ATE86870T1 - Transdermales verabreichungssystem. - Google Patents

Transdermales verabreichungssystem.

Info

Publication number
ATE86870T1
ATE86870T1 AT87900446T AT87900446T ATE86870T1 AT E86870 T1 ATE86870 T1 AT E86870T1 AT 87900446 T AT87900446 T AT 87900446T AT 87900446 T AT87900446 T AT 87900446T AT E86870 T1 ATE86870 T1 AT E86870T1
Authority
AT
Austria
Prior art keywords
delivery system
transdermal delivery
weight
carrier
oleic acid
Prior art date
Application number
AT87900446T
Other languages
English (en)
Inventor
Nicholas Bodor
Thorsteinn Loftsson
Original Assignee
Key Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Key Pharma filed Critical Key Pharma
Application granted granted Critical
Publication of ATE86870T1 publication Critical patent/ATE86870T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT87900446T 1985-12-06 1986-12-05 Transdermales verabreichungssystem. ATE86870T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/806,257 US4764381A (en) 1985-12-06 1985-12-06 Percutaneous penetration enhancer of oleic acid and 2-ethyl-1, 3-hexanediol
PCT/US1986/002584 WO1987003490A2 (en) 1985-12-06 1986-12-05 Transdermal delivery system
EP87900446A EP0250542B1 (de) 1985-12-06 1986-12-05 Transdermales verabreichungssystem

Publications (1)

Publication Number Publication Date
ATE86870T1 true ATE86870T1 (de) 1993-04-15

Family

ID=25193671

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87900446T ATE86870T1 (de) 1985-12-06 1986-12-05 Transdermales verabreichungssystem.

Country Status (11)

Country Link
US (2) US4764381A (de)
EP (2) EP0393727A3 (de)
JP (1) JPS63502108A (de)
KR (1) KR900002653B1 (de)
AT (1) ATE86870T1 (de)
AU (2) AU602324B2 (de)
CA (1) CA1280974C (de)
DE (1) DE3688075T2 (de)
DK (1) DK407587A (de)
MY (1) MY102378A (de)
WO (1) WO1987003490A2 (de)

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US4931283A (en) * 1983-12-22 1990-06-05 American Home Products Corp. (Del) Menthol enhancement of transdermal drug delivery
US4933184A (en) * 1983-12-22 1990-06-12 American Home Products Corp. (Del) Menthol enhancement of transdermal drug delivery
US4983396A (en) * 1985-12-06 1991-01-08 Key Pharmaceuticals, Inc. Percutaneous penetration enhancer of oleic acid and 2-ethyl-1,3-hexanediol
US5051260A (en) * 1987-07-16 1991-09-24 The Regents Of The University Of California Method and composition for enhancing the cutaneous penetration of pharmacologically active agents
US5045317A (en) * 1987-07-16 1991-09-03 The Regents Of The University Of California Enhancing the cutaneous penetration of pharmacologically active agents
US4971800A (en) * 1988-07-08 1990-11-20 The Regents Of The University Of California Method and compositions for enhancing the cutaneous penetration of pharmacologically active agents
US4994267A (en) * 1988-03-04 1991-02-19 Noven Pharmaceuticals, Inc. Transdermal acrylic multipolymer drug delivery system
US5059603A (en) * 1989-06-12 1991-10-22 Centuries Laboratories, Inc. Method and composition for treating impotence
IL95387A0 (en) * 1989-08-17 1991-06-30 Schering Corp Transdermal nitroglycerin patch with penetration enhancers
US5262165A (en) * 1992-02-04 1993-11-16 Schering Corporation Transdermal nitroglycerin patch with penetration enhancers
AR246186A1 (es) * 1989-11-17 1994-07-29 Beta Pharm Co Procedimiento para fabricar un dispositivo para administrar estradiol por via transdermica.
JP2849950B2 (ja) * 1990-11-30 1999-01-27 日東電工株式会社 経皮吸収製剤
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US5518734A (en) * 1991-09-25 1996-05-21 Beta Pharmaceuticals Co. Transdermal delivery system for estradiol and process for manufacturing said device
US5705185A (en) * 1991-09-25 1998-01-06 Beta Pharmaceuticals Co. Transdermal delivery of estradiol and process for manufacturing said device
JP2960832B2 (ja) * 1992-05-08 1999-10-12 ペルマテック テクノロジー アクチェンゲゼルシャフト エストラジオールの投与システム
US5613958A (en) * 1993-05-12 1997-03-25 Pp Holdings Inc. Transdermal delivery systems for the modulated administration of drugs
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US5552153A (en) * 1994-04-28 1996-09-03 Hoffman-La Roche Inc. Pharmaceutical composition for transdermal delivery
US5580574A (en) * 1994-04-28 1996-12-03 Hoffmann-La Roche Inc. Pharmaceutical composition for transdermal delivery
EP1051972B1 (de) 1994-05-27 2007-10-03 Strakan International Limited Zusammensetzung enthaltend Stickstoffoxid-donatoren und Methode zur Behandlung analer Krankheiten
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US5707612A (en) * 1996-04-08 1998-01-13 Alzo, Inc. Use urethane polymers of castor oil skin and personal care product compositiions
KR20000049125A (ko) * 1996-10-14 2000-07-25 요시히로 미와 외용 국소 마취제
US6797276B1 (en) 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
US20060002949A1 (en) 1996-11-14 2006-01-05 Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. Transcutaneous immunization without heterologous adjuvant
US5980898A (en) 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
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AU8206401A (en) * 2000-08-03 2002-02-18 Antares Pharma Ipl Ag Novel composition for transdermal and/or transmucosal administration of active compounds that ensures adequate therapeutic levels
US20040198706A1 (en) * 2003-03-11 2004-10-07 Carrara Dario Norberto R. Methods and formulations for transdermal or transmucosal application of active agents
US7198801B2 (en) * 2000-08-03 2007-04-03 Antares Pharma Ipl Ag Formulations for transdermal or transmucosal application
US20070225379A1 (en) * 2001-08-03 2007-09-27 Carrara Dario Norberto R Transdermal delivery of systemically active central nervous system drugs
US8980290B2 (en) 2000-08-03 2015-03-17 Antares Pharma Ipl Ag Transdermal compositions for anticholinergic agents
DK1372708T3 (da) 2001-02-13 2008-10-20 Us Gov Sec Army Vaccine til transkutan immunisering mod rejsediarre
US6727287B2 (en) 2001-04-16 2004-04-27 Pts International, Inc. Toluene sulfonamide-containing anti-tumor composition and method of use thereof
DE20107040U1 (de) * 2001-04-24 2002-10-02 Novartis Ag, Basel Dosierlanze
AT411327B (de) * 2001-08-23 2003-12-29 Heil Bettina Hormonpräparat mit ungesättigten fettsäuren
CA2530407A1 (en) * 2003-07-23 2005-02-03 The Regents Of The University Of California Penetration enhancer combinations for transdermal delivery
PL1670433T3 (pl) 2003-10-10 2013-03-29 Ferring Bv Przezskórna formulacja farmaceutyczna do zmniejszania pozostałości na skórze
WO2005107834A1 (en) 2004-04-30 2005-11-17 Clawson Burrell E Apparatus and methods for isolating human body areas for localized cooling
US7425340B2 (en) * 2004-05-07 2008-09-16 Antares Pharma Ipl Ag Permeation enhancing compositions for anticholinergic agents
US7740875B2 (en) * 2004-10-08 2010-06-22 Mediquest Therapeutics, Inc. Organo-gel formulations for therapeutic applications
US20060078580A1 (en) 2004-10-08 2006-04-13 Mediquest Therapeutics, Inc. Organo-gel formulations for therapeutic applications
WO2006125642A1 (en) * 2005-05-27 2006-11-30 Antares Pharma Ipl Ag Methods and apparatus for transdermal or transmucosal application of testosterone
WO2007102242A1 (ja) * 2006-03-08 2007-09-13 Nihon Nohyaku Co., Ltd. 外用の医薬組成物
NZ571818A (en) * 2006-03-08 2011-10-28 Nihon Nohyaku Co Ltd External pharmaceutical composition comprising luliconazole and an alpha-hydroxycarboxylic acid such as lactic acid, glycolic acid or malic acid.
US8058303B2 (en) * 2006-03-08 2011-11-15 Nihon Nohyaku Co, Ltd Pharmaceutical composition for external use
CA2646667C (en) * 2006-04-21 2014-03-11 Antares Pharma Ipl Ag Methods of treating hot flashes with formulations for transdermal or transmucosal application
WO2008067991A2 (en) * 2006-12-08 2008-06-12 Antares Pharma Ipl Ag Skin-friendly drug complexes for transdermal administration
US9283177B2 (en) * 2007-01-16 2016-03-15 Juventio, Llc Topical anesthetic for rapid local anesthesia and method of applying a topical anesthetic
WO2008089242A1 (en) * 2007-01-16 2008-07-24 Dermworx, Incorporated Topical anesthetic for rapid local anesthesia and method of applying a topical anesthetic
KR20100068271A (ko) * 2007-09-05 2010-06-22 가부시키가이샤 폴라 파마 항진균 의약 조성물
EP2191827B1 (de) * 2007-09-05 2013-10-30 Pola Pharma Inc. Antimykotische zusammensetzung
WO2009031642A1 (ja) * 2007-09-05 2009-03-12 Pola Pharma Inc. 医薬組成物
WO2010008600A1 (en) * 2008-07-16 2010-01-21 Dermworx Incorporated Topical drug delivery system
DE102009013469B4 (de) 2009-03-19 2014-04-17 Bubbles And Beyond Gmbh Zubereitung zur äußerlichen Anwendung
CN102387786B (zh) 2009-04-09 2015-09-09 宝丽制药股份有限公司 抗真菌药物组合物
JP5688405B2 (ja) 2009-04-09 2015-03-25 株式会社ポーラファルマ 抗真菌医薬組成物
US8952044B2 (en) 2009-08-25 2015-02-10 Pola Pharma Inc. Antimycotic pharmaceutical composition
ITMI20111284A1 (it) 2011-07-11 2013-01-12 Giovanni Nusca Composizione farmaceutica.
BR112015006176B1 (pt) 2012-09-21 2023-04-18 Intensity Therapeutics, Inc Uso de um agente terapêutico e de um agente de intensificação de permeação intracelular
CN111620830A (zh) 2014-03-14 2020-09-04 北卡罗来纳大学教堂山分校 用于抑制雄性生育力的小分子
CA3155267A1 (en) 2019-11-06 2021-05-14 Thomas Hnat Topical formulations of cyclooxygenase inhibitors and their use

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Also Published As

Publication number Publication date
WO1987003490A3 (en) 1987-07-30
EP0393727A3 (de) 1990-11-22
MY102378A (en) 1992-06-17
KR900002653B1 (ko) 1990-04-21
AU6115890A (en) 1991-02-07
DE3688075T2 (de) 1993-06-24
AU6733687A (en) 1987-06-30
US4764381A (en) 1988-08-16
EP0250542A1 (de) 1988-01-07
US4885174A (en) 1989-12-05
DE3688075D1 (de) 1993-04-22
EP0393727A2 (de) 1990-10-24
AU602324B2 (en) 1990-10-11
WO1987003490A2 (en) 1987-06-18
JPS63502108A (ja) 1988-08-18
KR880700675A (ko) 1988-04-11
DK407587D0 (da) 1987-08-05
AU625830B2 (en) 1992-07-16
EP0250542B1 (de) 1993-03-17
CA1280974C (en) 1991-03-05
DK407587A (da) 1987-08-05

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee