AU2001288714A1 - A method for treating allergies - Google Patents
A method for treating allergiesInfo
- Publication number
- AU2001288714A1 AU2001288714A1 AU2001288714A AU8871401A AU2001288714A1 AU 2001288714 A1 AU2001288714 A1 AU 2001288714A1 AU 2001288714 A AU2001288714 A AU 2001288714A AU 8871401 A AU8871401 A AU 8871401A AU 2001288714 A1 AU2001288714 A1 AU 2001288714A1
- Authority
- AU
- Australia
- Prior art keywords
- aryl
- hydrogen
- alkyl
- optionally substituted
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 230000007815 allergy Effects 0.000 title description 11
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- 150000001875 compounds Chemical class 0.000 claims description 46
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- 229940122805 Cathepsin S inhibitor Drugs 0.000 claims description 39
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 31
- 239000000203 mixture Substances 0.000 claims description 23
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 19
- 150000003839 salts Chemical class 0.000 claims description 19
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- 125000000623 heterocyclic group Chemical group 0.000 claims description 15
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 13
- 229910052717 sulfur Inorganic materials 0.000 claims description 13
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- 239000003112 inhibitor Substances 0.000 claims description 12
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- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 5
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- 125000005143 heteroarylsulfonyl group Chemical group 0.000 claims 2
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 claims 2
- KJAMZCVTJDTESW-UHFFFAOYSA-N tiracizine Chemical compound C1CC2=CC=CC=C2N(C(=O)CN(C)C)C2=CC(NC(=O)OCC)=CC=C21 KJAMZCVTJDTESW-UHFFFAOYSA-N 0.000 claims 2
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims 1
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 claims 1
- LJGHYPLBDBRCRZ-UHFFFAOYSA-N 3-(3-aminophenyl)sulfonylaniline Chemical group NC1=CC=CC(S(=O)(=O)C=2C=C(N)C=CC=2)=C1 LJGHYPLBDBRCRZ-UHFFFAOYSA-N 0.000 claims 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
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- 125000002723 alicyclic group Chemical group 0.000 claims 1
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- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims 1
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- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
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- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 1
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- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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PCT/US2001/027441 WO2002020002A2 (en) | 2000-09-06 | 2001-09-05 | A method for treating allergies |
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US20040147503A1 (en) * | 2002-06-04 | 2004-07-29 | Sheila Zipfeil | Novel compounds and compositions as cathepsin inhibitors |
US6784288B2 (en) * | 2001-11-08 | 2004-08-31 | Ortho-Mcneil Pharmaceutical, Inc. | Polynucleotide and polypeptide sequences of monkey cathepsin S |
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FR2834216B1 (fr) * | 2001-12-27 | 2004-04-30 | Pharmascience Lab | Composition cosmetique ou pharmaceutique comprenant au moins une oxazoline pour inhiber la migration des cellules de langerhans, et ses utilisations |
EP1694357A1 (en) * | 2003-12-11 | 2006-08-30 | Axys Pharmaceuticals, Inc. | Use of cathepsin s inhibitors for treating an immune response caused by administration of a small molecule therapeutic or biologic |
GB0400895D0 (en) * | 2004-01-15 | 2004-02-18 | Smithkline Beecham Corp | Chemical compounds |
RU2403252C2 (ru) | 2004-03-30 | 2010-11-10 | Вертекс Фармасьютикалз Инкорпорейтед | Азаиндолы, полезные в качестве ингибиторов jak и других протеинкиназ |
ATE412651T1 (de) | 2004-06-09 | 2008-11-15 | Glaxo Group Ltd | Pyrrolopyridinderivate |
PE20060373A1 (es) * | 2004-06-24 | 2006-04-29 | Smithkline Beecham Corp | Derivados 3-piperidinil-7-carboxamida-indazol como inhibidores de la actividad cinasa de ikk2 |
PE20060748A1 (es) * | 2004-09-21 | 2006-10-01 | Smithkline Beecham Corp | Derivados de indolcarboxamida como inhibidores de quinasa ikk2 |
US8063071B2 (en) | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
BRPI0614272A2 (pt) * | 2005-08-09 | 2011-03-22 | Glaxo Group Ltd | derivados de imidazopiridinas como ligantes de receptores canabinóides |
US20080269291A1 (en) * | 2005-11-18 | 2008-10-30 | Kerns Jeffrey K | Chemical Compounds |
AU2007338754A1 (en) | 2006-12-21 | 2008-07-03 | Vertex Pharmaceuticals Incorporated | 5-cyan0-4- (pyrrolo [2, 3B] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors |
US20090118274A1 (en) * | 2007-02-15 | 2009-05-07 | Darin Allen | Monocyclic aminopropyl tetrahydro-pyrazolo-pyridine modulators of cathepsin s |
US20080269241A1 (en) * | 2007-02-15 | 2008-10-30 | Darin Allen | Bicyclic aminopropyl tetrahydro-pyrazolo-pyridine modulators of cathepsin s |
US20090099157A1 (en) * | 2007-02-15 | 2009-04-16 | Ameriks Michael K | Tetrahydro-pyrazolo-pyridine thioether modulators of cathepsin s |
US20080207683A1 (en) * | 2007-02-15 | 2008-08-28 | Darin Allen | Biaryl-substituted tetrahydro-pyrazolo-pyridine modulators of cathepsin s |
US20080200454A1 (en) * | 2007-02-15 | 2008-08-21 | Ameriks Michael K | Carbon-linked tetrahydro-pyrazolo-pyridine modulators of cathepsin s |
AR065804A1 (es) * | 2007-03-23 | 2009-07-01 | Smithkline Beecham Corp | Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento |
US8852569B2 (en) * | 2008-08-28 | 2014-10-07 | The General Hospital Corporation | Prevention and treatment of itch with cysteine protease inhibition |
EP2406249A1 (en) | 2009-03-10 | 2012-01-18 | Glaxo Group Limited | Indole derivatives as ikk2 inhibitors |
RS57869B1 (sr) | 2009-06-17 | 2018-12-31 | Vertex Pharma | Inhibitori replikacije virusa gripa |
RU2013132681A (ru) | 2010-12-16 | 2015-01-27 | Вертекс Фармасьютикалз Инкорпорейтед | Ингибиторы репликации вирусов гриппа |
UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
US9663533B2 (en) | 2012-11-14 | 2017-05-30 | Glaxosmithkline Llc | Thieno[3,2-C]pyridin-4(5H)-ones as BET inhibitors |
RS57541B1 (sr) | 2013-11-13 | 2018-10-31 | Vertex Pharma | Postupci za pripremu inhibitora replikacije virusa gripa |
ES2741444T3 (es) | 2013-11-13 | 2020-02-11 | Vertex Pharma | Inhibidores de la replicación de virus de la gripe |
WO2016041915A1 (en) * | 2014-09-18 | 2016-03-24 | F. Hoffmann-La Roche Ag | Method for monitoring cathepsin s inhibition |
JP6713465B2 (ja) * | 2014-12-30 | 2020-06-24 | ノヴィラ・セラピューティクス・インコーポレイテッド | B型肝炎感染症治療のための誘導体及び方法 |
US10426815B2 (en) | 2015-01-20 | 2019-10-01 | The General Hospital Corporation | Prevention and treatment of itch with an MRGPR antagonist |
EP3294735B8 (en) | 2015-05-13 | 2022-01-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
JP6704416B2 (ja) | 2015-05-13 | 2020-06-03 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | インフルエンザウイルスの複製の阻害剤を調製する方法 |
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FR2742052B1 (fr) | 1995-12-12 | 1998-04-10 | Esteve Labor Dr | Utilisation des derives 1-(4-(4-aryl (ou heteroaryl)-1-piper azinyl)-buty)-1h-azole pour le traitement de la depression, des troubles obsessifs compulsifs, l'apnee du sommeil, les dysfonctions sexuelles, l'emese et le mal des transports |
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MXPA02002873A (es) * | 1999-09-16 | 2002-08-30 | Axys Pharm Inc | Compuestos y composiciones farmaceuticas como inhibidores de la catepsina s. |
KR20020062312A (ko) | 1999-12-03 | 2002-07-25 | 오노 야꾸힝 고교 가부시키가이샤 | 1,3,4-옥사디아졸린 유도체 및 이들을 유효 성분으로하는 약제 |
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2003
- 2003-04-03 ZA ZA200302637A patent/ZA200302637B/xx unknown
- 2003-04-03 ZA ZA200302635A patent/ZA200302635B/en unknown
- 2003-04-03 ZA ZA200302630A patent/ZA200302630B/en unknown
- 2003-04-03 ZA ZA200302634A patent/ZA200302634B/en unknown
- 2003-07-17 HK HK03105186.0A patent/HK1053129A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
ZA200302635B (en) | 2004-07-15 |
ZA200302637B (en) | 2004-07-05 |
US6369032B1 (en) | 2002-04-09 |
US20020147189A1 (en) | 2002-10-10 |
MXPA03001960A (es) | 2004-03-18 |
ZA200302630B (en) | 2004-07-05 |
CN1642973A (zh) | 2005-07-20 |
WO2002020002A3 (en) | 2002-11-28 |
US6579896B2 (en) | 2003-06-17 |
JP2004523469A (ja) | 2004-08-05 |
ZA200302634B (en) | 2005-08-15 |
US6583155B2 (en) | 2003-06-24 |
CA2421502A1 (en) | 2002-03-14 |
US20020035108A1 (en) | 2002-03-21 |
RU2290179C2 (ru) | 2006-12-27 |
HK1053129A1 (zh) | 2003-10-10 |
RU2003106192A (ru) | 2004-07-27 |
WO2002020002A2 (en) | 2002-03-14 |
US20020115656A1 (en) | 2002-08-22 |
EP1315741A2 (en) | 2003-06-04 |
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