AU2001250849A1 - Cyclic beta-amino acid derivatives as inhibitors of matrix metalloproteases and tnf-alpha - Google Patents

Cyclic beta-amino acid derivatives as inhibitors of matrix metalloproteases and tnf-alpha

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Publication number
AU2001250849A1
AU2001250849A1 AU2001250849A AU5084901A AU2001250849A1 AU 2001250849 A1 AU2001250849 A1 AU 2001250849A1 AU 2001250849 A AU2001250849 A AU 2001250849A AU 5084901 A AU5084901 A AU 5084901A AU 2001250849 A1 AU2001250849 A1 AU 2001250849A1
Authority
AU
Australia
Prior art keywords
methyl
quinolinyl
amino
carbonyl
methoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001250849A
Other languages
English (en)
Inventor
Linhua Chen
Carl P. Decicco
Jingwu Duan
Zhonghui Lu
Thomas P. MADUSKUIE JR.
Gregory Ott
Matthew E. Voss
Chu-Biao Xue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
DuPont Merck Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DuPont Merck Pharmaceutical Co filed Critical DuPont Merck Pharmaceutical Co
Publication of AU2001250849A1 publication Critical patent/AU2001250849A1/en
Abandoned legal-status Critical Current

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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/08—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of rings other than six-membered aromatic rings
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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AU2001250849A 2000-03-17 2001-03-15 Cyclic beta-amino acid derivatives as inhibitors of matrix metalloproteases and tnf-alpha Abandoned AU2001250849A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US19018200P 2000-03-17 2000-03-17
US60190182 2000-03-17
US23337300P 2000-09-18 2000-09-18
US60233373 2000-09-18
US25553900P 2000-12-14 2000-12-14
US60255539 2000-12-14
PCT/US2001/008334 WO2001070673A2 (en) 2000-03-17 2001-03-15 CYCLIC β-AMINO ACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEASES AND TNF-$g(a)

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AU2001250849A1 true AU2001250849A1 (en) 2001-10-03

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AU2001250849A Abandoned AU2001250849A1 (en) 2000-03-17 2001-03-15 Cyclic beta-amino acid derivatives as inhibitors of matrix metalloproteases and tnf-alpha

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US (2) US6743807B2 (sk)
EP (1) EP1263755A2 (sk)
JP (1) JP2003528072A (sk)
KR (1) KR20030009391A (sk)
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