DE68910288D1 - Derivate von 5-Hydroxy- und 5-Methoxy-2-amino-pyrimidin als Inhibitoren der Interleukin-1-Produktion. - Google Patents

Derivate von 5-Hydroxy- und 5-Methoxy-2-amino-pyrimidin als Inhibitoren der Interleukin-1-Produktion.

Info

Publication number
DE68910288D1
DE68910288D1 DE89312736T DE68910288T DE68910288D1 DE 68910288 D1 DE68910288 D1 DE 68910288D1 DE 89312736 T DE89312736 T DE 89312736T DE 68910288 T DE68910288 T DE 68910288T DE 68910288 D1 DE68910288 D1 DE 68910288D1
Authority
DE
Germany
Prior art keywords
interleukin
production
mammal
methoxy
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE89312736T
Other languages
English (en)
Other versions
DE68910288T2 (de
Inventor
Frederick Judson Walker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of DE68910288D1 publication Critical patent/DE68910288D1/de
Publication of DE68910288T2 publication Critical patent/DE68910288T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Saccharide Compounds (AREA)
DE89312736T 1988-12-14 1989-12-07 Derivate von 5-Hydroxy- und 5-Methoxy-2-amino-pyrimidin als Inhibitoren der Interleukin-1-Produktion. Expired - Fee Related DE68910288T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28450588A 1988-12-14 1988-12-14

Publications (2)

Publication Number Publication Date
DE68910288D1 true DE68910288D1 (de) 1993-12-02
DE68910288T2 DE68910288T2 (de) 1994-02-17

Family

ID=23090453

Family Applications (1)

Application Number Title Priority Date Filing Date
DE89312736T Expired - Fee Related DE68910288T2 (de) 1988-12-14 1989-12-07 Derivate von 5-Hydroxy- und 5-Methoxy-2-amino-pyrimidin als Inhibitoren der Interleukin-1-Produktion.

Country Status (13)

Country Link
EP (1) EP0373827B1 (de)
JP (1) JPH0651622B2 (de)
KR (1) KR920003578B1 (de)
AT (1) ATE96321T1 (de)
AU (1) AU605702B2 (de)
CA (1) CA2005196A1 (de)
DE (1) DE68910288T2 (de)
HU (1) HU206182B (de)
IE (1) IE893978L (de)
IL (1) IL92586A (de)
PH (1) PH27120A (de)
PT (1) PT92551A (de)
ZA (1) ZA899508B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5356898A (en) * 1991-01-31 1994-10-18 Warner-Lambert Company Substituted 4,6-di-tertiary-butyl 5-hydroxy-pyrimidines
US5248682A (en) * 1991-01-31 1993-09-28 Warner-Lambert Company 2-substituted-4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents
US5177079A (en) * 1991-01-31 1993-01-05 Warner-Lambert Company 2-substituted-4,6-di-tertiarybutyl-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents
US5270319A (en) * 1991-09-09 1993-12-14 Warner-Lambert Company 5-hydroxy-2-pyrimidinylmethylene derivatives useful as antiinflammatory agents
DE102004054080A1 (de) * 2004-11-09 2006-05-11 Wella Ag Haut- oder Haarbehandlungsmittel mit Schutzeffekt

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670536B2 (de) * 1966-11-09 1975-05-28 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt Neue 2-Anilino-5-acylamino-pyrimidlne
US4554276A (en) * 1983-10-03 1985-11-19 Pfizer Inc. 2-Amino-5-hydroxy-4-methylpyrimidine derivatives
IL77243A (en) * 1984-12-21 1996-11-14 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds
US4711888A (en) * 1985-07-24 1987-12-08 Pfizer Inc. Hydroxy and alkoxy pyrimidines

Also Published As

Publication number Publication date
ZA899508B (en) 1991-07-31
KR920003578B1 (ko) 1992-05-04
HU206182B (en) 1992-09-28
EP0373827A3 (de) 1991-11-06
KR900009078A (ko) 1990-07-02
JPH0651622B2 (ja) 1994-07-06
EP0373827B1 (de) 1993-10-27
DE68910288T2 (de) 1994-02-17
JPH02218613A (ja) 1990-08-31
IL92586A0 (en) 1990-08-31
PH27120A (en) 1993-03-16
CA2005196A1 (en) 1990-06-14
IE893978L (en) 1990-06-14
AU4613089A (en) 1990-07-19
HUT51897A (en) 1990-06-28
IL92586A (en) 1994-06-24
PT92551A (pt) 1990-06-29
EP0373827A2 (de) 1990-06-20
ATE96321T1 (de) 1993-11-15
AU605702B2 (en) 1991-01-17

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee