AU2001247615A1 - Intracorporeal medicaments for photodynamic treatment of disease - Google Patents

Intracorporeal medicaments for photodynamic treatment of disease

Info

Publication number
AU2001247615A1
AU2001247615A1 AU2001247615A AU4761501A AU2001247615A1 AU 2001247615 A1 AU2001247615 A1 AU 2001247615A1 AU 2001247615 A AU2001247615 A AU 2001247615A AU 4761501 A AU4761501 A AU 4761501A AU 2001247615 A1 AU2001247615 A1 AU 2001247615A1
Authority
AU
Australia
Prior art keywords
disease
photodynamic treatment
intracorporeal medicaments
intracorporeal
medicaments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001247615A
Other languages
English (en)
Inventor
H. Craig Dees
Walter Fisher
Timothy Scott
John Smolik
Eric Wachter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Photogen Inc
Original Assignee
Photogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Photogen Inc filed Critical Photogen Inc
Publication of AU2001247615A1 publication Critical patent/AU2001247615A1/en
Abandoned legal-status Critical Current

Links

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    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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    • A61K41/008Two-Photon or Multi-Photon PDT, e.g. with upconverting dyes or photosensitisers
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    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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    • A61K47/20Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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    • A61B2017/22082Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
    • A61B2017/22087Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance photodynamic
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    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T436/153333Halogen containing
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T436/00Chemistry: analytical and immunological testing
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    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/19Halogen containing
    • Y10T436/193333In aqueous solution

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Surgery (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
AU2001247615A 2000-03-24 2001-03-20 Intracorporeal medicaments for photodynamic treatment of disease Abandoned AU2001247615A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US19180300P 2000-03-24 2000-03-24
US60191803 2000-03-24
US09799785 2001-03-06
US09/799,785 US7390668B2 (en) 1996-10-30 2001-03-06 Intracorporeal medicaments for photodynamic treatment of disease
PCT/US2001/008924 WO2001072301A1 (en) 2000-03-24 2001-03-20 Intracorporeal medicaments for photodynamic treatment of disease

Publications (1)

Publication Number Publication Date
AU2001247615A1 true AU2001247615A1 (en) 2001-10-08

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Application Number Title Priority Date Filing Date
AU2001247615A Abandoned AU2001247615A1 (en) 2000-03-24 2001-03-20 Intracorporeal medicaments for photodynamic treatment of disease

Country Status (15)

Country Link
US (6) US7390668B2 (pt)
EP (1) EP1284727B1 (pt)
JP (1) JP2003528143A (pt)
KR (1) KR20030019329A (pt)
CN (1) CN1423557A (pt)
AR (1) AR028285A1 (pt)
AT (1) ATE472325T1 (pt)
AU (1) AU2001247615A1 (pt)
BR (1) BR0109446A (pt)
CA (1) CA2402187A1 (pt)
DE (1) DE60142473D1 (pt)
ES (1) ES2346289T3 (pt)
IL (1) IL151689A0 (pt)
MX (1) MXPA02009329A (pt)
WO (1) WO2001072301A1 (pt)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7390668B2 (en) * 1996-10-30 2008-06-24 Provectus Pharmatech, Inc. Intracorporeal medicaments for photodynamic treatment of disease
US8974363B2 (en) * 1997-12-11 2015-03-10 Provectus Pharmatech, Inc. Topical medicaments and methods for photodynamic treatment of disease
US8557298B2 (en) * 1998-08-06 2013-10-15 Provectus Pharmatech, Inc. Medicaments for chemotherapeutic treatment of disease
US7648695B2 (en) * 1998-08-06 2010-01-19 Provectus Pharmatech, Inc. Medicaments for chemotherapeutic treatment of disease
CA2358662A1 (en) * 1999-01-15 2000-07-20 James Chen Therapeutic compositions for metabolic bone disorders or bone metastases
US7897140B2 (en) 1999-12-23 2011-03-01 Health Research, Inc. Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents
HU224941B1 (en) * 2001-08-10 2006-04-28 Bgi Innovacios Kft Phototerapy apparatus
EP1517684B1 (en) 2002-06-27 2009-07-22 Health Research, Inc. Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy
DE10311027A1 (de) * 2003-03-13 2004-09-30 Siemens Ag Mess- und Simulationssystem für Werkzeug- oder Produktionsmaschinen
US20050053895A1 (en) 2003-09-09 2005-03-10 The Procter & Gamble Company Attention: Chief Patent Counsel Illuminated electric toothbrushes emitting high luminous intensity toothbrush
US20050059731A1 (en) * 2003-09-16 2005-03-17 Ceramoptec Industries, Inc. Erythrosin-based antimicrobial photodynamic therapy compound and its use
ES2398962T3 (es) * 2004-06-10 2013-03-22 Provectus Pharmatech, Inc. Agentes de diagnóstico para generación de imágenes por emisión de positrones usando xantenos halogenados radiomarcados y métodos para generación de imágenes por emisión de positrones con agentes de diagnóstico de xanteno halogenado radiomarcado
US20060222592A1 (en) * 2005-04-05 2006-10-05 Clemens Burda Nanoparticles and methods of manufacturing nanoparticles for electronic and non-electronic applications
ATE539733T1 (de) 2005-11-09 2012-01-15 Klox Technologies Inc Zusammensetzungen und verfahren für zahnbleichung
WO2007130465A2 (en) * 2006-05-02 2007-11-15 Green Medical, Inc. Systems and methods for treating superficial venous malformations like spider veins
US20090326435A1 (en) * 2006-05-02 2009-12-31 Green Medical, Inc. Systems and methods for treating superficial venous malformations like varicose or spider veins
US7465312B2 (en) * 2006-05-02 2008-12-16 Green Medical, Inc. Systems and methods for treating superficial venous malformations like spider veins
US20080275432A1 (en) * 2006-05-11 2008-11-06 Ceramoptec Industries, Inc. Photodynamic foam composition and sclerosis treatment
EP2051776A2 (en) * 2006-08-09 2009-04-29 Koninklijke Philips Electronics N.V. A device for and a method of activating a physiologically effective substance by ultrasonic waves, and a capsule
US20100266989A1 (en) 2006-11-09 2010-10-21 Klox Technologies Inc. Teeth whitening compositions and methods
AU2016210665B2 (en) * 2007-04-08 2017-12-07 Immunolight, Llc Methods and systems for treating cell proliferation disorders
US9358292B2 (en) * 2007-04-08 2016-06-07 Immunolight, Llc Methods and systems for treating cell proliferation disorders
US20080291541A1 (en) * 2007-05-23 2008-11-27 3M Innovative Properties Company Light redirecting solar control film
EA024827B1 (ru) 2008-11-07 2016-10-31 Клокс Текнолоджиз Инк. Комбинация оксиданта и фотоактиватора для заживления ран
SG10201401823RA (en) * 2009-07-17 2014-08-28 Klox Technologies Inc Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease
US10010439B2 (en) 2010-06-13 2018-07-03 Synerz Medical, Inc. Intragastric device for treating obesity
US8628554B2 (en) 2010-06-13 2014-01-14 Virender K. Sharma Intragastric device for treating obesity
US9526648B2 (en) 2010-06-13 2016-12-27 Synerz Medical, Inc. Intragastric device for treating obesity
US10420665B2 (en) 2010-06-13 2019-09-24 W. L. Gore & Associates, Inc. Intragastric device for treating obesity
US9642687B2 (en) 2010-06-15 2017-05-09 The Procter & Gamble Company Methods for whitening teeth
FR2962436B1 (fr) * 2010-07-09 2012-12-14 Fabre Pierre Dermo Cosmetique Derives de xanthedediones pour le traitement des troubles de la pigmentation et du vieillissement cutane
BR112013022889B8 (pt) 2011-03-08 2022-12-20 Univ Laval Dispositivo centrípeto fluídico para testar componentes de um material biológico em um fluido, aparelho de teste e método de teste usando tal dispositivo centrípeto fluídico
US8630703B2 (en) * 2011-03-09 2014-01-14 Technion Research & Development Foundation Limited Treatment utilizing hydrophobic weak bases chemotherapeutic agents and illumination
US20130281913A1 (en) 2012-04-20 2013-10-24 Klox Technologies Inc. Biophotonic compositions and methods for providing biophotonic treatment
US11116841B2 (en) * 2012-04-20 2021-09-14 Klox Technologies Inc. Biophotonic compositions, kits and methods
BR112015005593B1 (pt) 2012-09-14 2019-09-24 Valeant Pharmaceuticals International, Inc. Método para branqueamento de dentes
US20140276354A1 (en) 2013-03-14 2014-09-18 Klox Technologies Inc. Biophotonic materials and uses thereof
CA2916337C (en) 2013-07-03 2022-03-22 Klox Technologies Inc. Biophotonic compositions comprising a chromophore and a gelling agent for treating wounds
WO2015149177A1 (en) 2014-04-01 2015-10-08 Klox Technologies Inc. Tissue filler compositions and methods of use
ES2856841T3 (es) 2014-10-31 2021-09-28 Klox Tech Inc Fibras y medios de tela fotoactivables
USD799715S1 (en) 2015-10-23 2017-10-10 Gene POC, Inc. Fluidic centripetal device
US10779980B2 (en) 2016-04-27 2020-09-22 Synerz Medical, Inc. Intragastric device for treating obesity
US20200230238A1 (en) * 2017-08-08 2020-07-23 Board Of Trustees Of Michigan State University Tunable luminescent organic salts for enhanced imaging and photodynamic therapy
CN112996502B (zh) 2018-05-16 2023-10-31 普罗维克图斯药品技术公司 卤代呫吨针对难治性小儿实体瘤的体外和异种移植抗肿瘤活性
CN113660978A (zh) * 2019-03-04 2021-11-16 光疗胶囊医学有限公司 用于肠道微生物群操纵的方法和设备
CN110498802B (zh) * 2019-07-03 2021-02-02 山西大学 一种二溴荧光素衍生物及其合成方法和应用
US12064507B2 (en) 2019-11-19 2024-08-20 Provectus Pharmatech, Inc. Composition and method for oral treatment of leukemia
US11419844B2 (en) 2019-11-19 2022-08-23 Provectus Pharmatech, Inc. Halogenated xanthene composition and method for treating hematologic cancers
US11938182B2 (en) 2020-03-26 2024-03-26 Provectus Pharmatech, Inc. Halogenated xanthenes as vaccine adjuvants
CA3172124A1 (en) 2020-03-26 2021-09-30 Aru NARENDRAN Uses of halogenated xanthenes in oncology and virology

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2504535B1 (fr) * 1981-04-28 1987-08-14 Choay Sa Disaccharides derives d'un acide uronique et d'une glucosamine et compositions pharmaceutiques les contenant pour le controle de la coagulation sanguine
ATE26458T1 (de) * 1982-06-10 1987-04-15 Warwick Int Ltd Photohaertbare harze und ihre verwendung.
US4846789A (en) * 1982-07-19 1989-07-11 L. S. Van Landingham, Jr. Combatting internal parasites in warm blooded animals
US4490543A (en) * 1982-11-12 1984-12-25 University Of Northern Iowa Foundation Low toxicity radiation sensitizer
US4599227A (en) 1983-11-07 1986-07-08 Wisconsin Alumni Research Foundation Injectable pharmaceutical preparation for the induction of multiple follicular growth
US4647578A (en) * 1983-12-02 1987-03-03 Sterling Drug Inc. Phototoxic insecticidal compositions and method of use thereof
WO1986001720A1 (en) 1984-09-13 1986-03-27 Cytogen Corporation Antibody therapeutic agent conjugates
US4957481A (en) 1987-10-01 1990-09-18 U.S. Bioscience Photodynamic therapeutic technique
JPH0796669B2 (ja) * 1988-03-09 1995-10-18 日本化薬株式会社 変色性接着剤
US5053006A (en) * 1988-04-19 1991-10-01 Watson Brant D Method for the permanent occlusion of arteries
US5177073A (en) * 1988-09-30 1993-01-05 Baylor Research Institute Therapeutic compositions derived from photoactive compounds
US4973848A (en) * 1989-07-28 1990-11-27 J. Mccaughan Laser apparatus for concurrent analysis and treatment
US5149801A (en) 1990-11-21 1992-09-22 The Regents Of The University Of California Boronated porphyrin compounds
US5654423A (en) 1990-11-21 1997-08-05 Regents Of The University Of California Boronated metalloporphyrine and therapeutic methods
US5128139A (en) 1991-02-15 1992-07-07 Nu Skin International, Inc. Composition containing liposome-entrapped grapefruit seed extract and method for making
TW251236B (pt) 1992-09-10 1995-07-11 Ciba Vision Ag
KR960009640B1 (ko) * 1992-10-16 1996-07-23 주식회사 태평양 헤어칼라린스 조성물
US5556992A (en) 1994-09-02 1996-09-17 Universite De Montreal Novel rhodamine derivatives for photodynamic therapy of cancer and in vitro purging of the leukemias
US5837677A (en) * 1995-02-03 1998-11-17 Keystone Biomedical, Inc. Method for the treatment of cancer with Exochelins of Mycobacterium tuberculosis
US5576013A (en) 1995-03-21 1996-11-19 Eastern Virginia Medical School Treating vascular and neoplastic tissues
US5591422A (en) 1995-06-02 1997-01-07 Pharmacyclics, Inc. Texaphyrin complexes having improved functionalization
IT1275571B (it) * 1995-07-19 1997-08-07 Consiglio Nazionale Ricerche Substrati fluorogenici suscettibili di fotoattivazione previa trasformazione per via enzimatica atti alla diagnosi ed alla terapia fotodinamica dei tumori
DE19602295C2 (de) 1996-01-23 2003-08-14 Deutsches Krebsforsch Verwendung eines Konjugats aus einer zur Fluoreszenz-fähigen Verbindung, Cyanurchlorid oder einem Derivat davon als Linker und einem Protein
US6162931A (en) 1996-04-12 2000-12-19 Molecular Probes, Inc. Fluorinated xanthene derivatives
ATE243513T1 (de) 1996-05-01 2003-07-15 Gen Hospital Corp Wachstumshemmung und abtoetung solider tumore unter verwendung eines prolaktin-modulators und eines photosensitizers
US5829448A (en) 1996-10-30 1998-11-03 Photogen, Inc. Method for improved selectivity in photo-activation of molecular agents
US5832931A (en) 1996-10-30 1998-11-10 Photogen, Inc. Method for improved selectivity in photo-activation and detection of molecular diagnostic agents
US6493570B1 (en) 1998-11-02 2002-12-10 Photogen, Inc. Method for improved imaging and photodynamic therapy
US7353829B1 (en) * 1996-10-30 2008-04-08 Provectus Devicetech, Inc. Methods and apparatus for multi-photon photo-activation of therapeutic agents
US7390668B2 (en) * 1996-10-30 2008-06-24 Provectus Pharmatech, Inc. Intracorporeal medicaments for photodynamic treatment of disease
US6331286B1 (en) 1998-12-21 2001-12-18 Photogen, Inc. Methods for high energy phototherapeutics
AU6665098A (en) * 1997-02-24 1998-09-09 Omd Devices Llc Silver halide material for optical memory devices with luminescent reading and methods for the treatment thereof
US5827186A (en) 1997-04-11 1998-10-27 Light Sciences Limited Partnership Method and PDT probe for minimizing CT and MRI image artifacts
US6514983B1 (en) * 1997-09-03 2003-02-04 Guilford Pharmaceuticals Inc. Compounds, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage
US8974363B2 (en) * 1997-12-11 2015-03-10 Provectus Pharmatech, Inc. Topical medicaments and methods for photodynamic treatment of disease
US6034053A (en) 1998-07-13 2000-03-07 Wayne Hughes Institute EGF-isoflavone conjugates for the prevention of restenosis
JP2002522111A (ja) * 1998-08-06 2002-07-23 フォトゲン インク 疾患の標的局所治療の改善された方法
US7648695B2 (en) * 1998-08-06 2010-01-19 Provectus Pharmatech, Inc. Medicaments for chemotherapeutic treatment of disease
EP1126884A2 (en) 1998-10-29 2001-08-29 The General Hospital Corporation Radiodense compositions
US20020001567A1 (en) * 1998-12-21 2002-01-03 Photogen, Inc. Intracorporeal medicaments for high energy phototherapeutic treatment of disease
US7384623B1 (en) * 1998-12-21 2008-06-10 Provectus Pharmatech, Inc. High energy phototherapeutic agents
IL148139A0 (en) * 1999-08-13 2002-09-12 Photogen Inc Improved topical medicaments and methods for photodynamic treatment of disease

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