ATE98242T1 - Kristallines antibiotikum-zwischenprodukt. - Google Patents
Kristallines antibiotikum-zwischenprodukt.Info
- Publication number
- ATE98242T1 ATE98242T1 AT88308245T AT88308245T ATE98242T1 AT E98242 T1 ATE98242 T1 AT E98242T1 AT 88308245 T AT88308245 T AT 88308245T AT 88308245 T AT88308245 T AT 88308245T AT E98242 T1 ATE98242 T1 AT E98242T1
- Authority
- AT
- Austria
- Prior art keywords
- crystalline
- acetic acid
- hydroxy
- antibiotic intermediate
- hydroxy ester
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
- C07D463/16—Nitrogen atoms
- C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
- C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/095,721 US4782144A (en) | 1987-09-14 | 1987-09-14 | 1-carba(dethia)-3-hydroxy-3-cephem ester crystalline and crystalline solvate thereof |
| EP88308245A EP0308123B1 (de) | 1987-09-14 | 1988-09-07 | Kristallines Antibiotikum-Zwischenprodukt |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE98242T1 true ATE98242T1 (de) | 1993-12-15 |
Family
ID=22253299
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88308245T ATE98242T1 (de) | 1987-09-14 | 1988-09-07 | Kristallines antibiotikum-zwischenprodukt. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4782144A (de) |
| EP (1) | EP0308123B1 (de) |
| JP (1) | JPH01100170A (de) |
| KR (1) | KR960015966B1 (de) |
| AT (1) | ATE98242T1 (de) |
| CA (1) | CA1334590C (de) |
| DE (1) | DE3886151T2 (de) |
| ES (1) | ES2061666T3 (de) |
| HU (1) | HU201073B (de) |
| IE (1) | IE61559B1 (de) |
| IL (1) | IL87697A (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1334971C (en) * | 1988-06-22 | 1995-03-28 | Eli Lilly And Company | Intermediate for 1-carba(dethia)cephalosporin |
| US5412094A (en) * | 1993-06-28 | 1995-05-02 | Eli Lilly And Company | Bicyclic beta-lactam/paraben complexes |
| US6001996A (en) * | 1995-05-11 | 1999-12-14 | Eli Lilly And Company | Complexes of cephalosporins and carbacephalosporins with parabens |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE49374B1 (en) * | 1979-02-01 | 1985-09-18 | Lilly Co Eli | Crystalline 3-hydroxycephalosporin solvates |
| US4237279A (en) * | 1979-07-27 | 1980-12-02 | Eli Lilly And Company | Crystalline 3-hydroxycephalosporin solvates |
| US4665171A (en) * | 1985-07-17 | 1987-05-12 | Harvard University | Process and intermediates for β-lactam antibiotics |
| US4673737A (en) * | 1985-08-02 | 1987-06-16 | Harvard University | 7-acylamino-(or 7-amino)-3-trifluoromethylsulfonyloxy-1-carba(1-dethia)-3-cephem-4-carboxylic acids and esters thereof |
-
1987
- 1987-09-14 US US07/095,721 patent/US4782144A/en not_active Expired - Lifetime
-
1988
- 1988-09-07 AT AT88308245T patent/ATE98242T1/de not_active IP Right Cessation
- 1988-09-07 EP EP88308245A patent/EP0308123B1/de not_active Expired - Lifetime
- 1988-09-07 ES ES88308245T patent/ES2061666T3/es not_active Expired - Lifetime
- 1988-09-07 DE DE88308245T patent/DE3886151T2/de not_active Expired - Fee Related
- 1988-09-07 CA CA000576635A patent/CA1334590C/en not_active Expired - Fee Related
- 1988-09-07 KR KR1019880011519A patent/KR960015966B1/ko not_active IP Right Cessation
- 1988-09-07 IL IL87697A patent/IL87697A/xx not_active IP Right Cessation
- 1988-09-08 IE IE272188A patent/IE61559B1/en not_active IP Right Cessation
- 1988-09-09 JP JP63227341A patent/JPH01100170A/ja active Pending
- 1988-09-09 HU HU884664A patent/HU201073B/hu not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL87697A (en) | 1993-04-04 |
| CA1334590C (en) | 1995-02-28 |
| IE61559B1 (en) | 1994-11-16 |
| DE3886151T2 (de) | 1994-04-28 |
| KR960015966B1 (ko) | 1996-11-25 |
| IL87697A0 (en) | 1989-02-28 |
| HU201073B (en) | 1990-09-28 |
| IE882721L (en) | 1989-03-14 |
| HUT47931A (en) | 1989-04-28 |
| ES2061666T3 (es) | 1994-12-16 |
| US4782144A (en) | 1988-11-01 |
| JPH01100170A (ja) | 1989-04-18 |
| EP0308123B1 (de) | 1993-12-08 |
| EP0308123A1 (de) | 1989-03-22 |
| DE3886151D1 (de) | 1994-01-20 |
| KR890005099A (ko) | 1989-05-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |