AU2003257437A1 - Novel 2,5-disubstituted pyrimidine derivatives - Google Patents

Novel 2,5-disubstituted pyrimidine derivatives

Info

Publication number
AU2003257437A1
AU2003257437A1 AU2003257437A AU2003257437A AU2003257437A1 AU 2003257437 A1 AU2003257437 A1 AU 2003257437A1 AU 2003257437 A AU2003257437 A AU 2003257437A AU 2003257437 A AU2003257437 A AU 2003257437A AU 2003257437 A1 AU2003257437 A1 AU 2003257437A1
Authority
AU
Australia
Prior art keywords
novel
pyrimidine derivatives
disubstituted pyrimidine
disubstituted
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003257437A
Other languages
English (en)
Inventor
Achim Feurer
Gerhard Konig
Dieter Lang
Joachim Luithle
Rudy Schreiber
Elke Stahl
Johannes-Peter Stasch
Stephan-Nicholas Wirtz
Frank Wunder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer Healthcare AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare AG filed Critical Bayer Healthcare AG
Publication of AU2003257437A1 publication Critical patent/AU2003257437A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2003257437A 2002-07-18 2003-07-07 Novel 2,5-disubstituted pyrimidine derivatives Abandoned AU2003257437A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10232572.3 2002-07-18
DE10232572A DE10232572A1 (de) 2002-07-18 2002-07-18 Neue 2,5-disubstituierte Pyrimidinderivate
PCT/EP2003/007238 WO2004009589A1 (de) 2002-07-18 2003-07-07 Neue 2,5-disubstituierte pyrimidinderivate

Publications (1)

Publication Number Publication Date
AU2003257437A1 true AU2003257437A1 (en) 2004-02-09

Family

ID=30010152

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003257437A Abandoned AU2003257437A1 (en) 2002-07-18 2003-07-07 Novel 2,5-disubstituted pyrimidine derivatives

Country Status (8)

Country Link
US (1) US7091198B1 (https=)
EP (1) EP1525202B1 (https=)
JP (1) JP2006502119A (https=)
AU (1) AU2003257437A1 (https=)
CA (1) CA2492723C (https=)
DE (2) DE10232572A1 (https=)
ES (1) ES2256779T3 (https=)
WO (1) WO2004009589A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004274492B2 (en) * 2003-09-19 2010-04-29 Abbott Laboratories Substituted diazabicycloalkane derivatives as ligands at alpha 7 nicotinic acetylcholine receptors

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4605952B2 (ja) * 2001-08-29 2011-01-05 株式会社日立製作所 蓄電装置及びその制御方法
BRPI0409649A (pt) * 2003-04-23 2006-04-25 Pharmacia & Upjohn Co Llc pirimidinonas e pirimidinotionas substituìdas como antagonistas de crf
US7399765B2 (en) 2003-09-19 2008-07-15 Abbott Laboratories Substituted diazabicycloalkane derivatives
JPWO2005047286A1 (ja) * 2003-11-13 2007-05-31 小野薬品工業株式会社 スピロ複素環化合物
CN101449388B (zh) * 2006-03-02 2011-01-19 艾斯莫斯技术有限公司 光敏感面积与光不敏感面积的比例增加的光电二极管
DE102007026392A1 (de) 2007-06-06 2008-12-11 Bayer Healthcare Ag Lösungen für die Perfusion und Konservierung von Organen und Geweben
TW201004963A (en) * 2008-07-03 2010-02-01 Targacept Inc Derivatives of oxabispidine as neuronal nicotinic acetylcholine receptor ligands
US20110053923A1 (en) 2008-12-22 2011-03-03 Astrazeneca Chemical compounds 610
DE102010021637A1 (de) 2010-05-26 2011-12-01 Bayer Schering Pharma Aktiengesellschaft Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
DE102010040234A1 (de) * 2010-09-03 2012-03-08 Bayer Schering Pharma Aktiengesellschaft Verfahren zur Herstellung von 5-Flour-1H-pyrazolo[3,4-b]pyridin-3-carbonitril
DE102010043379A1 (de) 2010-11-04 2012-05-10 Bayer Schering Pharma Aktiengesellschaft Substituierte 6-Fluor-1H-Pyrazolo[4,3-b]pyridine und ihre Verwendung
DE102010043380A1 (de) 2010-11-04 2012-05-10 Bayer Schering Pharma Aktiengesellschaft Benzyl-substituierte Carbamate und ihre Verwendung
EP2453000A1 (en) * 2010-11-08 2012-05-16 Infineum International Limited Lubricating Oil Composition comprising a hydrogenated imide derived from a Diels-Alder adduct of maleic anhydride and a furan
ES2603028T3 (es) 2011-11-25 2017-02-23 Adverio Pharma Gmbh Procedimiento para la preparación de (Z)-alfa-fluoro-beta-amino-acrilaldehídos sustituidos
MX2015010725A (es) 2013-02-21 2016-05-31 Adverio Pharma Gmbh Formas de metil {4,6-diamino-2-[1-(2-fluorobencil)-1h-pirazolo [3,4-b] piridino-3-il] pirimidino-5-il} metil carbamato.
EP3094327A1 (en) 2014-01-13 2016-11-23 Ironwood Pharmaceuticals, Inc. USE OF sGC STIMULATORS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS
MX2017014057A (es) 2015-05-06 2018-04-10 Bayer Pharma AG El uso de estimuladores sgc, activadores gc, solos y combinaciones con inhibidores pde5 para el tratamiento de ulceras digitales (du) concomitante con esclerosis sistemica (ssc).
JP6849618B2 (ja) 2015-07-23 2021-03-24 バイエル・ファルマ・アクティエンゲゼルシャフト 中性エンドペプチダーゼの阻害剤（ＮＥＰ阻害剤）および／またはアンジオテンシンＩＩ拮抗薬と組み合わせた可溶性グアニル酸シクラーゼ（ｓＧＣ）の刺激薬および／または活性化薬ならびにその使用
CN105367567B (zh) * 2015-11-18 2017-11-28 浙江京新药业股份有限公司 一种化合物及其在制备利奥西呱中的应用
CN105367569B (zh) * 2015-11-18 2017-10-27 浙江京新药业股份有限公司 一种化合物及其作为利奥西呱中间体的应用
US20180344735A1 (en) 2015-12-14 2018-12-06 Ironwood Pharmaceuticals, Inc. USE OF sGC STIMULATORS FOR THE TREATMENT OF GASTROINTESTINAL SPHINCTER DYSFUNCTION
EP3525779B1 (de) 2016-10-11 2024-06-05 Bayer Pharma Aktiengesellschaft Kombination enthaltend den sgc stimulator vericuguat und den mineralcorticoid-rezeptor-antagonist finerenone
CN109890379A (zh) 2016-10-11 2019-06-14 拜耳制药股份公司 包含sGC活化剂和盐皮质激素受体拮抗剂的组合产品
CN110267949A (zh) 2016-11-08 2019-09-20 塞科里昂医疗股份有限公司 sGC刺激剂
EP3554488A2 (en) 2016-12-13 2019-10-23 Cyclerion Therapeutics, Inc. Use of sgc stimulators for the treatment of esophageal motility disorders
EP3793553A1 (en) 2018-05-15 2021-03-24 Bayer Aktiengesellschaft 1,3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization
KR20250141845A (ko) 2018-07-11 2025-09-29 티센토 쎄라퓨틱스 인크. 미토콘드리아 장애의 치료를 위한 sGC 자극제의 용도
WO2020164008A1 (en) 2019-02-13 2020-08-20 Bayer Aktiengesellschaft Process for the preparation of porous microparticles
CN112457308B (zh) * 2019-09-09 2024-01-02 上海长森药业有限公司 新型三环芳香杂环化合物，及其制备方法、药物组合物和应用
CN118772140B (zh) * 2023-04-07 2026-04-17 四川大学 一类化合物及其在治疗hDHODH介导的疾病中的用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19649460A1 (de) * 1996-11-26 1998-05-28 Bayer Ag Neue substituierte Pyrazolderivate
DE19834045A1 (de) * 1998-07-29 2000-02-03 Bayer Ag (4-Amino-5-ethylpyrimidin-2-yl)-1-(2-fluorbenzyl)-1H-pyrazolo[3,4-b]pyridin
DE19834047A1 (de) * 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate
DE19846514A1 (de) * 1998-10-09 2000-04-20 Bayer Ag Neue Heterocyclyl-methyl-substituierte Pyrazole
DE10054278A1 (de) * 2000-11-02 2002-05-08 Bayer Ag Verwendung von Stimulatoren der löslichen Guanylatcyclase zur Behandlung von Osteoporose
ES2231581T3 (es) * 2000-11-22 2005-05-16 Bayer Healthcare Ag Nuevos derivados de pirazolopiridina sustituidos con lactama.
AR031176A1 (es) * 2000-11-22 2003-09-10 Bayer Ag Nuevos derivados de pirazolpiridina sustituidos con piridina
DE10057754A1 (de) * 2000-11-22 2002-05-23 Bayer Ag Neue Sulfonamid-substituierte Pyrazolopyridinderivate

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004274492B2 (en) * 2003-09-19 2010-04-29 Abbott Laboratories Substituted diazabicycloalkane derivatives as ligands at alpha 7 nicotinic acetylcholine receptors

Also Published As

Publication number Publication date
ES2256779T3 (es) 2006-07-16
WO2004009589A1 (de) 2004-01-29
EP1525202B1 (de) 2006-01-11
EP1525202A1 (de) 2005-04-27
CA2492723A1 (en) 2004-01-29
JP2006502119A (ja) 2006-01-19
US20060167016A1 (en) 2006-07-27
US7091198B1 (en) 2006-08-15
DE10232572A1 (de) 2004-02-05
CA2492723C (en) 2012-09-04
DE50302202D1 (de) 2006-04-06

Similar Documents

Publication Publication Date Title
AU2003257437A1 (en) Novel 2,5-disubstituted pyrimidine derivatives
AU2002341195A1 (en) Substituted 2-pyridine-cyclohexane-1,4-diamine derivatives
SI2308855T1 (sl) 2,4-diaminopirimidinski derivati
EP1416935B8 (en) 4-amino-6-phenyl-pyrrolo[2,3-d]pyrimidine derivatives
AU2003292007A1 (en) 4-AMINO-5-PHENYL-7-CYCLOHEXYL-PYRROLO(2,3-d)PYRIMIDINE DERIVATIVES
AU2003209077A1 (en) Pyrimidine compounds
AU2003255492A1 (en) Heterocyclic derivatives
AU2003296586A1 (en) Pyridazinone derivatives as cdk2-inhibitors
AU2002349754A1 (en) Novel 1,2,4-triazole compound
AU2002361992A1 (en) 1,4-dihydro-1,4-diphenylpyridine derivatives
SI1699795T1 (sl) Substituirani 8-piri(mi)dinil-dihidrospiro-(cikloalkilamin)pirimido(1,2a) pirimidin-6-onski derivati
AU2003274022A1 (en) 3-heterocyclylpyridine derivatives useful as herbicides
AU2003264207A1 (en) 1,4-substituted cyclohexane derivatives
AU2003301968A1 (en) 4-aminomethyl-1-aryl-cyclohexylamine derivatives
AU2003299648A1 (en) Substituted 4-phenyl-(1,3)-dioxanes
AU3819200A (en) 2,4-diamino-pyrimidine derivatives
AU2003247706A1 (en) 6, 11-4-carbon bridged erythromycin derivatives
AU2002362806A1 (en) Pyrimidine derivatives
AU2003208467A1 (en) Pyrimidine compounds
AU2003278369A1 (en) 3-cyano-quinoline derivatives
AU2003296564A1 (en) 4-hydroxymethyl-1-aryl-cyclohexylamine derivatives
AU2002352357A1 (en) Trioxane derivatives
AU2003269949A1 (en) Substituted 1,4-pyrazine derivatives
PL373883A1 (en) 2,5-disubstituted 3-mercaptopentanoic acid
AU2003222659A1 (en) 23-o-substituted 5-o-mycaminosyltylonide derivatives

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase