AU2003204404B2 - Real time radiation treatment planning system - Google Patents
Real time radiation treatment planning system Download PDFInfo
- Publication number
- AU2003204404B2 AU2003204404B2 AU2003204404A AU2003204404A AU2003204404B2 AU 2003204404 B2 AU2003204404 B2 AU 2003204404B2 AU 2003204404 A AU2003204404 A AU 2003204404A AU 2003204404 A AU2003204404 A AU 2003204404A AU 2003204404 B2 AU2003204404 B2 AU 2003204404B2
- Authority
- AU
- Australia
- Prior art keywords
- anatomical portion
- planning system
- radiation
- radiation treatment
- treatment planning
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/103—Treatment planning systems
- A61N5/1031—Treatment planning systems using a specific method of dose optimization
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1007—Arrangements or means for the introduction of sources into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/103—Treatment planning systems
- A61N5/1039—Treatment planning systems using functional images, e.g. PET or MRI
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/40—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H30/00—ICT specially adapted for the handling or processing of medical images
- G16H30/40—ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1007—Arrangements or means for the introduction of sources into the body
- A61N2005/1012—Templates or grids for guiding the introduction of sources
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/103—Treatment planning systems
- A61N5/1031—Treatment planning systems using a specific method of dose optimization
- A61N2005/1032—Genetic optimization methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N2005/1074—Details of the control system, e.g. user interfaces
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Veterinary Medicine (AREA)
- Pathology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Primary Health Care (AREA)
- Medical Informatics (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Surgery (AREA)
- Radiation-Therapy Devices (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Finger-Pressure Massage (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02077436.0 | 2002-06-17 | ||
| EP20020077436 EP1374949B1 (en) | 2002-06-17 | 2002-06-17 | Real time radiation treatment planning system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2003204404A1 AU2003204404A1 (en) | 2004-01-15 |
| AU2003204404B2 true AU2003204404B2 (en) | 2007-05-10 |
Family
ID=29716888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003204404A Ceased AU2003204404B2 (en) | 2002-06-17 | 2003-05-28 | Real time radiation treatment planning system |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US7899517B2 (enExample) |
| EP (1) | EP1374949B1 (enExample) |
| JP (1) | JP4439843B2 (enExample) |
| AT (2) | ATE312648T1 (enExample) |
| AU (1) | AU2003204404B2 (enExample) |
| CA (1) | CA2432493C (enExample) |
| DE (2) | DE60208009T2 (enExample) |
| ES (2) | ES2254599T3 (enExample) |
| PT (1) | PT1374951E (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1374949B1 (en) * | 2002-06-17 | 2005-12-14 | Nucletron B.V. | Real time radiation treatment planning system |
| US7742902B1 (en) * | 2003-10-22 | 2010-06-22 | Oracle America, Inc. | Using interval techniques of direct comparison and differential formulation to solve a multi-objective optimization problem |
| DE102004040629B4 (de) * | 2004-08-19 | 2011-05-19 | MedCom Gesellschaft für medizinische Bildverarbeitung mbH | Einstellen einer Relativposition einer Bestrahlungseinrichtung und eines Patienten |
| US20060067467A1 (en) * | 2004-09-28 | 2006-03-30 | Minnesota Medical Physics Llc | Apparatus and method for conformal radiation brachytherapy for breast and other tumors |
| PL1674129T3 (pl) * | 2004-12-23 | 2010-02-26 | Nucletron Operations Bv | Sposób i urządzenie do obliczania rozkładu dawki promieniowania w układzie leczenia radiacyjnego dla celów terapii radiacyjnej ciała zwierzęcia |
| US8775207B2 (en) * | 2005-02-02 | 2014-07-08 | Siemens Medical Solutions Usa, Inc. | Integrated treatment planning and scheduling system |
| US8409071B2 (en) * | 2005-05-17 | 2013-04-02 | Wisconsin Alumni Research Foundation | Method and apparatus for treatment planning using implanted radioactive sources |
| EP1745822B1 (en) | 2005-07-18 | 2008-10-22 | Nucletron B.V. | Apparatus for effecting radiation treatment on a pre-selected anatomical portion of an animal body |
| EP1745820B1 (en) | 2005-07-18 | 2010-02-17 | Nucletron B.V. | System for effecting radiation treatment on a pre-selected anatomical portion of an animal body. |
| US20080214933A1 (en) * | 2005-08-25 | 2008-09-04 | Koninklijke Philips Electronics, N.V. | Image-Based Planning Methods and Apparatus for Targeted Therapy |
| EP2018627B1 (en) * | 2006-05-11 | 2017-03-22 | Koninklijke Philips N.V. | Deformable registration of images for image guided radiation therapy |
| US7771339B2 (en) * | 2006-05-31 | 2010-08-10 | Ab Mimator | Method and system for radiotherapy treatment |
| WO2008017051A2 (en) | 2006-08-02 | 2008-02-07 | Inneroptic Technology Inc. | System and method of providing real-time dynamic imagery of a medical procedure site using multiple modalities |
| EP2355708B1 (en) * | 2008-10-20 | 2015-01-21 | Vanderbilt University | System and methods for accelerating simulations of radiation treatment |
| US8690776B2 (en) | 2009-02-17 | 2014-04-08 | Inneroptic Technology, Inc. | Systems, methods, apparatuses, and computer-readable media for image guided surgery |
| US11464578B2 (en) | 2009-02-17 | 2022-10-11 | Inneroptic Technology, Inc. | Systems, methods, apparatuses, and computer-readable media for image management in image-guided medical procedures |
| NL1037032C2 (en) | 2009-06-11 | 2010-12-16 | Nucletron Bv | A system and method for generating a radiation treatment plan for use in effecting radiation therapy in a human or animal body. |
| NL1037031C2 (en) * | 2009-06-11 | 2010-12-16 | Nucletron Bv | Radiation therapy delivery system and radiation therapy treatment planning system. |
| US8315357B2 (en) * | 2009-10-08 | 2012-11-20 | The Board Of Trustees Of The Leland Stanford Junior University | Radiation therapy inverse treatment planning using a regularization of sparse segments |
| US8819591B2 (en) * | 2009-10-30 | 2014-08-26 | Accuray Incorporated | Treatment planning in a virtual environment |
| NZ601857A (en) | 2010-03-31 | 2015-07-31 | Medi Physics Inc | Brachytherapy template adaptor |
| TW201221117A (en) * | 2010-11-29 | 2012-06-01 | Iner Aec Executive Yuan | Enhancing segmentation for molecular image quantification system and the method thereof |
| CN102136041B (zh) * | 2011-04-18 | 2017-04-26 | 深圳市海博科技有限公司 | 治疗计划系统 |
| WO2013057609A1 (en) * | 2011-10-18 | 2013-04-25 | Koninklijke Philips Electronics N.V. | Medical apparatus for displaying the catheter placement position |
| WO2013116240A1 (en) * | 2012-01-30 | 2013-08-08 | Inneroptic Technology, Inc. | Multiple medical device guidance |
| JP6328110B2 (ja) | 2012-07-17 | 2018-05-23 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | 導入要素の姿勢及び形状を決定する決定装置 |
| US9943702B2 (en) | 2012-10-29 | 2018-04-17 | Koninklijke Philips N.V. | Automatic optimal IMRT/VMAT treatment plan generation |
| BR112015013047A2 (pt) | 2012-12-06 | 2017-07-11 | Koninklijke Philips Nv | aparelho de calibração para calibrar um sistema para introduzir um elemento de influência em um objeto, aparelho de determinação de plano de influência, método de calibração para calibrar um sistema para introduzir um elemento de influência em um objeto, método de determinação de plano de influência e programa de computador de calibração para calibrar um sistema para introduzir um elemento de influência em um objeto |
| US20140206926A1 (en) * | 2013-01-18 | 2014-07-24 | Robert van der LAARSE | Methods for optimizing and evaluating dose distributions in brachytherpay |
| US10092251B2 (en) * | 2013-03-15 | 2018-10-09 | Varian Medical Systems, Inc. | Prospective evaluation of tumor visibility for IGRT using templates generated from planning CT and contours |
| US20150202464A1 (en) * | 2014-01-23 | 2015-07-23 | Mitsubis | Multi-Criteria Optimization in Particle Beam Dose Optimization |
| CN106132323B (zh) * | 2014-03-24 | 2019-06-04 | 皇家飞利浦有限公司 | 用于电磁跟踪系统的质量保证和数据协调 |
| US9844684B2 (en) * | 2014-04-30 | 2017-12-19 | Stc.Unm | Optimization methods for radiation therapy planning |
| US9901406B2 (en) | 2014-10-02 | 2018-02-27 | Inneroptic Technology, Inc. | Affected region display associated with a medical device |
| US10188467B2 (en) | 2014-12-12 | 2019-01-29 | Inneroptic Technology, Inc. | Surgical guidance intersection display |
| EP3076317B1 (en) * | 2015-04-02 | 2018-08-15 | RaySearch Laboratories AB | System and method for providing a radiation therapy treatment plan and a radiation therapy machine |
| US9949700B2 (en) | 2015-07-22 | 2018-04-24 | Inneroptic Technology, Inc. | Medical device approaches |
| US10933254B2 (en) | 2015-09-01 | 2021-03-02 | Koninklijke Philips N.V. | Device and method for assisting in a brachytherapy procedure |
| US11565126B2 (en) * | 2015-09-11 | 2023-01-31 | Varian Medical Systems International Ag | Knowledge based multi-criteria optimization for radiotherapy treatment planning |
| US9675319B1 (en) | 2016-02-17 | 2017-06-13 | Inneroptic Technology, Inc. | Loupe display |
| ES2961752T3 (es) * | 2016-09-01 | 2024-03-13 | Univ Oregon Health & Science | Dispositivo para biopsia de próstata endorectal guiada por un sistema de detección anatómica |
| US10278778B2 (en) | 2016-10-27 | 2019-05-07 | Inneroptic Technology, Inc. | Medical device navigation using a virtual 3D space |
| JP2020501698A (ja) | 2016-12-16 | 2020-01-23 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | 焦点放射線治療のための位置決め支援デバイス |
| FI131860B1 (en) * | 2017-03-17 | 2026-01-13 | Planmeca Oy | Self-calibrating medical imaging device |
| US11259879B2 (en) | 2017-08-01 | 2022-03-01 | Inneroptic Technology, Inc. | Selective transparency to assist medical device navigation |
| US11484365B2 (en) | 2018-01-23 | 2022-11-01 | Inneroptic Technology, Inc. | Medical image guidance |
| WO2020113381A1 (zh) * | 2018-12-03 | 2020-06-11 | 深圳先进技术研究院 | 一种超声成像方法及装置 |
| US11744643B2 (en) | 2019-02-04 | 2023-09-05 | Covidien Lp | Systems and methods facilitating pre-operative prediction of post-operative tissue function |
| EP3892224A1 (en) | 2020-04-10 | 2021-10-13 | Koninklijke Philips N.V. | Grid template positioning in interventional medicine |
| CN111986777B (zh) * | 2020-07-31 | 2024-08-02 | 上海联影医疗科技股份有限公司 | 放射治疗计划优化系统、装置和存储介质 |
| CN112516471B (zh) * | 2020-12-01 | 2021-08-27 | 北京航空航天大学 | 基于扩展收缩理论的放疗计划仿真设计方法及系统 |
| EP4015038A1 (en) * | 2020-12-18 | 2022-06-22 | Koninklijke Philips N.V. | Radiation therapy planning |
| GB2642070A (en) * | 2024-06-21 | 2025-12-31 | Nucletron Operations Bv | Medical applicator |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5868757A (en) * | 1994-11-16 | 1999-02-09 | Pgk, Enterprises, Inc. | Method and apparatus for interstitial radiation of the prostate gland |
| US5931786A (en) * | 1997-06-13 | 1999-08-03 | Barzell Whitmore Maroon Bells, Inc. | Ultrasound probe support and stepping device |
| US20020091315A1 (en) * | 1998-02-27 | 2002-07-11 | Varian Medical Systems, Inc. | Brachytherapy system for prostate cancer treatment with computer implemented systems and processes to facilitate pre-implantation planning and post-implantation evaluations with storage of multiple plan variations for a single patient |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5372138A (en) * | 1988-03-21 | 1994-12-13 | Boston Scientific Corporation | Acousting imaging catheters and the like |
| US5391139A (en) | 1992-09-03 | 1995-02-21 | William Beaumont Hospital | Real time radiation treatment planning system |
| DK0633041T3 (da) * | 1993-07-01 | 2000-04-03 | Schneider Europ Gmbh | Medicinske apparater til behandling af blodkar ved hjælp af ioniserende stråling |
| JP2852178B2 (ja) * | 1993-12-28 | 1999-01-27 | 日本電気株式会社 | フィルムキャリアテープ |
| US6256529B1 (en) * | 1995-07-26 | 2001-07-03 | Burdette Medical Systems, Inc. | Virtual reality 3D visualization for surgical procedures |
| US6234951B1 (en) * | 1996-02-29 | 2001-05-22 | Scimed Life Systems, Inc. | Intravascular radiation delivery system |
| US6095975A (en) * | 1997-05-27 | 2000-08-01 | Silvern; David A. | Apparatus and method for determining optimal locations to place radioactive seeds at a cancerous site |
| US6019718A (en) * | 1997-05-30 | 2000-02-01 | Scimed Life Systems, Inc. | Apparatus for intravascular radioactive treatment |
| US6083167A (en) * | 1998-02-10 | 2000-07-04 | Emory University | Systems and methods for providing radiation therapy and catheter guides |
| US6360116B1 (en) * | 1998-02-27 | 2002-03-19 | Varian Medical Systems, Inc. | Brachytherapy system for prostate cancer treatment with computer implemented systems and processes to facilitate pre-operative planning and post-operative evaluations |
| US6387034B1 (en) * | 1998-08-17 | 2002-05-14 | Georia Tech Research Corporation | Brachytherapy treatment planning method and apparatus |
| US6200255B1 (en) * | 1998-10-30 | 2001-03-13 | University Of Rochester | Prostate implant planning engine for radiotherapy |
| US6610013B1 (en) * | 1999-10-01 | 2003-08-26 | Life Imaging Systems, Inc. | 3D ultrasound-guided intraoperative prostate brachytherapy |
| US6438401B1 (en) * | 2000-04-28 | 2002-08-20 | Alpha Intervention Technology, Inc. | Indentification and quantification of needle displacement departures from treatment plan |
| US6561980B1 (en) * | 2000-05-23 | 2003-05-13 | Alpha Intervention Technology, Inc | Automatic segmentation of prostate, rectum and urethra in ultrasound imaging |
| US6500109B2 (en) * | 2000-07-21 | 2002-12-31 | Tayman Medical, Inc. | Prostate treatment template |
| US7022062B1 (en) * | 2000-08-30 | 2006-04-04 | Murphy Brian B | Radioactive seed implantation system and method |
| ES2246999T3 (es) * | 2001-11-23 | 2006-03-01 | Nucletron B.V. | Dispositivo autocontrolado guiado por imagenes para insertar una aguja en el cuerpo de un animal para realizar radioterapia en dicho cuerpo. |
| EP1374949B1 (en) * | 2002-06-17 | 2005-12-14 | Nucletron B.V. | Real time radiation treatment planning system |
| US7041048B2 (en) * | 2002-10-16 | 2006-05-09 | Sourcetech Medical, Llc | Apparatus and method for dose administration in brachytherapy |
-
2002
- 2002-06-17 EP EP20020077436 patent/EP1374949B1/en not_active Expired - Lifetime
- 2002-06-17 ES ES02077436T patent/ES2254599T3/es not_active Expired - Lifetime
- 2002-06-17 AT AT02077436T patent/ATE312648T1/de not_active IP Right Cessation
- 2002-06-17 DE DE2002608009 patent/DE60208009T2/de not_active Expired - Lifetime
-
2003
- 2003-05-28 AU AU2003204404A patent/AU2003204404B2/en not_active Ceased
- 2003-05-30 US US10/448,311 patent/US7899517B2/en not_active Expired - Lifetime
- 2003-06-05 AT AT03076748T patent/ATE488271T1/de not_active IP Right Cessation
- 2003-06-05 PT PT03076748T patent/PT1374951E/pt unknown
- 2003-06-05 DE DE60334956T patent/DE60334956D1/de not_active Expired - Lifetime
- 2003-06-05 ES ES03076748T patent/ES2355700T3/es not_active Expired - Lifetime
- 2003-06-16 CA CA2432493A patent/CA2432493C/en not_active Expired - Lifetime
- 2003-06-17 JP JP2003172377A patent/JP4439843B2/ja not_active Expired - Fee Related
-
2011
- 2011-01-25 US US13/013,051 patent/US8301228B2/en not_active Expired - Fee Related
-
2012
- 2012-09-24 US US13/625,662 patent/US8744553B2/en not_active Expired - Fee Related
-
2014
- 2014-04-23 US US14/260,009 patent/US9381377B2/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5868757A (en) * | 1994-11-16 | 1999-02-09 | Pgk, Enterprises, Inc. | Method and apparatus for interstitial radiation of the prostate gland |
| US5931786A (en) * | 1997-06-13 | 1999-08-03 | Barzell Whitmore Maroon Bells, Inc. | Ultrasound probe support and stepping device |
| US20020091315A1 (en) * | 1998-02-27 | 2002-07-11 | Varian Medical Systems, Inc. | Brachytherapy system for prostate cancer treatment with computer implemented systems and processes to facilitate pre-implantation planning and post-implantation evaluations with storage of multiple plan variations for a single patient |
Also Published As
| Publication number | Publication date |
|---|---|
| US20150105606A1 (en) | 2015-04-16 |
| ATE488271T1 (de) | 2010-12-15 |
| US8744553B2 (en) | 2014-06-03 |
| ATE312648T1 (de) | 2005-12-15 |
| PT1374951E (pt) | 2011-02-07 |
| CA2432493C (en) | 2016-08-30 |
| DE60208009D1 (de) | 2006-01-19 |
| US20110288361A1 (en) | 2011-11-24 |
| ES2254599T3 (es) | 2006-06-16 |
| US9381377B2 (en) | 2016-07-05 |
| DE60334956D1 (de) | 2010-12-30 |
| US20030233123A1 (en) | 2003-12-18 |
| US20130102831A1 (en) | 2013-04-25 |
| JP4439843B2 (ja) | 2010-03-24 |
| EP1374949A1 (en) | 2004-01-02 |
| DE60208009T2 (de) | 2006-08-24 |
| JP2004041725A (ja) | 2004-02-12 |
| US8301228B2 (en) | 2012-10-30 |
| AU2003204404A1 (en) | 2004-01-15 |
| CA2432493A1 (en) | 2003-12-17 |
| EP1374949B1 (en) | 2005-12-14 |
| ES2355700T3 (es) | 2011-03-30 |
| US7899517B2 (en) | 2011-03-01 |
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