AU2002313542B2 - N-phenylpyrrole guanidine derivatives as melanocortin reception ligands - Google Patents
N-phenylpyrrole guanidine derivatives as melanocortin reception ligands Download PDFInfo
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- AU2002313542B2 AU2002313542B2 AU2002313542A AU2002313542A AU2002313542B2 AU 2002313542 B2 AU2002313542 B2 AU 2002313542B2 AU 2002313542 A AU2002313542 A AU 2002313542A AU 2002313542 A AU2002313542 A AU 2002313542A AU 2002313542 B2 AU2002313542 B2 AU 2002313542B2
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- guanidine
- pyrrol
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- 239000003446 ligand Substances 0.000 title description 7
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
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Landscapes
- Health & Medical Sciences (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0119172.5A GB0119172D0 (en) | 2001-08-06 | 2001-08-06 | Phenyl pyrrole derivatives |
| GB0119172.5 | 2001-08-06 | ||
| PCT/GB2002/003620 WO2003013509A1 (en) | 2001-08-06 | 2002-08-06 | N-phenylpyrrole guanidine derivatives as melanocortin reception ligands |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2002313542A1 AU2002313542A1 (en) | 2003-06-19 |
| AU2002313542B2 true AU2002313542B2 (en) | 2007-03-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2002313542A Ceased AU2002313542B2 (en) | 2001-08-06 | 2002-08-06 | N-phenylpyrrole guanidine derivatives as melanocortin reception ligands |
Country Status (19)
Families Citing this family (53)
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| GB0019357D0 (en) * | 2000-08-07 | 2000-09-27 | Melacure Therapeutics Ab | Novel phenyl guanidines |
| US7354923B2 (en) | 2001-08-10 | 2008-04-08 | Palatin Technologies, Inc. | Piperazine melanocortin-specific compounds |
| US7456184B2 (en) | 2003-05-01 | 2008-11-25 | Palatin Technologies Inc. | Melanocortin receptor-specific compounds |
| JP2005504043A (ja) | 2001-08-10 | 2005-02-10 | パラチン テクノロジーズ インク． | 生物学的に活性な金属ペプチド類のペプチド模倣体類 |
| KR100836547B1 (ko) | 2002-01-11 | 2008-06-10 | 상꾜 가부시키가이샤 | 아미노 알코올 유도체 또는 포스폰산 유도체 및 이들을함유하는 의약 조성물 |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| GB2398299A (en) * | 2003-02-13 | 2004-08-18 | Melacure Therapeutics Ab | Pharmaceutically active phenyl-pyrrole derivatives |
| TWI355934B (en) | 2004-02-24 | 2012-01-11 | Sankyo Co | Pharmaceutical composition for treatment or prophy |
| EP2305352A1 (en) | 2004-04-02 | 2011-04-06 | Merck Sharp & Dohme Corp. | 5-alpha-reductase inhibitors for use in the treatment of men with metabolic and anthropometric disorders |
| ATE508111T1 (de) | 2006-06-09 | 2011-05-15 | Action Pharma As | Phenylpyrrolaminoguanidinderivate |
| ES2559319T3 (es) | 2007-06-04 | 2016-02-11 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato cliclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| ES2569660T3 (es) | 2007-06-08 | 2016-05-12 | Mannkind Corporation | Inhibidores de la IRE-1alfa |
| EP2045250A1 (en) * | 2007-09-26 | 2009-04-08 | Action Pharma A/S | Ring-substituted phenyl pyrrole aminoguanidine derivatives |
| WO2009071101A1 (en) * | 2007-12-07 | 2009-06-11 | Action Pharma A/S | N-modified aminoguanidine derivatives |
| WO2009074157A1 (en) * | 2007-12-13 | 2009-06-18 | Action Pharma A/S | Fully-modified phenyl pyrrole aminoguanidines |
| JP2011522828A (ja) | 2008-06-04 | 2011-08-04 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト |
| AU2009270833B2 (en) | 2008-07-16 | 2015-02-19 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| EP2315590B1 (en) | 2008-08-15 | 2012-09-26 | N30 Pharmaceuticals, LLC | Pyrrole inhibitors of s-nitrosoglutathione reductase |
| RU2500668C2 (ru) * | 2008-08-15 | 2013-12-10 | Н30 Фармасьютиклз, ИНК. | Новые пиррольные ингибиторы s-нитрозоглутатионредуктазы в качестве терапевтических агентов |
| DK2318007T3 (da) | 2008-08-15 | 2013-03-25 | N30 Pharmaceuticals Inc | Nye pyrrol-inhibitorer af s-nitrosoglutathion-reduktase som terapeutiske midler |
| WO2010047982A1 (en) | 2008-10-22 | 2010-04-29 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| CN102271509A (zh) | 2008-10-31 | 2011-12-07 | 默沙东公司 | 用于抗糖尿病药的新型环苯并咪唑衍生物 |
| US8759539B2 (en) | 2008-11-17 | 2014-06-24 | Merck Sharp & Dohme Corp. | Substituted bicyclic amines for the treatment of diabetes |
| WO2011011508A1 (en) | 2009-07-23 | 2011-01-27 | Schering Corporation | Benzo-fused oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors |
| WO2011011506A1 (en) | 2009-07-23 | 2011-01-27 | Schering Corporation | Spirocyclic oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors |
| EP2298541A1 (en) | 2009-09-17 | 2011-03-23 | Rieter Technologies AG | Moulded automotive part |
| JP5990101B2 (ja) | 2009-09-16 | 2016-09-07 | オートニアム マネジメント アクチエンゲゼルシャフトＡｕｔｏｎｅｕｍ Ｍａｎａｇｅｍｅｎｔ ＡＧ | 自動車パネル用成型製品 |
| AU2011218830B2 (en) | 2010-02-25 | 2014-07-24 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| EP2563764B1 (en) | 2010-04-26 | 2015-02-25 | Merck Sharp & Dohme Corp. | Novel spiropiperidine prolylcarboxypeptidase inhibitors |
| US9365539B2 (en) | 2010-05-11 | 2016-06-14 | Merck Sharp & Dohme Corp. | Prolylcarboxypeptidase inhibitors |
| EP2579873A4 (en) | 2010-06-11 | 2013-11-27 | Merck Sharp & Dohme | NOVEL PROLYLCARBOXYPEPTIDASE HEMMER |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| JP5728099B2 (ja) | 2011-02-25 | 2015-06-03 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | 抗糖尿病剤として有用な新規環状アザベンゾイミダゾール誘導体 |
| PL2502788T3 (pl) | 2011-03-23 | 2014-08-29 | Autoneum Man Ag | Sposób wytwarzania formowanej wielowarstwowej wykładziny |
| EP2503040A1 (en) | 2011-03-23 | 2012-09-26 | Autoneum Management AG | Moulded multilayer lining |
| EP2602248A1 (en) | 2011-12-05 | 2013-06-12 | University Of Leicester | Novel pyrrole compounds |
| EP2880028B1 (en) | 2012-08-02 | 2020-09-30 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
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| BR112015030326A2 (pt) | 2013-06-05 | 2017-08-29 | Synergy Pharmaceuticals Inc | Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos |
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| US11072602B2 (en) | 2016-12-06 | 2021-07-27 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
| EP3558298A4 (en) | 2016-12-20 | 2020-08-05 | Merck Sharp & Dohme Corp. | ANTIDIABETIC SPIROCHROMAN COMPOUNDS |
| TWI846853B (zh) | 2019-04-03 | 2024-07-01 | 美商艾利格斯醫療公司 | 吡咯化合物 |
| JP7546599B2 (ja) | 2019-05-10 | 2024-09-06 | シナクト ファーマ エーピーエス | 関節炎性疾患の組み合わせ療法 |
| ES3045575T3 (en) | 2021-06-21 | 2025-11-28 | Synact Pharma Aps | Phenyl pyrrole aminoguanidine salts and formulations |
| CN113651673A (zh) * | 2021-07-01 | 2021-11-16 | 烟台泰和新材料股份有限公司 | 一种芳烃侧链甲基氯代物的制备方法 |
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| SE9604348D0 (sv) | 1996-11-26 | 1996-11-26 | Wapharm Ab | Användning av hydroxyguanidiner |
| US6127381A (en) * | 1998-04-28 | 2000-10-03 | Basu; Amaresh | Isoquinoline compound melanocortin receptor ligands and methods of using same |
| WO2001025192A1 (en) | 1999-10-06 | 2001-04-12 | Melacure Therapeutics Ab | Guanidine derivatives and their use in the production of a medicament for blocking xanthine oxidase/dehydrogenase |
| GB0002059D0 (en) | 2000-01-28 | 2000-03-22 | Melacure Therapeutics Ab | Novel aromatic amines |
| GB0019357D0 (en) * | 2000-08-07 | 2000-09-27 | Melacure Therapeutics Ab | Novel phenyl guanidines |
| GB0019359D0 (en) * | 2000-08-07 | 2000-09-27 | Melacure Therapeutics Ab | Novel guanidines |
| GB0108631D0 (en) * | 2001-04-05 | 2001-05-30 | Melacure Therapeutics Ab | Novel benzylideneamino guanidines and their uses as ligands to the melanocortin receptors |
| US6951881B2 (en) * | 2002-05-10 | 2005-10-04 | Wyeth | (1-substituted-indol-3-yl) alkylidenehydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands |
-
2001
- 2001-08-06 GB GBGB0119172.5A patent/GB0119172D0/en not_active Ceased
-
2002
- 2002-08-06 PT PT02753136T patent/PT1414440E/pt unknown
- 2002-08-06 EP EP02753136A patent/EP1414440B1/en not_active Expired - Lifetime
- 2002-08-06 JP JP2003518518A patent/JP4450620B2/ja not_active Expired - Fee Related
- 2002-08-06 NZ NZ529666A patent/NZ529666A/en not_active IP Right Cessation
- 2002-08-06 ES ES02753136T patent/ES2280555T3/es not_active Expired - Lifetime
- 2002-08-06 WO PCT/GB2002/003620 patent/WO2003013509A1/en not_active Ceased
- 2002-08-06 KR KR10-2003-7016099A patent/KR20040019302A/ko not_active Withdrawn
- 2002-08-06 CA CA2448356A patent/CA2448356C/en not_active Expired - Fee Related
- 2002-08-06 BR BR0210445-8A patent/BR0210445A/pt not_active IP Right Cessation
- 2002-08-06 AU AU2002313542A patent/AU2002313542B2/en not_active Ceased
- 2002-08-06 DE DE60217503T patent/DE60217503T2/de not_active Expired - Lifetime
- 2002-08-06 MX MXPA04001037A patent/MXPA04001037A/es unknown
- 2002-08-06 US US10/484,444 patent/US7186748B2/en not_active Expired - Fee Related
- 2002-08-06 IL IL16018102A patent/IL160181A0/xx unknown
- 2002-08-06 DK DK02753136T patent/DK1414440T3/da active
- 2002-08-06 SI SI200230506T patent/SI1414440T1/sl unknown
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2004
- 2004-02-02 NO NO20040465A patent/NO20040465L/no not_active Application Discontinuation
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2006
- 2006-03-15 US US11/374,956 patent/US7442807B2/en not_active Expired - Fee Related
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2007
- 2007-03-30 CY CY20071100446T patent/CY1106424T1/el unknown
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2008
- 2008-09-17 US US12/232,399 patent/US20090018183A1/en not_active Abandoned
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- 2009-06-17 JP JP2009143997A patent/JP2009242414A/ja not_active Withdrawn
Also Published As
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|---|---|
| KR20040019302A (ko) | 2004-03-05 |
| DE60217503D1 (de) | 2007-02-22 |
| JP2005504039A (ja) | 2005-02-10 |
| NO20040465L (no) | 2004-02-02 |
| GB0119172D0 (en) | 2001-09-26 |
| IL160181A0 (en) | 2004-07-25 |
| JP2009242414A (ja) | 2009-10-22 |
| PT1414440E (pt) | 2007-04-30 |
| US20090018183A1 (en) | 2009-01-15 |
| US7442807B2 (en) | 2008-10-28 |
| CY1106424T1 (el) | 2011-10-12 |
| CA2448356C (en) | 2010-04-20 |
| NZ529666A (en) | 2006-04-28 |
| US20040254093A1 (en) | 2004-12-16 |
| EP1414440A1 (en) | 2004-05-06 |
| CA2448356A1 (en) | 2003-02-20 |
| SI1414440T1 (sl) | 2007-06-30 |
| DE60217503T2 (de) | 2007-08-09 |
| WO2003013509A1 (en) | 2003-02-20 |
| EP1414440B1 (en) | 2007-01-10 |
| DK1414440T3 (da) | 2007-05-21 |
| US20060148798A1 (en) | 2006-07-06 |
| JP4450620B2 (ja) | 2010-04-14 |
| ES2280555T3 (es) | 2007-09-16 |
| MXPA04001037A (es) | 2004-06-03 |
| US7186748B2 (en) | 2007-03-06 |
| BR0210445A (pt) | 2004-08-17 |
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