AU2001263215A1 - Method for treating cartilage disorders - Google Patents
Method for treating cartilage disordersInfo
- Publication number
- AU2001263215A1 AU2001263215A1 AU2001263215A AU6321501A AU2001263215A1 AU 2001263215 A1 AU2001263215 A1 AU 2001263215A1 AU 2001263215 A AU2001263215 A AU 2001263215A AU 6321501 A AU6321501 A AU 6321501A AU 2001263215 A1 AU2001263215 A1 AU 2001263215A1
- Authority
- AU
- Australia
- Prior art keywords
- igf
- cartilage
- cartilage disorders
- treating cartilage
- igfbp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000000034 method Methods 0.000 title abstract 3
- 208000015100 cartilage disease Diseases 0.000 title abstract 2
- 102000028416 insulin-like growth factor binding Human genes 0.000 abstract 4
- 108091022911 insulin-like growth factor binding Proteins 0.000 abstract 4
- 102100037852 Insulin-like growth factor I Human genes 0.000 abstract 2
- 210000000845 cartilage Anatomy 0.000 abstract 2
- 206010061762 Chondropathy Diseases 0.000 abstract 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 abstract 1
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 230000003412 degenerative effect Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4743—Insulin-like growth factor binding protein
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Marine Sciences & Fisheries (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20449000P | 2000-05-16 | 2000-05-16 | |
US60204490 | 2000-05-16 | ||
US24898500P | 2000-11-15 | 2000-11-15 | |
US60248985 | 2000-11-15 | ||
PCT/US2001/015904 WO2001087323A2 (en) | 2000-05-16 | 2001-05-16 | Method for treating cartilage disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
AU2001263215A1 true AU2001263215A1 (en) | 2001-11-26 |
Family
ID=26899527
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2001263215A Abandoned AU2001263215A1 (en) | 2000-05-16 | 2001-05-16 | Method for treating cartilage disorders |
Country Status (9)
Country | Link |
---|---|
US (4) | US20030069177A1 (da) |
EP (1) | EP1282437B1 (da) |
AT (1) | ATE389416T1 (da) |
AU (1) | AU2001263215A1 (da) |
DE (1) | DE60133271T2 (da) |
DK (1) | DK1282437T3 (da) |
ES (1) | ES2301547T3 (da) |
HK (1) | HK1050321A1 (da) |
WO (1) | WO2001087323A2 (da) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1099443A1 (en) | 1999-11-11 | 2001-05-16 | Sulzer Orthopedics Ltd. | Transplant/implant device and method for its production |
US7387889B2 (en) * | 2002-08-22 | 2008-06-17 | Massachusetts Institute Of Technology | Measurement of concentrations and binding energetics |
ES2405080T3 (es) * | 2003-02-26 | 2013-05-30 | Zimmer Orthobiologics, Inc. | Preparado para la reparación de un tejido cartilaginoso, en particular de defectos de cartílagos articulares |
CA2558497A1 (en) * | 2004-03-05 | 2005-09-15 | Synthes (U.S.A.) | Use of a mixture for the production of an agent for treating defective or degenerated cartilage in the production of natural cartilage replacement in vitro |
US20080031819A1 (en) * | 2004-06-09 | 2008-02-07 | Beth Israel Deaconess Medical Center | Compositions and Methods that Enhance Articular Cartilage Repair |
EP1764117A1 (en) | 2005-09-20 | 2007-03-21 | Zimmer GmbH | Implant for the repair of a cartilage defect and method for manufacturing the implant |
US7850983B2 (en) | 2006-02-07 | 2010-12-14 | Spinalcyte, Llc | Methods and compositions for repair of cartilage using an in vivo bioreactor |
CL2007002502A1 (es) * | 2006-08-31 | 2008-05-30 | Hoffmann La Roche | Variantes del factor de crecimiento similar a insulina-1 humano (igf-1) pegilados en lisina; metodo de produccion; proteina de fusion que la comprende; y su uso para tratar la enfermedad de alzheimer. |
US20100137204A1 (en) * | 2006-12-29 | 2010-06-03 | Zheng Xin Dong | Glp-1 pharmaceutical compositions |
EP3470093B1 (en) | 2008-10-06 | 2020-08-19 | 3-D Matrix Ltd. | Tissue plug |
BRPI0922344A2 (pt) | 2008-12-19 | 2017-10-24 | 3B Pharmaceuticals Gmbh | inibidores de tfpi e métodos de uso |
ES2983470T3 (es) | 2010-03-19 | 2024-10-23 | Takeda Pharmaceuticals Co | Inhibidores del TFPI y métodos de uso |
EP3760707A1 (en) * | 2011-11-09 | 2021-01-06 | Spinalcyte, LLC | Dermal fibroblasts for treatment of degenerative disc disease |
JP2015514070A (ja) | 2012-03-21 | 2015-05-18 | バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated | Tfpi阻害剤および使用方法 |
WO2014004467A1 (en) * | 2012-06-25 | 2014-01-03 | The Brigham And Women's Hospital, Inc. | Selective cartilage therapy |
WO2014008400A2 (en) | 2012-07-06 | 2014-01-09 | 3-D Matrix, Inc. | Fill-finish process for peptide solutions |
CN105452447A (zh) | 2013-06-19 | 2016-03-30 | 脊核细胞有限责任公司 | 用于软骨细胞应用的脂肪细胞 |
WO2015136370A2 (en) | 2014-03-10 | 2015-09-17 | 3-D Matrix, Ltd. | Sterilization and filtration of peptide compositions |
EP3116524B1 (en) | 2014-03-10 | 2018-11-28 | 3-D Matrix Ltd. | Autoassembling peptides for the treatment of pulmonary bulla |
JP6628733B2 (ja) | 2014-03-10 | 2020-01-15 | 株式会社スリー・ディー・マトリックス | 自己組織化ペプチド組成物 |
WO2017120092A1 (en) | 2016-01-06 | 2017-07-13 | 3-D Matrix, Ltd. | Combination compositions |
CN117085140A (zh) | 2017-12-15 | 2023-11-21 | 立美基股份有限公司 | 表面活性剂肽纳米结构及在药物递送中的用途 |
Family Cites Families (87)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4411890A (en) * | 1981-04-14 | 1983-10-25 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
US3721252A (en) * | 1971-04-01 | 1973-03-20 | Catheter And Instr Corp | Spring guide washer |
US4444047A (en) * | 1979-06-29 | 1984-04-24 | Vdo Adolf Schindling A.G. | Apparatus for determining the fuel consumption of injection internal combustion engines |
NO154236C (no) | 1979-07-16 | 1986-08-20 | Ciba Geigy Ag | Etterbehandling av med flammebeskyttelsesmiddel behandlede, celluloseholdige fibermaterialer med flytende ammoniakk. |
US4511503A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
IL71991A (en) | 1983-06-06 | 1994-05-30 | Genentech Inc | Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes |
WO1985000831A1 (en) | 1983-08-10 | 1985-02-28 | Amgen | Microbial expression of insulin-like growth factor |
AU598205B2 (en) * | 1985-08-22 | 1990-06-21 | Gropep Pty Ltd | Peptide analogues of mammalian insulin-like growth factor-1 |
PH25772A (en) | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
SE8505922D0 (sv) | 1985-12-13 | 1985-12-13 | Kabigen Ab | Construction of an igg binding protein to facilitate downstream processing using protein engineering |
ES2058341T3 (es) | 1987-04-06 | 1994-11-01 | Celtrix Pharma | Subunidades de proteina portadoras de somatomedina humana y proceso para producirlas. |
ES2007309T3 (es) | 1987-04-23 | 1994-11-01 | Monsanto Co | Secrecion del factor de crecimiento insulinoide 1 en e.coli. |
SE8703625D0 (sv) * | 1987-09-18 | 1987-09-18 | Kabivitrum Ab | New medical use |
US4876242A (en) * | 1987-09-21 | 1989-10-24 | Merck & Co., Inc. | Human insulin-like growth factor analoges with reduced binding to serum carrier proteins and their production in yeast |
EP0346429B1 (en) * | 1987-12-24 | 1994-12-28 | Gropep Pty. Ltd. | Peptide analogues of insulin-like growth factor 1 (igf-1) or factor 2 (igf-2) |
US5470828A (en) * | 1987-12-24 | 1995-11-28 | Gropep Pty. Ltd. | Peptide analogs of insulin-like growth factor II |
US4988675A (en) * | 1988-02-05 | 1991-01-29 | Ciba-Geigy Corporation | Method for preventing secondary effects |
ATE86496T1 (de) * | 1988-02-05 | 1993-03-15 | Ciba Geigy Ag | Verwendung von igf i zur herstellung eines praeparates fuer die behandlung von nierenkrankheiten. |
DK131988A (da) | 1988-03-11 | 1989-09-12 | Erasmus University | Igf-bindingsprotein, dna-struktur, der koder for igf-bindingsproteinet og vektor indeholdende denne dna-struktur |
US5258287A (en) | 1988-03-22 | 1993-11-02 | Genentech, Inc. | DNA encoding and methods of production of insulin-like growth factor binding protein BP53 |
WO1989009792A1 (en) | 1988-04-12 | 1989-10-19 | Synergen, Inc. | Method for potentiating and inhibiting insulin-like growth factor activity |
US5223409A (en) * | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5534617A (en) * | 1988-10-28 | 1996-07-09 | Genentech, Inc. | Human growth hormone variants having greater affinity for human growth hormone receptor at site 1 |
US6780613B1 (en) * | 1988-10-28 | 2004-08-24 | Genentech, Inc. | Growth hormone variants |
GB8826451D0 (en) | 1988-11-11 | 1988-12-14 | Sandoz Ltd | Improvements in/relating to organic compounds |
IL92816A0 (en) | 1988-12-22 | 1990-09-17 | Biogrowth Inc | Recombinant dna molecules,hosts,processes and human somatomedin carrier protein-like polypeptides |
CA2007886A1 (en) | 1989-01-17 | 1990-07-17 | Marvin L. Bayne | Human insulin-like growth factor analogs with reduced binding to 28 k igf binding proteins and their production in yeast |
US5514646A (en) * | 1989-02-09 | 1996-05-07 | Chance; Ronald E. | Insulin analogs modified at position 29 of the B chain |
US5093317A (en) * | 1989-06-05 | 1992-03-03 | Cephalon, Inc. | Treating disorders by application of insulin-like growth factor |
US5652214A (en) * | 1989-06-05 | 1997-07-29 | Cephalon, Inc. | Treating disorders by application of insulin-like growth factors and analogs |
GB8920381D0 (en) | 1989-09-08 | 1989-10-25 | Greater Glasgow Health Board | Treatment of insulin-resistant diabetes |
SE500903C2 (sv) | 1989-12-20 | 1994-09-26 | Atlas Copco Constr & Mining | Bergborrningsrigg |
ZA9010332B (en) | 1989-12-22 | 1991-08-28 | Ciba Geigy | Method of reducing or preventing adverse effect of steroid therapy and compositions therefor |
NZ236618A (en) | 1990-01-03 | 1997-06-24 | Ciba Geigy Ag | Treating and preventing osteoporosis using insulin-like growth factor i (igf i) in conjunction with a bone antiresorptive active compound |
US5126324A (en) * | 1990-06-07 | 1992-06-30 | Genentech, Inc. | Method of enhancing growth in patients using combination therapy |
US5374620A (en) * | 1990-06-07 | 1994-12-20 | Genentech, Inc. | Growth-promoting composition and its use |
US5364839A (en) | 1990-06-18 | 1994-11-15 | Genetics Institute, Inc. | Osteoinductive pharmaceutical formulations |
US5210017A (en) | 1990-11-19 | 1993-05-11 | Genentech, Inc. | Ligand-mediated immunofunctional hormone binding protein assay method |
US5593844A (en) | 1990-11-19 | 1997-01-14 | Genentech, Inc. | Ligand-mediated immunofunctional hormone binding protein assay method |
DE69129154T2 (de) * | 1990-12-03 | 1998-08-20 | Genentech, Inc., South San Francisco, Calif. | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
SE9100099D0 (sv) | 1991-01-11 | 1991-01-11 | Kabi Pharmacia Ab | Use of growth factor |
US5206023A (en) | 1991-01-31 | 1993-04-27 | Robert F. Shaw | Method and compositions for the treatment and repair of defects or lesions in cartilage |
US5187151A (en) * | 1991-02-12 | 1993-02-16 | Genentech, Inc. | Use of binding protein with igf-i as an anabolic growth promoting agent |
ATE439435T1 (de) | 1991-03-01 | 2009-08-15 | Dyax Corp | Chimäres protein mit mikroprotein mit zwei oder mehr disulfidbindungen und ausgestaltungen davon |
US5206235A (en) * | 1991-03-20 | 1993-04-27 | Merck & Co., Inc. | Benzo-fused lactams that promote the release of growth hormone |
US5202119A (en) * | 1991-06-28 | 1993-04-13 | Genentech, Inc. | Method of stimulating immune response |
CA2114251C (en) * | 1991-08-01 | 2007-11-06 | Peter Gluckman | Igf-1 to improve the neural condition |
US6310040B1 (en) | 1991-11-08 | 2001-10-30 | Cephalon, Inc. | Treating retinal neuronal disorders by the application of insulin-like growth factors and analogs |
TW267102B (da) | 1992-03-13 | 1996-01-01 | Ciba Geigy | |
SE9201573D0 (sv) * | 1992-05-19 | 1992-05-19 | Kabi Pharmacia Ab | Use of igf-1 |
DK0659083T3 (da) | 1992-06-12 | 2000-06-13 | Einstein Coll Med | Forebyggelse og behandling af perifer neuropati |
GB9217696D0 (en) | 1992-08-20 | 1992-09-30 | Agricultural & Food Res | Use of specific binding molecules |
US5273961A (en) * | 1992-09-22 | 1993-12-28 | Genentech, Inc. | Method of prophylaxis of acute renal failure |
US5342763A (en) * | 1992-11-23 | 1994-08-30 | Genentech, Inc. | Method for producing polypeptide via bacterial fermentation |
EP0642350A4 (en) | 1993-01-25 | 1995-06-28 | Beth Israel Hospital | PROCESS FOR MODIFICATION, DIAGNOSIS AND SCREENING OF IGF-I SENSITIVE CELL BARRIER CHARACTERISTICS. |
JPH09500088A (ja) | 1993-01-29 | 1997-01-07 | アムジェン ボールダー インコーポレイテッド | 創傷治癒用組成物 |
US5478852C1 (en) | 1993-09-15 | 2001-03-13 | Sankyo Co | Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of impaired glucose tolerance in order to prevent or delay the onset of noninsulin-dependent diabetes mellitus |
SK281963B6 (sk) | 1993-12-23 | 2001-09-11 | Novo Nordisk A/S | Zlúčeniny ovplyvňujúce uvoľňovanie rastového hormónu, farmaceutické prostriedky s ich obsahom a ich použitie |
AU683121B2 (en) | 1993-12-23 | 1997-10-30 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
US5597700A (en) * | 1994-04-28 | 1997-01-28 | California Research, Llc | Method for detecting free insulin-like growth-factor-binding protein 1 and a test device for detecting the ruptures of fetal membranes using the above method |
US5444047A (en) | 1994-06-16 | 1995-08-22 | Dipasquale; Gene | Treatment of arthritic and post-surgical orthopedic conditions with Insulin-like Growth Factor-I |
SE9402331D0 (sv) * | 1994-07-01 | 1994-07-01 | Pharmacia Ab | New use |
SE9402370D0 (sv) | 1994-07-04 | 1994-07-04 | Pharmacia Ab | Use of IGF-I |
US5728676A (en) * | 1994-09-08 | 1998-03-17 | Ciba-Geigy Corporation | Use of insulin-like growth factors I and II for inhibition of inflammatory response |
US5798337A (en) | 1994-11-16 | 1998-08-25 | Genentech, Inc. | Low molecular weight peptidomimetic growth hormone secretagogues |
US5596844A (en) * | 1995-02-03 | 1997-01-28 | Kalinowski; Juan R. | Foldable portable building |
SE9501472D0 (sv) | 1995-04-21 | 1995-04-21 | Pharmacia Ab | Truncated IGF-I |
US5622932A (en) * | 1995-05-05 | 1997-04-22 | Eli Lilly And Company | IGF-1 superagonists |
US5741776A (en) * | 1995-05-22 | 1998-04-21 | Genentech, Inc. | Method of administration of IGF-I |
US5565428A (en) * | 1995-05-22 | 1996-10-15 | Genentech, Inc. | Method of administration of IGF-I |
PT828758E (pt) | 1995-05-26 | 2002-02-28 | Theratechnologies Inc | Analogos quimericos de corpo gordo-pro-grf com potencia biologica aumentada |
AU6046696A (en) | 1995-06-07 | 1996-12-30 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
PT885242E (pt) | 1995-06-07 | 2008-06-18 | Glaxo Group Ltd | Péptidos e compostos que se ligam a um receptor de trombopoietina |
US5958872A (en) | 1996-04-01 | 1999-09-28 | Apoptosis Technology, Inc. | Active survival domains of IGF-IR and methods of use |
AU2676297A (en) | 1996-04-17 | 1997-11-07 | Neurocrine Biosciences, Inc. | Ligand inhibitors of insulin-like growth factor binding proteins and methods of use therefor |
WO1998011913A1 (en) * | 1996-09-16 | 1998-03-26 | Dalhousie University | Use of igf-i for the treatment of polycystic kidney disease and related indications |
WO1998020036A1 (en) | 1996-11-06 | 1998-05-14 | Genentech, Inc. | Constrained helical peptides and methods of making same |
AU7891098A (en) | 1996-12-27 | 1998-07-31 | Daiichi Pharmaceutical Co., Ltd. | Method for elevating the concentration of free insulin-like growth factor |
US6121416A (en) * | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
CO4750643A1 (es) | 1997-06-13 | 1999-03-31 | Lilly Co Eli | Formulacion estable de la insulina que contiene l-arginina y protamina |
DE19757250A1 (de) | 1997-12-22 | 1999-07-01 | Forssmann Wolf Georg Prof Dr | Insulin-like growth factor binding protein und seine Verwendung |
AU3548999A (en) * | 1998-04-03 | 1999-10-25 | Chiron Corporation | Use of igfi for treating articular cartilage disorders |
AU767141B2 (en) | 1998-10-02 | 2003-10-30 | Celtrix Pharmaceuticals, Inc. | Null IGF for the treatment of cancer |
WO2000023469A2 (en) | 1998-10-16 | 2000-04-27 | Musc Foundation For Research Development | Fragments of insulin-like growth factor binding protein and insulin-like growth factor, and uses thereof |
AU762047B2 (en) * | 1999-01-06 | 2003-06-19 | Genentech Inc. | Insulin-like growth factor (IGF) I mutant variants |
JP2003518917A (ja) | 1999-05-19 | 2003-06-17 | ゼンコー | 糖尿病の処置に有用なインシュリン様活性を有する新規タンパク質 |
CA2402780A1 (en) | 2000-03-29 | 2001-10-04 | Dgi Biotechnologies, L.L.C. | Insulin and igf-1 receptor agonists and antagonists |
-
2001
- 2001-05-16 WO PCT/US2001/015904 patent/WO2001087323A2/en active Application Filing
- 2001-05-16 AT AT01937482T patent/ATE389416T1/de active
- 2001-05-16 US US09/858,935 patent/US20030069177A1/en not_active Abandoned
- 2001-05-16 DE DE60133271T patent/DE60133271T2/de not_active Expired - Lifetime
- 2001-05-16 EP EP01937482A patent/EP1282437B1/en not_active Expired - Lifetime
- 2001-05-16 DK DK01937482T patent/DK1282437T3/da active
- 2001-05-16 ES ES01937482T patent/ES2301547T3/es not_active Expired - Lifetime
- 2001-05-16 AU AU2001263215A patent/AU2001263215A1/en not_active Abandoned
-
2002
- 2002-10-16 US US10/271,869 patent/US7423017B2/en not_active Expired - Fee Related
-
2003
- 2003-04-04 HK HK03102436A patent/HK1050321A1/xx not_active IP Right Cessation
-
2007
- 2007-10-30 US US11/929,468 patent/US7947650B2/en not_active Expired - Fee Related
- 2007-11-02 US US11/934,582 patent/US8110548B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20100130411A1 (en) | 2010-05-27 |
DK1282437T3 (da) | 2008-06-30 |
EP1282437B1 (en) | 2008-03-19 |
US20030069177A1 (en) | 2003-04-10 |
EP1282437A2 (en) | 2003-02-12 |
WO2001087323A2 (en) | 2001-11-22 |
DE60133271T2 (de) | 2009-04-23 |
US8110548B2 (en) | 2012-02-07 |
US7423017B2 (en) | 2008-09-09 |
US7947650B2 (en) | 2011-05-24 |
DE60133271D1 (de) | 2008-04-30 |
US20030211992A1 (en) | 2003-11-13 |
ES2301547T3 (es) | 2008-07-01 |
HK1050321A1 (en) | 2003-06-20 |
WO2001087323A3 (en) | 2002-04-11 |
US20090011988A1 (en) | 2009-01-08 |
ATE389416T1 (de) | 2008-04-15 |
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