ES2061666T3 - Intermedio antibiotico cristalino. - Google Patents

Intermedio antibiotico cristalino.

Info

Publication number
ES2061666T3
ES2061666T3 ES88308245T ES88308245T ES2061666T3 ES 2061666 T3 ES2061666 T3 ES 2061666T3 ES 88308245 T ES88308245 T ES 88308245T ES 88308245 T ES88308245 T ES 88308245T ES 2061666 T3 ES2061666 T3 ES 2061666T3
Authority
ES
Spain
Prior art keywords
crystalline
hydroxy
ester
acid
acetic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88308245T
Other languages
English (en)
Inventor
John Paul Gardner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2061666T3 publication Critical patent/ES2061666T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA INVENCION PROPORCIONA P - NITROBENCIL - 7 - BETA FENOXIACETILAMINO - 3 - HIDROXI - 1 - CARBA(DETIA) - 3 - CEFEM 4 - CARBOXILATO Y SU SOLUTO CRISTALINO DE ACIDO MONOACETICO, POR MEZCLADO DE UN ACIDO CARBOXILICO O SULFONICO CON UNA SOLUCION DEL 3 - HIDROXI - ESTER EN DMF O DMAC. EL ACIDO ACETICO DA LUGAR AL SOLVATO DE ACIDO ACETICO CRISTALINO MIENTRAS QUE OTROS ACIDOS PROPORCIONAN EL 3 - HIDROXI ESTER CRISTALINO NO SOLVATADO. LAS FORMAS CRISTALINAS SON COMPUESTOS INTERMEDIOS PURIFICADOS UTILES PARA LA OBTENCION DE ANTIBIOTICOS.
ES88308245T 1987-09-14 1988-09-07 Intermedio antibiotico cristalino. Expired - Lifetime ES2061666T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/095,721 US4782144A (en) 1987-09-14 1987-09-14 1-carba(dethia)-3-hydroxy-3-cephem ester crystalline and crystalline solvate thereof

Publications (1)

Publication Number Publication Date
ES2061666T3 true ES2061666T3 (es) 1994-12-16

Family

ID=22253299

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88308245T Expired - Lifetime ES2061666T3 (es) 1987-09-14 1988-09-07 Intermedio antibiotico cristalino.

Country Status (11)

Country Link
US (1) US4782144A (es)
EP (1) EP0308123B1 (es)
JP (1) JPH01100170A (es)
KR (1) KR960015966B1 (es)
AT (1) ATE98242T1 (es)
CA (1) CA1334590C (es)
DE (1) DE3886151T2 (es)
ES (1) ES2061666T3 (es)
HU (1) HU201073B (es)
IE (1) IE61559B1 (es)
IL (1) IL87697A (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2809711B2 (ja) * 1988-06-22 1998-10-15 イーライ・リリー・アンド・カンパニー １―カルバ（デチア）セファロスポリンの中間体
US5412094A (en) * 1993-06-28 1995-05-02 Eli Lilly And Company Bicyclic beta-lactam/paraben complexes
US6001996A (en) * 1995-05-11 1999-12-14 Eli Lilly And Company Complexes of cephalosporins and carbacephalosporins with parabens

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE49374B1 (en) * 1979-02-01 1985-09-18 Lilly Co Eli Crystalline 3-hydroxycephalosporin solvates
US4237279A (en) * 1979-07-27 1980-12-02 Eli Lilly And Company Crystalline 3-hydroxycephalosporin solvates
US4665171A (en) * 1985-07-17 1987-05-12 Harvard University Process and intermediates for β-lactam antibiotics
US4673737A (en) * 1985-08-02 1987-06-16 Harvard University 7-acylamino-(or 7-amino)-3-trifluoromethylsulfonyloxy-1-carba(1-dethia)-3-cephem-4-carboxylic acids and esters thereof

Also Published As

Publication number Publication date
KR890005099A (ko) 1989-05-11
IL87697A0 (en) 1989-02-28
IE61559B1 (en) 1994-11-16
EP0308123A1 (en) 1989-03-22
IE882721L (en) 1989-03-14
ATE98242T1 (de) 1993-12-15
DE3886151T2 (de) 1994-04-28
HUT47931A (en) 1989-04-28
IL87697A (en) 1993-04-04
KR960015966B1 (ko) 1996-11-25
US4782144A (en) 1988-11-01
DE3886151D1 (de) 1994-01-20
HU201073B (en) 1990-09-28
JPH01100170A (ja) 1989-04-18
EP0308123B1 (en) 1993-12-08
CA1334590C (en) 1995-02-28

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