CA2421585A1 - Method and composition for treating tumors by selective induction of apoptosis - Google Patents

Method and composition for treating tumors by selective induction of apoptosis Download PDF

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Publication number
CA2421585A1
CA2421585A1 CA002421585A CA2421585A CA2421585A1 CA 2421585 A1 CA2421585 A1 CA 2421585A1 CA 002421585 A CA002421585 A CA 002421585A CA 2421585 A CA2421585 A CA 2421585A CA 2421585 A1 CA2421585 A1 CA 2421585A1
Authority
CA
Canada
Prior art keywords
promoter
cells
expression vector
trail
apoptosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002421585A
Other languages
English (en)
French (fr)
Inventor
Jian-Yun Dong
James S. Norris
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medical University of South Carolina Foundation
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2421585A1 publication Critical patent/CA2421585A1/en
Abandoned legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/191Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CA002421585A 2000-09-11 2001-09-10 Method and composition for treating tumors by selective induction of apoptosis Abandoned CA2421585A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65877900A 2000-09-11 2000-09-11
US09/658,779 2000-09-11
PCT/US2001/028259 WO2002022175A2 (en) 2000-09-11 2001-09-10 Method and composition for treating tumors by selective induction of apoptosis

Publications (1)

Publication Number Publication Date
CA2421585A1 true CA2421585A1 (en) 2002-03-21

Family

ID=24642656

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002421585A Abandoned CA2421585A1 (en) 2000-09-11 2001-09-10 Method and composition for treating tumors by selective induction of apoptosis

Country Status (6)

Country Link
EP (1) EP1317288A2 (zh)
JP (1) JP2004526666A (zh)
CN (1) CN1744919A (zh)
AU (1) AU2001290720A1 (zh)
CA (1) CA2421585A1 (zh)
WO (1) WO2002022175A2 (zh)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1621550A1 (en) * 2004-07-29 2006-02-01 Dompé S.P.A. Tumor-homing cells engineered to produce tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)
CA2585775C (en) 2004-10-29 2013-10-01 Musc Foundation For Research Development Cationic ceramides, and analogs thereof, and their use for preventing or treating cancer
WO2006050265A2 (en) 2004-10-29 2006-05-11 Musc Foundation For Research Development Ceramides and apoptosis-signaling ligand
CN101144081B (zh) * 2006-09-14 2011-06-22 复旦大学 核苷酸分子trail及其在制备治疗肿瘤药物中的应用
WO2010054223A1 (en) 2008-11-06 2010-05-14 Musc Foundation For Research Development Lysosomotropic inhibitors of acid ceramidase
CN102712933A (zh) * 2009-11-05 2012-10-03 西马生物医学计划公司 调控的表达系统
KR101380840B1 (ko) * 2010-04-01 2014-04-04 한국생명공학연구원 Trail 센서타이저 타겟 유전자인 tip41의 발현 또는 활성 억제제를 함유하는 trail 감수성 증진용 조성물
US9428565B2 (en) * 2011-01-31 2016-08-30 The General Hospital Corporation Treatment and bioluminescent visualization using multimodal TRAIL molecules
WO2014018113A1 (en) 2012-07-24 2014-01-30 The General Hospital Corporation Oncolytic virus therapy for resistant tumors
EP2890720B1 (en) 2012-08-30 2019-07-17 The General Hospital Corporation Compositions and methods for treating cancer
JP6785653B2 (ja) 2013-06-25 2020-11-18 ザ・ウォルター・アンド・エリザ・ホール・インスティテュート・オブ・メディカル・リサーチ 細胞内感染の処置方法
CN105126120B (zh) * 2015-08-24 2018-12-21 浙江大学 长非编码rna h19与癌症铂类化疗药物耐药相关性
EP3464627B1 (en) * 2016-06-03 2020-10-21 Institut national de recherche pour l'agriculture, l'alimentation et l'environnement Diet controlled expression of a nucleic acid encoding a pro-apoptotic protein
US20200248149A1 (en) * 2017-03-24 2020-08-06 Ohio State Innovation Foundation Novel recombinant adeno-associated viral vectors restricting off-target transduction in liver and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6900185B1 (en) * 2000-04-12 2005-05-31 University Of Iowa Research Foundation Method of inducing tumor cell apoptosis using trail/Apo-2 ligand gene transfer

Also Published As

Publication number Publication date
JP2004526666A (ja) 2004-09-02
EP1317288A2 (en) 2003-06-11
WO2002022175A3 (en) 2002-08-08
CN1744919A (zh) 2006-03-08
WO2002022175A2 (en) 2002-03-21
AU2001290720A1 (en) 2002-03-26

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