AU2002368055B2 - Method of treating autoimmune diseases with interferon-beta and IL-2R antagonist - Google Patents
Method of treating autoimmune diseases with interferon-beta and IL-2R antagonist Download PDFInfo
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- AU2002368055B2 AU2002368055B2 AU2002368055A AU2002368055A AU2002368055B2 AU 2002368055 B2 AU2002368055 B2 AU 2002368055B2 AU 2002368055 A AU2002368055 A AU 2002368055A AU 2002368055 A AU2002368055 A AU 2002368055A AU 2002368055 B2 AU2002368055 B2 AU 2002368055B2
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Classifications
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- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
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- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
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- Biomedical Technology (AREA)
- Molecular Biology (AREA)
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- Neurology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Biochemistry (AREA)
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- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- High Energy & Nuclear Physics (AREA)
- Hospice & Palliative Care (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39302102P | 2002-06-28 | 2002-06-28 | |
| US60/393,021 | 2002-06-28 | ||
| PCT/US2002/038290 WO2004002500A1 (en) | 2002-06-28 | 2002-11-27 | Method of treating autoimmune diseases with interferon-beta and il-2r antagonist |
Publications (2)
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| AU2002368055A1 AU2002368055A1 (en) | 2004-01-19 |
| AU2002368055B2 true AU2002368055B2 (en) | 2008-09-18 |
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| AU2003247813A Ceased AU2003247813C1 (en) | 2002-06-28 | 2003-06-27 | Method for the treatment of multiple sclerosis |
| AU2008212004A Ceased AU2008212004B2 (en) | 2002-06-28 | 2008-09-04 | Method for the treatment of multiple sclerosis |
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| AU2003247813A Ceased AU2003247813C1 (en) | 2002-06-28 | 2003-06-27 | Method for the treatment of multiple sclerosis |
| AU2008212004A Ceased AU2008212004B2 (en) | 2002-06-28 | 2008-09-04 | Method for the treatment of multiple sclerosis |
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| US (11) | US7575742B2 (OSRAM) |
| EP (3) | EP3269377A1 (OSRAM) |
| JP (8) | JP2005535636A (OSRAM) |
| AU (3) | AU2002368055B2 (OSRAM) |
| CA (3) | CA2490804C (OSRAM) |
| CY (2) | CY2016043I2 (OSRAM) |
| DK (2) | DK2314627T3 (OSRAM) |
| ES (2) | ES2474718T3 (OSRAM) |
| HK (1) | HK1249850A1 (OSRAM) |
| HU (2) | HUE036677T2 (OSRAM) |
| IL (2) | IL165973A (OSRAM) |
| LU (1) | LU93315I2 (OSRAM) |
| PT (2) | PT1539200E (OSRAM) |
| SI (2) | SI1539200T1 (OSRAM) |
| WO (2) | WO2004002500A1 (OSRAM) |
Families Citing this family (19)
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| KR100884973B1 (ko) * | 2001-04-26 | 2009-02-23 | 모션 테크놀로지즈 엘엘씨 | 연속 가변 변속기의 속력비를 조절하는 장치 및 방법 |
| AU2002368055B2 (en) * | 2002-06-28 | 2008-09-18 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of treating autoimmune diseases with interferon-beta and IL-2R antagonist |
| US20060134750A1 (en) * | 2004-03-10 | 2006-06-22 | Pepgen Corporation | Method of treatment using interferon-tau |
| MX2007008220A (es) | 2005-01-12 | 2007-08-17 | Biogen Idec Inc | Metodo para liberar interferon-beta. |
| WO2006089066A1 (en) * | 2005-02-15 | 2006-08-24 | Neuromolecular Pharmaceuticals, Inc. | Combinations therapy for treatment of demyelinating conditions |
| NZ580686A (en) | 2007-05-02 | 2012-11-30 | Ambrx Inc | Modified interferon beta polypeptides and their uses |
| US20100055098A1 (en) * | 2008-08-28 | 2010-03-04 | Facet Biotech Corporation | Method for treating multiple sclerosis patients with anti-il2r antibodies |
| WO2010045265A1 (en) * | 2008-10-13 | 2010-04-22 | Biovista, Inc. | Compositions and methods for treating multiple sclerosis |
| WO2010068923A2 (en) * | 2008-12-12 | 2010-06-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Agents that selectively inhibit cd25 on dendritic cells or t cells and their use |
| CA2771335A1 (en) * | 2009-08-31 | 2011-03-03 | Abbott Biotherapeutics Corp. | Use of an immunoregulatory nk cell population for monitoring the efficacy of anti-il-2r antibodies in multiple sclerosis patients |
| CN102939305B (zh) * | 2010-04-08 | 2016-08-17 | Jn生物科学有限责任公司 | 对cd122的抗体 |
| WO2015089217A2 (en) | 2013-12-10 | 2015-06-18 | Bionz, Llc | Methods of developing selective peptide antagonists |
| ES2778053T3 (es) | 2011-01-18 | 2020-08-07 | Bioniz Llc | Composiciones para modular la actividad de la citocina gamma-c |
| WO2013022972A1 (en) | 2011-08-08 | 2013-02-14 | Abbott Biotherapeutics Corporation | Methods of treating progressive forms of multiple sclerosis |
| KR102654684B1 (ko) | 2015-10-09 | 2024-04-04 | 바이오니즈 테라퓨틱스, 아이엔씨. | 감마-ｃ-사이토카인 활성의 조정 |
| WO2018027195A1 (en) | 2016-08-05 | 2018-02-08 | Abbvie Biotherapeutics Inc. | Compositions containing reduced amounts of daclizumab acidic isoforms and methods for preparing the same |
| DE102017104088A1 (de) * | 2017-02-28 | 2018-08-30 | L&O Hunting Group GmbH | Integralschalldämpfer für einen Gewehrlauf |
| US12030936B2 (en) | 2019-05-03 | 2024-07-09 | Bioniz Therapeutics, Inc. | Modulating the effects of gamma-c-cytokine signaling for the treatment of alopecia and alopecia associated disorders |
| CN114449941A (zh) * | 2019-08-07 | 2022-05-06 | 艾迪菲斯健康有限公司 | 心血管疾病的治疗和预防 |
Family Cites Families (39)
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| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| US4819150A (en) | 1985-04-05 | 1989-04-04 | Unisys Corporation | Array for simulating computer functions for large computer systems |
| US5011684A (en) * | 1985-09-05 | 1991-04-30 | Beth Israel Hospital Association | Lysing or blocking unwanted cells with IL-2 receptor-specific binding substance |
| US5336489A (en) | 1985-09-05 | 1994-08-09 | The Beth Israel Hospital Association | Treatment of allograft rejection with IL-2 receptor-specific cytotoxins |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| GB2188941B (en) * | 1986-04-14 | 1990-06-06 | Bayer Ag | Monoclonal antibodies recognizing human interleukin-2-receptor |
| US6051405A (en) * | 1986-09-24 | 2000-04-18 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Constructs encoding recombinant antibody-toxin fusion proteins |
| US5013548A (en) | 1987-09-08 | 1991-05-07 | Duke University | Production of antibodies to HIV |
| US5695927A (en) | 1988-03-31 | 1997-12-09 | The University Of Arizona, Department Of Internal Medicine, Section Of Hematology And Oncology | Monoclonal antibodies specific for HIV and the hybridomas for production thereof |
| JPH02503867A (ja) | 1988-04-15 | 1990-11-15 | プロテイン デザイン ラブズ インコーポレーテッド | Ｉｌ‐２レセプター特異的キメラ抗体 |
| DE3815472A1 (de) * | 1988-05-06 | 1989-11-16 | Centre Regional De Transfusion | Monoklonaler antikoerper und seine verwendung |
| US5152980A (en) | 1988-05-19 | 1992-10-06 | The Beth Israel Hospital Association | Induction of tolerance to a foreign antigen IL-2 receptor-binding substances |
| IL162181A (en) * | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| ATE356869T1 (de) | 1990-01-12 | 2007-04-15 | Amgen Fremont Inc | Bildung von xenogenen antikörpern |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| ES2139598T3 (es) | 1990-07-10 | 2000-02-16 | Medical Res Council | Procedimientos para la produccion de miembros de parejas de union especifica. |
| WO1993012227A1 (en) | 1991-12-17 | 1993-06-24 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5620686A (en) | 1990-09-28 | 1997-04-15 | British Technology Group Limited | Antigen-antibody conjugates |
| US5840496A (en) * | 1990-10-09 | 1998-11-24 | Chiron Corporation | Method for diagnosing endometrial cancer |
| FR2672291A1 (fr) | 1991-01-31 | 1992-08-07 | Inst Nat Sante Rech Med | Composition d'anticorps diriges contre le recepteur de l'interleukine-2 humaine ou animale. |
| GB9115010D0 (en) | 1991-07-11 | 1991-08-28 | Wellcome Found | Antibody |
| JPH05244982A (ja) * | 1991-12-06 | 1993-09-24 | Sumitomo Chem Co Ltd | 擬人化ｂ−ｂ１０ |
| US5571507A (en) | 1992-02-25 | 1996-11-05 | Seragen, Inc. | Methods of treating diabetes |
| US5643756A (en) | 1992-08-28 | 1997-07-01 | The Public Health Research Institute Of The City Of New York, Inc. | Fusion glycoproteins |
| PT699077E (pt) | 1993-05-07 | 2002-04-29 | Bio Merieux Inc | Complexo imunogenico de hiv |
| CA2159366A1 (en) | 1993-08-27 | 1995-03-02 | Michael R. Perry | Mechanical gas flushing system |
| US5635597A (en) | 1994-05-27 | 1997-06-03 | Affymax Technologies, N.V. | Peptides that bind IL-2 receptors |
| JP3468773B2 (ja) | 1994-07-15 | 2003-11-17 | ザ ユニバーシティ オブ アイオワ リサーチ ファウンデーション | 免疫調節オリゴヌクレオチド |
| US6096728A (en) * | 1996-02-09 | 2000-08-01 | Amgen Inc. | Composition and method for treating inflammatory diseases |
| US6013256A (en) | 1996-09-24 | 2000-01-11 | Protein Design Labs, Inc. | Method of preventing acute rejection following solid organ transplantation |
| US6833135B1 (en) * | 1997-08-06 | 2004-12-21 | Laboratorio Medinfar Produtos Farmaceuticos, Lda. | DNA integration into “Mycobacterium spp.” genome by trans-complementation using a site-specific integration system |
| WO2000025816A1 (en) | 1998-10-30 | 2000-05-11 | The University Of Miami | Treatment of hepatitis c by administration of anti-il-2 receptor monoclonal antibody and an antiviral compound |
| US6346247B1 (en) | 1999-10-28 | 2002-02-12 | Promega Corporation | Prevention and treatment of autoimmune disease with luminally administered polyclonal antibodies |
| AU2001248839A1 (en) | 2000-04-25 | 2001-11-07 | Tomoaki Hoshino | Remedies for interstitial pneumonia, method of constructing animal model of this disease and screening method with the use of the same |
| HUP0400986A3 (en) * | 2001-04-06 | 2012-09-28 | Univ Bristol | Use of cd25 binding molecules in steroid-resistant patients |
| AU2002368055B2 (en) * | 2002-06-28 | 2008-09-18 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of treating autoimmune diseases with interferon-beta and IL-2R antagonist |
| AU2003251633A1 (en) | 2002-07-01 | 2004-01-19 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of | Il-21 as a regulator of immunoglobin production |
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2004
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Non-Patent Citations (3)
| Title |
|---|
| "Study of Zenapax in the treatment of multiple sclerosis" 27 November 2000. Retrieved from the internet: * |
| JACOBS et al. Annals of Neurology. 1996. 39(3): 285-294 * |
| PATTY et al. Neuorology. 1993. 43:662-667 * |
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