AU2003288534B2 - Variously substituted derivatives of guanidine, and their use as medicines with anti-diabetes and/or anti-obesity activity - Google Patents

Variously substituted derivatives of guanidine, and their use as medicines with anti-diabetes and/or anti-obesity activity Download PDF

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Publication number
AU2003288534B2
AU2003288534B2 AU2003288534A AU2003288534A AU2003288534B2 AU 2003288534 B2 AU2003288534 B2 AU 2003288534B2 AU 2003288534 A AU2003288534 A AU 2003288534A AU 2003288534 A AU2003288534 A AU 2003288534A AU 2003288534 B2 AU2003288534 B2 AU 2003288534B2
Authority
AU
Australia
Prior art keywords
guanidine
dimethylallyl
aminobutyl
mmol
pct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2003288534A
Other languages
English (en)
Other versions
AU2003288534A1 (en
Inventor
Maurizio Botta
Federico Corelli
Fabio Giannessi
Pompeo Pessotto
Emanuela Tassoni
Maria Ornella Tinti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of AU2003288534A1 publication Critical patent/AU2003288534A1/en
Application granted granted Critical
Publication of AU2003288534B2 publication Critical patent/AU2003288534B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
AU2003288534A 2002-12-17 2003-12-01 Variously substituted derivatives of guanidine, and their use as medicines with anti-diabetes and/or anti-obesity activity Ceased AU2003288534B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITRM2002A000625 2002-12-17
IT000625A ITRM20020625A1 (it) 2002-12-17 2002-12-17 Derivati di guanidine variamente sostituite, loro uso come medicamenti ad attivita' antidiabetica e/o antiobesita'.
PCT/IT2003/000792 WO2004054967A1 (en) 2002-12-17 2003-12-01 Variously substituted derivatives of guanidine, and their use as medicines with anti-diabetes and/or anti-obesity activity

Publications (2)

Publication Number Publication Date
AU2003288534A1 AU2003288534A1 (en) 2004-07-09
AU2003288534B2 true AU2003288534B2 (en) 2009-07-02

Family

ID=32587901

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003288534A Ceased AU2003288534B2 (en) 2002-12-17 2003-12-01 Variously substituted derivatives of guanidine, and their use as medicines with anti-diabetes and/or anti-obesity activity

Country Status (12)

Country Link
US (1) US7368605B2 (enExample)
EP (1) EP1575912A1 (enExample)
JP (1) JP2006509816A (enExample)
KR (1) KR20050089058A (enExample)
CN (1) CN1729172A (enExample)
AU (1) AU2003288534B2 (enExample)
BR (1) BR0317397A (enExample)
CA (1) CA2506685A1 (enExample)
IT (1) ITRM20020625A1 (enExample)
MX (1) MXPA05006326A (enExample)
PL (1) PL378416A1 (enExample)
WO (1) WO2004054967A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2873368B1 (fr) * 2004-07-26 2008-01-04 Merck Sante Soc Par Actions Si Derives de guanidine et leurs utilisations en therapeutique
CN101062906B (zh) * 2006-04-26 2012-02-08 中国人民解放军军事医学科学院毒物药物研究所 胍丁胺硫酸盐水合物及其用于戒毒,抗炎,降血糖以及胍丁胺代谢异常所致疾病的用途
CN101121677B (zh) * 2006-08-09 2011-05-11 中国人民解放军军事医学科学院毒物药物研究所 胍丁胺硫酸盐二水合物及其医药用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4731383A (en) * 1983-12-12 1988-03-15 Biogal Gyogyszergyar Aminoguanidine compounds, their compositions and pharmaceutical uses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1219846B (it) * 1988-02-24 1990-05-24 Consiglio Nazionale Ricerche Nuovi derivati guandinici ad attivita' ipotensia,composizione che li contengono e relativo procedimento di estrazione e purificazione da materiale botanico
EP0600973A1 (en) * 1991-08-27 1994-06-15 The Upjohn Company A method for treatment of metabolic disorders and metabolism
GB9511757D0 (en) * 1995-05-19 1995-08-02 Univ Strathclyde Agents for reducing weight
PL327471A1 (en) * 1995-12-22 1998-12-07 Smithkline Beecham Plc Aminoguanidines for trweating niddm

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4731383A (en) * 1983-12-12 1988-03-15 Biogal Gyogyszergyar Aminoguanidine compounds, their compositions and pharmaceutical uses

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
The Merck Index-Tenth Edition, Published by Merck & Co., Inc. Rahwey NJ, U.S.A. 1983 *
Wilkinson-Berka, J. L. et al., Diabetes (2002), 51, 3283-3289 *

Also Published As

Publication number Publication date
JP2006509816A (ja) 2006-03-23
KR20050089058A (ko) 2005-09-07
CA2506685A1 (en) 2004-07-01
AU2003288534A1 (en) 2004-07-09
EP1575912A1 (en) 2005-09-21
US20060069100A1 (en) 2006-03-30
PL378416A1 (pl) 2006-04-03
WO2004054967A1 (en) 2004-07-01
CN1729172A (zh) 2006-02-01
US7368605B2 (en) 2008-05-06
BR0317397A (pt) 2005-11-16
ITRM20020625A1 (it) 2004-06-18
MXPA05006326A (es) 2005-08-26

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Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired