AU2001290720A1 - Method and composition for treating tumors by selective induction of apoptosis - Google Patents

Method and composition for treating tumors by selective induction of apoptosis

Info

Publication number
AU2001290720A1
AU2001290720A1 AU2001290720A AU9072001A AU2001290720A1 AU 2001290720 A1 AU2001290720 A1 AU 2001290720A1 AU 2001290720 A AU2001290720 A AU 2001290720A AU 9072001 A AU9072001 A AU 9072001A AU 2001290720 A1 AU2001290720 A1 AU 2001290720A1
Authority
AU
Australia
Prior art keywords
promoter
cells
expression vector
apoptosis
trail
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001290720A
Other languages
English (en)
Inventor
Jianyun Dong
James S. Norris
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MUSC Foundation for Research Development
Original Assignee
MUSC Foundation for Research Development
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MUSC Foundation for Research Development filed Critical MUSC Foundation for Research Development
Publication of AU2001290720A1 publication Critical patent/AU2001290720A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2001290720A 2000-09-11 2001-09-10 Method and composition for treating tumors by selective induction of apoptosis Abandoned AU2001290720A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65877900A 2000-09-11 2000-09-11
US09/658,779 2000-09-11
PCT/US2001/028259 WO2002022175A2 (en) 2000-09-11 2001-09-10 Method and composition for treating tumors by selective induction of apoptosis

Publications (1)

Publication Number Publication Date
AU2001290720A1 true AU2001290720A1 (en) 2002-03-26

Family

ID=24642656

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001290720A Abandoned AU2001290720A1 (en) 2000-09-11 2001-09-10 Method and composition for treating tumors by selective induction of apoptosis

Country Status (6)

Country Link
EP (1) EP1317288A2 (zh)
JP (1) JP2004526666A (zh)
CN (1) CN1744919A (zh)
AU (1) AU2001290720A1 (zh)
CA (1) CA2421585A1 (zh)
WO (1) WO2002022175A2 (zh)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1621550A1 (en) * 2004-07-29 2006-02-01 Dompé S.P.A. Tumor-homing cells engineered to produce tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
EP1814841A4 (en) 2004-10-29 2011-03-16 Musc Found For Res Dev CERAMIDES AND LIGANDS OF SIGNALING APOPTOSIS
US8093393B2 (en) 2004-10-29 2012-01-10 Musc Foundation For Research Development Cationic ceramides, and analogs thereof, and their use for preventing or treating cancer
CN101144081B (zh) * 2006-09-14 2011-06-22 复旦大学 核苷酸分子trail及其在制备治疗肿瘤药物中的应用
AU2009313400A1 (en) 2008-11-06 2010-05-14 Musc Foundation For Research Development Lysosomotropic inhibitors of acid ceramidase
US20120225933A1 (en) * 2009-11-05 2012-09-06 Gonzalez Aseguinolaza Gloria Regulated expression systems
CN102821778B (zh) * 2010-04-01 2014-07-30 韩国生命工学研究院 含有tip41表达或活性抑制剂作为靶基因或trail敏化剂的用于增强trail敏感性的组合物
WO2012106281A2 (en) 2011-01-31 2012-08-09 The General Hospital Corporation Multimodal trail molecules and uses in cellular therapies
WO2014018113A1 (en) 2012-07-24 2014-01-30 The General Hospital Corporation Oncolytic virus therapy for resistant tumors
WO2014035474A1 (en) 2012-08-30 2014-03-06 The General Hospital Corporation Compositions and methods for treating cancer
AU2014301958B2 (en) 2013-06-25 2017-11-16 The Walter And Eliza Hall Institute Of Medical Research Method of treating intracellular infection
CN105126120B (zh) * 2015-08-24 2018-12-21 浙江大学 长非编码rna h19与癌症铂类化疗药物耐药相关性
CA3064645C (en) * 2016-06-03 2023-06-27 Institut National De La Recherche Agronomique Diet controlled expression of a nucleic acid encoding a pro-apoptotic protein.
AU2018240577A1 (en) * 2017-03-24 2019-10-17 Ohio State Innovation Foundation Novel recombinant adeno-associated viral vectors restricting off-target transduction in liver and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6900185B1 (en) * 2000-04-12 2005-05-31 University Of Iowa Research Foundation Method of inducing tumor cell apoptosis using trail/Apo-2 ligand gene transfer

Also Published As

Publication number Publication date
EP1317288A2 (en) 2003-06-11
WO2002022175A3 (en) 2002-08-08
CA2421585A1 (en) 2002-03-21
CN1744919A (zh) 2006-03-08
WO2002022175A2 (en) 2002-03-21
JP2004526666A (ja) 2004-09-02

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Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted