AU2001280581A1 - A process for discriminating between biological states based on hidden patterns from biological data - Google Patents
A process for discriminating between biological states based on hidden patterns from biological dataInfo
- Publication number
- AU2001280581A1 AU2001280581A1 AU2001280581A AU8058101A AU2001280581A1 AU 2001280581 A1 AU2001280581 A1 AU 2001280581A1 AU 2001280581 A AU2001280581 A AU 2001280581A AU 8058101 A AU8058101 A AU 8058101A AU 2001280581 A1 AU2001280581 A1 AU 2001280581A1
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/10—Signal processing, e.g. from mass spectrometry [MS] or from PCR
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H10/00—ICT specially adapted for the handling or processing of patient-related medical or healthcare data
- G16H10/40—ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/70—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S707/00—Data processing: database and file management or data structures
- Y10S707/99931—Database or file accessing
- Y10S707/99933—Query processing, i.e. searching
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10S707/99941—Database schema or data structure
- Y10S707/99943—Generating database or data structure, e.g. via user interface
Landscapes
- Health & Medical Sciences (AREA)
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- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2008201163A AU2008201163A1 (en) | 2000-07-18 | 2008-03-11 | A process for discriminating between biological states based on hidden patterns from biological data |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21906700P | 2000-07-18 | 2000-07-18 | |
| US60/219,067 | 2000-07-18 | ||
| US23229900P | 2000-09-12 | 2000-09-12 | |
| US60/232,909 | 2000-09-15 | ||
| US27855001P | 2001-03-23 | 2001-03-23 | |
| US60/278,550 | 2001-03-23 | ||
| US28936201P | 2001-05-08 | 2001-05-08 | |
| US60/289,362 | 2001-05-08 | ||
| PCT/US2001/022447 WO2002006829A2 (en) | 2000-07-18 | 2001-07-18 | A process for discriminating between biological states based on hidden patterns from biological data |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2001280581A1 true AU2001280581A1 (en) | 2002-01-30 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2001280581A Abandoned AU2001280581A1 (en) | 2000-07-18 | 2001-07-18 | A process for discriminating between biological states based on hidden patterns from biological data |
| AU2010246364A Abandoned AU2010246364A1 (en) | 2000-07-18 | 2010-11-23 | A process for discriminating between biological states based on hidden patterns from biological data |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2010246364A Abandoned AU2010246364A1 (en) | 2000-07-18 | 2010-11-23 | A process for discriminating between biological states based on hidden patterns from biological data |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6925389B2 (ko) |
| EP (1) | EP1386275A2 (ko) |
| JP (2) | JP5246984B2 (ko) |
| KR (1) | KR101054732B1 (ko) |
| CN (1) | CN1484806A (ko) |
| AU (2) | AU2001280581A1 (ko) |
| BR (1) | BR0112667A (ko) |
| CA (1) | CA2415775A1 (ko) |
| EA (1) | EA200300161A1 (ko) |
| IL (1) | IL153856A0 (ko) |
| MX (1) | MXPA03000506A (ko) |
| NO (1) | NO20030251L (ko) |
| NZ (1) | NZ524171A (ko) |
| SG (1) | SG144731A1 (ko) |
| WO (1) | WO2002006829A2 (ko) |
Families Citing this family (184)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003535594A (ja) * | 2000-06-02 | 2003-12-02 | ラージ スケール プロテオミクス コーポレーション | 医薬および関連の毒性についてのタンパク質マーカー |
| AU2001269877A1 (en) | 2000-06-19 | 2002-01-02 | Correlogic Systems, Inc. | Heuristic method of classification |
| EA200300161A1 (ru) * | 2000-07-18 | 2003-12-25 | Коррелоджик Системз, Инк. | Способ распознавания биологических состояний, базирующихся на скрытых параметрах биологических данных |
| US6539102B1 (en) * | 2000-09-01 | 2003-03-25 | Large Scale Proteomics | Reference database |
| US6980674B2 (en) * | 2000-09-01 | 2005-12-27 | Large Scale Proteomics Corp. | Reference database |
| AU4153502A (en) * | 2000-11-16 | 2002-06-03 | Ciphergen Biosystems Inc | Method for analyzing mass spectra |
| US7981420B2 (en) | 2000-12-22 | 2011-07-19 | Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften E.V. | Therapeutic use of antibodies directed against repulsive guidance molecule (RGM) |
| US8041541B2 (en) * | 2001-05-24 | 2011-10-18 | Test Advantage, Inc. | Methods and apparatus for data analysis |
| US20030009293A1 (en) * | 2001-01-09 | 2003-01-09 | Anderson Norman G. | Reference database |
| US20050170372A1 (en) * | 2001-08-13 | 2005-08-04 | Afeyan Noubar B. | Methods and systems for profiling biological systems |
| CA2457432A1 (en) * | 2001-08-13 | 2003-02-27 | Jan Van Der Greef | Method and system for profiling biological systems |
| US20050222972A1 (en) * | 2002-01-04 | 2005-10-06 | Hewlett-Packard Development Company, L.P. | Computer implemented, fast, approximate clustering based on sampling |
| US20020193950A1 (en) * | 2002-02-25 | 2002-12-19 | Gavin Edward J. | Method for analyzing mass spectra |
| AU2003214724B2 (en) * | 2002-03-15 | 2010-04-01 | Pacific Edge Biotechnology Limited | Medical applications of adaptive learning systems using gene expression data |
| JP2005526972A (ja) * | 2002-05-02 | 2005-09-08 | シファーゲン バイオシステムズ， インコーポレイテッド | 多糖系ヒドロゲルをコーティングした表面を有するバイオチップ |
| AR040712A1 (es) * | 2002-07-29 | 2005-04-20 | Correlogic Systems Inc | Un metodo para inicialar un modelo de control para proceso de bioensayo |
| EP1394715A1 (en) * | 2002-08-02 | 2004-03-03 | Europroteome AG | An expert system for clinicial outcome prediction |
| EP1394549A1 (en) * | 2002-08-23 | 2004-03-03 | Bayer HealthCare AG | Biomarkers for diagnosing Alzheimer's disease |
| JP4643445B2 (ja) | 2002-11-12 | 2011-03-02 | ベクトン，ディッキンソン アンド カンパニー | バイオマーカープロフィールを使用した敗血症またはｓｉｒｓの診断 |
| WO2004043236A2 (en) | 2002-11-12 | 2004-05-27 | Becton, Dickinson And Company | Diagnosis of sepsis or sirs using biomarker profiles |
| EP1573054A4 (en) * | 2002-11-12 | 2005-12-28 | Becton Dickinson Co | DIAGNOSIS FOR SEPTICEMIA OR SIRS USING BIOMARKER PROFILES |
| US20040096896A1 (en) * | 2002-11-14 | 2004-05-20 | Cedars-Sinai Medical Center | Pattern recognition of serum proteins for the diagnosis or treatment of physiologic conditions |
| WO2004052191A1 (ja) * | 2002-12-09 | 2004-06-24 | Ajinomoto Co., Inc. | 生体状態情報処理装置、生体状態情報処理方法、生体状態情報管理システム、プログラム、および、記録媒体 |
| US8014952B2 (en) | 2002-12-18 | 2011-09-06 | Queen Elizabeth Hospital | Serum biomarkers in lung cancer |
| WO2004077021A2 (en) * | 2003-02-27 | 2004-09-10 | Lesko Stephen A | Standardized evaluation of therapeutic efficacy based on cellular biomarkers |
| US6977370B1 (en) | 2003-04-07 | 2005-12-20 | Ciphergen Biosystems, Inc. | Off-resonance mid-IR laser desorption ionization |
| EP1616181B1 (en) | 2003-04-17 | 2009-08-12 | Vermillion, Inc. | Polypeptides related to natriuretic peptides and methods of their identification and use |
| US20060177870A1 (en) * | 2003-04-28 | 2006-08-10 | Ciphergen Biosystems, Inc | Immunoassays |
| US7425700B2 (en) | 2003-05-22 | 2008-09-16 | Stults John T | Systems and methods for discovery and analysis of markers |
| US20040236603A1 (en) * | 2003-05-22 | 2004-11-25 | Biospect, Inc. | System of analyzing complex mixtures of biological and other fluids to identify biological state information |
| WO2004111201A2 (en) * | 2003-06-11 | 2004-12-23 | Research Foundation Of State University Of New York | Data classification using point-wise tests |
| DE602004020351D1 (de) * | 2003-07-02 | 2009-05-14 | Canon Kk | Verfahren zur informationsbeschaffung und verfahren zur krankheitsdiagnose mittels sekundärionenmassenspektrometrie |
| WO2005008247A2 (en) * | 2003-07-11 | 2005-01-27 | Science & Technology Corporation @ Unm. | Detection of endometrial pathology |
| CA2534336A1 (en) * | 2003-08-01 | 2005-02-10 | Correlogic Systems, Inc. | Multiple high-resolution serum proteomic features for ovarian cancer detection |
| US7634360B2 (en) * | 2003-09-23 | 2009-12-15 | Prediction Sciences, LL | Cellular fibronectin as a diagnostic marker in stroke and methods of use thereof |
| JP4796967B2 (ja) | 2003-11-07 | 2011-10-19 | ヴァーミリオン インコーポレイテッド | アルツハイマー病のためのバイオマーカー |
| US8043825B2 (en) | 2003-12-05 | 2011-10-25 | Mcgill University | Serum biomarkers for Chagas disease |
| JP4774534B2 (ja) * | 2003-12-11 | 2011-09-14 | アングーク ファーマシューティカル カンパニー，リミティド | 集中化適応モデル及び遠隔操作サンプルプロセッシングの使用を介した生物学的状態の診断方法 |
| US7259258B2 (en) | 2003-12-17 | 2007-08-21 | Illumina, Inc. | Methods of attaching biological compounds to solid supports using triazine |
| US20050181398A1 (en) * | 2004-01-16 | 2005-08-18 | Fung Eric T. | Specific detection of host response protein clusters |
| US7608458B2 (en) * | 2004-02-05 | 2009-10-27 | Medtronic, Inc. | Identifying patients at risk for life threatening arrhythmias |
| EP1723432A1 (en) * | 2004-02-05 | 2006-11-22 | Medtronic, Inc. | Methods and apparatus for identifying patients at risk for life threatening arrhythmias |
| US20050209785A1 (en) * | 2004-02-27 | 2005-09-22 | Wells Martin D | Systems and methods for disease diagnosis |
| US7035740B2 (en) * | 2004-03-24 | 2006-04-25 | Illumina, Inc. | Artificial intelligence and global normalization methods for genotyping |
| US7485430B2 (en) * | 2004-04-15 | 2009-02-03 | The Curators Of The University Of Missouri | Methods and compositions for evaluation of fertility |
| JP4864875B2 (ja) * | 2004-04-20 | 2012-02-01 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | 血液悪性腫瘍における診断、分類、治療に対する反応および臨床的挙動の予測、治療の階層化、ならびに疾患のモニタリングのための血漿プロテオミクスパターンの使用法 |
| EP1743031A4 (en) | 2004-04-26 | 2008-05-28 | Childrens Medical Center | BLOOD PLATE BIOMARKERS FOR THE DETECTION OF ILLNESSES |
| US20050244973A1 (en) * | 2004-04-29 | 2005-11-03 | Predicant Biosciences, Inc. | Biological patterns for diagnosis and treatment of cancer |
| US8335652B2 (en) * | 2004-06-23 | 2012-12-18 | Yougene Corp. | Self-improving identification method |
| US8027791B2 (en) * | 2004-06-23 | 2011-09-27 | Medtronic, Inc. | Self-improving classification system |
| US20050287574A1 (en) * | 2004-06-23 | 2005-12-29 | Medtronic, Inc. | Genetic diagnostic method for SCD risk stratification |
| US20060024746A1 (en) * | 2004-07-14 | 2006-02-02 | Artann Laboratories, Inc. | Methods and devices for optical monitoring and rapid analysis of drying droplets |
| US20100057368A1 (en) * | 2004-11-30 | 2010-03-04 | Noubar Afeyan | Biological Systems Analysis |
| US20060115429A1 (en) * | 2004-11-30 | 2006-06-01 | Noubar Afeyan | Biological systems analysis |
| ATE501267T1 (de) * | 2005-01-06 | 2011-03-15 | Eastern Virginia Med School | Apolipoprotein-a-ii-isoform als biomarker für prostatakrebs |
| US20060160156A1 (en) * | 2005-01-13 | 2006-07-20 | Suzanne Klimberg | Tears as a screening medium |
| US20060157647A1 (en) * | 2005-01-18 | 2006-07-20 | Becton, Dickinson And Company | Multidimensional liquid chromatography/spectrometry |
| WO2007053170A2 (en) * | 2005-02-09 | 2007-05-10 | Correlogic Systems, Inc. | Identification of bacteria and spores |
| WO2006086846A1 (en) * | 2005-02-16 | 2006-08-24 | Genetic Technologies Limited | Methods of genetic analysis involving the amplification of complementary duplicons |
| JPWO2006098192A1 (ja) * | 2005-03-16 | 2008-08-21 | 味の素株式会社 | 生体状態評価装置、生体状態評価方法、生体状態評価システム、生体状態評価プログラム、評価関数作成装置、評価関数作成方法、評価関数作成プログラムおよび記録媒体 |
| JP4843987B2 (ja) * | 2005-04-05 | 2011-12-21 | ソニー株式会社 | 情報処理装置、情報処理方法、およびプログラム |
| EP1869463A4 (en) | 2005-04-15 | 2010-05-05 | Becton Dickinson Co | SEPSIS DIAGNOSIS |
| US7499751B2 (en) * | 2005-04-28 | 2009-03-03 | Cardiac Pacemakers, Inc. | Cardiac signal template generation using waveform clustering |
| WO2006124628A2 (en) * | 2005-05-12 | 2006-11-23 | Correlogic Systems, Inc. | A model for classifying a biological sample in relation to breast cancer based on mass spectral data |
| AU2006261904B2 (en) | 2005-06-24 | 2012-05-31 | Aspira Women’s Health Inc. | Biomarkers for ovarian cancer: beta-2 microglobulin |
| US20070178526A1 (en) * | 2005-07-20 | 2007-08-02 | Kountakis Stilianos E | Use of protein profiles in disease diagnosis and treatment |
| JP2009501992A (ja) * | 2005-07-21 | 2009-01-22 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 優先度を最大にしたサブセット選択のための方法及び装置 |
| US8921102B2 (en) * | 2005-07-29 | 2014-12-30 | Gpb Scientific, Llc | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
| EP1913503A1 (en) | 2005-08-05 | 2008-04-23 | Koninklijke Philips Electronics N.V. | Search space coverage with dynamic gene distribution |
| US20070072226A1 (en) * | 2005-09-27 | 2007-03-29 | Indiana University Research & Technology Corporation | Mining protein interaction networks |
| US9955438B2 (en) | 2005-09-27 | 2018-04-24 | Qualcomm Incorporated | Method and apparatus for carrier allocation and management in multi-carrier communication systems |
| CA2624562A1 (en) | 2005-09-30 | 2007-04-12 | Abbott Gmbh & Co. Kg | Binding domains of proteins of the repulsive guidance molecule (rgm) protein family and functional fragments thereof, and their use |
| US7599893B2 (en) * | 2005-10-13 | 2009-10-06 | Aureon Laboratories, Inc. | Methods and systems for feature selection in machine learning based on feature contribution and model fitness |
| WO2007070809A2 (en) * | 2005-12-12 | 2007-06-21 | Mcgill University | Biomarkers for babesia |
| CA2640614A1 (en) * | 2006-01-27 | 2007-08-09 | Eastern Virginia Medical School | Proteomic fingerprinting of human ivf-derived embryos: identification of biomarkers of developmental potential |
| JP5357746B2 (ja) | 2006-03-11 | 2013-12-04 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 末梢性の動脈疾患のためのバイオマーカーとしてのβ−２ミクログロブリン |
| US7736905B2 (en) | 2006-03-31 | 2010-06-15 | Biodesix, Inc. | Method and system for determining whether a drug will be effective on a patient with a disease |
| US7533070B2 (en) * | 2006-05-30 | 2009-05-12 | Honeywell International Inc. | Automatic fault classification for model-based process monitoring |
| US8137912B2 (en) | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
| US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
| US8372584B2 (en) | 2006-06-14 | 2013-02-12 | The General Hospital Corporation | Rare cell analysis using sample splitting and DNA tags |
| US20080124721A1 (en) * | 2006-06-14 | 2008-05-29 | Martin Fuchs | Analysis of rare cell-enriched samples |
| WO2007147074A2 (en) | 2006-06-14 | 2007-12-21 | Living Microsystems, Inc. | Use of highly parallel snp genotyping for fetal diagnosis |
| US20080163824A1 (en) * | 2006-09-01 | 2008-07-10 | Innovative Dairy Products Pty Ltd, An Australian Company, Acn 098 382 784 | Whole genome based genetic evaluation and selection process |
| WO2008100941A2 (en) * | 2007-02-12 | 2008-08-21 | Correlogic Systems Inc. | A method for calibrating an analytical instrument |
| JP2010522882A (ja) | 2007-03-27 | 2010-07-08 | ヴァーミリオン インコーポレイテッド | 卵巣癌のバイオマーカー |
| US20110091377A1 (en) | 2007-05-11 | 2011-04-21 | The Johns Hopkins University | Biomarkers for melanoma |
| SG182976A1 (en) | 2007-06-29 | 2012-08-30 | Ahngook Pharmaceutical Co Ltd | Predictive markers for ovarian cancer |
| US20090049856A1 (en) * | 2007-08-20 | 2009-02-26 | Honeywell International Inc. | Working fluid of a blend of 1,1,1,3,3-pentafluoropane, 1,1,1,2,3,3-hexafluoropropane, and 1,1,1,2-tetrafluoroethane and method and apparatus for using |
| EP2220506B1 (en) | 2007-10-29 | 2013-10-02 | Vermillion, Inc. | Biomarkers for the detection of early stage ovarian cancer |
| US20110143956A1 (en) * | 2007-11-14 | 2011-06-16 | Medtronic, Inc. | Diagnostic Kits and Methods for SCD or SCA Therapy Selection |
| EP2222877A4 (en) * | 2007-11-14 | 2011-10-12 | Medtronic Inc | GENETIC MARKERS FOR SCD OR SCA THERAPY SELECTION |
| JP5616797B2 (ja) | 2008-02-19 | 2014-10-29 | ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ | 高い信頼性で微生物に対して陽性として培養物を認定するためのシステムおよび方法 |
| US8962803B2 (en) | 2008-02-29 | 2015-02-24 | AbbVie Deutschland GmbH & Co. KG | Antibodies against the RGM A protein and uses thereof |
| US8669113B2 (en) | 2008-04-03 | 2014-03-11 | Becton, Dickinson And Company | Advanced detection of sepsis |
| US7776522B2 (en) * | 2008-04-24 | 2010-08-17 | Becton, Dickinson And Company | Methods for diagnosing oncogenic human papillomavirus (HPV) |
| CA3069081C (en) | 2008-09-20 | 2023-05-23 | The Board Of Trustees Of The Leland Stanford Junior University | Noninvasive diagnosis of fetal aneuploidy by sequencing |
| US11298113B2 (en) | 2008-10-01 | 2022-04-12 | Covidien Lp | Device for needle biopsy with integrated needle protection |
| US9782565B2 (en) | 2008-10-01 | 2017-10-10 | Covidien Lp | Endoscopic ultrasound-guided biliary access system |
| US9186128B2 (en) | 2008-10-01 | 2015-11-17 | Covidien Lp | Needle biopsy device |
| US8968210B2 (en) | 2008-10-01 | 2015-03-03 | Covidien LLP | Device for needle biopsy with integrated needle protection |
| US9332973B2 (en) | 2008-10-01 | 2016-05-10 | Covidien Lp | Needle biopsy device with exchangeable needle and integrated needle protection |
| US8543625B2 (en) * | 2008-10-16 | 2013-09-24 | Intelliscience Corporation | Methods and systems for analysis of multi-sample, two-dimensional data |
| GB2464677A (en) | 2008-10-20 | 2010-04-28 | Univ Nottingham Trent | A method of analysing data by using an artificial neural network to identify relationships between the data and one or more conditions. |
| AU2009333489A1 (en) | 2008-12-30 | 2010-07-08 | Centocor Ortho Biotech Inc. | Serum markers predicting clinical response to anti-TNF antibodies in patients with ankylosing spondylitis |
| US20100191790A1 (en) * | 2009-01-29 | 2010-07-29 | Agilent Technologies, Inc. | System and method for correlation scoring of signals |
| EP2430184A2 (en) * | 2009-05-12 | 2012-03-21 | Medtronic, Inc. | Sca risk stratification by predicting patient response to anti-arrhythmics |
| EP2480883B1 (en) | 2009-09-23 | 2020-04-01 | Celmatix, Inc. | Methods for assessing infertility and/or egg quality |
| US20110105856A1 (en) * | 2009-10-29 | 2011-05-05 | Robyn Aylor Haines | Diagnostic testing |
| AU2010329955A1 (en) | 2009-12-08 | 2012-05-24 | Abbott Gmbh & Co. Kg | Monoclonal antibodies against the RGM A protein for use in the treatment of retinal nerve fiber layer degeneration |
| US8187979B2 (en) * | 2009-12-23 | 2012-05-29 | Varian Semiconductor Equipment Associates, Inc. | Workpiece patterning with plasma sheath modulation |
| EP2539704A4 (en) * | 2010-02-24 | 2015-12-02 | Biodesix Inc | CANCER PATIENT SELECTION FOR ADMINISTRATION OF THERAPEUTIC AGENTS USING MASS SPECTROMETRY ANALYSIS |
| WO2011129382A1 (en) | 2010-04-16 | 2011-10-20 | Abbott Japan Co. Ltd. | Methods and reagents for diagnosing rheumatoid arthritis |
| EP2628013B1 (en) | 2010-10-14 | 2019-06-12 | The Johns Hopkins University | Biomarkers of brain injury |
| WO2012076148A1 (en) * | 2010-12-08 | 2012-06-14 | Roche Diagnostics Gmbh | Systems and methods for automatically displaying patterns in biological monitoring data |
| GB2503148A (en) | 2011-02-24 | 2013-12-18 | Vermillion Inc | Biomarker panels diagnostic methods and test kits for ovarian cancer |
| CA2840196C (en) | 2011-06-27 | 2022-09-20 | Eisai R&D Management Co., Ltd. | Microrna biomarkers indicative of alzheimer's disease |
| US20130073221A1 (en) * | 2011-09-16 | 2013-03-21 | Daniel Attinger | Systems and methods for identification of fluid and substrate composition or physico-chemical properties |
| EP3323897A1 (en) | 2011-10-03 | 2018-05-23 | Celmatix, Inc. | Methods and devices for assessing risk to a putative offspring of developing a condition |
| WO2013090633A2 (en) | 2011-12-14 | 2013-06-20 | AbbVie Deutschland GmbH & Co. KG | Composition and method for the diagnosis and treatment of iron-related disorders |
| WO2013090635A2 (en) | 2011-12-14 | 2013-06-20 | AbbVie Deutschland GmbH & Co. KG | Composition and method for the diagnosis and treatment of iron-related disorders |
| RU2017145268A (ru) | 2012-01-27 | 2019-02-18 | Эббви Дойчланд Гмбх Унд Ко. Кг | Композиции и способы диагностики и лечения заболеваний, ассоциированных с дегенерацией нейритов |
| SG11201405214YA (en) | 2012-03-13 | 2014-10-30 | Abbvie Inc | Method for selecting or identifying a subject for v1b antagonist therapy |
| US20140024546A1 (en) | 2012-05-01 | 2014-01-23 | Synapdx Corporation | Systems and methods for normalizing gene expression profiles of biological samples having a mixed cell population |
| US9512477B2 (en) | 2012-05-04 | 2016-12-06 | Boreal Genomics Inc. | Biomarker anaylsis using scodaphoresis |
| CN104640856B (zh) | 2012-05-11 | 2017-09-15 | 复位治疗公司 | 作为隐花色素调节剂的含有咔唑的磺酰胺类 |
| US10288626B2 (en) | 2012-09-14 | 2019-05-14 | University Of Kentucky Research Foundation | Secreted tumor-associated cytochrome as a blood-based biomarker for cancer |
| US9177098B2 (en) | 2012-10-17 | 2015-11-03 | Celmatix Inc. | Systems and methods for determining the probability of a pregnancy at a selected point in time |
| US10162800B2 (en) | 2012-10-17 | 2018-12-25 | Celmatix Inc. | Systems and methods for determining the probability of a pregnancy at a selected point in time |
| US10865446B2 (en) | 2012-11-02 | 2020-12-15 | The Johns Hopkins University | DNA methylation biomarkers of post-partum depression risk |
| US9087298B2 (en) | 2012-12-05 | 2015-07-21 | International Business Machines Corporation | Inference of anomalous behavior of members of cohorts and associate actors related to the anomalous behavior based on divergent movement from the cohort context centroid |
| US9836577B2 (en) | 2012-12-14 | 2017-12-05 | Celmatix, Inc. | Methods and devices for assessing risk of female infertility |
| EP4286853A3 (en) | 2013-05-10 | 2024-03-06 | Johns Hopkins University | Compositions for ovarian cancer assessment having improved specificity |
| CA2919768C (en) * | 2013-06-28 | 2019-12-03 | Nantomics, Llc | Pathway analysis for identification of diagnostic tests |
| CA2918054C (en) | 2013-07-11 | 2022-12-13 | The Johns Hopkins University | A dna methylation and genotype specific biomarker of suicide attempt and/or suicide ideation |
| EP3022322A4 (en) | 2013-07-17 | 2017-05-17 | The Johns Hopkins University | A multi-protein biomarker assay for brain injury detection and outcome |
| US9898575B2 (en) | 2013-08-21 | 2018-02-20 | Seven Bridges Genomics Inc. | Methods and systems for aligning sequences |
| US9116866B2 (en) | 2013-08-21 | 2015-08-25 | Seven Bridges Genomics Inc. | Methods and systems for detecting sequence variants |
| KR102446941B1 (ko) | 2013-09-30 | 2022-09-23 | 세븐 브릿지스 지노믹스 인크. | 서열 변이체 검출 방법 및 시스템 |
| US9753131B2 (en) * | 2013-10-09 | 2017-09-05 | Massachusetts Institute Of Technology | Motion tracking via body radio reflections |
| KR101473705B1 (ko) * | 2013-10-11 | 2014-12-18 | 삼성에스디에스 주식회사 | 생물학적 샘플 분석 시스템 및 방법 |
| WO2015058120A1 (en) | 2013-10-18 | 2015-04-23 | Seven Bridges Genomics Inc. | Methods and systems for aligning sequences in the presence of repeating elements |
| AU2014337089B2 (en) | 2013-10-18 | 2019-08-08 | Seven Bridges Genomics Inc. | Methods and systems for genotyping genetic samples |
| WO2015058095A1 (en) | 2013-10-18 | 2015-04-23 | Seven Bridges Genomics Inc. | Methods and systems for quantifying sequence alignment |
| EP3058093B1 (en) | 2013-10-18 | 2019-07-17 | Seven Bridges Genomics Inc. | Methods and systems for identifying disease-induced mutations |
| US9063914B2 (en) | 2013-10-21 | 2015-06-23 | Seven Bridges Genomics Inc. | Systems and methods for transcriptome analysis |
| AU2015204819B2 (en) | 2014-01-10 | 2021-05-06 | Seven Bridges Genomics Inc. | Systems and methods for use of known alleles in read mapping |
| US10619210B2 (en) | 2014-02-07 | 2020-04-14 | The Johns Hopkins University | Predicting response to epigenetic drug therapy |
| US9817944B2 (en) | 2014-02-11 | 2017-11-14 | Seven Bridges Genomics Inc. | Systems and methods for analyzing sequence data |
| TWI690521B (zh) | 2014-04-07 | 2020-04-11 | 美商同步製藥公司 | 作為隱花色素調節劑之含有咔唑之醯胺類、胺基甲酸酯類及脲類 |
| KR20150137283A (ko) * | 2014-05-29 | 2015-12-09 | 사회복지법인 삼성생명공익재단 | 생물학적 샘플 분석 시스템 및 방법 |
| US10208350B2 (en) | 2014-07-17 | 2019-02-19 | Celmatix Inc. | Methods and systems for assessing infertility and related pathologies |
| US10222386B2 (en) | 2014-09-19 | 2019-03-05 | The Johns Hopkins University | Biomarkers of congnitive dysfunction |
| CN107408043A (zh) | 2014-10-14 | 2017-11-28 | 七桥基因公司 | 用于序列流水线中的智能工具的系统和方法 |
| GB2533098B (en) * | 2014-12-09 | 2016-12-14 | Ibm | Automated management of confidential data in cloud environments |
| US11041865B2 (en) | 2015-02-20 | 2021-06-22 | The Johns Hopkins University | Biomarkers of myocardial injury |
| US10192026B2 (en) | 2015-03-05 | 2019-01-29 | Seven Bridges Genomics Inc. | Systems and methods for genomic pattern analysis |
| US10275567B2 (en) | 2015-05-22 | 2019-04-30 | Seven Bridges Genomics Inc. | Systems and methods for haplotyping |
| US10793895B2 (en) | 2015-08-24 | 2020-10-06 | Seven Bridges Genomics Inc. | Systems and methods for epigenetic analysis |
| US10724110B2 (en) | 2015-09-01 | 2020-07-28 | Seven Bridges Genomics Inc. | Systems and methods for analyzing viral nucleic acids |
| US10584380B2 (en) | 2015-09-01 | 2020-03-10 | Seven Bridges Genomics Inc. | Systems and methods for mitochondrial analysis |
| US11347704B2 (en) | 2015-10-16 | 2022-05-31 | Seven Bridges Genomics Inc. | Biological graph or sequence serialization |
| US20170199960A1 (en) | 2016-01-07 | 2017-07-13 | Seven Bridges Genomics Inc. | Systems and methods for adaptive local alignment for graph genomes |
| US10364468B2 (en) | 2016-01-13 | 2019-07-30 | Seven Bridges Genomics Inc. | Systems and methods for analyzing circulating tumor DNA |
| US10460829B2 (en) | 2016-01-26 | 2019-10-29 | Seven Bridges Genomics Inc. | Systems and methods for encoding genetic variation for a population |
| US10262102B2 (en) | 2016-02-24 | 2019-04-16 | Seven Bridges Genomics Inc. | Systems and methods for genotyping with graph reference |
| US11250931B2 (en) | 2016-09-01 | 2022-02-15 | Seven Bridges Genomics Inc. | Systems and methods for detecting recombination |
| US11266344B2 (en) | 2016-09-21 | 2022-03-08 | Samsung Electronics Co., Ltd. | Method for measuring skin condition and electronic device therefor |
| EP3522893B1 (en) | 2016-10-04 | 2024-12-04 | University Of Maryland, Baltimore | Methods of treating sepsis using anti-sepsis lipid a (asla) based therapeutics |
| WO2018164580A1 (en) | 2017-03-09 | 2018-09-13 | Rijksuniversiteit Groningen | Biomarkers for cellular senescence |
| WO2018227202A1 (en) * | 2017-06-09 | 2018-12-13 | Bellwether Bio, Inc. | Determination of cancer type in a subject by probabilistic modeling of circulating nucleic acid fragment endpoints |
| EP3732489A1 (en) | 2017-12-29 | 2020-11-04 | Abbott Laboratories | Novel biomarkers and methods for diagnosing and evaluating traumatic brain injury |
| JP6852004B2 (ja) * | 2018-03-07 | 2021-03-31 | 株式会社東芝 | データ解析システム、データ解析方法、及びプログラム |
| EP3788377A1 (en) | 2018-05-04 | 2021-03-10 | Abbott Laboratories | Hbv diagnostic, prognostic, and therapeutic methods and products |
| US20200097879A1 (en) * | 2018-09-25 | 2020-03-26 | Oracle International Corporation | Techniques for automatic opportunity evaluation and action recommendation engine |
| US11467803B2 (en) | 2019-09-13 | 2022-10-11 | Oracle International Corporation | Identifying regulator and driver signals in data systems |
| KR102206905B1 (ko) | 2018-12-28 | 2021-01-25 | (주)아이쿱 | 혈액검사 결과 기반 생활패턴 및 변화인자 추정방법 |
| CN113677994A (zh) | 2019-02-27 | 2021-11-19 | 外延轴治疗股份有限公司 | 用于评估t细胞功能和预测对疗法的应答的方法和药剂 |
| JP7441303B2 (ja) | 2019-08-05 | 2024-02-29 | シアー， インコーポレイテッド | サンプル調製、データ生成、タンパク質コロナ分析のためのシステムおよび方法 |
| US20230386662A1 (en) * | 2020-10-19 | 2023-11-30 | B. G. Negev Technologies And Applications Ltd., At Ben-Gurion University | Rapid and direct identification and determination of urine bacterial susceptibility to antibiotics |
| WO2022187818A1 (en) * | 2021-03-03 | 2022-09-09 | Lanzatech, Inc. | System for control and analysis of gas fermentation processes |
| WO2023122723A1 (en) | 2021-12-23 | 2023-06-29 | The Broad Institute, Inc. | Panels and methods for diagnosing and treating lung cancer |
| WO2024044578A1 (en) | 2022-08-22 | 2024-02-29 | University Of Virginia | Dna methylation biomarkers of premenstrual dysphoric disorder and perimenopausal depression |
| WO2025003416A1 (en) | 2023-06-28 | 2025-01-02 | Endodiag | Non-invasive diagnostic biomarker-based test of endometriosis |
Family Cites Families (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3935562A (en) * | 1974-02-22 | 1976-01-27 | Stephens Richard G | Pattern recognition method and apparatus |
| US4075475A (en) * | 1976-05-03 | 1978-02-21 | Chemetron Corporation | Programmed thermal degradation-mass spectrometry analysis method facilitating identification of a biological specimen |
| US4697242A (en) * | 1984-06-11 | 1987-09-29 | Holland John H | Adaptive computing system capable of learning and discovery |
| US4646355A (en) * | 1985-03-15 | 1987-02-24 | Tektronix, Inc. | Method and apparatus for input picture enhancement by removal of undersired dots and voids |
| GB2187035A (en) * | 1986-01-27 | 1987-08-26 | Eric James Sjoberg | Pyrolysis mass spectrometer disease diagnosis aid |
| US4881178A (en) * | 1987-05-07 | 1989-11-14 | The Regents Of The University Of Michigan | Method of controlling a classifier system |
| US5697369A (en) * | 1988-12-22 | 1997-12-16 | Biofield Corp. | Method and apparatus for disease, injury and bodily condition screening or sensing |
| WO1991014990A1 (en) * | 1990-03-28 | 1991-10-03 | Koza John R | Non-linear genetic algorithms for solving problems by finding a fit composition of functions |
| US5210412A (en) * | 1991-01-31 | 1993-05-11 | Wayne State University | Method for analyzing an organic sample |
| US5784162A (en) * | 1993-08-18 | 1998-07-21 | Applied Spectral Imaging Ltd. | Spectral bio-imaging methods for biological research, medical diagnostics and therapy |
| ATE151546T1 (de) * | 1991-08-28 | 1997-04-15 | Becton Dickinson Co | Schwerkraftsattraktionsmaschine zur anpassungsfähigen autoclusterbildung n- dimensionaler datenströme |
| US5632957A (en) * | 1993-11-01 | 1997-05-27 | Nanogen | Molecular biological diagnostic systems including electrodes |
| AU5099593A (en) * | 1992-09-01 | 1994-03-29 | Apple Computer, Inc. | Improved vector quantization |
| US5790761A (en) * | 1992-12-11 | 1998-08-04 | Heseltine; Gary L. | Method and apparatus for the diagnosis of colorectal cancer |
| AU676582B2 (en) * | 1993-05-28 | 1997-03-13 | Baylor College Of Medicine | Method and apparatus for desorption and ionization of analytes |
| US5995645A (en) * | 1993-08-18 | 1999-11-30 | Applied Spectral Imaging Ltd. | Method of cancer cell detection |
| US5352613A (en) * | 1993-10-07 | 1994-10-04 | Tafas Triantafillos P | Cytological screening method |
| US6025128A (en) * | 1994-09-29 | 2000-02-15 | The University Of Tulsa | Prediction of prostate cancer progression by analysis of selected predictive parameters |
| AU1837495A (en) * | 1994-10-13 | 1996-05-06 | Horus Therapeutics, Inc. | Computer assisted methods for diagnosing diseases |
| US5848177A (en) * | 1994-12-29 | 1998-12-08 | Board Of Trustees Operating Michigan State University | Method and system for detection of biological materials using fractal dimensions |
| GB2301897B (en) * | 1995-06-08 | 1999-05-26 | Univ Wales Aberystwyth The | Composition analysis |
| KR100197580B1 (ko) * | 1995-09-13 | 1999-06-15 | 이민화 | 무선 통신망을 이용한 실시간 생체신호모니터링시스템 |
| US5716825A (en) * | 1995-11-01 | 1998-02-10 | Hewlett Packard Company | Integrated nucleic acid analysis system for MALDI-TOF MS |
| US5687716A (en) * | 1995-11-15 | 1997-11-18 | Kaufmann; Peter | Selective differentiating diagnostic process based on broad data bases |
| DE19543020A1 (de) * | 1995-11-18 | 1997-05-22 | Boehringer Mannheim Gmbh | Verfahren und Vorrichtung zur Bestimmung von analytischen Daten über das Innere einer streuenden Matrix |
| SE9602545L (sv) * | 1996-06-25 | 1997-12-26 | Michael Mecklenburg | Metod för att diskriminera komplexa biologiska prover |
| US5839438A (en) * | 1996-09-10 | 1998-11-24 | Neuralmed, Inc. | Computer-based neural network system and method for medical diagnosis and interpretation |
| WO1998020459A1 (en) * | 1996-11-04 | 1998-05-14 | 3-Dimensional Pharmaceuticals, Inc. | System, method, and computer program product for the visualization and interactive processing and analysis of chemical data |
| US6571227B1 (en) * | 1996-11-04 | 2003-05-27 | 3-Dimensional Pharmaceuticals, Inc. | Method, system and computer program product for non-linear mapping of multi-dimensional data |
| EP1164203B1 (en) * | 1996-11-06 | 2007-10-10 | Sequenom, Inc. | DNA Diagnostics based on mass spectrometry |
| US6157921A (en) | 1998-05-01 | 2000-12-05 | Barnhill Technologies, Llc | Enhancing knowledge discovery using support vector machines in a distributed network environment |
| US5905258A (en) | 1997-06-02 | 1999-05-18 | Advanced Research & Techology Institute | Hybrid ion mobility and mass spectrometer |
| NZ516848A (en) * | 1997-06-20 | 2004-03-26 | Ciphergen Biosystems Inc | Retentate chromatography apparatus with applications in biology and medicine |
| US6081797A (en) * | 1997-07-09 | 2000-06-27 | American Heuristics Corporation | Adaptive temporal correlation network |
| US5974412A (en) * | 1997-09-24 | 1999-10-26 | Sapient Health Network | Intelligent query system for automatically indexing information in a database and automatically categorizing users |
| WO1999041612A1 (en) | 1998-02-13 | 1999-08-19 | Oxford Glycosciences (Uk) Ltd. | Methods and compositions for diagnosis of hepatoma |
| GB9805477D0 (en) | 1998-03-13 | 1998-05-13 | Oxford Glycosciences Limited | Methods and compositions for diagnosis of rheumatoid arthritis |
| US6085576A (en) * | 1998-03-20 | 2000-07-11 | Cyrano Sciences, Inc. | Handheld sensing apparatus |
| US6558955B1 (en) * | 1998-03-30 | 2003-05-06 | Esa Inc. | Methodology for predicting and/or diagnosing disease |
| US6882990B1 (en) * | 1999-05-01 | 2005-04-19 | Biowulf Technologies, Llc | Methods of identifying biological patterns using multiple data sets |
| US6723564B2 (en) | 1998-05-07 | 2004-04-20 | Sequenom, Inc. | IR MALDI mass spectrometry of nucleic acids using liquid matrices |
| KR100691043B1 (ko) | 1998-05-09 | 2007-03-09 | 아이코니시스 인코포레이티드 | 컴퓨터 제어된 태아 세포 포함 희귀 세포 진단 방법 및 장치 |
| US6077693A (en) * | 1998-05-14 | 2000-06-20 | Incyte Pharmaceuticals, Inc. | Polynucleotide encoding a promonocyte associated protein |
| JP2002532181A (ja) * | 1998-12-23 | 2002-10-02 | メディスペクトラ， インコーポレイテッド | 頚部のスクリーニングのための光学的方法およびシステム |
| EP1153300A2 (en) | 1999-02-16 | 2001-11-14 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Lcm (laser capture microdissection) for cellular protein analysis |
| GB9905817D0 (en) | 1999-03-12 | 1999-05-05 | Oxford Glycosciences Uk Ltd | Methods |
| US7057168B2 (en) * | 1999-07-21 | 2006-06-06 | Sionex Corporation | Systems for differential ion mobility analysis |
| US6329652B1 (en) | 1999-07-28 | 2001-12-11 | Eastman Kodak Company | Method for comparison of similar samples in liquid chromatography/mass spectrometry |
| US6615199B1 (en) * | 1999-08-31 | 2003-09-02 | Accenture, Llp | Abstraction factory in a base services pattern environment |
| AU7586100A (en) | 1999-09-17 | 2001-04-17 | Affymetrix, Inc. | Method of cluster analysis of gene expression profiles |
| WO2001031580A2 (en) | 1999-10-27 | 2001-05-03 | Biowulf Technologies, Llc | Methods and devices for identifying patterns in biological systems |
| AU1350501A (en) | 1999-10-27 | 2001-05-08 | Barnhill Technologies, Llc | Methods and devices for identifying patterns in biological systems and methods for uses thereof |
| DE10021737C2 (de) | 2000-05-04 | 2002-10-17 | Hermann Haller | Verfahren und Vorrichtung zur qualitativen und/oder quantitativen Bestimmung eines Protein- und/oder Peptidmusters einer Flüssigkeitsprobe, die dem menschlichen oder tierischen Körper entnommen wird |
| AU2001269877A1 (en) * | 2000-06-19 | 2002-01-02 | Correlogic Systems, Inc. | Heuristic method of classification |
| US6680203B2 (en) * | 2000-07-10 | 2004-01-20 | Esperion Therapeutics, Inc. | Fourier transform mass spectrometry of complex biological samples |
| WO2002007064A2 (en) * | 2000-07-17 | 2002-01-24 | Labnetics, Inc. | Method and apparatus for the processing of remotely collected electronic information characterizing properties of biological entities |
| EA200300161A1 (ru) * | 2000-07-18 | 2003-12-25 | Коррелоджик Системз, Инк. | Способ распознавания биологических состояний, базирующихся на скрытых параметрах биологических данных |
| AU4153502A (en) | 2000-11-16 | 2002-06-03 | Ciphergen Biosystems Inc | Method for analyzing mass spectra |
| CA2435254C (en) | 2001-01-24 | 2012-05-15 | Biowulf Technologies, Llc | Methods of identifying patterns in biological systems and uses thereof |
| WO2002079491A2 (en) | 2001-02-16 | 2002-10-10 | Ciphergen Biosystems, Inc. | Method for correlating gene expression profiles with protein expression profiles |
| CN1463291A (zh) | 2001-04-19 | 2003-12-24 | 赛弗根生物系统股份有限公司 | 用质谱法和亲和标记物鉴定生物分子的特性 |
| US20020160420A1 (en) | 2001-04-30 | 2002-10-31 | George Jackowski | Process for diagnosis of physiological conditions by characterization of proteomic materials |
| US20040260478A1 (en) * | 2001-08-03 | 2004-12-23 | Schwamm Lee H. | System, process and diagnostic arrangement establishing and monitoring medication doses for patients |
| CA2457432A1 (en) * | 2001-08-13 | 2003-02-27 | Jan Van Der Greef | Method and system for profiling biological systems |
| US20020193950A1 (en) | 2002-02-25 | 2002-12-19 | Gavin Edward J. | Method for analyzing mass spectra |
| JP4585167B2 (ja) * | 2002-11-29 | 2010-11-24 | 東芝医用システムエンジニアリング株式会社 | Ｘ線コンピュータ断層撮影システム |
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| EA200300161A1 (ru) | 2003-12-25 |
| CA2415775A1 (en) | 2002-01-24 |
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