ATE80877T1 - Verfahren zur herstellung von 6-piperidino-2,4diaminopyrimidin-3-oxid, und verbindungen. - Google Patents
Verfahren zur herstellung von 6-piperidino-2,4diaminopyrimidin-3-oxid, und verbindungen.Info
- Publication number
- ATE80877T1 ATE80877T1 AT88112023T AT88112023T ATE80877T1 AT E80877 T1 ATE80877 T1 AT E80877T1 AT 88112023 T AT88112023 T AT 88112023T AT 88112023 T AT88112023 T AT 88112023T AT E80877 T1 ATE80877 T1 AT E80877T1
- Authority
- AT
- Austria
- Prior art keywords
- oxide
- compound
- formula
- piperidino
- preparation
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000001204 N-oxides Chemical class 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 238000007259 addition reaction Methods 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 239000012948 isocyanate Substances 0.000 abstract 1
- 150000002513 isocyanates Chemical class 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 150000003672 ureas Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/50—Three nitrogen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU86960A LU86960A1 (fr) | 1987-07-31 | 1987-07-31 | Procede de preparation de piperidino-6 diamino-2,4 pyrimidine oxyde-3 et composes nouveaux |
| EP88112023A EP0304648B1 (de) | 1987-07-31 | 1988-07-26 | Verfahren zur Herstellung von 6-Piperidino-2,4-diaminopyrimidin-3-oxid, und Verbindungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE80877T1 true ATE80877T1 (de) | 1992-10-15 |
Family
ID=19730956
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT88112023T ATE80877T1 (de) | 1987-07-31 | 1988-07-26 | Verfahren zur herstellung von 6-piperidino-2,4diaminopyrimidin-3-oxid, und verbindungen. |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US4985563A (de) |
| EP (1) | EP0304648B1 (de) |
| JP (2) | JP2647444B2 (de) |
| AT (1) | ATE80877T1 (de) |
| CA (1) | CA1318914C (de) |
| DE (1) | DE3874842T2 (de) |
| LU (1) | LU86960A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0467026B1 (de) * | 1990-07-17 | 1993-03-03 | Goldwell Aktiengesellschaft | Mittel zur Färbung von Haaren und Anwendung desselben |
| US5502050A (en) * | 1993-11-29 | 1996-03-26 | Cornell Research Foundation, Inc. | Blocking utilization of tetrahydrobiopterin to block induction of nitric oxide synthesis |
| CA2581835C (en) * | 2004-09-29 | 2012-12-18 | Bayer Healthcare Ag | Process for the preparation of 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-n-methylpyridine-2-carboxamide |
| CA2612227C (en) * | 2005-06-14 | 2014-04-22 | Taigen Biotechnology Co., Ltd. | Pyrimidine compounds |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3382248A (en) * | 1965-11-01 | 1968-05-07 | Upjohn Co | 6-amino-4, 5-di(substituted amino)-1, 2-dihydro-1-hydroxy-2-iminopyrimidines |
| US3910928A (en) * | 1974-04-26 | 1975-10-07 | Upjohn Co | 3-(Cyanimino)-propionitriles |
| AU519993B2 (en) * | 1977-02-04 | 1982-01-07 | F. Hoffmann-La Roche & Co. | Pyrimidine derivatives |
| HU177601B (en) * | 1978-10-27 | 1981-11-28 | Egyt Gyogyszervegyeszeti Gyar | New process for preparing 6-piperidino-2,4-diamino-pyrimidine-3-oxide |
-
1987
- 1987-07-31 LU LU86960A patent/LU86960A1/fr unknown
-
1988
- 1988-07-26 DE DE8888112023T patent/DE3874842T2/de not_active Expired - Fee Related
- 1988-07-26 EP EP88112023A patent/EP0304648B1/de not_active Expired - Lifetime
- 1988-07-26 AT AT88112023T patent/ATE80877T1/de active
- 1988-07-29 JP JP63188536A patent/JP2647444B2/ja not_active Expired - Lifetime
- 1988-07-29 US US07/225,819 patent/US4985563A/en not_active Expired - Lifetime
- 1988-08-01 CA CA000573529A patent/CA1318914C/fr not_active Expired - Fee Related
-
1990
- 1990-12-31 US US07/636,126 patent/US5126453A/en not_active Expired - Fee Related
-
1997
- 1997-02-03 JP JP9032596A patent/JP2726653B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE3874842T2 (de) | 1993-02-04 |
| JP2726653B2 (ja) | 1998-03-11 |
| US5126453A (en) | 1992-06-30 |
| DE3874842D1 (de) | 1992-10-29 |
| JPH0248570A (ja) | 1990-02-19 |
| CA1318914C (fr) | 1993-06-08 |
| EP0304648A1 (de) | 1989-03-01 |
| JPH09216872A (ja) | 1997-08-19 |
| EP0304648B1 (de) | 1992-09-23 |
| LU86960A1 (fr) | 1989-03-08 |
| US4985563A (en) | 1991-01-15 |
| JP2647444B2 (ja) | 1997-08-27 |
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