AU2002355686B2 - Gastric retention controlled drug delivery system - Google Patents
Gastric retention controlled drug delivery system Download PDFInfo
- Publication number
- AU2002355686B2 AU2002355686B2 AU2002355686A AU2002355686A AU2002355686B2 AU 2002355686 B2 AU2002355686 B2 AU 2002355686B2 AU 2002355686 A AU2002355686 A AU 2002355686A AU 2002355686 A AU2002355686 A AU 2002355686A AU 2002355686 B2 AU2002355686 B2 AU 2002355686B2
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- Australia
- Prior art keywords
- drug delivery
- delivery system
- gastric retention
- controlled drug
- core
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229960003819 vecuronium Drugs 0.000 description 1
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- PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 description 1
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- 229920002554 vinyl polymer Polymers 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- Neurology (AREA)
- Physiology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN612MU2001 | 2001-07-04 | ||
| IN612/MUM/2001 | 2001-07-04 | ||
| PCT/IN2002/000144 WO2003011255A1 (en) | 2001-07-04 | 2002-07-04 | Gastric retention controlled drug delivery system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2002355686A1 AU2002355686A1 (en) | 2003-05-29 |
| AU2002355686B2 true AU2002355686B2 (en) | 2007-11-29 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2002355686A Ceased AU2002355686B2 (en) | 2001-07-04 | 2002-07-04 | Gastric retention controlled drug delivery system |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7776345B2 (https=) |
| EP (2) | EP1411901B1 (https=) |
| JP (2) | JP4994570B2 (https=) |
| KR (1) | KR20040018394A (https=) |
| CN (1) | CN1520286B (https=) |
| AT (1) | ATE477795T1 (https=) |
| AU (1) | AU2002355686B2 (https=) |
| BR (1) | BR0211317A (https=) |
| CA (1) | CA2452738C (https=) |
| DE (1) | DE60237372D1 (https=) |
| ES (1) | ES2398348T3 (https=) |
| HU (1) | HUP0500795A3 (https=) |
| MX (1) | MXPA03012041A (https=) |
| PL (1) | PL370793A1 (https=) |
| RU (1) | RU2325152C2 (https=) |
| WO (1) | WO2003011255A1 (https=) |
| ZA (1) | ZA200400799B (https=) |
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| US5744500A (en) * | 1990-01-03 | 1998-04-28 | Teva Pharmaceutical Industries, Ltd. | Use of R-enantiomer of N-propargyl-1-aminoindan, salts, and compositions thereof |
| ATE540678T1 (de) | 2001-06-11 | 2012-01-15 | Xenoport Inc | Prodrugs aus gaba-analoga, zusammensetzungen und ihre verwendungen |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| MXPA03012041A (es) * | 2001-07-04 | 2004-03-26 | Sun Pharmaceutical Ind Ltd | Sistema de administracion controlada de farmacos de retencion gastrica. |
| US7612112B2 (en) | 2001-10-25 | 2009-11-03 | Depomed, Inc. | Methods of treatment using a gastric retained gabapentin dosage |
| TWI312285B (en) | 2001-10-25 | 2009-07-21 | Depomed Inc | Methods of treatment using a gastric retained gabapentin dosage |
| CA2486794A1 (en) * | 2002-06-04 | 2003-12-11 | J. B. Chemicals & Pharmaceuticals Ltd. | Pharmaceutical composition for controlled drug delivery system |
| AR040682A1 (es) | 2002-07-25 | 2005-04-13 | Pharmacia Corp | Forma de dosificacion una vez al dia de pramipexol |
| US8821915B2 (en) | 2002-08-09 | 2014-09-02 | Veroscience, Llc | Therapeutic process for the treatment of the metabolic syndrome and associated metabolic disorders |
| EP2354120A1 (en) | 2003-08-20 | 2011-08-10 | XenoPort, Inc. | Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof |
| KR20110097942A (ko) | 2003-08-20 | 2011-08-31 | 제노포트 인코포레이티드 | 아실옥시알킬 카르바메이트 프로드러그, 합성 및 사용 방법 |
| US8246996B2 (en) * | 2003-08-29 | 2012-08-21 | Shionogi Inc. | Antibiotic product, use and formulation thereof |
| US20050169991A1 (en) * | 2003-12-12 | 2005-08-04 | Penwest Pharmaceuticals Co. | Sustained release torsemide dosage forms |
| WO2005060942A1 (en) * | 2003-12-19 | 2005-07-07 | Aurobindo Pharma Ltd | Extended release pharmaceutical composition of metformin |
| TW200533391A (en) | 2004-03-25 | 2005-10-16 | Sun Pharmaceutical Ind Ltd | Gastric retention drug delivery system |
| WO2006014973A2 (en) | 2004-07-26 | 2006-02-09 | Teva Pharmaceutical Industries, Ltd. | Pharmaceutical dosage forms including rasagiline |
| EA200700388A1 (ru) | 2004-08-13 | 2007-08-31 | Бёрингер Ингельхайм Интернациональ Гмбх | Композиция пеллеты пролонгированного высвобождения, содержащая прамипексол или его фармацевтически приемлемую соль, способ её изготовления и её применение |
| FR2874325B1 (fr) * | 2004-08-19 | 2006-10-20 | Sanofi Synthelabo | Composition pharmaceutique sous forme de comprime a residence gastrique contenant de l'alfuzosine |
| DE102004042139B4 (de) * | 2004-08-31 | 2009-06-10 | Aristocon Verwaltungs- Gmbh | Perorale Darreichungsformen zur Erzielung eines Retardierungseffektes nach der Arzneimitteleinnahme mit einer Mahlzeit |
| US20080020041A1 (en) * | 2004-10-19 | 2008-01-24 | Ayres James W | Enteric Coated Compositions that Release Active Ingredient(s) in Gastric Fluid and Intestinal Fluid |
| WO2006050471A2 (en) | 2004-11-03 | 2006-05-11 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs of sulfinic acids, methods of synthesis, and use |
| WO2006050472A2 (en) | 2004-11-03 | 2006-05-11 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphonous and -phosphinic acids |
| CA2584338C (en) | 2004-11-04 | 2013-08-06 | Xenoport, Inc. | Gabapentin prodrug sustained release oral dosage forms |
| ES2540929T3 (es) * | 2005-02-01 | 2015-07-14 | Emisphere Technologies, Inc. | Sistema de administración de retención gástrica y liberación controlada |
| EP1690540A1 (en) * | 2005-02-15 | 2006-08-16 | Neuro3D | Composition comprising ocaperidone |
| US8431156B2 (en) * | 2005-02-22 | 2013-04-30 | Sun Pharma Advanced Research Company Ltd. | Pharmaceutical composition |
| WO2006091657A1 (en) * | 2005-02-23 | 2006-08-31 | Teva Pharmaceutical Industries, Ltd. | Rasagiline formulations of improved content uniformity |
| EP1745775B1 (en) * | 2005-07-19 | 2008-05-28 | Ethypharm | Gastroretentive formulations and manufacturing process thereof. |
| WO2007048223A2 (en) * | 2005-10-25 | 2007-05-03 | Pharmascience Inc. | A gastric retention drug delivery system |
| US20090176882A1 (en) * | 2008-12-09 | 2009-07-09 | Depomed, Inc. | Gastric retentive gabapentin dosage forms and methods for using same |
| AU2007201808B8 (en) * | 2006-04-26 | 2013-09-05 | Sun Pharmaceutical Advanced Research Company Ltd | A method for alleviating signs and symptoms of spasticity |
| US8703191B2 (en) * | 2006-07-25 | 2014-04-22 | Intelgenx Corp. | Controlled-release pharmaceutical tablets |
| UA96457C2 (ru) | 2006-08-03 | 2011-11-10 | Нитек Фарма Аг | Лечение ревматоидного артрита глюкокортикоидами с отсроченным высвобождением |
| CL2007002214A1 (es) * | 2006-08-14 | 2008-03-07 | Boehringer Ingelheim Int | Composicion farmaceutica en la forma de comprimido, donde al menos la longitud del comprimido en el estado anterior de la aplicacion es al menos 7/12 del diametro pilorico del paciente y despues de ingerirlo en estado alimentado, la longitud del comp |
| US20100016310A1 (en) * | 2006-08-17 | 2010-01-21 | Boehringer Ingelheim International Gmbh | Methods of using aryl sulfonyl compounds effective as soluble epoxide hydrolase inhibitors |
| WO2008033572A1 (en) | 2006-09-15 | 2008-03-20 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use |
| KR20090057399A (ko) * | 2006-09-26 | 2009-06-05 | 노파르티스 아게 | Ｓ１ｐ 조정제를 포함하는 제약 조성물 |
| EP2121107B1 (en) | 2006-12-18 | 2012-10-31 | Eatlittle Inc. | Device for delivery of a substance |
| TR201910825T4 (tr) * | 2006-12-22 | 2019-08-21 | Ironwood Pharmaceuticals Inc | Yemek borusu rahatsizliklarini tedavi̇ etmek i̇çi̇n yöntemler ve bi̇leşi̇mler |
| KR20080076382A (ko) * | 2007-02-15 | 2008-08-20 | (주)아모레퍼시픽 | 실로스타졸의 제어방출 제제 및 그 제조방법 |
| CN101011393B (zh) * | 2007-02-16 | 2010-10-06 | 广州柏赛罗药业有限公司 | 厄贝沙坦胃内滞留型缓释药物组合物 |
| DE102007026037A1 (de) | 2007-06-04 | 2008-12-11 | Lts Lohmann Therapie-Systeme Ag | Gastroretentives System mit Alginat-Körper |
| US20100035886A1 (en) | 2007-06-21 | 2010-02-11 | Veroscience, Llc | Parenteral formulations of dopamine agonists |
| US8741918B2 (en) | 2007-06-21 | 2014-06-03 | Veroscience Llc | Parenteral formulations of dopamine agonists |
| HUP0700469A2 (en) * | 2007-07-09 | 2009-04-28 | Richter Gedeon Nyrt | Floating pharmaceutical composition of sustained release containing metronidazol |
| EP2192892A2 (en) * | 2007-07-27 | 2010-06-09 | Depomed, Inc. | Pulsatile gastric retentive dosage forms |
| EP2175840A2 (en) * | 2007-08-14 | 2010-04-21 | Dr. Reddy's Laboratories, Ltd. | Pharmaceutical compositions comprising ropinirole |
| US20120003307A1 (en) * | 2007-11-29 | 2012-01-05 | Ranbaxy Laboratories Limited | Levetiracetam controlled release composition |
| EP2065038A1 (en) * | 2007-11-30 | 2009-06-03 | Pharnext | New therapeutic approaches for treating Charcot-Marie-Tooth disease |
| WO2009097156A1 (en) * | 2008-02-01 | 2009-08-06 | Barr Laboratories, Inc. | Pharmaceutical capsules comprising extended release dipyridamole pellets |
| US9457048B2 (en) | 2008-02-05 | 2016-10-04 | Wellosophy Corporation | Absorbent ingestible agents and associated methods of manufacture and use |
| KR101601649B1 (ko) * | 2008-04-18 | 2016-03-09 | 인텍 파마 리미티드 | 카르비도파／레보도파 위체류 약물 전달 |
| ZA200903858B (en) * | 2008-06-19 | 2013-10-30 | Univ Of Witwatesrand Johannesburg | Pharmaceutical dosage form |
| WO2009158625A2 (en) * | 2008-06-26 | 2009-12-30 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing gastrointestinal disorders and gerd-related respiratory disorders |
| US8173637B2 (en) * | 2008-07-24 | 2012-05-08 | Handa Pharmaceuticals, Llc | Stabilized atypical antipsychotic formulation |
| JP2012500221A (ja) * | 2008-08-15 | 2012-01-05 | ディポメド，インコーポレイティド | Ｃｎｓ障害の処理及び予防のための胃保持性医薬組成物 |
| JP2012510987A (ja) | 2008-12-04 | 2012-05-17 | インテック ファーマ リミテッド | ザレプロン胃内滞留性薬剤送達システム |
| CA3014688A1 (en) | 2008-12-19 | 2010-07-15 | Supernus Pharmaceuticals, Inc. | Use of molindone for the treatment of aggression, irritability, or impulsivity |
| AU2010207740B2 (en) * | 2009-01-26 | 2016-06-16 | Nitec Pharma Ag | Delayed-release glucocorticoid treatment of asthma |
| EP2263657B1 (en) * | 2009-05-20 | 2013-07-17 | Ranbaxy Laboratories Limited | Controlled release lamotrigine formulations |
| CN102438598B (zh) * | 2009-05-27 | 2015-06-10 | 株式会社茶山医化 | 含有泡腾层的多层片 |
| US9352025B2 (en) | 2009-06-05 | 2016-05-31 | Veroscience Llc | Combination of dopamine agonists plus first phase insulin secretagogues for the treatment of metabolic disorders |
| US20110104273A1 (en) * | 2009-11-05 | 2011-05-05 | Depomed, Inc. | Gastric retentive pharmaceutical compositions for immediate and extended release of phenylephrine |
| JP6045347B2 (ja) * | 2010-02-03 | 2016-12-14 | ファーマ ツー ビー リミテッド | ラサギリンの持続放出性製剤およびその使用 |
| CA2790164A1 (en) * | 2010-02-17 | 2011-08-25 | Sun Pharma Advanced Research Company Ltd. | Method of treating a disease condition susceptible to baclofen therapy |
| WO2011123497A1 (en) * | 2010-03-31 | 2011-10-06 | Supernus Pharmaceuticals Inc. | Stabilized formulations of cns compounds |
| KR101270751B1 (ko) * | 2010-05-06 | 2013-06-07 | (주)비씨월드제약 | 위 체류 및 방출 조절을 위한 조성물 |
| US20130078290A1 (en) | 2010-06-01 | 2013-03-28 | Rubicon Research Private Limited | Gastroretentive Dosage Forms Of GABA Analogs |
| HRP20151321T1 (hr) | 2011-01-20 | 2016-01-29 | Bionevia Pharmaceuticals Inc. | Epalrestat ili njegov derivat u oblicima s prilagođenim otpuštanjem te postupci uporabe istih |
| AT511671A1 (de) * | 2011-07-13 | 2013-01-15 | Bischof Georg Dr | Zusammensetzung zur erzeugung einer vorübergehenden okklusion des darms eines säugetiers |
| KR101438546B1 (ko) * | 2011-08-26 | 2014-09-17 | 근화제약주식회사 | 프레가발린을 포함하는 서방성 제제 |
| RU2489147C2 (ru) * | 2011-08-31 | 2013-08-10 | Людмила Петровна Лазурина | Фармацевтическая антибактериальная композиция для местного применения на основе активных биометаллокомплексов |
| US20130143867A1 (en) | 2011-12-02 | 2013-06-06 | Sychroneuron Inc. | Acamprosate formulations, methods of using the same, and combinations comprising the same |
| CN102440976A (zh) * | 2011-12-21 | 2012-05-09 | 南京海陵中药制药工艺技术研究有限公司 | 依帕司他缓释片及其制备方法 |
| NZ700474A (en) * | 2012-04-18 | 2016-10-28 | Contera Pharma Aps | Orally available pharmaceutical formulation suitable for improved management of movement disorders |
| EP2950822B1 (en) * | 2013-01-30 | 2019-04-24 | Daewoong Co., Ltd. | Pharmaceutical composition for protecting wounds, providing hemostasis, or preventing adhesion in the gastrointestinal tract |
| WO2014197744A1 (en) | 2013-06-05 | 2014-12-11 | Synchroneuron, Inc. | Acamprosate formulations, methods of using the same, and combinations comprising the same |
| FR3014692B1 (fr) * | 2013-12-18 | 2016-01-29 | Ethypharm Sa | Compositions pharmaceutiques orales a retention gastrique. |
| WO2016001843A1 (en) * | 2014-06-30 | 2016-01-07 | Sun Pharmaceutical Industries Limited | Extended-release gastroretentive tablets of voglibose |
| US10172800B2 (en) | 2015-02-20 | 2019-01-08 | Osmotica Kereskedelmi Es Szolgaltato Kft | Controlled release dosage form with enhanced pharmacokinetics |
| WO2016132218A1 (en) | 2015-02-20 | 2016-08-25 | Osmotica Kereskedelmi Es Szolgaltato Kft | Method of administering r-baclofen in an extended release dosage form |
| US10987328B2 (en) | 2015-02-20 | 2021-04-27 | Osmotica Kereskedelmi Es Szolgaltato Kft | Controlled release dosage form |
| US10300032B2 (en) | 2015-02-20 | 2019-05-28 | Osmotica Kereskedelmi Es Szolgaltato Kft | Controlled release dosage form |
| RU2649834C1 (ru) * | 2016-07-06 | 2018-04-04 | Фармалидер С.А. | Фармацевтическая композиция силденафила цитрата в форме суспензии для перорального применения |
| AU2017297718B2 (en) | 2016-07-11 | 2023-06-08 | Contera Pharma A/S | Pulsatile drug delivery system for treating morning akinesia |
| FR3054218B1 (fr) * | 2016-07-22 | 2020-03-06 | Universite De Rouen | Procede de dedoublement de sels de baclofene |
| US10736905B1 (en) | 2016-09-09 | 2020-08-11 | Shahin Fatholahi | Nefopam dosage forms and methods of treatment |
| EP3509592A4 (en) | 2016-09-09 | 2020-07-22 | Cutispharma, Inc. | SUSPENSIONS AND DILUENTS FOR METRONIDAZOLE AND BACLOFEN |
| EP3345591A1 (en) * | 2017-01-06 | 2018-07-11 | Oystershell NV | Oral dosage form for enhanced solubilization of a poorly soluble active agent and method of preparation |
| WO2018127594A1 (en) * | 2017-01-06 | 2018-07-12 | Oystershell Nv | Oral dosage form for enhanced solubilization of a poorly soluble active agent and method of preparation |
| JP7521897B2 (ja) | 2017-03-31 | 2024-07-24 | アキュラ・ファーマシューティカルズ・インコーポレーテッド | 医薬品有効成分の自己調節放出のための方法及び組成物 |
| JP6823539B2 (ja) * | 2017-05-26 | 2021-02-03 | 株式会社ファンケル | 胃内滞留性錠剤 |
| US10987311B2 (en) * | 2017-06-16 | 2021-04-27 | Kashiv Specialty Pharmaceuticals, Llc | Extended release compositions comprising pyridostigmine |
| EP3648747B1 (en) * | 2017-06-16 | 2022-09-07 | Amneal Complex Products Research LLC | Gastroretentive dosage forms for sustained drug delivery |
| US10588863B2 (en) * | 2017-06-16 | 2020-03-17 | Kashiv Biosciences, Llc | Extended release compositions comprising pyridostigmine |
| US11446311B2 (en) | 2017-09-08 | 2022-09-20 | Shahin Fatholahi | Methods for treating pain associated with sickle cell disease |
| US10736874B1 (en) | 2017-09-08 | 2020-08-11 | Shahin Fatholahi | Methods for treating pain associated with sickle cell disease |
| EP3678648B1 (en) * | 2017-09-08 | 2023-07-26 | Insignis Therapeutics, Inc. | Methods of using dipivefrin |
| CN109985016B (zh) * | 2017-12-29 | 2021-07-27 | 江苏恒瑞医药股份有限公司 | 一种非布司他的控释组合物及其制备方法 |
| ES2861153T3 (es) * | 2018-06-18 | 2021-10-05 | Composiciones de liberación prolongada que comprenden piridostigmina | |
| CN112469400A (zh) * | 2018-06-19 | 2021-03-09 | 新加坡国立大学 | 对于各种适应症的生物利用度更佳的5-羟色氨酸(5-htp)制剂 |
| JP7034343B2 (ja) | 2018-06-27 | 2022-03-11 | アムニール コンプレックス プロダクツ リサーチ エルエルシー | 自己調節性の浸透性胃保持性薬物送達システム |
| JP7044649B2 (ja) * | 2018-06-28 | 2022-03-30 | 株式会社ファンケル | 胃内浮遊錠剤 |
| WO2020011938A1 (en) | 2018-07-11 | 2020-01-16 | Medizinische Universität Wien | Glucocorticoids for the topical treatment of autoimmune gastritis |
| WO2020131780A1 (en) * | 2018-12-18 | 2020-06-25 | Ddp Specialty Electronics Materials Us, Inc. | A sustained release composition comprising a methylcellulose |
| EP3968980A1 (en) | 2019-05-14 | 2022-03-23 | Clexio Biosciences Ltd. | Treatment of nocturnal symptoms and morning akinesia in subjects with parkinson's disease |
| RU2751163C9 (ru) * | 2020-04-06 | 2021-10-20 | Общество С Ограниченной Ответственностью "Ниармедик Плюс" | Фармацевтическая композиция на основе макозинона для лечения туберкулеза, включая его формы с множественной и широкой лекарственной устойчивостью. |
| WO2022195476A1 (en) | 2021-03-15 | 2022-09-22 | Clexio Biosciences Ltd. | Gastroretentive devices for assessment of intragastric conditions |
| AU2022395186A1 (en) * | 2021-11-25 | 2024-05-30 | Orexa B.V. | Gastro-retentive oral dosage unit containing a local anaesthetic |
| CN114796142A (zh) * | 2022-04-08 | 2022-07-29 | 黄山学院 | 萘普生胃漂浮片及其制备方法 |
| CN115444831B (zh) * | 2022-10-25 | 2023-08-22 | 南京康川济医药科技有限公司 | 一种依帕司他胃漂浮片及其制备方法 |
| CN115721621A (zh) * | 2022-12-16 | 2023-03-03 | 杭州剂泰医药科技有限责任公司 | 一种依帕司他缓释制剂 |
| CN117137877A (zh) * | 2023-10-09 | 2023-12-01 | 重庆士立德医药科技有限公司 | 一种巴氯芬缓释片及其制备方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000038650A1 (en) * | 1998-12-23 | 2000-07-06 | Alza Corporation | Gastric retention dosage form having multiple layers |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4101650A (en) * | 1977-04-06 | 1978-07-18 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Pepstatin floating minicapsules |
| SE8404467D0 (sv) * | 1984-09-06 | 1984-09-06 | Ferrosan Ab | Controlled-release medical preparations |
| DE3681348D1 (de) * | 1985-06-11 | 1991-10-17 | Teijin Ltd | Oral-arzneizubereitung mit retardwirkung. |
| JPS62195323A (ja) * | 1986-02-24 | 1987-08-28 | Eisai Co Ltd | 胃内滞留型粒子 |
| US4772473A (en) * | 1986-06-16 | 1988-09-20 | Norwich Eaton Pharmaceuticals, Inc. | Nitrofurantoin dosage form |
| JPH0798742B2 (ja) | 1986-07-03 | 1995-10-25 | ゼリア新薬工業株式会社 | 徐放性製剤組成物 |
| US4851232A (en) * | 1987-02-13 | 1989-07-25 | Alza Corporation | Drug delivery system with means for obtaining desirable in vivo release rate pattern |
| IL87710A (en) * | 1987-09-18 | 1992-06-21 | Ciba Geigy Ag | Covered floating retard form for controlled release in gastric juice |
| US4892739A (en) * | 1988-04-25 | 1990-01-09 | Ciba-Geigy Corporation | Osmotic continuous dispensing oral delivery system containing a pharmaceutically acceptable active agent having a improved core membrane adhesion properties |
| US5096714A (en) * | 1988-06-28 | 1992-03-17 | Hauser-Kuhrts, Inc. | Prolonged release drug tablet formulations |
| PH26730A (en) * | 1988-12-30 | 1992-09-28 | Ciba Geigy Ag | Coated adhesive tablets |
| HU213407B (en) * | 1993-12-09 | 1997-06-30 | Egyt Gyogyszervegyeszeti Gyar | Process for producing tablet with diffusive-osmotic release |
| DE4406424A1 (de) | 1994-02-28 | 1995-08-31 | Bayer Ag | Expandierbare Arzneiformen |
| US5654005A (en) * | 1995-06-07 | 1997-08-05 | Andrx Pharmaceuticals, Inc. | Controlled release formulation having a preformed passageway |
| WO1997020551A1 (en) * | 1995-12-05 | 1997-06-12 | Adcock Ingram Limited | Pharmaceutical composition comprising a skeletal muscle relaxant, a non-steroidal antiinflammatory agent and an analgesic |
| US6271278B1 (en) | 1997-05-13 | 2001-08-07 | Purdue Research Foundation | Hydrogel composites and superporous hydrogel composites having fast swelling, high mechanical strength, and superabsorbent properties |
| CA2290624C (en) * | 1997-06-06 | 2006-12-05 | John W. Shell | Gastric-retentive oral drug dosage forms for controlled release of highly soluble drugs |
| IN186245B (https=) * | 1997-09-19 | 2001-07-14 | Ranbaxy Lab Ltd | |
| EP1063973B1 (en) | 1998-03-19 | 2016-11-16 | Bristol-Myers Squibb Company | Biphasic controlled release delivery system for high solubility pharmaceuticals and method |
| ATE245414T1 (de) * | 1998-09-14 | 2003-08-15 | Ranbaxy Lab Ltd | Oral verabreichtes system zur zeitlich und räumlich gesteuerten arzneistoffabgabe |
| FR2784583B1 (fr) | 1998-10-16 | 2002-01-25 | Synthelabo | Composition pharmaceutique a residence gastrique et a liberation controlee |
| WO2000035419A2 (en) * | 1998-12-17 | 2000-06-22 | Alza Corporation | Conversion of liquid filled gelatin capsules into controlled release systems by multiple coatings |
| AU6381000A (en) | 1999-07-29 | 2001-02-19 | Interneuron Pharmaceuticals, Inc. | Methods and compositions for alleviating stuttering |
| WO2001010405A1 (en) | 1999-08-04 | 2001-02-15 | Ranbaxy Laboratories Limited | Hydrodynamically balanced oral drug delivery system |
| FR2797185B1 (fr) | 1999-08-06 | 2001-10-26 | Galenix Dev | Composition pharmaceutique flottante comprenant une phase active et une phase non active |
| EP1095650A1 (en) * | 1999-10-29 | 2001-05-02 | Universiteit Leiden | Double phase time-controlled release system |
| MXPA03012041A (es) * | 2001-07-04 | 2004-03-26 | Sun Pharmaceutical Ind Ltd | Sistema de administracion controlada de farmacos de retencion gastrica. |
| KR20110097942A (ko) * | 2003-08-20 | 2011-08-31 | 제노포트 인코포레이티드 | 아실옥시알킬 카르바메이트 프로드러그, 합성 및 사용 방법 |
| AU2007201808B8 (en) * | 2006-04-26 | 2013-09-05 | Sun Pharmaceutical Advanced Research Company Ltd | A method for alleviating signs and symptoms of spasticity |
-
2002
- 2002-07-04 MX MXPA03012041A patent/MXPA03012041A/es active IP Right Grant
- 2002-07-04 CA CA2452738A patent/CA2452738C/en not_active Expired - Fee Related
- 2002-07-04 AT AT02751608T patent/ATE477795T1/de not_active IP Right Cessation
- 2002-07-04 DE DE60237372T patent/DE60237372D1/de not_active Expired - Lifetime
- 2002-07-04 BR BR0211317-1A patent/BR0211317A/pt not_active Application Discontinuation
- 2002-07-04 US US10/482,770 patent/US7776345B2/en active Active
- 2002-07-04 AU AU2002355686A patent/AU2002355686B2/en not_active Ceased
- 2002-07-04 EP EP02751608A patent/EP1411901B1/en not_active Expired - Lifetime
- 2002-07-04 PL PL02370793A patent/PL370793A1/xx unknown
- 2002-07-04 CN CN028128575A patent/CN1520286B/zh not_active Expired - Lifetime
- 2002-07-04 RU RU2003138075/15A patent/RU2325152C2/ru not_active IP Right Cessation
- 2002-07-04 ES ES10165807T patent/ES2398348T3/es not_active Expired - Lifetime
- 2002-07-04 JP JP2003516487A patent/JP4994570B2/ja not_active Expired - Fee Related
- 2002-07-04 KR KR10-2003-7016967A patent/KR20040018394A/ko not_active Ceased
- 2002-07-04 WO PCT/IN2002/000144 patent/WO2003011255A1/en not_active Ceased
- 2002-07-04 EP EP10165807A patent/EP2238975B1/en not_active Expired - Lifetime
- 2002-07-04 HU HU0500795A patent/HUP0500795A3/hu unknown
-
2004
- 2004-01-30 ZA ZA2004/00799A patent/ZA200400799B/en unknown
-
2009
- 2009-12-11 JP JP2009281402A patent/JP2010090161A/ja active Pending
-
2010
- 2010-08-13 US US12/856,097 patent/US8012496B2/en not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000038650A1 (en) * | 1998-12-23 | 2000-07-06 | Alza Corporation | Gastric retention dosage form having multiple layers |
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| EP1411901B1 (en) | 2010-08-18 |
| CA2452738C (en) | 2011-06-14 |
| US7776345B2 (en) | 2010-08-17 |
| MXPA03012041A (es) | 2004-03-26 |
| ES2398348T3 (es) | 2013-03-15 |
| KR20040018394A (ko) | 2004-03-03 |
| CN1520286B (zh) | 2010-12-01 |
| JP2010090161A (ja) | 2010-04-22 |
| ATE477795T1 (de) | 2010-09-15 |
| CA2452738A1 (en) | 2003-02-13 |
| EP2238975B1 (en) | 2012-12-05 |
| US8012496B2 (en) | 2011-09-06 |
| JP4994570B2 (ja) | 2012-08-08 |
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| ZA200400799B (en) | 2005-07-27 |
| PL370793A1 (en) | 2005-05-30 |
| WO2003011255A1 (en) | 2003-02-13 |
| RU2003138075A (ru) | 2005-06-10 |
| BR0211317A (pt) | 2004-12-14 |
| EP2238975A1 (en) | 2010-10-13 |
| RU2325152C2 (ru) | 2008-05-27 |
| HUP0500795A2 (en) | 2007-02-28 |
| DE60237372D1 (de) | 2010-09-30 |
| EP1411901A1 (en) | 2004-04-28 |
| HUP0500795A3 (en) | 2008-04-28 |
| US20100305208A1 (en) | 2010-12-02 |
| JP2004538301A (ja) | 2004-12-24 |
| CN1520286A (zh) | 2004-08-11 |
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