DE3768603D1 - Fluorierte abkoemmlinge von vitamin-d3 und verfahren zu deren herstellung. - Google Patents

Fluorierte abkoemmlinge von vitamin-d3 und verfahren zu deren herstellung.

Info

Publication number
DE3768603D1
DE3768603D1 DE8787115258T DE3768603T DE3768603D1 DE 3768603 D1 DE3768603 D1 DE 3768603D1 DE 8787115258 T DE8787115258 T DE 8787115258T DE 3768603 T DE3768603 T DE 3768603T DE 3768603 D1 DE3768603 D1 DE 3768603D1
Authority
DE
Germany
Prior art keywords
denotes
hydroxyl group
hydrogen atom
production
fluorine atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787115258T
Other languages
English (en)
Inventor
Noritaka Hamma
Toshio Nishizawa
Yoshikazu Saito
Takashi Katsumata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharmaceuticals Co Ltd
Original Assignee
Sumitomo Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Pharmaceuticals Co Ltd filed Critical Sumitomo Pharmaceuticals Co Ltd
Application granted granted Critical
Publication of DE3768603D1 publication Critical patent/DE3768603D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
DE8787115258T 1986-10-20 1987-10-19 Fluorierte abkoemmlinge von vitamin-d3 und verfahren zu deren herstellung. Expired - Fee Related DE3768603D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP24909586 1986-10-20

Publications (1)

Publication Number Publication Date
DE3768603D1 true DE3768603D1 (de) 1991-04-18

Family

ID=17187901

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787115258T Expired - Fee Related DE3768603D1 (de) 1986-10-20 1987-10-19 Fluorierte abkoemmlinge von vitamin-d3 und verfahren zu deren herstellung.

Country Status (6)

Country Link
US (1) US4853378A (de)
EP (1) EP0264880B1 (de)
AT (1) ATE61577T1 (de)
CA (1) CA1297869C (de)
DE (1) DE3768603D1 (de)
ES (1) ES2032416T3 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU649057B2 (en) * 1990-08-24 1994-05-12 Wisconsin Alumni Research Foundation Methods and compositions containing vitamin D compounds for improvement of skin conditions
US5459136A (en) * 1990-08-24 1995-10-17 Wisconsin Alumni Research Foundation Methods using vitamin D compounds for improvement of skin conditions
FR2677022B1 (fr) * 1991-05-29 1995-03-10 Medgenix Group Sa Derives de la vitamine d comportant un groupe epoxyde sur la chaine laterale.
US5278155A (en) * 1991-06-05 1994-01-11 Daikin Industries, Ltd. Fluorine-containing vitamin D3 analogues and cell differentiation-inducing agent containing the same
US5210237A (en) * 1991-08-27 1993-05-11 Daikin Industries, Ltd. Vitamin d3 analogues
DE4221961A1 (de) * 1992-06-30 1994-01-05 Schering Ag 22-En-25-oxa-Derivate in der Vitamin D-Reihe, Verfahren zu ihrer Herstellung, diese Derivate enthaltenen pharmazeutische Präparate sowie deren Verwendung als Arzneimittel
US5696103A (en) * 1995-11-17 1997-12-09 Syntex (U.S.A.) Inc. Method for treating osteoporosis
US6043386A (en) * 1998-06-03 2000-03-28 John Hopkins University Non-calcemic, antiproliferative, transcriptionally active 24-fluorinated hybrid analogs of 1α,-25-dihydroxy vitamin D3
JP5472217B2 (ja) * 2011-06-29 2014-04-16 信越化学工業株式会社 ２，２−ビス（フルオロアルキル）オキシラン類を用いた光酸発生剤の製造方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4201881A (en) * 1979-03-28 1980-05-06 Wisconsin Alumni Research Foundation 24,24-Difluoro-1α,25-dihydroxycholecalciferol
US4248791A (en) * 1980-02-04 1981-02-03 Wisconsin Alumni Research Foundation 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol
US4305880A (en) * 1980-09-22 1981-12-15 Wisconsin Alumni Research Foundation Process for preparing 24-fluoro-25-hydroxycholecalciferol
US4358406A (en) * 1981-07-27 1982-11-09 Wisconsin Alumni Research Foundation 26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol and process for preparing same
IE55801B1 (en) * 1982-07-26 1991-01-16 Wisconsin Alumni Res Found Novel vitamin d analogs
US4502991A (en) * 1983-08-18 1985-03-05 Wisconsin Alumni Research Foundation 23,23-Difluoro-1α,25-dihydroxy-vitamin D3
US4495181A (en) * 1983-10-03 1985-01-22 The Regents Of The University Of California 1,25-Dihydroxy-24-oxo-vitamin D3 and 1,23,25-trihydroxy-24-oxo-vitamin D3
US4728643A (en) * 1984-11-02 1988-03-01 The General Hospital Corporation Method of treating psoriasis
EP0205025A1 (de) * 1985-05-27 1986-12-17 Sumitomo Pharmaceuticals Company, Limited Fluorin enthaltende Vitamin-D3-Derivate und Zelldifferenzierung induzierende Mittel, die sie als aktiven Wirkstoff enthalten
US4619920A (en) * 1985-09-16 1986-10-28 Wisconsin Alumni Research Foundation 26,26,26,27,27-pentafluoro-1α-hydroxy-27-methoxyvitamin D3

Also Published As

Publication number Publication date
ES2032416T3 (es) 1993-02-16
CA1297869C (en) 1992-03-24
EP0264880A1 (de) 1988-04-27
EP0264880B1 (de) 1991-03-13
ATE61577T1 (de) 1991-03-15
US4853378A (en) 1989-08-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee