AU2001288219C1 - Stimulation of cellular regeneration and differentiation in the inner ear - Google Patents
Stimulation of cellular regeneration and differentiation in the inner ear Download PDFInfo
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- AU2001288219C1 AU2001288219C1 AU2001288219A AU2001288219A AU2001288219C1 AU 2001288219 C1 AU2001288219 C1 AU 2001288219C1 AU 2001288219 A AU2001288219 A AU 2001288219A AU 2001288219 A AU2001288219 A AU 2001288219A AU 2001288219 C1 AU2001288219 C1 AU 2001288219C1
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Classifications
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/062—Sensory transducers, e.g. photoreceptors; Sensory neurons, e.g. for hearing, taste, smell, pH, touch, temperature, pain
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61409900A | 2000-07-11 | 2000-07-11 | |
| US09/614,099 | 2000-07-11 | ||
| PCT/US2001/021793 WO2002004605A2 (en) | 2000-07-11 | 2001-07-10 | Stimulation of cellular regeneration and differentiation in the inner ear |
Publications (4)
| Publication Number | Publication Date |
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| AU2001288219A1 AU2001288219A1 (en) | 2002-04-18 |
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| AU8821901A Pending AU8821901A (en) | 2000-07-11 | 2001-07-10 | Stimulation of cellular regeneration and differentiation in the inner ear |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7745209B2 (en) | 2005-07-26 | 2010-06-29 | Corning Incorporated | Multilayered cell culture apparatus |
| CA2669693C (en) | 2006-11-15 | 2018-06-12 | Massachusetts Eye & Ear Infirmary | Generation of inner ear cells |
| US20080176318A1 (en) | 2006-12-07 | 2008-07-24 | Wilson John R | Highly efficient devices and methods for culturing cells |
| DE102010007281A1 (de) * | 2010-02-08 | 2011-08-11 | EMC microcollections GmbH, 72070 | Neue Aminoalkyl-oxazol- und Aminoalkyl-thiazolcarbonsäureamide und ihre Anwendung zur Stimulation der endogenen situ Regeneration von Haarsinneszellen im Corti'schen Organ des Innenohres beim Säuger |
| AU2012289865A1 (en) * | 2011-08-03 | 2014-02-20 | Quark Pharmaceuticals, Inc. | Double-stranded oligonucleotide compounds for treating hearing and balance disorders |
| EP2802657B1 (en) | 2012-01-12 | 2018-05-02 | Quark Pharmaceuticals, Inc. | Combination therapy for treating hearing and balance disorders |
| AU2013312358B2 (en) | 2012-09-07 | 2018-08-09 | Massachusetts Eye & Ear Infirmary | Treating hearing loss |
| US11185536B2 (en) | 2015-12-04 | 2021-11-30 | Massachusetts Eye And Ear Infirmary | Treatment of hearing loss by inhibition of casein kinase 1 |
| CN109219439B (zh) * | 2016-01-29 | 2022-09-20 | 马萨诸塞眼科耳科诊所 | 内耳支持细胞的扩增和分化及其使用方法 |
| CN114736924B (zh) * | 2021-01-07 | 2024-11-22 | 中国科学院脑科学与智能技术卓越创新中心 | 异位联合过表达Atoh1和Ikzf2再生耳蜗外毛细胞及其应用 |
| JP7760144B2 (ja) * | 2021-04-21 | 2025-10-27 | 学校法人順天堂 | 内耳細胞の製造法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6593290B1 (en) * | 1996-11-01 | 2003-07-15 | Genentech, Inc. | Treatment of inner ear hair cells |
| WO2000023084A1 (en) * | 1998-10-21 | 2000-04-27 | Jonathan Kil | Methods for stimulating the regeneration of inner ear cells |
| DE19807426A1 (de) * | 1998-02-23 | 1999-10-14 | Otogene Biotechnologische Fors | Verfahren zur Behandlung von Erkrankungen oder Störungen des Innenohrs |
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2001
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- 2001-07-10 WO PCT/US2001/021793 patent/WO2002004605A2/en not_active Ceased
- 2001-07-10 KR KR1020037000388A patent/KR100896489B1/ko not_active Expired - Fee Related
- 2001-07-10 JP JP2002509459A patent/JP2004502785A/ja active Pending
- 2001-07-10 AU AU2001288219A patent/AU2001288219C1/en not_active Ceased
- 2001-07-10 CN CN018126065A patent/CN1441841B/zh not_active Expired - Lifetime
- 2001-07-10 EP EP01967939A patent/EP1307542A2/en not_active Withdrawn
- 2001-07-10 AU AU8821901A patent/AU8821901A/xx active Pending
Non-Patent Citations (1)
| Title |
|---|
| Brain Research, 813: 57-66, 1998 * |
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| KR20030046386A (ko) | 2003-06-12 |
| AU2001288219B9 (en) | 2009-11-19 |
| KR100896489B1 (ko) | 2009-05-08 |
| WO2002004605A2 (en) | 2002-01-17 |
| EP1307542A2 (en) | 2003-05-07 |
| CA2412764A1 (en) | 2002-01-17 |
| CN1441841A (zh) | 2003-09-10 |
| AU8821901A (en) | 2002-01-21 |
| AU2001288219B2 (en) | 2006-11-23 |
| JP2004502785A (ja) | 2004-01-29 |
| WO2002004605A3 (en) | 2003-02-27 |
| CN1441841B (zh) | 2013-03-20 |
| CA2412764C (en) | 2014-06-03 |
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