AU2003271555B2 - Use of IkappaB kinase inhibitors for the treatment of pain - Google Patents
Use of IkappaB kinase inhibitors for the treatment of pain Download PDFInfo
- Publication number
- AU2003271555B2 AU2003271555B2 AU2003271555A AU2003271555A AU2003271555B2 AU 2003271555 B2 AU2003271555 B2 AU 2003271555B2 AU 2003271555 A AU2003271555 A AU 2003271555A AU 2003271555 A AU2003271555 A AU 2003271555A AU 2003271555 B2 AU2003271555 B2 AU 2003271555B2
- Authority
- AU
- Australia
- Prior art keywords
- alkyl
- pain
- hydrogen atom
- independently
- pain associated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Paper (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10237723.5 | 2002-08-17 | ||
| DE10237723A DE10237723A1 (de) | 2002-08-17 | 2002-08-17 | Verwendung von IKappaB-Kinase Inhibitoren in der Schmerztherapie |
| PCT/EP2003/008628 WO2004022057A1 (de) | 2002-08-17 | 2003-08-05 | VERWENDUNG VON IκB-KINASE INHIBITOREN IN DER SCHMERZTHERAPIE |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2003271555A1 AU2003271555A1 (en) | 2004-03-29 |
| AU2003271555B2 true AU2003271555B2 (en) | 2009-03-26 |
Family
ID=31968975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003271555A Ceased AU2003271555B2 (en) | 2002-08-17 | 2003-08-05 | Use of IkappaB kinase inhibitors for the treatment of pain |
Country Status (33)
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8022058B2 (en) | 2000-05-10 | 2011-09-20 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| US7312044B2 (en) | 2003-03-07 | 2007-12-25 | The Trustees Of Columbia University In The City Of New York | Type 1 ryanodine receptor-based methods |
| US7879840B2 (en) | 2005-08-25 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| US7718644B2 (en) | 2004-01-22 | 2010-05-18 | The Trustees Of Columbia University In The City Of New York | Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof |
| US7393652B2 (en) | 2000-05-10 | 2008-07-01 | The Trustees Of Columbia University In The City Of New York | Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2) |
| DE10237722A1 (de) * | 2002-08-17 | 2004-08-19 | Aventis Pharma Deutschland Gmbh | Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase |
| US7544678B2 (en) | 2002-11-05 | 2009-06-09 | The Trustees Of Columbia University In The City Of New York | Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) |
| US8710045B2 (en) | 2004-01-22 | 2014-04-29 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the ryanodine receptors |
| US7868037B2 (en) | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| EA200700243A1 (ru) | 2004-07-14 | 2007-08-31 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Способы лечения гепатита с |
| US7772271B2 (en) | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
| EP1781289A1 (en) | 2004-07-22 | 2007-05-09 | PTC Therapeutics, Inc. | Thienopyridines for treating hepatitis c |
| DE102005025225A1 (de) * | 2005-06-01 | 2006-12-07 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung von 2-(2-Amino-pyrimidin-4-yl)-1H-indol-5-carbonsäure-derivaten |
| US7704990B2 (en) | 2005-08-25 | 2010-04-27 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| AR072297A1 (es) | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201242962A (en) | 2010-12-01 | 2012-11-01 | Sumitomo Chemical Co | Pyrimidine compound and use for pest control thereof |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2532755A1 (en) * | 2011-06-10 | 2012-12-12 | Sanofi-Aventis | Methods and uses based on Slfn2 expression and relating to the identification and profiling of compounds for use in the treatment or prevention of pain |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| DK2787998T3 (en) * | 2011-12-06 | 2017-02-06 | Sanofi Sa | Crystalline Forms of 2- (2-METHYLAMINOPYRIMIDIN-4-YL) -1H-INDOL-5-CARBOXYLIC ACID - [(S) -1-CARBAMOYL-2- (PHENYLPYRIMIDIN-2-YLAMINO) -ETHYL] -AMIDE |
| EP3184095A1 (en) | 2013-05-23 | 2017-06-28 | IP Gesellschaft für Management mbH | Administration units comprising polymorph 1 of 2-(2-methylamino-pyrimidin-4-yl]-1h-indole-5-carboxylic acid [(s)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino)-ethyl]-amide |
| JO3425B1 (ar) * | 2013-07-15 | 2019-10-20 | Novartis Ag | مشتقات البابيريدينيل-اندول واستخدامها كعامل متمم لمثبطات b |
| SG11201610429YA (en) * | 2014-07-03 | 2017-01-27 | Sanofi Sa | 2-(2-methylamino-pyrimidin-4-yl)-1h-indole-5-carboxylic acid [(s)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino)-ethyl]-amide for use in the treatment of pain associated to osteoarthritis |
| AU2019304216B2 (en) | 2018-07-16 | 2022-06-02 | Novartis Ag | Chemical process for preparing phenylpiperidinyl indole derivatives |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001000610A1 (de) * | 1999-06-23 | 2001-01-04 | Aventis Pharma Deutschland Gmbh | Substituierte benzimidazole |
| WO2001030774A1 (de) * | 1999-10-26 | 2001-05-03 | Aventis Pharma Deutschland Gmbh | Substituierte indole zur modulierung von nfkb-aktivität |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10237722A1 (de) * | 2002-08-17 | 2004-08-19 | Aventis Pharma Deutschland Gmbh | Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase |
-
2002
- 2002-08-17 DE DE10237723A patent/DE10237723A1/de not_active Withdrawn
-
2003
- 2003-05-08 UA UAA200502388A patent/UA80837C2/uk unknown
- 2003-08-05 KR KR1020057002712A patent/KR101119845B1/ko not_active Expired - Fee Related
- 2003-08-05 RU RU2005107419/15A patent/RU2320338C2/ru not_active IP Right Cessation
- 2003-08-05 HR HRP20050041AA patent/HRP20050041B1/hr not_active IP Right Cessation
- 2003-08-05 AU AU2003271555A patent/AU2003271555B2/en not_active Ceased
- 2003-08-05 PT PT03753349T patent/PT1531819E/pt unknown
- 2003-08-05 PL PL373568A patent/PL212356B1/pl unknown
- 2003-08-05 EP EP03753349A patent/EP1531819B1/de not_active Expired - Lifetime
- 2003-08-05 WO PCT/EP2003/008628 patent/WO2004022057A1/de not_active Ceased
- 2003-08-05 MX MXPA05001218A patent/MXPA05001218A/es active IP Right Grant
- 2003-08-05 RS YU20050070A patent/RS51878B/sr unknown
- 2003-08-05 ES ES03753349T patent/ES2320118T3/es not_active Expired - Lifetime
- 2003-08-05 JP JP2004533318A patent/JP4504811B2/ja not_active Expired - Fee Related
- 2003-08-05 KR KR1020117028345A patent/KR20110135428A/ko not_active Withdrawn
- 2003-08-05 SI SI200331531T patent/SI1531819T1/sl unknown
- 2003-08-05 AT AT03753349T patent/ATE418336T1/de active
- 2003-08-05 DK DK03753349T patent/DK1531819T3/da active
- 2003-08-05 BR BR0313555-1A patent/BR0313555A/pt not_active Application Discontinuation
- 2003-08-05 DE DE50310980T patent/DE50310980D1/de not_active Expired - Lifetime
- 2003-08-05 OA OA1200500046A patent/OA12907A/en unknown
- 2003-08-05 CA CA2495455A patent/CA2495455C/en not_active Expired - Fee Related
- 2003-08-05 CN CNB038195429A patent/CN100398107C/zh not_active Expired - Fee Related
- 2003-08-14 AR ARP030102944A patent/AR043045A1/es not_active Application Discontinuation
- 2003-08-14 TW TW092122310A patent/TWI325782B/zh not_active IP Right Cessation
- 2003-08-15 MY MYPI20033112A patent/MY138059A/en unknown
-
2005
- 2005-01-13 ZA ZA200500323A patent/ZA200500323B/xx unknown
- 2005-02-09 IL IL166780A patent/IL166780A/en not_active IP Right Cessation
- 2005-02-15 CO CO05013333A patent/CO5690585A2/es not_active Application Discontinuation
- 2005-02-15 MA MA28107A patent/MA27334A1/fr unknown
- 2005-02-16 TN TNP2005000044A patent/TNSN05044A1/en unknown
- 2005-02-17 EC EC2005005609A patent/ECSP055609A/es unknown
- 2005-03-07 CR CR7716A patent/CR7716A/es unknown
- 2005-03-15 NO NO20051339A patent/NO334309B1/no not_active IP Right Cessation
-
2009
- 2009-03-17 CY CY20091100291T patent/CY1108874T1/el unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001000610A1 (de) * | 1999-06-23 | 2001-01-04 | Aventis Pharma Deutschland Gmbh | Substituierte benzimidazole |
| WO2001030774A1 (de) * | 1999-10-26 | 2001-05-03 | Aventis Pharma Deutschland Gmbh | Substituierte indole zur modulierung von nfkb-aktivität |
Also Published As
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| Publication | Publication Date | Title |
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| CA2495455C (en) | Use of i.kappa.b-kinase inhibitors in pain therapy | |
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| JP3843012B2 (ja) | ＮＦκＢ活性を調節するための置換インドール | |
| DE10237722A1 (de) | Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase | |
| JP2003503400A (ja) | 置換されたベンゾイミダゾール | |
| BRPI0712938A2 (pt) | mÉtodo para modular excrescÊncia de neurito pelo uso de um antagonista de receptor de galanina-3 | |
| NZ538297A (en) | Use of IkB kinase inhibitors for the treatment of pain | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC1 | Assignment before grant (sect. 113) |
Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH Free format text: FORMER APPLICANT(S): AVENTIS PHARMA DEUTSCHLAND GMBH |
|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |