ATE88184T1 - Heterocyclische derivate mit lipoxygenase hemmender wirkung. - Google Patents

Heterocyclische derivate mit lipoxygenase hemmender wirkung.

Info

Publication number
ATE88184T1
ATE88184T1 AT90402692T AT90402692T ATE88184T1 AT E88184 T1 ATE88184 T1 AT E88184T1 AT 90402692 T AT90402692 T AT 90402692T AT 90402692 T AT90402692 T AT 90402692T AT E88184 T1 ATE88184 T1 AT E88184T1
Authority
AT
Austria
Prior art keywords
group
atom
alkatriynyl
alkadiynyl
alkatrienyl
Prior art date
Application number
AT90402692T
Other languages
English (en)
Inventor
Masaru Ubasawa
Shuitiro Kadowaki
Yoshio Hayashi
Original Assignee
Mitsubishi Chem Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Chem Ind filed Critical Mitsubishi Chem Ind
Application granted granted Critical
Publication of ATE88184T1 publication Critical patent/ATE88184T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT90402692T 1989-09-29 1990-09-28 Heterocyclische derivate mit lipoxygenase hemmender wirkung. ATE88184T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP25453089 1989-09-29
EP90402692A EP0420762B1 (de) 1989-09-29 1990-09-28 Heterocyclische Derivate mit lipoxygenase hemmender Wirkung

Publications (1)

Publication Number Publication Date
ATE88184T1 true ATE88184T1 (de) 1993-04-15

Family

ID=17266325

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90402692T ATE88184T1 (de) 1989-09-29 1990-09-28 Heterocyclische derivate mit lipoxygenase hemmender wirkung.

Country Status (8)

Country Link
US (1) US5206255A (de)
EP (1) EP0420762B1 (de)
JP (1) JPH03173874A (de)
AT (1) ATE88184T1 (de)
CA (1) CA2026227A1 (de)
DE (1) DE69001342T2 (de)
DK (1) DK0420762T3 (de)
ES (1) ES2054300T3 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5380738A (en) * 1993-05-21 1995-01-10 Monsanto Company 2-substituted oxazoles further substituted by 4-fluorophenyl and 4-methylsulfonylphenyl as antiinflammatory agents
GB9312853D0 (en) * 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5591776A (en) * 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
US5922751A (en) * 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
PL319605A1 (en) * 1994-10-12 1997-08-18 Euro Celtique Sa Novel benzoxazoles
US5665737B1 (en) * 1994-10-12 1999-02-16 Euro Celtique Sa Substituted benzoxazoles
US6372770B1 (en) 1994-10-12 2002-04-16 Euro-Celtique, S.A. Benzoxazoles
US6025361A (en) * 1994-12-13 2000-02-15 Euro-Celtique, S.A. Trisubstituted thioxanthines
AU4527896A (en) * 1994-12-13 1996-07-03 Euro-Celtique S.A. Aryl thioxanthines
DE69531555T2 (de) * 1994-12-13 2004-06-17 Euroceltique S.A. Dreifachsubstituierte thioxanthine
US6166041A (en) * 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US6075016A (en) * 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
US5864037A (en) * 1996-06-06 1999-01-26 Euro-Celtique, S.A. Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
US5744473A (en) * 1996-09-16 1998-04-28 Euro-Celtique, S.A. PDE IV inhibitors: "bis-compounds"
US20050234394A1 (en) * 2004-03-26 2005-10-20 Rod Ross Dual cylinder vacuum pump for medical aspiration system
MY141272A (en) * 2006-06-29 2010-04-16 Dow Agrosciences Llc High-strength, low-temperature stable herbicidal formulations of fluroxypyr esters
KR100910151B1 (ko) 2007-11-22 2009-07-30 (주)그라쎌 신규한 유기 발광 화합물 및 이를 발광재료로 채용하고있는 전기발광소자
ES2887354T3 (es) * 2009-01-07 2021-12-22 Med Logics Inc Dispositivos para la eliminación de tejido
US9999710B2 (en) 2009-01-07 2018-06-19 Med-Logics, Inc. Tissue removal devices, systems and methods
EP2741607B1 (de) 2011-08-11 2018-10-17 Bayer CropScience Aktiengesellschaft Verwendung und agrochemische zusammensetzung von carbonsäure-dibutylamiden
JP6427169B2 (ja) 2013-04-26 2018-11-21 メッド−ロジックス，インク． 組織除去装置、システム、及び方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3574218A (en) * 1969-08-11 1971-04-06 Egyt Gyogyszervegyeszeti Gyar 2-aryl- or aralkyl-substituted benzazole derivatives
GB1491863A (en) * 1973-10-23 1977-11-16 Lilly Industries Ltd 2,5-or 2,6-disubstituted benzoxazoles
DE2711656A1 (de) * 1977-03-17 1978-09-21 Basf Ag Neue pyridin-3-ole
DE2907089A1 (de) * 1979-02-23 1980-09-04 Hoechst Ag Herbizide mittel
US4594425A (en) * 1984-02-09 1986-06-10 American Home Products Corporation Heterocyclic compounds as antiallergic agents
US4675405A (en) * 1984-09-21 1987-06-23 American Home Products Corporation Quinoline compounds as antiallergic and antithrombotic agents
US4732978A (en) * 1985-10-03 1988-03-22 American Home Products Corporation Novel substituted naphthyloxymethyl quinoline derivatives as anti-inflammatory and antiallergy agents
JPS62142168A (ja) * 1985-10-16 1987-06-25 Mitsubishi Chem Ind Ltd チアゾ−ル誘導体及びそれを有効成分とするロイコトリエンきつ抗剤
US4904786A (en) * 1986-01-27 1990-02-27 American Home Products Corporation Quinoline compounds as antiallergic and antiinflammatory agents
US4772703A (en) * 1986-01-27 1988-09-20 American Home Products Corporation 2-(phenoxymethyl)-quinazolines as antiallergic and antiinflammatory agents
FI91869C (fi) * 1987-03-18 1994-08-25 Tanabe Seiyaku Co Menetelmä antidiabeettisena aineena käytettävien bensoksatsolijohdannaisten valmistamiseksi
EP0318085A3 (de) * 1987-11-25 1990-03-14 Merck Frosst Canada Inc. Heterazoldialkansäure
CA1322005C (en) * 1987-11-25 1993-09-07 Robert N. Young Benzoheterazoles
NZ229761A (en) * 1988-07-12 1991-10-25 Ici Pharma Substituted thiazole derivatives for use as inhibitors of enzyme 5-lipoxygenase; pharmaceutical compositions and preparatory processes

Also Published As

Publication number Publication date
ES2054300T3 (es) 1994-08-01
US5206255A (en) 1993-04-27
DE69001342T2 (de) 1993-07-29
EP0420762A3 (en) 1991-07-31
CA2026227A1 (en) 1991-03-30
DE69001342D1 (de) 1993-05-19
DK0420762T3 (da) 1993-08-16
EP0420762B1 (de) 1993-04-14
JPH03173874A (ja) 1991-07-29
EP0420762A2 (de) 1991-04-03

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