AU2002305061B2 - Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid support - Google Patents

Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid support Download PDF

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Publication number
AU2002305061B2
AU2002305061B2 AU2002305061A AU2002305061A AU2002305061B2 AU 2002305061 B2 AU2002305061 B2 AU 2002305061B2 AU 2002305061 A AU2002305061 A AU 2002305061A AU 2002305061 A AU2002305061 A AU 2002305061A AU 2002305061 B2 AU2002305061 B2 AU 2002305061B2
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Prior art keywords
anchor
oligonucleotide
linkers
group
synthesis
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Ceased
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AU2002305061A
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AU2002305061A1 (en
Inventor
Xiaolian Goa
Eric Leproust
Jean Phillipe Pellois
Qin Xiang
Peilin Yu
Hua Zhang
Xiaochuan Zhou
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University of Michigan
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University of Michigan
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Publication of AU2002305061B2 publication Critical patent/AU2002305061B2/en
Priority to AU2006252281A priority Critical patent/AU2006252281B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C40B50/18—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support using a particular method of attachment to the solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B80/00—Linkers or spacers specially adapted for combinatorial chemistry or libraries, e.g. traceless linkers or safety-catch linkers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Structural Engineering (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Saccharide Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AU2002305061A 2001-03-14 2002-03-14 Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid support Ceased AU2002305061B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2006252281A AU2006252281B2 (en) 2001-03-14 2006-12-28 Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid support

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US27566601P 2001-03-14 2001-03-14
US60/275,666 2001-03-14
US10/099,382 2002-03-13
US10/099,382 US7211654B2 (en) 2001-03-14 2002-03-13 Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports
PCT/US2002/008171 WO2002072791A2 (en) 2001-03-14 2002-03-14 Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid support

Related Child Applications (1)

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AU2006252281A Division AU2006252281B2 (en) 2001-03-14 2006-12-28 Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid support

Publications (2)

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AU2002305061A1 AU2002305061A1 (en) 2003-03-20
AU2002305061B2 true AU2002305061B2 (en) 2006-09-28

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AU2006252281A Ceased AU2006252281B2 (en) 2001-03-14 2006-12-28 Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid support

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US (6) US7211654B2 (US07211654-20070501-C00003.png)
EP (2) EP1373286A4 (US07211654-20070501-C00003.png)
AU (2) AU2002305061B2 (US07211654-20070501-C00003.png)
CA (1) CA2443557A1 (US07211654-20070501-C00003.png)
WO (1) WO2002072791A2 (US07211654-20070501-C00003.png)

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