ES2039485T3 - Un procedimiento para la preparacion de un compuesto 3,4-dihidropirimidina n-sustituido. - Google Patents
Un procedimiento para la preparacion de un compuesto 3,4-dihidropirimidina n-sustituido.Info
- Publication number
- ES2039485T3 ES2039485T3 ES198888102557T ES88102557T ES2039485T3 ES 2039485 T3 ES2039485 T3 ES 2039485T3 ES 198888102557 T ES198888102557 T ES 198888102557T ES 88102557 T ES88102557 T ES 88102557T ES 2039485 T3 ES2039485 T3 ES 2039485T3
- Authority
- ES
- Spain
- Prior art keywords
- substituted
- carbon atoms
- agents
- procedure
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A COMPUESTOS DE 3,4-DIHIDROPIRIMIDINA N-SUSTITUIDOS DE FORMULA (I), EN LA QUE R ES ALQUILO LINEAL, RAMIFICADO, CICLICO O CICLICO-LINEAL QUE TIENE DE UNO A CUATRO ATOMOS DE C, Y X1, X2 Y X3 QUE SON IGUALES O DIFERENTES SON HIDROGENO, HALOGENO, ALQUILO O ALCOXI DE 1 A 4 ATOMOS DEC, NITRO, TRIFLUORMETILO, HIDROXI O TERC-BUTIL-DIMETILSILILOXI, CON LA CONDICION DE QUE NO SEAN LOS TRES HIDROGENO. ESTOS COMPUESTOS TIENEN EFECTOS VASODILATADORES SUSTANCIALMENTE FUERTES Y DURADERO, POR LO QUE SON UTILES COMO AGENTES PARA EL TRATAMIENTO DE DESORDENES DES SISTEMA CARDIOVASCULAR, POR EJEMPLO COMO AGENTES ANTIHIPERTENSORES, MEJORADORES DE LA CIRCULACION Y ANTIANGINOSOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62038345A JPS63208580A (ja) | 1987-02-21 | 1987-02-21 | N置換3,4−ジヒドロピリミジン誘導体および循環器系疾患治療剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2039485T3 true ES2039485T3 (es) | 1993-10-01 |
Family
ID=12522695
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES198888102557T Expired - Lifetime ES2039485T3 (es) | 1987-02-21 | 1988-02-22 | Un procedimiento para la preparacion de un compuesto 3,4-dihidropirimidina n-sustituido. |
Country Status (6)
Country | Link |
---|---|
US (1) | US4920124A (es) |
EP (1) | EP0280227B1 (es) |
JP (1) | JPS63208580A (es) |
AT (1) | ATE71620T1 (es) |
DE (1) | DE3867652D1 (es) |
ES (1) | ES2039485T3 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EE9700209A (et) | 1994-11-16 | 1998-04-15 | Synaptic Pharmaceutical Corporation | Dihüdropürimidiinid ja nende kasutamine |
US6268369B1 (en) | 1994-11-16 | 2001-07-31 | Synaptic Pharmaceutical Corporation | 5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines |
US6228861B1 (en) | 1995-11-16 | 2001-05-08 | Synaptic Pharmaceutical Corporation | Dihydropyrimidines and uses thereof |
US6172066B1 (en) | 1996-05-16 | 2001-01-09 | Synaptic Pharmaceutical Corporation | Dihydropyrimidines and uses thereof |
US6245773B1 (en) | 1996-05-16 | 2001-06-12 | Synaptic Pharmaceutical Corporation | 5-(heterocyclic alkyl)-6-aryl-dihydropyrimidines |
US6274585B1 (en) | 1998-12-23 | 2001-08-14 | Synaptic Pharmaceutical Corporation | Dihydropyrimidines and uses thereof |
US6680323B2 (en) | 1998-12-23 | 2004-01-20 | Synaptic Pharmaceutical Corporation | Dihydropyrimidines and uses thereof |
US6720324B2 (en) | 2000-07-05 | 2004-04-13 | Synaptic Pharmaceutical Corporation | Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof |
WO2005007124A2 (en) | 2003-07-23 | 2005-01-27 | Bristol-Myers Squibb Company | Substituted dihydropyrimidine inhibitors of calcium channel function |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3234684A1 (de) * | 1982-09-18 | 1984-03-22 | Bayer Ag, 5090 Leverkusen | Neue dihydropyrimidine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
JPS60214778A (ja) * | 1984-03-08 | 1985-10-28 | Suntory Ltd | Ν置換3,4−ジヒドロピリミジン誘導体ならびにその製造法および用途 |
US4683234A (en) * | 1984-05-19 | 1987-07-28 | Suntory Limited | 2,6-Dimethyl-3N,5-disubstituted-4-(substituted phenyl)3,4-dihydropyrimidine compounds and a method for treating disorders of cardiocircular system |
EP0195374B1 (en) * | 1985-03-15 | 1992-07-29 | Suntory Limited | N-substituted 3,4-dihydropyrimidine derivatives, process for the production thereof and composition containing same for treating disorders of cardiovascular system |
-
1987
- 1987-02-21 JP JP62038345A patent/JPS63208580A/ja active Pending
-
1988
- 1988-02-19 US US07/157,777 patent/US4920124A/en not_active Expired - Fee Related
- 1988-02-22 DE DE8888102557T patent/DE3867652D1/de not_active Expired - Lifetime
- 1988-02-22 EP EP88102557A patent/EP0280227B1/en not_active Expired - Lifetime
- 1988-02-22 AT AT88102557T patent/ATE71620T1/de not_active IP Right Cessation
- 1988-02-22 ES ES198888102557T patent/ES2039485T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0280227B1 (en) | 1992-01-15 |
DE3867652D1 (de) | 1992-02-27 |
EP0280227A1 (en) | 1988-08-31 |
JPS63208580A (ja) | 1988-08-30 |
ATE71620T1 (de) | 1992-02-15 |
US4920124A (en) | 1990-04-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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