AU2002319033B2 - Methods for increasing in vivo efficacy of oligonucleotides and inhibiting inflammation in mammals - Google Patents

Methods for increasing in vivo efficacy of oligonucleotides and inhibiting inflammation in mammals Download PDF

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Publication number
AU2002319033B2
AU2002319033B2 AU2002319033A AU2002319033A AU2002319033B2 AU 2002319033 B2 AU2002319033 B2 AU 2002319033B2 AU 2002319033 A AU2002319033 A AU 2002319033A AU 2002319033 A AU2002319033 A AU 2002319033A AU 2002319033 B2 AU2002319033 B2 AU 2002319033B2
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nucleic acid
acid molecule
diseases
group
dap
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AU2002319033A1 (en
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Zoulfia Allakhverdi
Mustapha Allam
Paolo Renzi
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Pharmaxis Ltd
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
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    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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AU2002319033A 2001-07-06 2002-07-08 Methods for increasing in vivo efficacy of oligonucleotides and inhibiting inflammation in mammals Ceased AU2002319033B2 (en)

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US30307101P 2001-07-06 2001-07-06
US60/303,071 2001-07-06
PCT/CA2002/001046 WO2003004511A2 (en) 2001-07-06 2002-07-08 Methods for increasing in vivo efficacy of oligonucleotides and inhibiting inflammation in mammals

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AU2002319033A1 AU2002319033A1 (en) 2003-05-22
AU2002319033B2 true AU2002319033B2 (en) 2008-01-10

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AU2002319033A Ceased AU2002319033B2 (en) 2001-07-06 2002-07-08 Methods for increasing in vivo efficacy of oligonucleotides and inhibiting inflammation in mammals

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US (2) US7745420B2 (https=)
EP (1) EP1406667B1 (https=)
JP (1) JP4903984B2 (https=)
AT (1) ATE386548T1 (https=)
AU (1) AU2002319033B2 (https=)
CA (1) CA2451738C (https=)
DE (1) DE60225141T2 (https=)
DK (1) DK1406667T3 (https=)
ES (1) ES2301659T3 (https=)
MX (1) MXPA04000162A (https=)
NZ (1) NZ530360A (https=)
PT (1) PT1406667E (https=)
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NZ554723A (en) * 2004-10-29 2009-12-24 Topigen Pharmaceuticals Inc Antisense oligonucleotides against CCR3 chemokine receptor
AU2007282224B2 (en) 2006-08-11 2013-08-29 Vico Therapeutics B.V. Methods and means for treating DNA repeat instability associated genetic disorders
AU2008317566B2 (en) 2007-10-26 2014-05-01 Academisch Ziekenhuis Leiden Means and methods for counteracting muscle disorders
USRE48468E1 (en) 2007-10-26 2021-03-16 Biomarin Technologies B.V. Means and methods for counteracting muscle disorders
EP2119783A1 (en) 2008-05-14 2009-11-18 Prosensa Technologies B.V. Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means
EP2285961A4 (en) * 2008-05-15 2012-10-17 Topigen Pharmaceuticals Inc OLIGONUCLEOTIDES FOR THE TREATMENT OF INFLAMMATION AND NEOPLASTIC CELL REPRODUCTION
WO2010048731A1 (en) * 2008-10-31 2010-05-06 Christopher John Ong Aminoacyl trna-synthetase inhibitors as broad-spectrum immunosuppressive agents
US9301871B2 (en) 2009-02-26 2016-04-05 Advanced Cooling Therapy, Inc. Devices and methods for controlling patient temperature
DK2401023T3 (en) * 2009-02-26 2016-06-06 Advanced Cooling Therapy Inc Devices for controlling patient temperature
US9622909B2 (en) 2009-02-26 2017-04-18 Advanced Cooling Therapy, Inc. Devices and methods for controlling patient temperature
US9326890B2 (en) 2009-02-26 2016-05-03 Advanced Cooling Therapy, Inc. Devices and methods for controlling patient temperature
EP2678431A4 (en) * 2011-02-24 2015-07-15 Pharmaxis Ltd OLIGONUCLEOTIDHEMMER WITH A CHIMERIC MAIN CHAIN AND 2-AMINO-2'-DEOXYADENOSINE
CN112251436A (zh) 2012-01-27 2021-01-22 比奥马林技术公司 治疗杜兴型肌营养不良症和贝克型肌营养不良症的具有改善特性的rna调节性寡核苷酸
US9272016B2 (en) * 2012-04-20 2016-03-01 University Of Iowa Research Foundation Methods to enhance RNAi oligonucleotide delivery to respiratory epithelial cells
SMT201700339T1 (it) 2012-04-23 2017-09-07 Biomarin Tech Bv Oligonucleotidi di modulazione dell'rna con caratteristiche migliorate per il trattamento dei disturbi neuromuscolari
FR3057774B1 (fr) * 2016-10-21 2025-11-07 Museum Nat Dhistoire Naturelle Derives de la purine pour leur utilisation dans le traitement ou la prevention de maladies dues a une mutation non-sens

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US5856466A (en) * 1990-01-11 1999-01-05 Isis Pharmaceuticals, Inc. Process for the preparation of 2'-O-alkyl purine phosphoramidites
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WO1999067378A1 (en) * 1998-06-19 1999-12-29 Mcgill University ANTISENSE OLIGONUCLEOTIDE CONSTRUCTS BASED ON β-ARABINOFURANOSE AND ITS ANALOGUES
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US5856466A (en) * 1990-01-11 1999-01-05 Isis Pharmaceuticals, Inc. Process for the preparation of 2'-O-alkyl purine phosphoramidites
WO1999066037A2 (en) * 1998-06-17 1999-12-23 Recherches Expertises Et Developpement Medicaux Parenz Inc. Antisense oligonucleotides for treating or preventing atopic diseases and neoplastic cell proliferation
WO1999067378A1 (en) * 1998-06-19 1999-12-29 Mcgill University ANTISENSE OLIGONUCLEOTIDE CONSTRUCTS BASED ON β-ARABINOFURANOSE AND ITS ANALOGUES
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US20100286235A1 (en) 2010-11-11
US20050032723A1 (en) 2005-02-10
JP4903984B2 (ja) 2012-03-28
WO2003004511A3 (en) 2003-07-10
JP2004532900A (ja) 2004-10-28
US7745420B2 (en) 2010-06-29
EP1406667B1 (en) 2008-02-20
CA2451738C (en) 2013-09-17
ES2301659T3 (es) 2008-07-01
DE60225141T2 (de) 2009-03-05
CA2451738A1 (en) 2003-01-16
DK1406667T3 (da) 2008-06-16
NZ530360A (en) 2006-01-27
ATE386548T1 (de) 2008-03-15
MXPA04000162A (es) 2006-05-22
PT1406667E (pt) 2008-05-23
DE60225141D1 (de) 2008-04-03
WO2003004511A2 (en) 2003-01-16

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