AU2004226280B2 - Method for the production of pyrrolidine-1,2-dicarboxylic acid-1-(phenyl(-amide))-2-(phenyl(-amide)) derivatives and 1-(phenylcarbamoyl)-pyrrolidine-2-carboxylic acid derivatives as intermediate products - Google Patents

Method for the production of pyrrolidine-1,2-dicarboxylic acid-1-(phenyl(-amide))-2-(phenyl(-amide)) derivatives and 1-(phenylcarbamoyl)-pyrrolidine-2-carboxylic acid derivatives as intermediate products Download PDF

Info

Publication number
AU2004226280B2
AU2004226280B2 AU2004226280A AU2004226280A AU2004226280B2 AU 2004226280 B2 AU2004226280 B2 AU 2004226280B2 AU 2004226280 A AU2004226280 A AU 2004226280A AU 2004226280 A AU2004226280 A AU 2004226280A AU 2004226280 B2 AU2004226280 B2 AU 2004226280B2
Authority
AU
Australia
Prior art keywords
formula
oxomorpholin
phenyl
dicarboxamide
oxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2004226280A
Other languages
English (en)
Other versions
AU2004226280A1 (en
Inventor
Bertram Cezanne
Dieter Dorsch
Johannes Gleitz
Werner Mederski
Christos Tsaklakidis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10315377A external-priority patent/DE10315377A1/de
Priority claimed from DE10327428A external-priority patent/DE10327428A1/de
Priority claimed from DE2003129295 external-priority patent/DE10329295A1/de
Priority claimed from DE2003134174 external-priority patent/DE10334174A1/de
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of AU2004226280A1 publication Critical patent/AU2004226280A1/en
Application granted granted Critical
Publication of AU2004226280B2 publication Critical patent/AU2004226280B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AU2004226280A 2003-04-03 2004-03-09 Method for the production of pyrrolidine-1,2-dicarboxylic acid-1-(phenyl(-amide))-2-(phenyl(-amide)) derivatives and 1-(phenylcarbamoyl)-pyrrolidine-2-carboxylic acid derivatives as intermediate products Ceased AU2004226280B2 (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
DE10315377.2 2003-04-03
DE10315377A DE10315377A1 (de) 2003-04-03 2003-04-03 Carbonylverbindungen
DE10327428.6 2003-06-18
DE10327428A DE10327428A1 (de) 2003-06-18 2003-06-18 Ethinylprolinderivate
DE10329295.0 2003-06-30
DE2003129295 DE10329295A1 (de) 2003-06-30 2003-06-30 Carbonylverbindungen
DE10329457.0 2003-07-01
DE10329457A DE10329457A1 (de) 2003-04-03 2003-07-01 Ethinylprolinderivate
DE10334174.9 2003-07-26
DE2003134174 DE10334174A1 (de) 2003-07-26 2003-07-26 Pyrrolidinderivate und Verfahren zur Herstellung
PCT/EP2004/002405 WO2004087695A1 (de) 2003-04-03 2004-03-09 Verfahren zur herstellung von pyrrolidin-1,2-dicarbonsäure-1-(phenyl(-amid))-2-(phenyl(-amid)) derivaten und 1-(phenylcarbamoyl)-pyrrolidin-2-carbonsäure derivate als zwischenprodukte

Publications (2)

Publication Number Publication Date
AU2004226280A1 AU2004226280A1 (en) 2004-10-14
AU2004226280B2 true AU2004226280B2 (en) 2010-06-17

Family

ID=33136213

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2004226280A Ceased AU2004226280B2 (en) 2003-04-03 2004-03-09 Method for the production of pyrrolidine-1,2-dicarboxylic acid-1-(phenyl(-amide))-2-(phenyl(-amide)) derivatives and 1-(phenylcarbamoyl)-pyrrolidine-2-carboxylic acid derivatives as intermediate products

Country Status (16)

Country Link
US (1) US7504500B2 (cg-RX-API-DMAC7.html)
EP (1) EP1608646B1 (cg-RX-API-DMAC7.html)
JP (1) JP4634369B2 (cg-RX-API-DMAC7.html)
KR (1) KR20050118709A (cg-RX-API-DMAC7.html)
AR (1) AR043831A1 (cg-RX-API-DMAC7.html)
AT (1) ATE366732T1 (cg-RX-API-DMAC7.html)
AU (1) AU2004226280B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0408888A (cg-RX-API-DMAC7.html)
CA (1) CA2520893C (cg-RX-API-DMAC7.html)
DE (2) DE10329457A1 (cg-RX-API-DMAC7.html)
ES (1) ES2287708T3 (cg-RX-API-DMAC7.html)
MX (1) MXPA05010433A (cg-RX-API-DMAC7.html)
PE (1) PE20050395A1 (cg-RX-API-DMAC7.html)
PL (1) PL377138A1 (cg-RX-API-DMAC7.html)
TW (1) TW200500339A (cg-RX-API-DMAC7.html)
WO (1) WO2004087695A1 (cg-RX-API-DMAC7.html)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050119266A1 (en) * 2003-10-01 2005-06-02 Yan Shi Pyrrolidine and piperidine derivatives as factor Xa inhibitors
DE102004004731A1 (de) * 2004-01-30 2005-08-18 Merck Patent Gmbh Harnstoffderivate
DE102004045796A1 (de) * 2004-09-22 2006-03-23 Merck Patent Gmbh Arzneimittel enthaltend Carbonylverbindungen sowie deren Verwendung
DE102004047254A1 (de) * 2004-09-29 2006-04-13 Merck Patent Gmbh Carbonylverbindungen
DE102004050283A1 (de) * 2004-10-15 2006-04-27 Lanxess Deutschland Gmbh 4-Aminophenyl-morpholinon-Derivate und deren Herstellung
US7301817B2 (en) 2005-10-27 2007-11-27 Sandisk Corporation Method for programming of multi-state non-volatile memory using smart verify
US7601752B2 (en) * 2005-11-16 2009-10-13 Hoffmann-La Roche Inc. Pyrrolidine derivatives
EP1818330A1 (de) * 2006-02-14 2007-08-15 Boehringer Ingelheim Pharma GmbH & Co.KG Substituierte Prolinamide, deren Herstellung und deren Verwendung als Arzneimittel
PL2051975T3 (pl) * 2006-05-16 2013-01-31 Boehringer Ingelheim Int Podstawione prolinamidy, ich wytwarzanie oraz ich zastosowanie jako środków leczniczych
US8673920B2 (en) * 2009-05-06 2014-03-18 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2632465B1 (en) 2010-10-27 2015-12-30 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2012058134A1 (en) 2010-10-29 2012-05-03 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
ES2605164T3 (es) 2011-08-19 2017-03-13 Merck Sharp & Dohme Corp. Inhibidores del canal de potasio de la médula renal externa
WO2013039802A1 (en) 2011-09-16 2013-03-21 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2771004B1 (en) 2011-10-25 2016-05-18 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2771005B1 (en) 2011-10-25 2016-05-18 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2773199B1 (en) 2011-10-31 2019-04-10 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9108947B2 (en) 2011-10-31 2015-08-18 Merck Sharp & Dohme Corp. Inhibitors of the Renal Outer Medullary Potassium channel
US9493474B2 (en) 2011-10-31 2016-11-15 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9206199B2 (en) 2011-12-16 2015-12-08 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
AR092031A1 (es) 2012-07-26 2015-03-18 Merck Sharp & Dohme Inhibidores del canal de potasio medular externo renal
WO2014085210A1 (en) 2012-11-29 2014-06-05 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
WO2014099633A2 (en) 2012-12-19 2014-06-26 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
EP2956142B1 (en) 2013-02-18 2017-09-20 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9765074B2 (en) 2013-03-15 2017-09-19 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9751881B2 (en) 2013-07-31 2017-09-05 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel
US9951052B2 (en) 2013-10-31 2018-04-24 Merck Sharp & Dohme Corp. Inhibitors of the renal outer medullary potassium channel

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4217130A (en) * 1977-10-29 1980-08-12 Kyowa Hakko Kogyo Co., Ltd. Agents for and method of modifying citrus fruit
JPS63232846A (ja) * 1987-03-20 1988-09-28 Haruo Ogura 新規な固定相担体

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998022432A1 (en) * 1996-11-18 1998-05-28 Yamanouchi Pharmaceutical Co., Ltd. Novel acylamino-substituted acylanilide derivatives or pharmaceutical composition comprising the same
US7030141B2 (en) * 2001-11-29 2006-04-18 Christopher Franklin Bigge Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4217130A (en) * 1977-10-29 1980-08-12 Kyowa Hakko Kogyo Co., Ltd. Agents for and method of modifying citrus fruit
JPS63232846A (ja) * 1987-03-20 1988-09-28 Haruo Ogura 新規な固定相担体

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
& JP 63232846 A2 28 September 1988 *
Chemical Abstracts Accesssion No. 1989:595406 *

Also Published As

Publication number Publication date
AU2004226280A1 (en) 2004-10-14
CA2520893A1 (en) 2004-10-14
CA2520893C (en) 2012-07-10
TW200500339A (en) 2005-01-01
US20060211692A1 (en) 2006-09-21
ATE366732T1 (de) 2007-08-15
PL377138A1 (pl) 2006-01-23
KR20050118709A (ko) 2005-12-19
US7504500B2 (en) 2009-03-17
PE20050395A1 (es) 2005-06-04
AR043831A1 (es) 2005-08-17
JP4634369B2 (ja) 2011-02-16
EP1608646B1 (de) 2007-07-11
DE502004004294D1 (de) 2007-08-23
MXPA05010433A (es) 2005-11-04
ES2287708T3 (es) 2007-12-16
WO2004087695A1 (de) 2004-10-14
JP2006522037A (ja) 2006-09-28
DE10329457A1 (de) 2005-01-20
BRPI0408888A (pt) 2006-04-11
EP1608646A1 (de) 2005-12-28

Similar Documents

Publication Publication Date Title
CA2520893C (en) Process for the preparation of 1-n-(phenyl)-2-n-(phenyl)pyrrolidine-1,2-dicarboxamide derivatives and 1-(phenylcarbamoyl)pyrrolidine-2-carboxylic acid derivatives as intermediates
AU2004296553B2 (en) DPP-IV inhibitors
CA2520894C (en) Pyrazolidine-1,2-dicarboxyldiphenylamide derivatives as coagulation factor xa inhibitors for the treatment of thromboses
CA2771601A1 (en) Morpholinone compounds as factor ixa inhibitors
EP3199536B1 (en) Preparation method for benzoxazoleoxazine ketone compound and intermediate and crystal form thereof
KR101522119B1 (ko) 카텝신 억제제로서 사용되는 피롤리딘 유도체
CN1771248A (zh) 制备 1 － n －苯基 － 2 － n －苯基吡咯烷 － 1 , 2 －二甲酰胺衍生物以及作为中间体的 1 －苯基氨基甲酰基吡咯烷－ 2 －羧酸衍生物的方法
AU2006314637A1 (en) Novel pyrrolidine derivatives as inhibitors of coagulation factor Xa
WO2008140220A1 (en) Fxa inhibitors with cyclic amidines as p4 subunit, processes for their preparations, and pharmaceutical compositions and derivatives thereof
NO338531B1 (no) Pyrrolidin-3,4-dikarboksamidderivater, farmasøytisk preparat omfattende slike forbindelser, slike forbindelser for anvendelse som terapeutiske substanser samt anvendelse av slike forbindelser for behandling og eller forebyggelse av sykdommer
US5244910A (en) Renin inhibitors
US6774243B2 (en) Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates
US6355807B1 (en) Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates
EP1760081A1 (de) Verfahren zur Herstellung von Pyrrolidin-1,2-dicarbonsäure-1-(phenyl(-amid))-2-(phenyl(-amid))Derivaten und 1-(Phenylcarbamoyl)-pyrrolidin-2-carbonsäure Derivaten als Zwischenprodukte
CA2485065A1 (en) Semicarbazide derivatives for combating thromboembolic diseases
WO1992003429A1 (en) Renin inhibitors
AU653959B2 (en) Renin inhibitors
AU2005229666A1 (en) Nitrogen-containing 5-membered ring compound

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired