |
| AU2004238139A1 (en) | 2004-11-25 |
| US7790189B2 (en) | 2010-09-07 |
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