AU2002306596B2 - Analogs of thalidomide as potential angiogenesis inhibitors - Google Patents
Analogs of thalidomide as potential angiogenesis inhibitors Download PDFInfo
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- AU2002306596B2 AU2002306596B2 AU2002306596A AU2002306596A AU2002306596B2 AU 2002306596 B2 AU2002306596 B2 AU 2002306596B2 AU 2002306596 A AU2002306596 A AU 2002306596A AU 2002306596 A AU2002306596 A AU 2002306596A AU 2002306596 B2 AU2002306596 B2 AU 2002306596B2
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- Prior art keywords
- pharmaceutically acceptable
- substituted
- compound
- alkyl
- hydrogen
- Prior art date
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- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
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- Cardiology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
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| PCT/US2002/005868 WO2002068414A2 (en) | 2001-02-27 | 2002-02-26 | Analogs of thalidomide as potential angiogenesis inhibitors |
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| DE (1) | DE60234585D1 (enExample) |
| ES (1) | ES2338534T3 (enExample) |
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| US7629360B2 (en) * | 1999-05-07 | 2009-12-08 | Celgene Corporation | Methods for the treatment of cachexia and graft v. host disease |
| US6458810B1 (en) | 2000-11-14 | 2002-10-01 | George Muller | Pharmaceutically active isoindoline derivatives |
| WO2002064083A2 (en) * | 2000-11-30 | 2002-08-22 | The Children's Medical Center Corporation | Synthesis of 3-amino-thalidomide and its enantiomers |
| ES2338534T3 (es) | 2001-02-27 | 2010-05-10 | The Governement Of The Usa, Represented By The Secretary Department Of Health And Human Services | Analogos de talidomina como inhibidores de la angiogenesis. |
| US7393862B2 (en) | 2002-05-17 | 2008-07-01 | Celgene Corporation | Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias |
| US7323479B2 (en) * | 2002-05-17 | 2008-01-29 | Celgene Corporation | Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline |
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- 2002-02-26 WO PCT/US2002/005868 patent/WO2002068414A2/en not_active Ceased
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2009
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|---|---|---|---|---|
| WO1998003502A1 (en) * | 1996-07-24 | 1998-01-29 | Celgene Corporation | Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and method of reducing tnf-alpha levels |
| US6110941A (en) * | 1997-02-01 | 2000-08-29 | Gruenenthal Gmbh | Compounds analogous to thalidomide from the class comprising piperidine-2,6-diones |
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2439410A1 (en) | 2002-09-06 |
| JP4361273B2 (ja) | 2009-11-11 |
| ES2338534T3 (es) | 2010-05-10 |
| WO2002068414A3 (en) | 2002-10-17 |
| US20040077685A1 (en) | 2004-04-22 |
| CA2439410C (en) | 2011-09-06 |
| WO2002068414A2 (en) | 2002-09-06 |
| US20070293519A1 (en) | 2007-12-20 |
| US8716315B2 (en) | 2014-05-06 |
| WO2002068414A8 (en) | 2010-02-25 |
| DE60234585D1 (enExample) | 2010-01-14 |
| US7320991B2 (en) | 2008-01-22 |
| ATE450529T1 (de) | 2009-12-15 |
| EP1389203A2 (en) | 2004-02-18 |
| JP2009263376A (ja) | 2009-11-12 |
| EP1389203B8 (en) | 2010-03-10 |
| EP1389203B1 (en) | 2009-12-02 |
| JP2004523561A (ja) | 2004-08-05 |
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