ATE85810T1 - Oxidationsbestaendige il-2-muteine und ihre herstellung, diese muteine enthaltende zusammensetzungen, solche muteine kodierende dns- sequenzen und expressionsvektoren und korrespondierende transformierte wirtzellen. - Google Patents

Oxidationsbestaendige il-2-muteine und ihre herstellung, diese muteine enthaltende zusammensetzungen, solche muteine kodierende dns- sequenzen und expressionsvektoren und korrespondierende transformierte wirtzellen.

Info

Publication number
ATE85810T1
ATE85810T1 AT86200766T AT86200766T ATE85810T1 AT E85810 T1 ATE85810 T1 AT E85810T1 AT 86200766 T AT86200766 T AT 86200766T AT 86200766 T AT86200766 T AT 86200766T AT E85810 T1 ATE85810 T1 AT E85810T1
Authority
AT
Austria
Prior art keywords
muteins
oxidation
correspondent
resistant
production
Prior art date
Application number
AT86200766T
Other languages
English (en)
Inventor
Kirston Edward Koths
Robert Forgan Halenbeck
Michael Allan Innis
Original Assignee
Cetus Oncology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cetus Oncology Corp filed Critical Cetus Oncology Corp
Application granted granted Critical
Publication of ATE85810T1 publication Critical patent/ATE85810T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Dental Preparations (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
AT86200766T 1985-01-18 1986-01-17 Oxidationsbestaendige il-2-muteine und ihre herstellung, diese muteine enthaltende zusammensetzungen, solche muteine kodierende dns- sequenzen und expressionsvektoren und korrespondierende transformierte wirtzellen. ATE85810T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69259685A 1985-01-18 1985-01-18
US81065685A 1985-12-17 1985-12-17

Publications (1)

Publication Number Publication Date
ATE85810T1 true ATE85810T1 (de) 1993-03-15

Family

ID=36846757

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86200766T ATE85810T1 (de) 1985-01-18 1986-01-17 Oxidationsbestaendige il-2-muteine und ihre herstellung, diese muteine enthaltende zusammensetzungen, solche muteine kodierende dns- sequenzen und expressionsvektoren und korrespondierende transformierte wirtzellen.

Country Status (7)

Country Link
EP (1) EP0200280B1 (de)
JP (1) JP2595206B2 (de)
AT (1) ATE85810T1 (de)
AU (2) AU5245186A (de)
CA (1) CA1340265C (de)
DE (1) DE3687763T2 (de)
NZ (1) NZ214854A (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6107465A (en) * 1984-12-21 2000-08-22 Otsuka Pharmaceutical Co., Ltd. IL-1β and derivatives thereof and drugs
US5342614A (en) * 1984-12-21 1994-08-30 Otsuka Pharmaceutical Co., Ltd. Method of treating arthritus or inflammation with IL-1β or derivatives thereof
CA1340265C (en) * 1985-01-18 1998-12-15 Kirston E. Koths Oxidation resistant muteins
AU595864B2 (en) * 1986-03-14 1990-04-12 Otsuka Pharmaceutical Co., Ltd. Il-1 alpha derivatives and drugs
US4835260A (en) * 1987-03-20 1989-05-30 Genetics Institute, Inc. Erythropoietin composition
WO1990000565A1 (en) * 1988-07-05 1990-01-25 Amgen Inc. Interleukin ii analogs
EP1199355B1 (de) * 1999-06-29 2007-03-14 National Institute of Advanced Industrial Science and Technology Schwefelfreie enzyme
PT1682178E (pt) 2003-11-04 2010-10-21 Novartis Vaccines & Diagnostic Métodos de terapêutica para cancros que expressam o antigénio cd40
US20110183861A1 (en) * 2008-01-29 2011-07-28 Ablynn N.V. Methods to stabilize proteins and polypeptides
EP3766513A1 (de) 2011-03-11 2021-01-20 Assistance Publique Hôpitaux de Paris Niedrige il-2 dosierungen zur behandlung von vaskulitis
US10183061B2 (en) 2013-06-25 2019-01-22 Icm (Institut Du Cerveau Et De La Moelle Epiniere) Boosting Treg cells for treating Alzheimer disease and related disorders
EP2918285A1 (de) 2014-03-11 2015-09-16 Université Pierre et Marie Curie (Paris 6) Interleukin-2 zur Behandlung einer Lebensmittelallergie
RU2573933C1 (ru) * 2014-08-21 2016-01-27 Дафот Энтерпрайсис Лимитед Пептид для лечения сахарного диабета 2-го типа и его осложнений
AU2016341241B9 (en) 2015-10-22 2021-11-18 Iltoo Pharma Pharmaceutical compositions of IL-2
EP3475413B1 (de) 2016-06-22 2024-02-14 David Klatzmann Genetisch modifizierte t-lymphozyten
CA3056630A1 (en) 2017-03-15 2018-09-20 Pandion Therapeutics, Inc. Targeted immunotolerance
CN111010866A (zh) 2017-05-24 2020-04-14 潘迪恩治疗公司 靶向免疫耐受性
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
US10174091B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
WO2019158764A1 (en) 2018-02-16 2019-08-22 Iltoo Pharma Use of interleukin 2 for treating sjögren's syndrome
EP3806888B1 (de) 2018-06-12 2024-01-31 Obsidian Therapeutics, Inc. Von pde5 abgeleitete regulatorische konstrukte und verfahren zur verwendung in der immuntherapie
WO2020007937A1 (en) 2018-07-03 2020-01-09 Iltoo Pharma Use of interleukin-2 for treating systemic sclerosis
EP3836954A1 (de) 2018-08-13 2021-06-23 Iltoo Pharma Kombination von interleukin-2 mit einem interleukin-1-inhibitor, konjugate und therapeutische verwendungen davon
WO2020102556A1 (en) 2018-11-15 2020-05-22 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods of prognosis and classification for preeclampsia
AU2020279240A1 (en) 2019-05-20 2021-12-23 Pandion Operations, Inc. MAdCAM targeted immunotolerance
JP2023505590A (ja) 2019-12-12 2023-02-09 イルトゥー・ファルマ インターロイキン２キメラ構築物
US11981715B2 (en) 2020-02-21 2024-05-14 Pandion Operations, Inc. Tissue targeted immunotolerance with a CD39 effector
EP4114440A1 (de) 2020-03-06 2023-01-11 Centre Hospitalier Universitaire de Nimes Niedrigdosiertes humanes interleukin-2 zur behandlung von amyotropher lateralsklerose
WO2023057588A1 (en) 2021-10-06 2023-04-13 Iltoo Pharma Interleukin 2 chimeric constructs with targeting specificy to inflamed tissues
WO2024056154A1 (en) 2022-09-12 2024-03-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Interleukin-2 for use in treating autism spectrum disorder
WO2024121173A1 (en) 2022-12-05 2024-06-13 Centre Hospitalier Universitaire De Nimes Low dose human interleukin-2 for the treatment of amyotrophic lateral sclerosis in a subgroup of patients

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2544348C3 (de) * 1975-10-03 1979-12-13 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen L-Leucin-13-Motilin, Verfahren zu dessen Herstellung und dasselbe enthaltendes Mittel
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
JPS605600B2 (ja) * 1982-10-25 1985-02-12 工業技術院長 新規なポリペプチド
AU574064B2 (en) * 1983-03-07 1988-06-30 F. Hoffmann-La Roche Ag Growth hormone releasing factor analogues
US4518584A (en) 1983-04-15 1985-05-21 Cetus Corporation Human recombinant interleukin-2 muteins
IE81141B1 (en) 1983-06-24 2000-04-05 Genencor Int Procaryotic carbonyl hydrolases
WO1985000817A1 (en) * 1983-08-10 1985-02-28 Amgen Microbial expression of interleukin ii
US4530787A (en) 1984-03-28 1985-07-23 Cetus Corporation Controlled oxidation of microbially produced cysteine-containing proteins
DE3419995A1 (de) * 1984-05-29 1985-12-05 Hoechst Ag, 6230 Frankfurt Gentechnologisches verfahren zur herstellung von human-interleukin-2 und mittel zur durchfuehrung dieses verfahrens
JPS6124599A (ja) * 1984-07-11 1986-02-03 Kyowa Hakko Kogyo Co Ltd 新規ヒトインタ−フエロン−ｒポリペプチド誘導体
CA1340265C (en) * 1985-01-18 1998-12-15 Kirston E. Koths Oxidation resistant muteins

Also Published As

Publication number Publication date
EP0200280B1 (de) 1993-02-17
AU6484686A (en) 1987-02-05
EP0200280A2 (de) 1986-11-05
JPS61224985A (ja) 1986-10-06
JP2595206B2 (ja) 1997-04-02
AU585084B2 (en) 1989-06-08
EP0200280A3 (en) 1988-08-24
DE3687763T2 (de) 1993-06-09
AU5245186A (en) 1986-07-31
CA1340265C (en) 1998-12-15
DE3687763D1 (de) 1993-03-25
NZ214854A (en) 1989-07-27

Similar Documents

Publication Publication Date Title
ATE85810T1 (de) Oxidationsbestaendige il-2-muteine und ihre herstellung, diese muteine enthaltende zusammensetzungen, solche muteine kodierende dns- sequenzen und expressionsvektoren und korrespondierende transformierte wirtzellen.
DE3380598D1 (en) Cysteine-depleted muteins of interferon-beta, their preparation, formulations containing them, and structural genes, vectors and organisms, and their production, suitable for use in the preparation of said muteins
ATE246246T1 (de) Herstellung von hämoglobin und analogen davon in nicht-erythrozytzellen
HK1005594A1 (en) Interleukin-4 protein having bcgf and tcgf activity on human cells (human interleukin-4)
FI102190B1 (fi) Menetelmä pesäkkeitä stimuloivan tekijä-1:n uusien muotojen valmistamiseksi ja siinä käytettäviä DNA-sekvenssejä, vektoreita, ilmentämisjärjestelmiä ja rekombinanttisoluja
ES8603574A1 (es) "procedimiento de tecnologia genetica para preparar secuen- cias parciales del gamma-interferon de humano".
EP0458959A4 (en) Novel platelet-derived growth factor b chain analogs and method for homogeneous production thereof
DE3382789D1 (de) Tierische Interferone, Verfahren bei deren Herstellung, dieselben enthaltende Zusammensetzungen, kodierende DNS-Sequenzen hierfür und diese Sequenzen enthaltende Expressionsvektoren und dadurch transformierte Zellen.
DE3750915D1 (de) Für Antitumor-Polypeptide kodierende DNS, die Polypeptide und diese Polypeptide enthaltenden Antitumor-Wirkstoffe.
ATE121776T1 (de) Expression des biologisch aktiven faktors xiii.
ATE72582T1 (de) Oxidationsresistente muteine von beta-interferon, deren herstellung und diese muteine enthaltende praeparate.
IL80562A0 (en) Recombinant human lysozyme,its preparation by recombinant dna technology and pharmaceutical compositions containing it
ES2081817T3 (es) Polipeptido con secuencias principales repetidas que se fijan en la celula.
EP0249096B1 (de) Reninhemmende Aminosäurederivate.
DE3574145D1 (en) Novel, distinct family of human leukocyte interferons, compositions containing them, methods for their production, and dna and transfected hosts therefor
SE8502430D0 (sv) A cdna molecule coding for the expression of an interferon alfa type polypeptide, a bacterial or cellular host transformed with such molecule and a polypeptide showing interferon activity prepared by such host
ATE152127T1 (de) Muteine des menschlichen parathormons und ihre herstellung
DE68918399D1 (de) Lymphokine, DNS-Sequenzen, die diese Lymphokine kodieren, und sie enthaltende pharmazeutische Zusammensetzungen.
ATE102997T1 (de) Thymosin und tnf-kodierende dna.
BG60657B2 (en) Human recombinant interleukin-2 muteins

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
EELA Cancelled due to lapse of time