AU2001245424B2 - Fluorescent membrane intercalating probes and methods for their use - Google Patents
Fluorescent membrane intercalating probes and methods for their use Download PDFInfo
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
- C09B23/0016—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being a halogen atom
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/0066—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid)
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
- C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
- C09B23/083—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines five >CH- groups
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
- C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
- C09B23/086—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Indole Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Materials By The Use Of Optical Means Adapted For Particular Applications (AREA)
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| US60/186,682 | 2000-03-03 | ||
| PCT/US2001/006923 WO2001066153A1 (en) | 2000-03-03 | 2001-03-05 | Fluorescent membrane intercalating probes and methods for their use |
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| AU2001245424A1 AU2001245424A1 (en) | 2001-11-29 |
| AU2001245424B2 true AU2001245424B2 (en) | 2005-08-18 |
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| AU (2) | AU2001245424B2 (enExample) |
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| DE (1) | DE60138531D1 (enExample) |
| WO (1) | WO2001066153A1 (enExample) |
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| CA2402352C (en) * | 2000-03-03 | 2012-08-28 | Phanos Technologies, Inc. | Fluorescent membrane intercalating probes and methods for their use |
| AU2005234696B2 (en) * | 2005-11-18 | 2012-02-16 | Phanos Technologies, Inc. | Fluorescent membrane intercalating probes and methods for their use |
| US20150223675A1 (en) * | 2012-09-04 | 2015-08-13 | Given Imaging Ltd. | Luminal administration of tag molecules for diagnostic applications |
| WO2014039699A1 (en) * | 2012-09-05 | 2014-03-13 | Arch Biopartners Inc. | Methods and composition for detecting intestinal cell-barrier dysfunction |
| US9034596B1 (en) | 2014-04-17 | 2015-05-19 | Kuwait University | Method for fluorescent staining of cellular and intracellular membranes |
| CN104098500B (zh) * | 2014-07-08 | 2016-03-16 | 中国科学院烟台海岸带研究所 | 基于花青的有机化合物及其应用 |
| JP2019508395A (ja) | 2016-02-02 | 2019-03-28 | マキシマス ダイアグノスティック テクノロジーズ エルエルシー | 炎症性腸疾患の処置を改善するための腸管バリア機能の評価 |
| WO2019094550A1 (en) * | 2017-11-09 | 2019-05-16 | Mindimmune Therapeutics, Inc. | Dendritic cell recruitment from blood to brain in neurodegenerative disease |
| RU2665628C1 (ru) * | 2018-01-25 | 2018-09-03 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ онкологии им. Н.Н. Блохина" Минздрава России) | Устройство для спектрально-флуоресцентного исследования содержания флуорохромов |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4762701A (en) * | 1986-10-31 | 1988-08-09 | Smithkline Beckman Corporation | In vivo cellular tracking |
| US5804389A (en) * | 1995-12-29 | 1998-09-08 | Phanos Technologies, Inc. | Method for detecting abnormal epithelial cell shedding |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4783401A (en) * | 1986-10-31 | 1988-11-08 | Smithkline Beckman Corporation | Viable cell labelling |
| US4859584A (en) * | 1986-10-31 | 1989-08-22 | Smithkline Beckman Corporation | Cell growth rate determination by measurement of changes in cyanine dye levels in plasma membranes |
| AU641361B2 (en) * | 1988-05-02 | 1993-09-23 | Zynaxis Technologies, Incorporated | Compounds, compositions and method for binding bio-affecting substances to surface membranes of bio-particles |
| JP3669752B2 (ja) * | 1995-01-30 | 2005-07-13 | 第一化学薬品株式会社 | 診断用マーカー |
| KR100397020B1 (ko) * | 1995-01-30 | 2004-04-29 | 다이이치 가가쿠 야쿠힝 가부시키가이샤 | 진단용마커 |
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| CA2402352C (en) * | 2000-03-03 | 2012-08-28 | Phanos Technologies, Inc. | Fluorescent membrane intercalating probes and methods for their use |
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2001
- 2001-03-05 CA CA2402352A patent/CA2402352C/en not_active Expired - Lifetime
- 2001-03-05 JP JP2001564805A patent/JP2003525915A/ja active Pending
- 2001-03-05 WO PCT/US2001/006923 patent/WO2001066153A1/en not_active Ceased
- 2001-03-05 EP EP01918334A patent/EP1265640B1/en not_active Expired - Lifetime
- 2001-03-05 DE DE60138531T patent/DE60138531D1/de not_active Expired - Lifetime
- 2001-03-05 AU AU2001245424A patent/AU2001245424B2/en not_active Expired
- 2001-03-05 AT AT01918334T patent/ATE429932T1/de not_active IP Right Cessation
- 2001-03-05 AU AU4542401A patent/AU4542401A/xx active Pending
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2006
- 2006-02-03 US US11/346,554 patent/US7462347B2/en not_active Expired - Lifetime
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2008
- 2008-12-08 US US12/330,073 patent/US8029767B2/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4762701A (en) * | 1986-10-31 | 1988-08-09 | Smithkline Beckman Corporation | In vivo cellular tracking |
| US5804389A (en) * | 1995-12-29 | 1998-09-08 | Phanos Technologies, Inc. | Method for detecting abnormal epithelial cell shedding |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE429932T1 (de) | 2009-05-15 |
| CA2402352A1 (en) | 2001-09-13 |
| EP1265640A4 (en) | 2003-07-09 |
| WO2001066153A1 (en) | 2001-09-13 |
| DE60138531D1 (de) | 2009-06-10 |
| US8029767B2 (en) | 2011-10-04 |
| AU4542401A (en) | 2001-09-17 |
| US20060193780A1 (en) | 2006-08-31 |
| JP2003525915A (ja) | 2003-09-02 |
| US20100003196A1 (en) | 2010-01-07 |
| US7462347B2 (en) | 2008-12-09 |
| CA2402352C (en) | 2012-08-28 |
| EP1265640A1 (en) | 2002-12-18 |
| EP1265640B1 (en) | 2009-04-29 |
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