ATE175113T1 - Verwendung von 4-amino-1-(2-pyridyl)piperidinen als 5-ht3-agonisten zur behandlung und verhütung von serotoninergen dysfunktionen - Google Patents
Verwendung von 4-amino-1-(2-pyridyl)piperidinen als 5-ht3-agonisten zur behandlung und verhütung von serotoninergen dysfunktionenInfo
- Publication number
- ATE175113T1 ATE175113T1 AT92400792T AT92400792T ATE175113T1 AT E175113 T1 ATE175113 T1 AT E175113T1 AT 92400792 T AT92400792 T AT 92400792T AT 92400792 T AT92400792 T AT 92400792T AT E175113 T1 ATE175113 T1 AT E175113T1
- Authority
- AT
- Austria
- Prior art keywords
- serotoninergic
- piperidines
- pyridyl
- amino
- dysfunctions
- Prior art date
Links
- 230000002295 serotoninergic effect Effects 0.000 title abstract 3
- 230000004064 dysfunction Effects 0.000 title abstract 2
- 150000003053 piperidines Chemical class 0.000 title 1
- 239000000198 serotonin 5-HT3 receptor agonist Substances 0.000 title 1
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000004455 (C1-C3) alkylthio group Chemical group 0.000 abstract 1
- CZINLSYKXBADTA-UHFFFAOYSA-N 1-pyridin-2-ylpiperidin-4-amine Chemical class C1CC(N)CCN1C1=CC=CC=N1 CZINLSYKXBADTA-UHFFFAOYSA-N 0.000 abstract 1
- 102000035037 5-HT3 receptors Human genes 0.000 abstract 1
- 108091005477 5-HT3 receptors Proteins 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
- 125000005034 trifluormethylthio group Chemical group FC(S*)(F)F 0.000 abstract 1
- -1 trifluoromethoxy, 2,2,2-trifluoroethoxy, methylthio Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9103735A FR2674435B1 (fr) | 1991-03-27 | 1991-03-27 | Utilisation de 4-amino-1-(2-pyridyl) piperidines pour la preparation d'agents psychotropes. |
| FR9110890A FR2674752B1 (fr) | 1991-09-03 | 1991-09-03 | Utilisation de 4-amino-1-(2-pyridyl)piperidines pour la preparation de medicaments pour le traitement et la prophylaxie des etats decoulant d'un dysfonctionnement du systeme serotoninergique. |
| EP91402753 | 1991-10-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE175113T1 true ATE175113T1 (de) | 1999-01-15 |
Family
ID=27234263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92400792T ATE175113T1 (de) | 1991-03-27 | 1992-03-24 | Verwendung von 4-amino-1-(2-pyridyl)piperidinen als 5-ht3-agonisten zur behandlung und verhütung von serotoninergen dysfunktionen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5604245A (de) |
| EP (1) | EP0506545B1 (de) |
| JP (1) | JP2603023B2 (de) |
| AT (1) | ATE175113T1 (de) |
| AU (1) | AU656563B2 (de) |
| CA (1) | CA2063941A1 (de) |
| DE (1) | DE69228017D1 (de) |
| HU (1) | HUT61465A (de) |
| SG (1) | SG47477A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2106840A1 (en) * | 1992-09-25 | 1994-03-26 | Marco Baroni | Heteroarylazetidines and -pyrrolidines, process for their preparation and pharmaceutical compositions containing them |
| EP0591030A3 (de) * | 1992-09-25 | 1994-04-27 | Sanofi | 1-Heteroaryl-azetidine und -pyrrolidine als 5-HT3-Agoniste |
| EP0647639A1 (de) * | 1993-10-11 | 1995-04-12 | Sanofi | Heteroarylpiperidinen, Verfahren zu deren Herstellung und diese enthaltende pharmazeutischen Zusammenstellungen |
| US5502063A (en) * | 1993-10-11 | 1996-03-26 | Sanofi | 1-halopyridin-4-amino-4-alkylpiperidines |
| FR2780057B1 (fr) * | 1998-06-18 | 2002-09-13 | Sanofi Sa | Phenoxypropanolamines, procede pour leur preparation et compositions pharmaceutiques les contenant |
| US6833370B1 (en) | 1999-05-21 | 2004-12-21 | Abbott Laboratories | Heterocycle substituted aminoazacycles useful as central nervous system agents |
| DE60025261T2 (de) * | 1999-11-23 | 2006-08-24 | Janssen Pharmaceutica N.V. | Verwendung von 5ht3 antagonisten zur fundusentspannung |
| CA2398388A1 (en) * | 2000-01-20 | 2001-07-26 | Koji Kato | Novel piperidine compound and pharmaceutical thereof |
| US20040191312A1 (en) * | 2002-12-31 | 2004-09-30 | Donna Oksenberg | 5-HT3 receptor agonists as neuroprotectors |
| PL3646886T3 (pl) | 2017-06-28 | 2024-03-04 | Osaka University | Leczenie bólu agonistą receptora serotoninowego 3 |
| WO2022118783A1 (ja) * | 2020-12-04 | 2022-06-09 | 国立大学法人大阪大学 | 治療抵抗性うつ病または緊急性を有するうつ病の症状を治療するための組成物 |
| TW202508584A (zh) | 2023-05-25 | 2025-03-01 | 日商丸石製藥股份有限公司 | 癌性疼痛預防或治療用組成物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2459240A1 (fr) * | 1979-06-21 | 1981-01-09 | Cm Ind | Aminopiperidines anorexigenes, procede pour leur preparation, intermediaires dans ledit procede et medicaments qui les contiennent |
-
1992
- 1992-03-24 SG SG1996002112A patent/SG47477A1/en unknown
- 1992-03-24 AT AT92400792T patent/ATE175113T1/de not_active IP Right Cessation
- 1992-03-24 DE DE69228017T patent/DE69228017D1/de not_active Expired - Lifetime
- 1992-03-24 EP EP92400792A patent/EP0506545B1/de not_active Expired - Lifetime
- 1992-03-25 CA CA002063941A patent/CA2063941A1/en not_active Abandoned
- 1992-03-25 AU AU13168/92A patent/AU656563B2/en not_active Ceased
- 1992-03-26 HU HU929200940A patent/HUT61465A/hu unknown
- 1992-03-26 JP JP4068374A patent/JP2603023B2/ja not_active Expired - Lifetime
- 1992-03-27 US US07/858,483 patent/US5604245A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU656563B2 (en) | 1995-02-09 |
| HU9200940D0 (en) | 1992-05-28 |
| US5604245A (en) | 1997-02-18 |
| DE69228017D1 (de) | 1999-02-11 |
| AU1316892A (en) | 1992-10-01 |
| EP0506545A3 (en) | 1993-01-27 |
| JPH07145166A (ja) | 1995-06-06 |
| SG47477A1 (en) | 1998-04-17 |
| CA2063941A1 (en) | 1992-09-28 |
| HUT61465A (en) | 1993-01-28 |
| JP2603023B2 (ja) | 1997-04-23 |
| EP0506545A2 (de) | 1992-09-30 |
| EP0506545B1 (de) | 1998-12-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |