AU2003291337B2 - Trans-9,10-dehydroepothilone C and D, analogs thereof and methos of making the same - Google Patents
Trans-9,10-dehydroepothilone C and D, analogs thereof and methos of making the same Download PDFInfo
- Publication number
- AU2003291337B2 AU2003291337B2 AU2003291337A AU2003291337A AU2003291337B2 AU 2003291337 B2 AU2003291337 B2 AU 2003291337B2 AU 2003291337 A AU2003291337 A AU 2003291337A AU 2003291337 A AU2003291337 A AU 2003291337A AU 2003291337 B2 AU2003291337 B2 AU 2003291337B2
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- Australia
- Prior art keywords
- compound
- dehydroepothilone
- epothilone
- oxo
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- XOZIUKBZLSUILX-GIQCAXHBSA-N epothilone D Chemical compound O1C(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@@H](O)[C@@H](C)CCC\C(C)=C/C[C@H]1C(\C)=C\C1=CSC(C)=N1 XOZIUKBZLSUILX-GIQCAXHBSA-N 0.000 description 27
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- 238000003786 synthesis reaction Methods 0.000 description 24
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- WRIKHQLVHPKCJU-UHFFFAOYSA-N sodium bis(trimethylsilyl)amide Chemical compound C[Si](C)(C)N([Na])[Si](C)(C)C WRIKHQLVHPKCJU-UHFFFAOYSA-N 0.000 description 23
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Classifications
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Reproductive Health (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42535202P | 2002-11-07 | 2002-11-07 | |
| US60/425,352 | 2002-11-07 | ||
| US47374303P | 2003-05-27 | 2003-05-27 | |
| US60/473,743 | 2003-05-27 | ||
| PCT/US2003/035411 WO2004043954A2 (en) | 2002-11-07 | 2003-11-07 | Trans-9,10-dehydroepothilone c and d, analogs thereof and methos of making the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2003291337A1 AU2003291337A1 (en) | 2004-06-03 |
| AU2003291337B2 true AU2003291337B2 (en) | 2010-09-09 |
Family
ID=32314587
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003291337A Ceased AU2003291337B2 (en) | 2002-11-07 | 2003-11-07 | Trans-9,10-dehydroepothilone C and D, analogs thereof and methos of making the same |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20040152708A1 (OSRAM) |
| EP (3) | EP2135868A1 (OSRAM) |
| JP (3) | JP4641941B2 (OSRAM) |
| KR (2) | KR100996996B1 (OSRAM) |
| AT (1) | ATE452888T1 (OSRAM) |
| AU (1) | AU2003291337B2 (OSRAM) |
| CA (1) | CA2505368C (OSRAM) |
| CY (1) | CY1110295T1 (OSRAM) |
| DE (1) | DE60330703D1 (OSRAM) |
| DK (1) | DK1562941T3 (OSRAM) |
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| SI (1) | SI1562941T1 (OSRAM) |
| WO (1) | WO2004043954A2 (OSRAM) |
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| US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US7384964B2 (en) * | 2002-08-23 | 2008-06-10 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| CN101088998A (zh) * | 2002-11-07 | 2007-12-19 | 科桑生物科学公司 | 反式－9,10－脱氢埃坡霉素c和d,其类似物以及制备这些化合物的方法 |
| KR100996996B1 (ko) * | 2002-11-07 | 2010-11-25 | 코산 바이오사이언시즈, 인코포레이티드 | 트랜스-9,10-디히드로에포틸론 ｃ 및 ｄ, 그것의 유사체 및 그것의 제조 방법 |
| RU2005133199A (ru) * | 2003-03-28 | 2006-02-10 | Козан Байосайенсиз, Инк. (Us) | Устройства, способы и композиции для предупреждения рестеноза |
| WO2005034964A1 (en) * | 2003-10-09 | 2005-04-21 | Kosan Biosciences, Inc. | Therapeutic formulations |
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| US7981998B2 (en) * | 2006-12-14 | 2011-07-19 | Aileron Therapeutics, Inc. | Bis-sulfhydryl macrocyclization systems |
| CN105061577A (zh) * | 2006-12-14 | 2015-11-18 | 爱勒让治疗公司 | 双巯基大环化系统 |
| PT2118123E (pt) | 2007-01-31 | 2016-02-10 | Harvard College | Péptidos de p53 estabilizados e suas utilizações |
| CN109627287A (zh) * | 2007-02-23 | 2019-04-16 | 爱勒让治疗公司 | 三唑大环系统 |
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| EP2376100B1 (en) | 2009-01-14 | 2017-10-25 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
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| MX355543B (es) | 2010-08-13 | 2018-04-20 | Aileron Therapeutics Inc Star | Macrociclos peptidomiméticos. |
| TWI643868B (zh) | 2011-10-18 | 2018-12-11 | 艾利倫治療公司 | 擬肽巨環化合物 |
| EP2819688A4 (en) | 2012-02-15 | 2015-10-28 | Aileron Therapeutics Inc | PEPTIDOMIMETIC MACROCYCLES CROSS-LINKED WITH TRIAZOLE AND THIOETHER |
| SG11201404648PA (en) | 2012-02-15 | 2014-09-26 | Aileron Therapeutics Inc | Peptidomimetic macrocycles |
| CA2776178A1 (en) | 2012-04-05 | 2013-10-05 | Hydro-Quebec | Ionic compounds |
| KR20150082307A (ko) | 2012-11-01 | 2015-07-15 | 에일러론 테라퓨틱스 인코포레이티드 | 이치환 아미노산 및 이의 제조 및 사용 방법 |
| SG11201702223UA (en) | 2014-09-24 | 2017-04-27 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and uses thereof |
| EP3197477A4 (en) | 2014-09-24 | 2018-07-04 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and formulations thereof |
| KR20170129879A (ko) | 2015-03-20 | 2017-11-27 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티드모방 거대고리 및 이의 용도 |
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| JP2018528217A (ja) | 2015-09-10 | 2018-09-27 | エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | Ｍｃｌ−１のモジュレーターとしてのペプチド模倣大環状分子 |
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- 2003-11-07 KR KR1020107000780A patent/KR100996996B1/ko not_active Expired - Fee Related
- 2003-11-07 AT AT03768730T patent/ATE452888T1/de active
- 2003-11-07 ES ES03768730T patent/ES2336911T3/es not_active Expired - Lifetime
- 2003-11-07 AU AU2003291337A patent/AU2003291337B2/en not_active Ceased
- 2003-11-07 ES ES09012671T patent/ES2436296T3/es not_active Expired - Lifetime
- 2003-11-07 KR KR1020057008039A patent/KR100966667B1/ko not_active Expired - Fee Related
- 2003-11-07 JP JP2005507102A patent/JP4641941B2/ja not_active Expired - Fee Related
- 2003-11-07 EP EP09012860A patent/EP2135868A1/en not_active Withdrawn
- 2003-11-07 CA CA2505368A patent/CA2505368C/en not_active Expired - Fee Related
- 2003-11-07 EP EP09012671.5A patent/EP2135867B1/en not_active Expired - Lifetime
- 2003-11-07 EP EP03768730A patent/EP1562941B1/en not_active Expired - Lifetime
- 2003-11-07 US US10/703,404 patent/US20040152708A1/en not_active Abandoned
- 2003-11-07 SI SI200331732T patent/SI1562941T1/sl unknown
- 2003-11-07 PT PT03768730T patent/PT1562941E/pt unknown
- 2003-11-07 DE DE60330703T patent/DE60330703D1/de not_active Expired - Lifetime
- 2003-11-07 DK DK03768730.8T patent/DK1562941T3/da active
- 2003-11-07 WO PCT/US2003/035411 patent/WO2004043954A2/en not_active Ceased
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2008
- 2008-07-11 US US12/172,174 patent/US20090186927A1/en not_active Abandoned
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Also Published As
| Publication number | Publication date |
|---|---|
| JP2013213054A (ja) | 2013-10-17 |
| DE60330703D1 (de) | 2010-02-04 |
| EP1562941B1 (en) | 2009-12-23 |
| EP2135868A1 (en) | 2009-12-23 |
| ES2436296T3 (es) | 2013-12-30 |
| KR20050084959A (ko) | 2005-08-29 |
| CA2505368C (en) | 2011-09-20 |
| JP4641941B2 (ja) | 2011-03-02 |
| PT1562941E (pt) | 2010-01-25 |
| DK1562941T3 (da) | 2010-04-19 |
| EP2135867A1 (en) | 2009-12-23 |
| ES2336911T3 (es) | 2010-04-19 |
| CY1110295T1 (el) | 2015-01-14 |
| JP2006510743A (ja) | 2006-03-30 |
| AU2003291337A1 (en) | 2004-06-03 |
| KR100966667B1 (ko) | 2010-06-29 |
| JP2011006480A (ja) | 2011-01-13 |
| US20040152708A1 (en) | 2004-08-05 |
| EP2135867B1 (en) | 2013-09-25 |
| WO2004043954A3 (en) | 2004-11-18 |
| KR100996996B1 (ko) | 2010-11-25 |
| WO2004043954A2 (en) | 2004-05-27 |
| CA2505368A1 (en) | 2004-05-27 |
| EP1562941A2 (en) | 2005-08-17 |
| KR20100018075A (ko) | 2010-02-16 |
| JP5679757B2 (ja) | 2015-03-04 |
| SI1562941T1 (sl) | 2010-05-31 |
| ATE452888T1 (de) | 2010-01-15 |
| US20090186927A1 (en) | 2009-07-23 |
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