AU2003250477B2 - Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury - Google Patents

Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury Download PDF

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Publication number
AU2003250477B2
AU2003250477B2 AU2003250477A AU2003250477A AU2003250477B2 AU 2003250477 B2 AU2003250477 B2 AU 2003250477B2 AU 2003250477 A AU2003250477 A AU 2003250477A AU 2003250477 A AU2003250477 A AU 2003250477A AU 2003250477 B2 AU2003250477 B2 AU 2003250477B2
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cells
cell population
culture medium
differentiated cell
culturing
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AU2003250477A1 (en
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Hans S. Keirstead
Gabriel I. Nistor
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University of California San Diego UCSD
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University of California Berkeley
University of California San Diego UCSD
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • C12N5/0622Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0618Cells of the nervous system
    • C12N5/0623Stem cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/115Basic fibroblast growth factor (bFGF, FGF-2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30Hormones
    • C12N2501/38Hormones with nuclear receptors
    • C12N2501/395Thyroid hormones
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2503/00Use of cells in diagnostics
    • C12N2503/02Drug screening
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    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

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  • Chemical Kinetics & Catalysis (AREA)
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AU2003250477A 2002-07-11 2003-07-11 Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury Ceased AU2003250477B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US39538202P 2002-07-11 2002-07-11
US60/395,382 2002-07-11
US10/406,817 2003-04-04
US10/406,817 US7285415B2 (en) 2002-07-11 2003-04-04 Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury
PCT/IB2003/003539 WO2004007696A2 (en) 2002-07-11 2003-07-11 Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury

Publications (2)

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AU2003250477A1 AU2003250477A1 (en) 2004-02-02
AU2003250477B2 true AU2003250477B2 (en) 2008-07-03

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AU2003250477A Ceased AU2003250477B2 (en) 2002-07-11 2003-07-11 Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury

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US (1) US7285415B2 (https=)
EP (2) EP1523549A2 (https=)
JP (2) JP4823689B2 (https=)
CN (2) CN1852971B (https=)
AU (1) AU2003250477B2 (https=)
CA (1) CA2489203C (https=)
GB (1) GB2407822B (https=)
WO (1) WO2004007696A2 (https=)

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