ATE83927T1 - Thrombinzusammensetzung. - Google Patents

Thrombinzusammensetzung.

Info

Publication number
ATE83927T1
ATE83927T1 AT86307922T AT86307922T ATE83927T1 AT E83927 T1 ATE83927 T1 AT E83927T1 AT 86307922 T AT86307922 T AT 86307922T AT 86307922 T AT86307922 T AT 86307922T AT E83927 T1 ATE83927 T1 AT E83927T1
Authority
AT
Austria
Prior art keywords
preparation
thrombin
thrombin composition
buffer
disclosed
Prior art date
Application number
AT86307922T
Other languages
German (de)
English (en)
Inventor
Steven B Silbering
Russell U Nesbitt
Mahdi B Fawzi
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25154936&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE83927(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of ATE83927T1 publication Critical patent/ATE83927T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A61L26/0047—Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00—Surgery
    • Y10S128/22—Blood coagulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Materials Engineering (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
AT86307922T 1985-10-28 1986-10-14 Thrombinzusammensetzung. ATE83927T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/791,836 US4696812A (en) 1985-10-28 1985-10-28 Thrombin preparations
EP86307922A EP0221700B1 (en) 1985-10-28 1986-10-14 A thrombin preparation

Publications (1)

Publication Number Publication Date
ATE83927T1 true ATE83927T1 (de) 1993-01-15

Family

ID=25154936

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86307922T ATE83927T1 (de) 1985-10-28 1986-10-14 Thrombinzusammensetzung.

Country Status (14)

Country Link
US (1) US4696812A (enExample)
EP (1) EP0221700B1 (enExample)
JP (1) JPH0764747B2 (enExample)
KR (1) KR870003793A (enExample)
AT (1) ATE83927T1 (enExample)
AU (1) AU586897B2 (enExample)
CA (1) CA1272128A (enExample)
DE (1) DE3687402T2 (enExample)
DK (1) DK512686A (enExample)
ES (1) ES2053442T3 (enExample)
GR (1) GR3006727T3 (enExample)
NZ (1) NZ217190A (enExample)
PH (1) PH23444A (enExample)
ZA (1) ZA868223B (enExample)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965203A (en) * 1987-01-28 1990-10-23 Warner-Lambert Company Purified thrombin preparations
ZA88227B (en) * 1987-01-28 1988-06-30 Warner-Lambert Company Thrombin preparations
JPS6440433A (en) * 1987-08-05 1989-02-10 Green Cross Corp Aqueous liquid composition of thrombin
JP2715104B2 (ja) * 1988-08-18 1998-02-18 株式会社ミドリ十字 トロンビン乾燥製剤
US4891359A (en) * 1988-12-08 1990-01-02 Johnson & Johnson Patient Care, Inc. Hemostatic collagen paste composition
GB8903438D0 (en) * 1989-02-15 1989-04-05 May & Baker Ltd New compositions of matter
DK223389D0 (da) * 1989-05-05 1989-05-05 Ferrosan As Saarsvamp
US5281528A (en) * 1989-12-18 1994-01-25 Warner-Lambert Company Process for purified thromboplastin for ultra-pure thrombin preparation
US5219328A (en) * 1990-01-03 1993-06-15 Cryolife, Inc. Fibrin sealant delivery method
US5318524A (en) * 1990-01-03 1994-06-07 Cryolife, Inc. Fibrin sealant delivery kit
IE73210B1 (en) * 1990-01-24 1997-05-07 Warner Lambert Co Process for the production of thrombin and high purity thrombin preparation thereby obtained
JPH0813750B2 (ja) * 1990-03-01 1996-02-14 持田製薬株式会社 経口用トロンビン製剤
US5595735A (en) * 1990-05-23 1997-01-21 Johnson & Johnson Medical, Inc. Hemostatic thrombin paste composition
ATE143411T1 (de) * 1991-03-28 1996-10-15 Warner Lambert Co Hochreine thrombinzubereitung
DK83092D0 (da) * 1992-06-24 1992-06-24 Unes As Fremgangsmaade til udvinding af thrombin
JP3230713B2 (ja) * 1992-10-23 2001-11-19 トヨタ自動車株式会社 ピークトルク低減機構
US5795780A (en) * 1993-06-23 1998-08-18 Bristol-Myers Squibb Company Method of use of autologous thrombin blood fraction in a cell culture with keratinocytes
US5506127A (en) * 1994-09-21 1996-04-09 Proba; Zbigniew Therapeutic grade thrombin produced by chromatography
WO1997037694A1 (en) * 1996-04-04 1997-10-16 Immuno Aktiengesellschaft Hemostatic sponge based on collagen
WO2000062828A1 (en) 1996-04-30 2000-10-26 Medtronic, Inc. Autologous fibrin sealant and method for making the same
JP3401162B2 (ja) * 1996-11-21 2003-04-28 積水化学工業株式会社 血液凝固促進剤及び血液検査用容器
JP3927425B2 (ja) * 1996-11-21 2007-06-06 積水化学工業株式会社 血液凝固促進剤及び血液検査用容器
JP3927403B2 (ja) * 1996-11-21 2007-06-06 積水化学工業株式会社 血液凝固促進剤及び血液検査用容器
US6274090B1 (en) 1998-08-05 2001-08-14 Thermogenesis Corp. Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby
US6472162B1 (en) 1999-06-04 2002-10-29 Thermogenesis Corp. Method for preparing thrombin for use in a biological glue
AU7320300A (en) * 1999-09-27 2001-04-30 International Reagents Corporation Means of stabilizing thrombin and compositions
DE10012732A1 (de) * 2000-03-18 2001-09-20 Aventis Behring Gmbh Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung
US8187625B2 (en) * 2001-03-12 2012-05-29 Boston Scientific Scimed, Inc. Cross-linked gelatin composition comprising a wetting agent
US7923431B2 (en) 2001-12-21 2011-04-12 Ferrosan Medical Devices A/S Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
EP1573295A2 (en) 2002-12-11 2005-09-14 Ferrosan A/S Gelatine-based materials as swabs
US20040243044A1 (en) * 2003-06-02 2004-12-02 Penegor Stephen A. Hemostatic wound dressing
US7927626B2 (en) * 2003-08-07 2011-04-19 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
WO2005072700A2 (en) 2004-01-30 2005-08-11 Ferrosan A/S Haemostatic sprays and compositions
ES2313383T3 (es) * 2004-06-22 2009-03-01 Zymogenetics, Inc. Composiciones de trombina.
US8021684B2 (en) 2004-07-09 2011-09-20 Ferrosan Medical Devices A/S Haemostatic composition comprising hyaluronic acid
ATE533491T1 (de) * 2004-09-21 2011-12-15 Trobio Ab Stabilisierte protease zusammensetzungen enthaltend eine serinprotease, morpholin-derivate und reversible serinprotease- inhibitoren
ES2226587B1 (es) 2004-10-22 2005-12-16 Probitas Pharma, S.A. Composicion de trombina estable.
US7341392B2 (en) * 2005-04-22 2008-03-11 Dofair Co., Ltd. Lock device in an articulated joint for a foldable ladder
BRPI0711900C1 (pt) * 2006-05-26 2021-05-25 Baxter Healthcare Sa sistema de múltiplos componentes para uma composição de enchimento de vazio ósseo injetável, composição injetável de enchimento de vazio ósseo, e, método para preencher um vazio em um osso em um paciente que sofre de um distúrbio ósseo
PL2029184T3 (pl) * 2006-05-26 2011-08-31 Baxter Int Wstrzykiwalna kompozycja do augmentacji kości
RU2009127718A (ru) * 2006-12-19 2011-01-27 Ферросан А/С (Dk) Раневой или тканевой перевязочный материал, содержащий молочнокислые бактерии
WO2008075455A1 (ja) 2006-12-21 2008-06-26 Sekisui Medical Co., Ltd. トロンビン含有溶液中のα－トロンビンの安定化方法
PL2136852T3 (pl) * 2007-03-26 2012-07-31 Baxter Int Wstrzykiwalny wypełniacz pustych przestrzeni do augmentacji tkanek miękkich
US8071090B2 (en) * 2007-06-15 2011-12-06 Zymogenetics, Inc. Stabilized thrombin compositions
US8642831B2 (en) 2008-02-29 2014-02-04 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing
US10046081B2 (en) 2008-04-11 2018-08-14 The Henry M Jackson Foundation For The Advancement Of Military Medicine, Inc. Electrospun dextran fibers and devices formed therefrom
CA2721335A1 (en) * 2008-04-16 2009-10-22 Ryoichi Kawamura Process for preparing bioabsorbable sheet preparation holding thrombin
JP6241624B2 (ja) 2012-03-06 2017-12-06 フェロサン メディカル デバイシーズ エイ／エス 止血ペーストを収容する加圧容器
CA2874290C (en) 2012-06-12 2020-02-25 Ferrosan Medical Devices A/S Dry haemostatic composition
US9149529B2 (en) 2012-10-24 2015-10-06 Orthovita, Inc. Stable compositions containing thrombin and methods for preparation and use thereof
CA2912357C (en) 2013-06-21 2019-12-31 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
CN105828844B (zh) 2013-12-11 2019-09-27 弗罗桑医疗设备公司 包含挤出增强剂的干组合物
EP3206726B1 (en) 2014-10-13 2020-05-27 Ferrosan Medical Devices A/S Dry composition for use in haemostasis and wound healing
BR112017013565B1 (pt) 2014-12-24 2021-12-28 Ferrosan Medical Devices A/S Seringa para retenção e mistura de primeira e segunda substâncias
CN104569446A (zh) * 2015-02-04 2015-04-29 上海长岛生物技术有限公司 一种液体型凝血酶时间检测试剂及其制备方法
CN104630325B (zh) * 2015-02-04 2018-03-02 上海长岛生物技术有限公司 一种液体型纤维蛋白原检测试剂及其制备方法
CA2986981A1 (en) 2015-07-03 2017-01-12 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
EP3373853A4 (en) 2015-11-12 2019-07-10 St. Teresa Medical, Inc. METHOD FOR SEALING A DUROTOMY
US10953128B2 (en) 2017-11-02 2021-03-23 St. Teresa Medical, Inc. Fibrin sealant products
CN112368028A (zh) 2018-05-09 2021-02-12 弗罗桑医疗设备公司 用于制备止血组合物的方法
IL261190A (en) 2018-08-16 2019-01-31 Omrix Biopharmaceuticals Ltd Stable liquid preparations of thrombin
IL262716A (en) * 2018-11-01 2018-11-29 Omrix Biopharmaceuticals Ltd Oxidized cellulose preparations

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US2433299A (en) * 1944-01-22 1947-12-23 Parke Davis & Co Blood coagulant and method of preserving same
US2532348A (en) * 1946-12-12 1950-12-05 Szent-Gyorgyi Albert Blood clotting preparation
JPS536483A (en) * 1976-07-02 1978-01-20 Tanabe Seiyaku Co Ltd Composition having enzymatic activity and its preparation
JPS5639782A (en) * 1979-09-04 1981-04-15 Dai Ichi Pure Chem Co Ltd Stabilization of thrombin
US4363319A (en) * 1980-06-30 1982-12-14 Applied Medical Devices, Inc. Ready-to-use bandage incorporating a coagulant composition and method of preparing same
JPS628137A (ja) * 1985-07-05 1987-01-16 Konishiroku Photo Ind Co Ltd 情報記録装置

Also Published As

Publication number Publication date
KR870003793A (ko) 1987-05-04
DE3687402T2 (de) 1993-05-06
JPH0764747B2 (ja) 1995-07-12
EP0221700B1 (en) 1992-12-30
ES2053442T3 (es) 1994-08-01
ZA868223B (en) 1987-07-29
DE3687402D1 (de) 1993-02-11
DK512686D0 (da) 1986-10-27
PH23444A (en) 1989-08-07
US4696812A (en) 1987-09-29
JPS62106028A (ja) 1987-05-16
NZ217190A (en) 1989-05-29
AU586897B2 (en) 1989-07-27
EP0221700A3 (en) 1987-08-26
CA1272128A (en) 1990-07-31
DK512686A (da) 1987-04-29
GR3006727T3 (enExample) 1993-06-30
AU6451786A (en) 1987-04-30
EP0221700A2 (en) 1987-05-13

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Legal Events

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UEP Publication of translation of european patent specification
RZN Patent revoked