CA2402352C - Fluorescent membrane intercalating probes and methods for their use - Google Patents
Fluorescent membrane intercalating probes and methods for their use Download PDFInfo
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- CA2402352C CA2402352C CA2402352A CA2402352A CA2402352C CA 2402352 C CA2402352 C CA 2402352C CA 2402352 A CA2402352 A CA 2402352A CA 2402352 A CA2402352 A CA 2402352A CA 2402352 C CA2402352 C CA 2402352C
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
- C09B23/0016—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being a halogen atom
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/0066—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid)
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
- C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
- C09B23/083—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines five >CH- groups
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
- C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
- C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
- C09B23/086—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Materials By The Use Of Optical Means Adapted For Particular Applications (AREA)
- Indole Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18668200P | 2000-03-03 | 2000-03-03 | |
| US60/186,682 | 2000-03-03 | ||
| PCT/US2001/006923 WO2001066153A1 (en) | 2000-03-03 | 2001-03-05 | Fluorescent membrane intercalating probes and methods for their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2402352A1 CA2402352A1 (en) | 2001-09-13 |
| CA2402352C true CA2402352C (en) | 2012-08-28 |
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| CA2402352A Expired - Lifetime CA2402352C (en) | 2000-03-03 | 2001-03-05 | Fluorescent membrane intercalating probes and methods for their use |
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| Country | Link |
|---|---|
| US (2) | US7462347B2 (enExample) |
| EP (1) | EP1265640B1 (enExample) |
| JP (1) | JP2003525915A (enExample) |
| AT (1) | ATE429932T1 (enExample) |
| AU (2) | AU4542401A (enExample) |
| CA (1) | CA2402352C (enExample) |
| DE (1) | DE60138531D1 (enExample) |
| WO (1) | WO2001066153A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2665628C1 (ru) * | 2018-01-25 | 2018-09-03 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ онкологии им. Н.Н. Блохина" Минздрава России) | Устройство для спектрально-флуоресцентного исследования содержания флуорохромов |
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| DE60138531D1 (de) * | 2000-03-03 | 2009-06-10 | Phanos Tech Inc | Fluoreszierende im membran interkalierende proben und verfahren zu deren verwendung |
| AU2005234696B2 (en) * | 2005-11-18 | 2012-02-16 | Phanos Technologies, Inc. | Fluorescent membrane intercalating probes and methods for their use |
| WO2014037941A1 (en) * | 2012-09-04 | 2014-03-13 | Given Imaging Ltd. | Luminal administration of tag molecules for diagnostic applications |
| EP2893032B1 (en) * | 2012-09-05 | 2018-01-17 | Maximus Diagnostic Technologies LLC | Methods and composition for detecting intestinal cell-barrier dysfunction |
| US9034596B1 (en) | 2014-04-17 | 2015-05-19 | Kuwait University | Method for fluorescent staining of cellular and intracellular membranes |
| CN104098500B (zh) * | 2014-07-08 | 2016-03-16 | 中国科学院烟台海岸带研究所 | 基于花青的有机化合物及其应用 |
| CA3013072A1 (en) | 2016-02-02 | 2017-08-10 | Maximus Diagnostic Technologies Llc | Assessment of intestinal barrier function to improve treatment of inflammatory bowel disease |
| US20210181185A1 (en) * | 2017-11-09 | 2021-06-17 | Mindimmune Therapeutics, Inc. | Dendritic cell recruitment from blood to brain in neurodegenerative disease |
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| US4783401A (en) * | 1986-10-31 | 1988-11-08 | Smithkline Beckman Corporation | Viable cell labelling |
| US4859584A (en) * | 1986-10-31 | 1989-08-22 | Smithkline Beckman Corporation | Cell growth rate determination by measurement of changes in cyanine dye levels in plasma membranes |
| US4762701A (en) * | 1986-10-31 | 1988-08-09 | Smithkline Beckman Corporation | In vivo cellular tracking |
| JP3038339B2 (ja) * | 1988-05-02 | 2000-05-08 | ザイナクシス・テクノロジーズ・インコーポレーテッド | バイオ粒子の表面膜に対してバイオアフェクティング物質を結合する化合物 |
| JP3669752B2 (ja) * | 1995-01-30 | 2005-07-13 | 第一化学薬品株式会社 | 診断用マーカー |
| US5968479A (en) * | 1995-01-30 | 1999-10-19 | Daiichi Pure Chemicals Co., Ltd. | Diagnostic marker |
| US6004536A (en) * | 1995-11-14 | 1999-12-21 | Molecular Probes, Inc. | Lipophilic cyanine dyes with enchanced aqueous solubilty |
| US5804389A (en) * | 1995-12-29 | 1998-09-08 | Phanos Technologies, Inc. | Method for detecting abnormal epithelial cell shedding |
| US6027709A (en) * | 1997-01-10 | 2000-02-22 | Li-Cor Inc. | Fluorescent cyanine dyes |
| DE60138531D1 (de) * | 2000-03-03 | 2009-06-10 | Phanos Tech Inc | Fluoreszierende im membran interkalierende proben und verfahren zu deren verwendung |
-
2001
- 2001-03-05 DE DE60138531T patent/DE60138531D1/de not_active Expired - Lifetime
- 2001-03-05 AU AU4542401A patent/AU4542401A/xx active Pending
- 2001-03-05 EP EP01918334A patent/EP1265640B1/en not_active Expired - Lifetime
- 2001-03-05 CA CA2402352A patent/CA2402352C/en not_active Expired - Lifetime
- 2001-03-05 AU AU2001245424A patent/AU2001245424B2/en not_active Expired
- 2001-03-05 AT AT01918334T patent/ATE429932T1/de not_active IP Right Cessation
- 2001-03-05 WO PCT/US2001/006923 patent/WO2001066153A1/en not_active Ceased
- 2001-03-05 JP JP2001564805A patent/JP2003525915A/ja active Pending
-
2006
- 2006-02-03 US US11/346,554 patent/US7462347B2/en not_active Expired - Lifetime
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2008
- 2008-12-08 US US12/330,073 patent/US8029767B2/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2665628C1 (ru) * | 2018-01-25 | 2018-09-03 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ онкологии им. Н.Н. Блохина" Минздрава России) | Устройство для спектрально-флуоресцентного исследования содержания флуорохромов |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1265640A1 (en) | 2002-12-18 |
| JP2003525915A (ja) | 2003-09-02 |
| CA2402352A1 (en) | 2001-09-13 |
| US7462347B2 (en) | 2008-12-09 |
| EP1265640A4 (en) | 2003-07-09 |
| US20100003196A1 (en) | 2010-01-07 |
| US20060193780A1 (en) | 2006-08-31 |
| EP1265640B1 (en) | 2009-04-29 |
| ATE429932T1 (de) | 2009-05-15 |
| US8029767B2 (en) | 2011-10-04 |
| DE60138531D1 (de) | 2009-06-10 |
| AU2001245424B2 (en) | 2005-08-18 |
| WO2001066153A1 (en) | 2001-09-13 |
| AU4542401A (en) | 2001-09-17 |
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