AU2004215133B2 - Nucleic acid molecules, polypeptides, antibodies and compositions containing same useful for treating and detecting influenza virus infection - Google Patents
Nucleic acid molecules, polypeptides, antibodies and compositions containing same useful for treating and detecting influenza virus infection Download PDFInfo
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- AU2004215133B2 AU2004215133B2 AU2004215133A AU2004215133A AU2004215133B2 AU 2004215133 B2 AU2004215133 B2 AU 2004215133B2 AU 2004215133 A AU2004215133 A AU 2004215133A AU 2004215133 A AU2004215133 A AU 2004215133A AU 2004215133 B2 AU2004215133 B2 AU 2004215133B2
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- nucleic acid
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- influenza virus
- influenza
- polypeptide
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Landscapes
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| US44986303P | 2003-02-27 | 2003-02-27 | |
| US60/449,863 | 2003-02-27 | ||
| PCT/IL2004/000182 WO2004076621A2 (en) | 2003-02-27 | 2004-02-24 | Compositions of nucleic acids for treating and detecting influenza virus |
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| AU2004215133A1 AU2004215133A1 (en) | 2004-09-10 |
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Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101130181B1 (ko) | 2003-02-27 | 2012-03-28 | 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 | 인플루엔자 바이러스 감염의 치료 및 검출에 유용한 핵산분자, 폴리펩티드, 항체 및 이를 포함하는 조성물 |
| US7494776B2 (en) * | 2005-07-07 | 2009-02-24 | Beckman Coulter, Inc. | Labeled complementary oligonucleotides to detect oligonucleotide-linked ligands |
| US9862770B2 (en) * | 2005-10-19 | 2018-01-09 | Ibc Pharmaceuticals, Inc. | Multivalent antibody complexes targeting IGF-1R show potent toxicity against solid tumors |
| US20070224205A1 (en) | 2006-03-07 | 2007-09-27 | Powell Thomas J | Compositions that include hemagglutinin, methods of making and methods of use thereof |
| EP1843158A1 (de) * | 2006-04-05 | 2007-10-10 | Micronas Holding GmbH | Nachweissystem für Krankheitserreger |
| AU2008206077A1 (en) * | 2007-01-19 | 2008-07-24 | Kai Pharmaceuticals, Inc. | Modifications of peptide compositions to increase stability and delivery efficiency |
| GB0702183D0 (en) * | 2007-02-05 | 2007-03-14 | Iti Scotland Ltd | Pathogen binding |
| WO2009096581A1 (ja) * | 2008-02-01 | 2009-08-06 | Kunihiro Kaihatsu | 膜融合阻害剤 |
| JP2011519828A (ja) | 2008-04-18 | 2011-07-14 | バクシネート コーポレーション | フラジェリンの欠失変異体と使用方法 |
| KR101034490B1 (ko) | 2009-06-23 | 2011-05-17 | 한밭대학교 산학협력단 | 생체 안전성이 뛰어난 인플루엔자 바이러스 백신용 항원성 에피토프로서의 재조합 헤마글루티닌 단백질 |
| WO2010150982A2 (ko) * | 2009-06-23 | 2010-12-29 | 한밭대학교 산학협력단 | 안전성이 뛰어난 인플루엔자 바이러스 백신용 재조합 헤마글루티닌 단백질 및 이를 함유하는 생분해성 plga 미립자의 제조 방법 |
| JP5279054B2 (ja) | 2009-07-31 | 2013-09-04 | 国立大学法人大阪大学 | 抗菌剤 |
| CN102770456B (zh) * | 2009-12-04 | 2018-04-06 | 弗·哈夫曼-拉罗切有限公司 | 多特异性抗体、抗体类似物、组合物和方法 |
| JP5996837B2 (ja) * | 2010-05-28 | 2016-09-21 | 小林製薬株式会社 | インフルエンザウイルスの感染抑制剤 |
| JP5717127B2 (ja) * | 2010-11-15 | 2015-05-13 | 独立行政法人産業技術総合研究所 | 新型インフルエンザウイルスのヘマグルチニンに結合するアプタマー |
| US20130064811A1 (en) * | 2011-09-09 | 2013-03-14 | International Business Machines Corporation | Methods to Enhance Cancer Treatment |
| US9220775B2 (en) | 2011-11-23 | 2015-12-29 | Medimmune Llc | Binding molecules specific for HER3 and uses thereof |
| US9969794B2 (en) | 2012-05-10 | 2018-05-15 | Visterra, Inc. | HA binding agents |
| US20150167106A1 (en) * | 2012-06-04 | 2015-06-18 | Nec Solution Innovators, Ltd. | Nucleic acid molecule that binds to influenza viruses and use thereof |
| US8932598B2 (en) | 2012-08-28 | 2015-01-13 | Vaxinnate Corporation | Fusion proteins and methods of use |
| CN104968364A (zh) * | 2012-12-03 | 2015-10-07 | 百时美施贵宝公司 | 强化免疫调变性Fc融合蛋白的抗癌活性 |
| AU2014220705C1 (en) * | 2013-02-22 | 2018-10-18 | Wilex Ag | CAIX stratification based cancer treatment |
| GB201303576D0 (en) * | 2013-02-28 | 2013-04-10 | Singapore Volition Pte Ltd | Method for predicting therapy efficacy using nucleosome structure biomarkers |
| EP2784510A1 (en) * | 2013-03-25 | 2014-10-01 | Universität Zu Köln | Methods of diagnosing and differentiating oncocytoma and malignant renal carcinoma as well as products and uses relating thereto |
| CN104436157A (zh) | 2013-09-23 | 2015-03-25 | 恩金生物有限公司 | 流感疫苗和治疗 |
| US10080792B2 (en) | 2013-09-23 | 2018-09-25 | Engen Bio, Inc. | Influenza vaccine and therapy |
| WO2015048008A2 (en) * | 2013-09-24 | 2015-04-02 | Medimmune, Llc | Binding molecules specific for her3 and uses thereof |
| US10745490B2 (en) | 2014-04-11 | 2020-08-18 | Celldex Therapeutics, Inc. | Anti-ErbB antibodies and methods of use thereof |
| US9903871B2 (en) * | 2014-07-15 | 2018-02-27 | Temple University Of The Commonwealth System Of Higher Education | Stabilized peptide fragments from nucleoredoxin X1 and uses thereof |
| GB201419976D0 (en) * | 2014-11-10 | 2014-12-24 | Univ Newcastle | Biomarkers for disease progression in melanoma |
| RU2017120388A (ru) * | 2014-11-14 | 2018-12-14 | Дженентек, Инк. | Прогнозирование ответа на антагонист vegf |
| NZ732073A (en) * | 2014-12-08 | 2019-04-26 | 1Globe Biomedical Co Ltd | Soluble universal adcc-enhancing synthetic fusion gene and peptide technology and its use thereof |
| JP2018516230A (ja) * | 2015-03-18 | 2018-06-21 | ザ・ジョンズ・ホプキンス・ユニバーシティ | カリウムチャネルkcnk9を標的とする新規モノクローナル抗体阻害剤 |
| US10513553B2 (en) | 2015-11-13 | 2019-12-24 | Visterra, Inc. | Compositions and methods for treating and preventing influenza |
| CA3015347A1 (en) | 2016-02-24 | 2017-08-31 | Visterra, Inc. | Formulations of antibody molecules to influenza virus |
| KR101796277B1 (ko) * | 2016-04-12 | 2017-11-13 | 앱클론(주) | 안정성이 개선된 her2에 특이적으로 결합하는 항체 |
| US20210247395A1 (en) * | 2018-06-11 | 2021-08-12 | Glaxosmithkline Consumer Healthcare Holdings (Us) Llc | Antibody pairs for use in a rapid influenza b diagnostic test |
| KR20200060969A (ko) * | 2018-11-23 | 2020-06-02 | (주)셀트리온 | 인플루엔자 바이러스 질환을 치료하기 위한 투여 요법 |
| LU101073B1 (en) * | 2018-12-21 | 2020-06-24 | Luxembourg Inst Science & Tech List | Dna aptamers specific of adenovirus types |
| JP2022521819A (ja) | 2019-03-25 | 2022-04-12 | ビステラ, インコーポレイテッド | インフルエンザを処置および予防するための組成物および方法 |
| KR102393872B1 (ko) * | 2019-08-28 | 2022-05-04 | 엠브릭스 주식회사 | 바이러스 외피를 손상시키는 m2 단백질 유래 항바이러스 펩타이드 및 그의 용도 |
| WO2022229350A2 (en) | 2021-04-30 | 2022-11-03 | Tirmed Pharma Ab | Single-stranded oligonucleotides for use in the medical treatment and/or prophylaxis of virus infections |
| CN113773401B (zh) * | 2021-09-15 | 2023-06-20 | 宜明昂科生物医药技术(上海)股份有限公司 | 靶向cd47和pd-l1的重组融合蛋白及其制备和用途 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992014843A1 (en) * | 1991-02-21 | 1992-09-03 | Gilead Sciences, Inc. | Aptamer specific for biomolecules and method of making |
| US6369208B1 (en) * | 1995-06-07 | 2002-04-09 | Merck & Co., Inc. | Capped synthetic RNA, analogs, and aptamers |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5405938A (en) | 1989-12-20 | 1995-04-11 | Anti-Gene Development Group | Sequence-specific binding polymers for duplex nucleic acids |
| US5166315A (en) | 1989-12-20 | 1992-11-24 | Anti-Gene Development Group | Sequence-specific binding polymers for duplex nucleic acids |
| US5185444A (en) | 1985-03-15 | 1993-02-09 | Anti-Gene Deveopment Group | Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5235033A (en) | 1985-03-15 | 1993-08-10 | Anti-Gene Development Group | Alpha-morpholino ribonucleoside derivatives and polymers thereof |
| JP2534529B2 (ja) * | 1986-07-24 | 1996-09-18 | ブリティシュ・テレコミュニケ−ションズ・パブリック・リミテッド・カンパニ | 放射発生器 |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5216141A (en) | 1988-06-06 | 1993-06-01 | Benner Steven A | Oligonucleotide analogs containing sulfur linkages |
| US5264562A (en) | 1989-10-24 | 1993-11-23 | Gilead Sciences, Inc. | Oligonucleotide analogs with novel linkages |
| US5264564A (en) | 1989-10-24 | 1993-11-23 | Gilead Sciences | Oligonucleotide analogs with novel linkages |
| US5470967A (en) | 1990-04-10 | 1995-11-28 | The Dupont Merck Pharmaceutical Company | Oligonucleotide analogs with sulfamate linkages |
| US5618704A (en) | 1990-07-27 | 1997-04-08 | Isis Pharmacueticals, Inc. | Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling |
| US5489677A (en) | 1990-07-27 | 1996-02-06 | Isis Pharmaceuticals, Inc. | Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms |
| US5541307A (en) | 1990-07-27 | 1996-07-30 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogs and solid phase synthesis thereof |
| US5623070A (en) | 1990-07-27 | 1997-04-22 | Isis Pharmaceuticals, Inc. | Heteroatomic oligonucleoside linkages |
| US5608046A (en) | 1990-07-27 | 1997-03-04 | Isis Pharmaceuticals, Inc. | Conjugated 4'-desmethyl nucleoside analog compounds |
| US5610289A (en) | 1990-07-27 | 1997-03-11 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogues |
| US5602240A (en) | 1990-07-27 | 1997-02-11 | Ciba Geigy Ag. | Backbone modified oligonucleotide analogs |
| US5677437A (en) | 1990-07-27 | 1997-10-14 | Isis Pharmaceuticals, Inc. | Heteroatomic oligonucleoside linkages |
| PT98562B (pt) | 1990-08-03 | 1999-01-29 | Sanofi Sa | Processo para a preparacao de composicoes que compreendem sequencias de nucleo-sidos com cerca de 6 a cerca de 200 bases resistentes a nucleases |
| US5214134A (en) | 1990-09-12 | 1993-05-25 | Sterling Winthrop Inc. | Process of linking nucleosides with a siloxane bridge |
| US5561225A (en) | 1990-09-19 | 1996-10-01 | Southern Research Institute | Polynucleotide analogs containing sulfonate and sulfonamide internucleoside linkages |
| JPH06505704A (ja) | 1990-09-20 | 1994-06-30 | ギリアド サイエンシズ,インコーポレイテッド | 改変ヌクレオシド間結合 |
| US5633360A (en) | 1992-04-14 | 1997-05-27 | Gilead Sciences, Inc. | Oligonucleotide analogs capable of passive cell membrane permeation |
| US5434257A (en) | 1992-06-01 | 1995-07-18 | Gilead Sciences, Inc. | Binding compentent oligomers containing unsaturated 3',5' and 2',5' linkages |
| US5756291A (en) | 1992-08-21 | 1998-05-26 | Gilead Sciences, Inc. | Aptamers specific for biomolecules and methods of making |
| GB9304618D0 (en) | 1993-03-06 | 1993-04-21 | Ciba Geigy Ag | Chemical compounds |
| HU9501974D0 (en) | 1993-03-31 | 1995-09-28 | Sterling Winthrop Inc | Oligonucleotides with amide linkages replacing phosphodiester linkages |
| US5807718A (en) | 1994-12-02 | 1998-09-15 | The Scripps Research Institute | Enzymatic DNA molecules |
| WO1997003085A1 (en) * | 1995-07-11 | 1997-01-30 | Nexstar Pharmaceuticals, Inc. | Intracellular action of nucleic acid ligands |
| KR101130181B1 (ko) * | 2003-02-27 | 2012-03-28 | 예다 리서치 앤드 디벨럽먼트 캄파니 리미티드 | 인플루엔자 바이러스 감염의 치료 및 검출에 유용한 핵산분자, 폴리펩티드, 항체 및 이를 포함하는 조성물 |
-
2004
- 2004-02-24 KR KR1020057016045A patent/KR101130181B1/ko not_active Expired - Fee Related
- 2004-02-24 JP JP2006502644A patent/JP2006525796A/ja active Pending
- 2004-02-24 WO PCT/IL2004/000182 patent/WO2004076621A2/en not_active Ceased
- 2004-02-24 CA CA 2517074 patent/CA2517074A1/en not_active Abandoned
- 2004-02-24 US US10/546,034 patent/US7786279B2/en not_active Expired - Fee Related
- 2004-02-24 AU AU2004215133A patent/AU2004215133B2/en not_active Ceased
- 2004-02-24 EP EP04713970.4A patent/EP1597350B1/en not_active Expired - Lifetime
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2009
- 2009-09-18 US US12/585,600 patent/US8357789B2/en not_active Expired - Fee Related
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- 2010-08-12 JP JP2010180666A patent/JP2010279385A/ja active Pending
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992014843A1 (en) * | 1991-02-21 | 1992-09-03 | Gilead Sciences, Inc. | Aptamer specific for biomolecules and method of making |
| US6369208B1 (en) * | 1995-06-07 | 2002-04-09 | Merck & Co., Inc. | Capped synthetic RNA, analogs, and aptamers |
Non-Patent Citations (1)
| Title |
|---|
| Lee, M. T. et al. Nucleic Acids Research, Vol. 30, No. 2, pages 429-438 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1597350A4 (en) | 2010-03-24 |
| JP2010279385A (ja) | 2010-12-16 |
| US20100021489A1 (en) | 2010-01-28 |
| US20130079390A1 (en) | 2013-03-28 |
| WO2004076621A2 (en) | 2004-09-10 |
| EP1597350A2 (en) | 2005-11-23 |
| WO2004076621A3 (en) | 2006-04-06 |
| US9029526B2 (en) | 2015-05-12 |
| US7786279B2 (en) | 2010-08-31 |
| JP2006525796A (ja) | 2006-11-16 |
| AU2004215133A1 (en) | 2004-09-10 |
| CA2517074A1 (en) | 2004-09-10 |
| US20070059806A1 (en) | 2007-03-15 |
| US8357789B2 (en) | 2013-01-22 |
| KR20050111336A (ko) | 2005-11-24 |
| KR101130181B1 (ko) | 2012-03-28 |
| EP1597350B1 (en) | 2015-04-08 |
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