ATE98684T1 - Herstellung eines enzyms des beta-glucuronidase- typs, glycyrrhizin-hydrolyse und herstellung von beta-glycyrrhetinsaeure. - Google Patents
Herstellung eines enzyms des beta-glucuronidase- typs, glycyrrhizin-hydrolyse und herstellung von beta-glycyrrhetinsaeure.Info
- Publication number
- ATE98684T1 ATE98684T1 AT88401501T AT88401501T ATE98684T1 AT E98684 T1 ATE98684 T1 AT E98684T1 AT 88401501 T AT88401501 T AT 88401501T AT 88401501 T AT88401501 T AT 88401501T AT E98684 T1 ATE98684 T1 AT E98684T1
- Authority
- AT
- Austria
- Prior art keywords
- beta
- production
- glycyrrhizine
- hydrolysis
- glucuronidase
- Prior art date
Links
- 102000004190 Enzymes Human genes 0.000 title abstract 4
- 108090000790 Enzymes Proteins 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 4
- 230000007062 hydrolysis Effects 0.000 title abstract 3
- 238000006460 hydrolysis reaction Methods 0.000 title abstract 3
- 239000002253 acid Substances 0.000 title 1
- 229960003720 enoxolone Drugs 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 3
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 abstract 2
- 235000019441 ethanol Nutrition 0.000 abstract 2
- 244000005700 microbiome Species 0.000 abstract 2
- 239000000419 plant extract Substances 0.000 abstract 2
- 241000228212 Aspergillus Species 0.000 abstract 1
- 239000002028 Biomass Substances 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 102000053187 Glucuronidase Human genes 0.000 abstract 1
- 108010060309 Glucuronidase Proteins 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000000284 extract Substances 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 235000011477 liquorice Nutrition 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01031—Beta-glucuronidase (3.2.1.31)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8708384A FR2616800B1 (fr) | 1987-06-16 | 1987-06-16 | Production d'une enzyme du type bglucuronidase, hydrolyse de la glycyrrhizine et production d'acide 18 b-glycyrrhetinique |
| EP88401501A EP0297944B1 (de) | 1987-06-16 | 1988-06-16 | Herstellung eines Enzyms des beta-Glucuronidase-Typs, Glycyrrhizin-Hydrolyse und Herstellung von beta-Glycyrrhetinsäure |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE98684T1 true ATE98684T1 (de) | 1994-01-15 |
Family
ID=9352103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88401501T ATE98684T1 (de) | 1987-06-16 | 1988-06-16 | Herstellung eines enzyms des beta-glucuronidase- typs, glycyrrhizin-hydrolyse und herstellung von beta-glycyrrhetinsaeure. |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0297944B1 (de) |
| AT (1) | ATE98684T1 (de) |
| DE (1) | DE3886281T2 (de) |
| ES (1) | ES2061703T3 (de) |
| FR (1) | FR2616800B1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7087420B1 (en) | 1997-07-17 | 2006-08-08 | Cambia | Microbial β-glucuronidase genes, gene products and uses thereof |
| US6641996B1 (en) | 1997-09-09 | 2003-11-04 | Cambia | Microbial β-glucuronidase genes, gene products and uses thereof |
| CN103992953B (zh) * | 2014-02-20 | 2016-10-05 | 江西师范大学 | 一株转化甘草酸生成甘草次苷的东乡野生稻内生真菌 |
| KR102079794B1 (ko) | 2018-09-18 | 2020-02-20 | 전북대학교산학협력단 | 신규한 엔테로코커스 패시움 균주 및 이의 용도 |
| CN115786133B (zh) * | 2022-10-08 | 2025-10-31 | 北京理工大学 | 一株热焦曲霉菌株clh-22及其用途、发酵剂和制备3-氧代甘草次酸的方法 |
| CN118207186B (zh) * | 2024-05-20 | 2024-07-30 | 北京理工大学 | 一种β-葡萄糖醛酸苷酶及其重组表达载体、工程菌、发酵剂和量产甘草次酸的方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5636915B1 (de) * | 1970-09-02 | 1981-08-27 | ||
| JPS5849310A (ja) * | 1981-09-17 | 1983-03-23 | Minofuaagen Seiyaku Honpo:Goushi | 有用なるグリチルリチン溶液の調製法 |
| JPS60163895A (ja) * | 1984-02-06 | 1985-08-26 | Maruzen Kasei Kk | グリチルレチン酸の製造法 |
-
1987
- 1987-06-16 FR FR8708384A patent/FR2616800B1/fr not_active Expired - Fee Related
-
1988
- 1988-06-16 DE DE88401501T patent/DE3886281T2/de not_active Expired - Fee Related
- 1988-06-16 ES ES88401501T patent/ES2061703T3/es not_active Expired - Lifetime
- 1988-06-16 AT AT88401501T patent/ATE98684T1/de not_active IP Right Cessation
- 1988-06-16 EP EP88401501A patent/EP0297944B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FR2616800B1 (fr) | 1990-01-12 |
| DE3886281T2 (de) | 1994-04-21 |
| FR2616800A1 (fr) | 1988-12-23 |
| EP0297944B1 (de) | 1993-12-15 |
| EP0297944A1 (de) | 1989-01-04 |
| ES2061703T3 (es) | 1994-12-16 |
| DE3886281D1 (de) | 1994-01-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |