ATE96321T1 - Derivate von 5-hydroxy- und 5-methoxy-2-aminopyrimidin als inhibitoren der interleukin-1produktion. - Google Patents
Derivate von 5-hydroxy- und 5-methoxy-2-aminopyrimidin als inhibitoren der interleukin-1produktion.Info
- Publication number
- ATE96321T1 ATE96321T1 AT89312736T AT89312736T ATE96321T1 AT E96321 T1 ATE96321 T1 AT E96321T1 AT 89312736 T AT89312736 T AT 89312736T AT 89312736 T AT89312736 T AT 89312736T AT E96321 T1 ATE96321 T1 AT E96321T1
- Authority
- AT
- Austria
- Prior art keywords
- interleukin
- production
- mammal
- methoxy
- hydroxy
- Prior art date
Links
- 230000018276 interleukin-1 production Effects 0.000 title abstract 3
- KAHHAPNRIQLSFT-UHFFFAOYSA-N 5-methoxypyrimidin-2-amine Chemical compound COC1=CN=C(N)N=C1 KAHHAPNRIQLSFT-UHFFFAOYSA-N 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 102000000589 Interleukin-1 Human genes 0.000 abstract 1
- 108010002352 Interleukin-1 Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 210000002808 connective tissue Anatomy 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28450588A | 1988-12-14 | 1988-12-14 | |
| EP89312736A EP0373827B1 (de) | 1988-12-14 | 1989-12-07 | Derivate von 5-Hydroxy- und 5-Methoxy-2-amino-pyrimidin als Inhibitoren der Interleukin-1-Produktion |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE96321T1 true ATE96321T1 (de) | 1993-11-15 |
Family
ID=23090453
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89312736T ATE96321T1 (de) | 1988-12-14 | 1989-12-07 | Derivate von 5-hydroxy- und 5-methoxy-2-aminopyrimidin als inhibitoren der interleukin-1produktion. |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0373827B1 (de) |
| JP (1) | JPH0651622B2 (de) |
| KR (1) | KR920003578B1 (de) |
| AT (1) | ATE96321T1 (de) |
| AU (1) | AU605702B2 (de) |
| CA (1) | CA2005196A1 (de) |
| DE (1) | DE68910288T2 (de) |
| HU (1) | HU206182B (de) |
| IE (1) | IE893978L (de) |
| IL (1) | IL92586A (de) |
| PH (1) | PH27120A (de) |
| PT (1) | PT92551A (de) |
| ZA (1) | ZA899508B (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5177079A (en) * | 1991-01-31 | 1993-01-05 | Warner-Lambert Company | 2-substituted-4,6-di-tertiarybutyl-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents |
| EP0569493A4 (en) * | 1991-01-31 | 1993-11-24 | Warner-Lambert Company | Substituted 4,6-di-tertiary-butyl-5-hydroxy-pyrimidines |
| US5248682A (en) * | 1991-01-31 | 1993-09-28 | Warner-Lambert Company | 2-substituted-4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents |
| US5270319A (en) * | 1991-09-09 | 1993-12-14 | Warner-Lambert Company | 5-hydroxy-2-pyrimidinylmethylene derivatives useful as antiinflammatory agents |
| DE102004054080A1 (de) * | 2004-11-09 | 2006-05-11 | Wella Ag | Haut- oder Haarbehandlungsmittel mit Schutzeffekt |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1670537A1 (de) * | 1966-11-09 | 1970-10-29 | Degussa | Verfahren zur Herstellung neuer substituierter Aminopyrimidine |
| US4554276A (en) * | 1983-10-03 | 1985-11-19 | Pfizer Inc. | 2-Amino-5-hydroxy-4-methylpyrimidine derivatives |
| IL77243A (en) * | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
| US4711888A (en) * | 1985-07-24 | 1987-12-08 | Pfizer Inc. | Hydroxy and alkoxy pyrimidines |
-
1989
- 1989-12-07 AT AT89312736T patent/ATE96321T1/de not_active IP Right Cessation
- 1989-12-07 EP EP89312736A patent/EP0373827B1/de not_active Expired - Lifetime
- 1989-12-07 IL IL9258689A patent/IL92586A/en not_active IP Right Cessation
- 1989-12-07 DE DE89312736T patent/DE68910288T2/de not_active Expired - Fee Related
- 1989-12-11 JP JP1321232A patent/JPH0651622B2/ja not_active Expired - Lifetime
- 1989-12-11 PH PH39661A patent/PH27120A/en unknown
- 1989-12-12 CA CA002005196A patent/CA2005196A1/en not_active Abandoned
- 1989-12-12 AU AU46130/89A patent/AU605702B2/en not_active Ceased
- 1989-12-12 PT PT92551A patent/PT92551A/pt not_active Application Discontinuation
- 1989-12-13 HU HU896526A patent/HU206182B/hu not_active IP Right Cessation
- 1989-12-13 KR KR1019890018435A patent/KR920003578B1/ko not_active Expired
- 1989-12-13 ZA ZA899508A patent/ZA899508B/xx unknown
- 1989-12-13 IE IE893978A patent/IE893978L/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR920003578B1 (ko) | 1992-05-04 |
| EP0373827A2 (de) | 1990-06-20 |
| EP0373827A3 (de) | 1991-11-06 |
| AU4613089A (en) | 1990-07-19 |
| KR900009078A (ko) | 1990-07-02 |
| DE68910288T2 (de) | 1994-02-17 |
| EP0373827B1 (de) | 1993-10-27 |
| IL92586A0 (en) | 1990-08-31 |
| PH27120A (en) | 1993-03-16 |
| PT92551A (pt) | 1990-06-29 |
| JPH0651622B2 (ja) | 1994-07-06 |
| HUT51897A (en) | 1990-06-28 |
| IL92586A (en) | 1994-06-24 |
| AU605702B2 (en) | 1991-01-17 |
| CA2005196A1 (en) | 1990-06-14 |
| ZA899508B (en) | 1991-07-31 |
| DE68910288D1 (de) | 1993-12-02 |
| IE893978L (en) | 1990-06-14 |
| JPH02218613A (ja) | 1990-08-31 |
| HU206182B (en) | 1992-09-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA200100135A1 (ru) | Алкинилзамещенные производные хинолин-2-она, полезные в качестве противораковых агентов | |
| SE8503888L (sv) | Heterocykliska derivat | |
| EA200000614A1 (ru) | 2,3-замещенные соединения индола в качестве ингибиторов сох-2 | |
| FI903939A0 (fi) | Benzopyranfoereningar, foerfaranden foer deras framstaellning och farmaceutiska kompositioner. | |
| DE68910288D1 (de) | Derivate von 5-Hydroxy- und 5-Methoxy-2-amino-pyrimidin als Inhibitoren der Interleukin-1-Produktion. | |
| ATE89724T1 (de) | 3-substituierte 2-oxindol-1-carboxamid-derivate als hemmer der biosynthese des interleukins-1. | |
| DE60002558D1 (de) | Derivate der Phosphonsäure zur Inhibierung von Carboxypeptidase B | |
| ES8606236A1 (es) | Un procedimiento para la preparacion de un compuesto de calixareno. | |
| DK0514942T3 (da) | Hidtil ukendte benzopyranderivater og fremgangsmåder til fremstilling deraf | |
| DK384388A (da) | Herbicid | |
| ES2039485T3 (es) | Un procedimiento para la preparacion de un compuesto 3,4-dihidropirimidina n-sustituido. | |
| ATE69605T1 (de) | Azolylpropenyl- und azolylmethyloxiran-derivate und diese enthaltende fungizide. | |
| IT1204462B (it) | Derivati eterociclici | |
| IT1204459B (it) | Derivati eterociclici | |
| FI844185L (fi) | N-substituerade isokinolinderivat och foerfarande foer framstaellning daerav. | |
| ATE84303T1 (de) | Cysteinderivate. | |
| ATE222583T1 (de) | Derivate substituierter amidinonaphthylester | |
| IT1204461B (it) | Derivati eterociclici | |
| IT1204460B (it) | Derivati eterociclici | |
| ATE28876T1 (de) | Triorganozinnacetylsalicylate und diese enthaltende biozide mittel. | |
| ES8303381A1 (es) | Procedimiento para la fabricacion de un compuesto de fenil- 1,3-perhidrotiacina-4-ona, 2-substituida |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |