AU2002330120B2 - Methods of increasing endogenous testosterone levels - Google Patents
Methods of increasing endogenous testosterone levels Download PDFInfo
- Publication number
- AU2002330120B2 AU2002330120B2 AU2002330120A AU2002330120A AU2002330120B2 AU 2002330120 B2 AU2002330120 B2 AU 2002330120B2 AU 2002330120 A AU2002330120 A AU 2002330120A AU 2002330120 A AU2002330120 A AU 2002330120A AU 2002330120 B2 AU2002330120 B2 AU 2002330120B2
- Authority
- AU
- Australia
- Prior art keywords
- optionally substituted
- tert
- pyrazol
- pyridin
- tyrosinamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 238000000034 method Methods 0.000 title claims description 63
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 title abstract description 91
- 229960003604 testosterone Drugs 0.000 title abstract description 46
- 150000001875 compounds Chemical class 0.000 claims abstract description 119
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- 208000035475 disorder Diseases 0.000 claims abstract description 19
- 201000010099 disease Diseases 0.000 claims abstract description 13
- 238000004519 manufacturing process Methods 0.000 claims abstract description 9
- -1 substituted pyrazole compound Chemical class 0.000 claims description 87
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 68
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Applications Claiming Priority (3)
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| US32547001P | 2001-09-27 | 2001-09-27 | |
| US60/325,470 | 2001-09-27 | ||
| PCT/US2002/030801 WO2003026649A1 (en) | 2001-09-27 | 2002-09-27 | Methods of increasing endogenous testosterone levels |
Publications (2)
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| AU2002330120A1 AU2002330120A1 (en) | 2003-06-26 |
| AU2002330120B2 true AU2002330120B2 (en) | 2007-10-11 |
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| AU2002330120A Ceased AU2002330120B2 (en) | 2001-09-27 | 2002-09-27 | Methods of increasing endogenous testosterone levels |
Country Status (12)
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|---|---|
| US (1) | US20040198799A1 (enExample) |
| EP (1) | EP1441724B8 (enExample) |
| JP (1) | JP2005504093A (enExample) |
| AT (1) | ATE372114T1 (enExample) |
| AU (1) | AU2002330120B2 (enExample) |
| CA (1) | CA2458661A1 (enExample) |
| DE (1) | DE60222286T2 (enExample) |
| DK (1) | DK1441724T3 (enExample) |
| ES (1) | ES2289143T3 (enExample) |
| IL (1) | IL161047A0 (enExample) |
| PT (1) | PT1441724E (enExample) |
| WO (1) | WO2003026649A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6914069B2 (en) * | 2000-05-19 | 2005-07-05 | Applied Research Systems Ars Holding N.V. | Pharmaceutically active compounds and methods of use |
| WO2004016592A1 (en) * | 2002-08-14 | 2004-02-26 | Ppd Discovery, Inc. | Prenylation inhibitors and methods of their synthesis and use |
| US8241664B2 (en) | 2005-04-15 | 2012-08-14 | Clarus Therapeutics, Inc | Pharmaceutical delivery systems for hydrophobic drugs and compositions comprising same |
| US8492369B2 (en) | 2010-04-12 | 2013-07-23 | Clarus Therapeutics Inc | Oral testosterone ester formulations and methods of treating testosterone deficiency comprising same |
| MX2008000141A (es) * | 2005-06-27 | 2008-04-07 | Exelixis Inc | Moduladores de lxr basados en imidazol. |
| JP5110478B2 (ja) | 2006-06-23 | 2012-12-26 | 株式会社Ｊ−オイルミルズ | テストステロン増加剤 |
| UY30892A1 (es) | 2007-02-07 | 2008-09-02 | Smithkline Beckman Corp | Inhibidores de la actividad akt |
| MY161598A (en) * | 2009-01-30 | 2017-04-28 | Glaxosmithkline Llc | Crystalline n-{ (1s)-2-amino-1-[(3-fluorophenyl)methyl]ethyl} -5-chloro-4-(4-chloro-1-methyl-1h-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride |
| WO2011161615A1 (en) | 2010-06-24 | 2011-12-29 | Ranbaxy Laboratories Limited | 5-lipoxygenase inhibitors |
| WO2011161645A1 (en) | 2010-06-25 | 2011-12-29 | Ranbaxy Laboratories Limited | 5-lipoxygenase inhibitors |
| JP5860459B2 (ja) | 2010-06-30 | 2016-02-16 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | ｓＧＣ刺激薬 |
| ES2572803T3 (es) | 2010-11-09 | 2016-06-02 | Ironwood Pharmaceuticals, Inc. | Estimuladores de GCs |
| US9139564B2 (en) | 2011-12-27 | 2015-09-22 | Ironwood Pharmaceuticals, Inc. | 2-benzyl, 3-(pyrimidin-2-yl) substituted pyrazoles useful as sGC stimulators |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6469401A (en) * | 2000-05-19 | 2001-11-26 | Serono Reproductive Biology In | Pharmaceutically active compounds and methods of use |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2665898B1 (fr) * | 1990-08-20 | 1994-03-11 | Sanofi | Derives d'amido-3 pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| DE4039733A1 (de) * | 1990-12-13 | 1992-06-17 | Basf Ag | Substituierte 5-aminopyrazole |
| BR9307664A (pt) * | 1992-12-17 | 1999-06-29 | Pfizer | Pirazóis substituídos como antagonistas |
| KR960705808A (ko) * | 1993-11-09 | 1996-11-08 | 조셉 에프. 디프리마 | 성장 호르몬의 방출을 촉진시키는 피페리딘, 피롤리딘 및 헥사하이드로-1H-아제핀(Piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone) |
| US5869688A (en) * | 1994-07-20 | 1999-02-09 | Monsanto Company | Preparation of substituted 3-aryl-5-haloalkyl-pyrazoles having herbicidal activity |
| CA2288787A1 (en) * | 1997-05-22 | 1998-11-26 | G.D. Searle And Co. | Pyrazole derivatives as p38 kinase inhibitors |
| CA2308428A1 (en) * | 1997-11-03 | 1999-05-14 | Boehringer Ingelheim Pharmaceuticals, Inc. | Aromatic heterocyclic compounds as anti-inflammatory agents |
| ATE301129T1 (de) * | 1999-05-04 | 2005-08-15 | Strakan Int Ltd | Androgen glykoside und die androgenische aktivität davon |
| CZ2003468A3 (cs) * | 2000-08-31 | 2004-05-12 | Pfizeráproductsáinc | Deriváty pyrazolu a jejich použití jako inhibitorů proteinkinázy |
-
2002
- 2002-09-27 JP JP2003530286A patent/JP2005504093A/ja active Pending
- 2002-09-27 AT AT02766382T patent/ATE372114T1/de not_active IP Right Cessation
- 2002-09-27 US US10/489,863 patent/US20040198799A1/en not_active Abandoned
- 2002-09-27 EP EP02766382A patent/EP1441724B8/en not_active Expired - Lifetime
- 2002-09-27 DK DK02766382T patent/DK1441724T3/da active
- 2002-09-27 DE DE60222286T patent/DE60222286T2/de not_active Expired - Fee Related
- 2002-09-27 CA CA002458661A patent/CA2458661A1/en not_active Abandoned
- 2002-09-27 WO PCT/US2002/030801 patent/WO2003026649A1/en not_active Ceased
- 2002-09-27 ES ES02766382T patent/ES2289143T3/es not_active Expired - Lifetime
- 2002-09-27 IL IL16104702A patent/IL161047A0/xx unknown
- 2002-09-27 PT PT02766382T patent/PT1441724E/pt unknown
- 2002-09-27 AU AU2002330120A patent/AU2002330120B2/en not_active Ceased
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6469401A (en) * | 2000-05-19 | 2001-11-26 | Serono Reproductive Biology In | Pharmaceutically active compounds and methods of use |
Also Published As
| Publication number | Publication date |
|---|---|
| DE60222286D1 (de) | 2007-10-18 |
| EP1441724B1 (en) | 2007-09-05 |
| DE60222286T2 (de) | 2008-06-19 |
| EP1441724B8 (en) | 2007-10-17 |
| DK1441724T3 (da) | 2007-12-03 |
| JP2005504093A (ja) | 2005-02-10 |
| IL161047A0 (en) | 2004-08-31 |
| ES2289143T3 (es) | 2008-02-01 |
| US20040198799A1 (en) | 2004-10-07 |
| WO2003026649A1 (en) | 2003-04-03 |
| EP1441724A1 (en) | 2004-08-04 |
| CA2458661A1 (en) | 2003-04-03 |
| ATE372114T1 (de) | 2007-09-15 |
| PT1441724E (pt) | 2007-10-15 |
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| PC1 | Assignment before grant (sect. 113) |
Owner name: LABORATOIRES SERONO SA Free format text: FORMER APPLICANT(S): APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. |
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| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |