AU2002322762B2 - Hybrid proteins with neuregulin heparin-binding domain for targeting to heparan sulfate proteoglycans - Google Patents

Hybrid proteins with neuregulin heparin-binding domain for targeting to heparan sulfate proteoglycans Download PDF

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Publication number
AU2002322762B2
AU2002322762B2 AU2002322762A AU2002322762A AU2002322762B2 AU 2002322762 B2 AU2002322762 B2 AU 2002322762B2 AU 2002322762 A AU2002322762 A AU 2002322762A AU 2002322762 A AU2002322762 A AU 2002322762A AU 2002322762 B2 AU2002322762 B2 AU 2002322762B2
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AU
Australia
Prior art keywords
polypeptide
nucleic acid
receptor
hbd
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2002322762A
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English (en)
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AU2002322762A1 (en
Inventor
Jeffrey A. Loeb
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Wayne State University
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Wayne State University
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Publication date
Application filed by Wayne State University filed Critical Wayne State University
Publication of AU2002322762A1 publication Critical patent/AU2002322762A1/en
Application granted granted Critical
Publication of AU2002322762B2 publication Critical patent/AU2002322762B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/4756Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2002322762A 2001-07-31 2002-07-31 Hybrid proteins with neuregulin heparin-binding domain for targeting to heparan sulfate proteoglycans Ceased AU2002322762B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30856301P 2001-07-31 2001-07-31
US60/308,563 2001-07-31
PCT/US2002/024053 WO2003012045A2 (en) 2001-07-31 2002-07-31 Hybrid proteins with neuregulin heparin-binding domain for targeting to heparan sulfate proteoglycans

Publications (2)

Publication Number Publication Date
AU2002322762A1 AU2002322762A1 (en) 2003-05-29
AU2002322762B2 true AU2002322762B2 (en) 2008-10-16

Family

ID=23194471

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002322762A Ceased AU2002322762B2 (en) 2001-07-31 2002-07-31 Hybrid proteins with neuregulin heparin-binding domain for targeting to heparan sulfate proteoglycans

Country Status (8)

Country Link
US (1) US7527794B2 (https=)
EP (1) EP1456239B1 (https=)
JP (1) JP4314113B2 (https=)
AT (1) ATE427317T1 (https=)
AU (1) AU2002322762B2 (https=)
CA (1) CA2455830C (https=)
DE (1) DE60231833D1 (https=)
WO (1) WO2003012045A2 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1824879B1 (en) * 2004-07-09 2014-10-29 Wayne State University HYBRID PROTEINS WITH ErbB4 EXTRACELLULAR DOMAIN AND NEUREGULIN HEPARIN-BINDING DOMAIN FOR TARGETING
US20110034383A1 (en) * 2007-10-15 2011-02-10 Institut Pasteur Cxcl12 gamma a chemokine and uses thereof
EP2346526A2 (en) 2008-09-22 2011-07-27 Massachusetts Institute of Technology Compositions of and methods of using ligand dimers
US9029328B2 (en) 2010-03-24 2015-05-12 The Brigham And Women's Hospital, Inc. Methods for cardioprotection and cardioregeneration with dimers of EGF family ligands
CN103118698A (zh) * 2010-05-28 2013-05-22 意识-Nrg公司 神经调节素同种型,神经调节素多肽和其使用
JP2014520148A (ja) * 2011-06-20 2014-08-21 セントルイス ユニバーシティ 治療のための神経筋接合部への標的化
US20130058871A1 (en) * 2011-07-28 2013-03-07 Howard Hughes Medical Institute Method and system for mapping synaptic connectivity using light microscopy
US9790264B2 (en) 2012-06-25 2017-10-17 The Brigham And Women's Hospital, Inc. Compounds and methods for modulating pharmacokinetics
EP2864360B1 (en) 2012-06-25 2017-09-06 The Brigham and Women's Hospital, Inc. Targeted therapeutics
EP3247380A1 (en) * 2015-01-20 2017-11-29 Universiteit Antwerpen Neuregulin in the treatment of fibrotic disorders
WO2016123163A2 (en) 2015-01-27 2016-08-04 Kardiatonos, Inc. Biomarkers of vascular disease
US12466865B2 (en) 2019-01-03 2025-11-11 The Board Of Trustees Of The University Of Illinois Method and kit for treating a neurodegenerative disease

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992007935A1 (en) * 1990-11-01 1992-05-14 The Scripps Research Institute Glycosaminoglycan-targeted fusion proteins, their design, construction and compositions
WO1993022424A1 (en) * 1992-04-29 1993-11-11 Amgen Inc. RECOMBINANT STIMULATING FACTOR OF THE neu RECEPTOR
US5367060A (en) * 1991-05-24 1994-11-22 Genentech, Inc. Structure, production and use of heregulin
US5665862A (en) * 1992-09-29 1997-09-09 President And Fellows Of Harvard College Neurotrophic factor
WO1999014323A1 (en) * 1997-09-17 1999-03-25 Urs Eppenberger Heregulin-gamma

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6037329A (en) * 1994-03-15 2000-03-14 Selective Genetics, Inc. Compositions containing nucleic acids and ligands for therapeutic treatment
WO1997009051A1 (en) 1995-09-05 1997-03-13 Cambridge Neuroscience, Inc. Analogs for specific oligosaccharide-neuregulin interactions and uses thereof
US6344436B1 (en) * 1996-01-08 2002-02-05 Baylor College Of Medicine Lipophilic peptides for macromolecule delivery
WO1998002540A1 (en) * 1996-07-12 1998-01-22 Genentech, Inc. Chimeric heteromultimer adhesins
CA2257839C (en) * 1996-07-12 2012-10-23 Genentech, Inc. Gamma-heregulin
KR100195886B1 (ko) 1996-11-01 1999-06-15 김상조 당뇨병 치료용 의약조성물
WO1998043649A2 (en) 1997-03-28 1998-10-08 Otsuka Pharmaceutical Co., Ltd. Age production inhibitory composition comprising a maillard reaction inhibitor and vitamin b¿6?
WO1999055351A1 (en) 1998-04-23 1999-11-04 Vladimir Leko Herbal composition and medicament against diabetes mellitus type ii manufactured thereof
US6344572B1 (en) 1999-01-29 2002-02-05 Kaneka Corporation Processes for the preparation of threo-1,2-epoxy-3-amino-4-phenylbutane derivatives

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992007935A1 (en) * 1990-11-01 1992-05-14 The Scripps Research Institute Glycosaminoglycan-targeted fusion proteins, their design, construction and compositions
US5367060A (en) * 1991-05-24 1994-11-22 Genentech, Inc. Structure, production and use of heregulin
WO1993022424A1 (en) * 1992-04-29 1993-11-11 Amgen Inc. RECOMBINANT STIMULATING FACTOR OF THE neu RECEPTOR
US5665862A (en) * 1992-09-29 1997-09-09 President And Fellows Of Harvard College Neurotrophic factor
WO1999014323A1 (en) * 1997-09-17 1999-03-25 Urs Eppenberger Heregulin-gamma

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Meier et al, Journal of Cell Biology, vol.141 (1998) pp.715-726 *

Also Published As

Publication number Publication date
DE60231833D1 (de) 2009-05-14
WO2003012045A2 (en) 2003-02-13
JP4314113B2 (ja) 2009-08-12
EP1456239B1 (en) 2009-04-01
EP1456239A4 (en) 2005-04-27
US7527794B2 (en) 2009-05-05
WO2003012045A3 (en) 2004-07-01
CA2455830C (en) 2012-10-09
CA2455830A1 (en) 2003-02-13
US20050107601A1 (en) 2005-05-19
JP2005500052A (ja) 2005-01-06
ATE427317T1 (de) 2009-04-15
EP1456239A2 (en) 2004-09-15

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired