ATE77384T1 - In liposomen inkorporierte hydrophobe cis-platin- komplexe. - Google Patents

In liposomen inkorporierte hydrophobe cis-platin- komplexe.

Info

Publication number
ATE77384T1
ATE77384T1 AT86906624T AT86906624T ATE77384T1 AT E77384 T1 ATE77384 T1 AT E77384T1 AT 86906624 T AT86906624 T AT 86906624T AT 86906624 T AT86906624 T AT 86906624T AT E77384 T1 ATE77384 T1 AT E77384T1
Authority
AT
Austria
Prior art keywords
liposomes
complex
platinum
platinum complexes
carboxylato
Prior art date
Application number
AT86906624T
Other languages
English (en)
Inventor
Abdul R Khokhar
Gabriel Lopez-Berestein
Roman Perez-Soler
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27120836&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE77384(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Texas filed Critical Univ Texas
Application granted granted Critical
Publication of ATE77384T1 publication Critical patent/ATE77384T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00—Metallocenes
    • C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Cosmetics (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
AT86906624T 1985-10-18 1986-10-17 In liposomen inkorporierte hydrophobe cis-platin- komplexe. ATE77384T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US78875085A 1985-10-18 1985-10-18
US06/914,591 US5041581A (en) 1985-10-18 1986-10-07 Hydrophobic cis-platinum complexes efficiently incorporated into liposomes
EP86906624A EP0248036B1 (de) 1985-10-18 1986-10-17 In liposomen inkorporierte hydrophobe cis-platin-komplexe
PCT/US1986/002181 WO1987002364A1 (en) 1985-10-18 1986-10-17 Hydrophobic cis-platinum complexes efficiently incorporated into liposomes

Publications (1)

Publication Number Publication Date
ATE77384T1 true ATE77384T1 (de) 1992-07-15

Family

ID=27120836

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86906624T ATE77384T1 (de) 1985-10-18 1986-10-17 In liposomen inkorporierte hydrophobe cis-platin- komplexe.

Country Status (10)

Country Link
US (3) US5041581A (de)
EP (1) EP0248036B1 (de)
KR (1) KR900003094B1 (de)
AT (1) ATE77384T1 (de)
CA (1) CA1312616C (de)
DE (1) DE3685751T2 (de)
DK (1) DK307787A (de)
FI (1) FI85492C (de)
IL (1) IL80349A (de)
WO (1) WO1987002364A1 (de)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6296A (ja) 1985-03-06 1987-01-06 Sumitomo Pharmaceut Co Ltd 脂溶性白金（２）錯体
US5117022A (en) * 1985-10-18 1992-05-26 The Board Of Regents, The University Of Texas System Hydrophobic cis-platinum complexes efficiently incorporated into liposomes
US5384127A (en) * 1985-10-18 1995-01-24 Board Of Regents, The University Of Texas System Stable liposomal formulations of lipophilic platinum compounds
US5206400A (en) * 1986-07-07 1993-04-27 Ohio State University Diastereomeric mono- and di-substituted diamino cyclohexane compounds and the method of preparation thereof
US5320906A (en) * 1986-12-15 1994-06-14 Vestar, Inc. Delivery vehicles with amphiphile-associated active ingredient
DK175531B1 (da) * 1986-12-15 2004-11-22 Nexstar Pharmaceuticals Inc Leveringsvehikel med amphiphil-associeret aktiv bestanddel
EP0284197A1 (de) * 1987-02-20 1988-09-28 Tanabe Seiyaku Co., Ltd. Organische Platinkomplexe und Verfahren zu deren Herstellung
DK86988A (da) * 1987-02-25 1988-08-26 Takeda Chemical Industries Ltd Liposompraeparat og anvendelse deraf
IL85595A0 (en) * 1987-03-06 1988-08-31 Tanabe Seiyaku Co Organic platinum complex and its preparation
DE3710371A1 (de) * 1987-03-28 1988-10-13 Dornier Medizintechnik Zerstoerung von krankhaft veraenderten gewebezellen
CA1339034C (en) * 1988-08-22 1997-04-01 Paul A. Tremblay Platinum complexes of single isomer neoalkyl acids
US5434256A (en) * 1988-11-22 1995-07-18 Board Of Regents, The University Of Texas System Diamine platinum complexes as antitumor agents
US5041578A (en) * 1988-11-22 1991-08-20 Board Of Regents, The University Of Texas System Water soluble 1,2-diaminocyclohexane platinum (IV) complexes as antitumor agents
US5393909A (en) * 1988-11-22 1995-02-28 Board Of Regents, The University Of Texas System Diamine platinum complexes as antitumor agents
CA2263455C (en) * 1996-08-23 2002-10-29 Sequus Pharmaceuticals, Inc. Liposomes containing a cisplatin compound
US5843475A (en) * 1996-12-06 1998-12-01 Board Of Regents, The University Of Texas System Delivery and activation through liposome incorporation of diaminocyclohexane platinum (II) complexes
US6548541B1 (en) * 1999-04-21 2003-04-15 Unitech Pharmaceuticals, Inc. Carboplatin analogs for cancer treatment
WO2001024763A2 (en) 1999-10-01 2001-04-12 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
CA2456746A1 (en) * 2001-08-20 2003-02-27 Transave, Inc. Method for treating lung cancers
WO2003075890A1 (en) * 2002-03-05 2003-09-18 Transave, Inc. Methods for entrapment of bioactive agent in a liposome or lipid complex
NZ538179A (en) * 2002-08-02 2008-09-26 Transave Inc Liposome or lipid complex with active platinum compound and process for producing the same
US9186322B2 (en) 2002-08-02 2015-11-17 Insmed Incorporated Platinum aggregates and process for producing the same
US7879351B2 (en) * 2002-10-29 2011-02-01 Transave, Inc. High delivery rates for lipid based drug formulations, and methods of treatment thereof
DK2363114T3 (da) * 2002-10-29 2015-06-22 Insmed Inc Opretholdt afgivelse af anti-infektionsmidler
US7718189B2 (en) 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
US7160908B2 (en) * 2003-03-04 2007-01-09 Unitech Pharmaceuticals, Inc. Dynamic anticancer platinum compounds
AU2004235781A1 (en) * 2003-05-02 2004-11-18 Aronex Pharmaceuticals, Inc. Lipid platinum complexes and methods of use thereof
EP1631301A4 (de) * 2003-05-20 2006-06-07 Aronex Pharmaceuticals Inc Kombinationschemotherapie mit 5-fluorouracil oder einem derivat davon und einem liposomalen platinkomplex
AU2003239511A1 (en) * 2003-05-20 2004-12-13 Aronex Pharmaceuticals, Inc. Combination chemotherapy comprising a liposomal platinum complex
CA2525952A1 (en) * 2003-05-20 2004-12-09 Aronex Pharmaceuticals, Inc. Combination chemotherapy comprising gemcitabine and a liposomal platinum complex
US20080026044A1 (en) * 2003-05-20 2008-01-31 Jonathan Lewis Combination Chemotherapy Comprising Capecitabine and a Liposomal Platinum Complex
WO2005044236A1 (en) * 2003-10-27 2005-05-19 Control Delivery Systems, Inc. Suspension delivery system for the sustained and controlled local release of pharmaceuticals
US20070065522A1 (en) * 2004-03-18 2007-03-22 Transave, Inc. Administration of high potency platinum compound formulations by inhalation
EP1729786A4 (de) * 2004-03-18 2008-03-26 Transave Inc Verabreichung von cisplatin durch inhalation
CA2566174A1 (en) * 2004-05-21 2005-12-01 Transave, Inc. Treatment of lung diseases and pre-lung disease conditions
JP5735724B2 (ja) * 2004-11-08 2015-06-17 インスメッド， インコーポレイテッド 腹腔内投与される脂質ベースの白金化合物製剤を用いた、癌の治療方法
WO2006113679A2 (en) 2005-04-15 2006-10-26 Board Of Regents, The University Of Texas System Delivery of sirna by neutral lipid compositions
CN1913508B (zh) * 2005-08-08 2010-05-05 华为技术有限公司 基于正交频分复用的信号调制方法及其调制装置
WO2007056264A2 (en) * 2005-11-08 2007-05-18 Transave, Inc. Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally
US9107824B2 (en) 2005-11-08 2015-08-18 Insmed Incorporated Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally
PL1962805T3 (pl) 2005-12-08 2017-01-31 Insmed Incorporated Kompozycje środków przeciwzapalnych oparte na lipidach do leczenia infekcji płucnych
WO2008137717A1 (en) 2007-05-04 2008-11-13 Transave, Inc. Compositions of multicationic drugs for reducing interactions with polyanionic biomolecules and methods and uses thereof
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
US9114081B2 (en) 2007-05-07 2015-08-25 Insmed Incorporated Methods of treating pulmonary disorders with liposomal amikacin formulations
US9333214B2 (en) 2007-05-07 2016-05-10 Insmed Incorporated Method for treating pulmonary disorders with liposomal amikacin formulations
FR2945946B1 (fr) 2009-05-29 2011-08-26 Univ Victor Segalen Bordeaux 2 Formulations a compartiments multiples a base de molecules ou macromolecules amphiphiles fonctionnelles
PT2852391T (pt) 2012-05-21 2022-02-18 Insmed Inc Sistemas para tratamento de infeções pulmonares
ES2848025T3 (es) 2012-09-04 2021-08-05 Eleison Pharmaceuticals LLC Prevención de la recidiva pulmonar del cáncer con cisplatino complejado con lípidos
BR112015012351A8 (pt) 2012-11-29 2019-10-01 Insmed Inc composição de antibiótico de glicopeptídeo à base de lipídeo estabilizado e uso de um componente lipídico, um componente de antibiótico de glicopeptídeo e um aminoácido ou derivado do mesmo
ME03536B (de) 2014-05-15 2020-04-20 Insmed Inc Verfahren zur behandlung von pulmonaler mykobakterieller nichttuberkuloseinfektionen
US20170208825A1 (en) * 2016-01-21 2017-07-27 Alan Backus Gaseous transfer device
US10925831B2 (en) * 2017-08-28 2021-02-23 Wake Forest University Liposomal formulations of platinum-acridine anticancer agents and methods thereof
US11571386B2 (en) 2018-03-30 2023-02-07 Insmed Incorporated Methods for continuous manufacture of liposomal drug products

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1432563A (en) * 1972-04-10 1976-04-22 Rustenburg Platinum Mines Ltd Platinum- co-ordination compounds
CH588505A5 (de) * 1972-06-08 1977-06-15 Research Corp
US3993754A (en) * 1974-10-09 1976-11-23 The United States Of America As Represented By The United States Energy Research And Development Administration Liposome-encapsulated actinomycin for cancer chemotherapy
US4115418A (en) * 1976-09-02 1978-09-19 Government Of The United States Of America 1,2-diaminocyclohexane platinum (ii) complexes having antineoplastic activity
JPS6041077B2 (ja) * 1976-09-06 1985-09-13 喜徳 喜谷 １，２‐ジアミノシクロヘキサン異性体のシス白金（２）錯体
US4137248A (en) * 1977-08-29 1979-01-30 The United States Of America As Represented By The Department Of Health, Education And Welfare Compound, 4-carboxyphthalato(1,2-diaminocyclohexane)-platinum(II) and alkali metal salts thereof
JPS5829957B2 (ja) * 1977-09-12 1983-06-25 喜徳 喜谷 新規な白金錯体
NL7810433A (nl) * 1977-10-19 1979-04-23 Johnson Matthey Co Ltd Nieuwe platinaverbindingen.
US4225529A (en) * 1977-10-19 1980-09-30 Johnson, Matthey & Co., Limited Compositions containing platinum
SE447385B (sv) * 1977-10-19 1986-11-10 Johnson Matthey Co Ltd Cis-koordinationsforeningar av platina
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4657927A (en) * 1978-05-04 1987-04-14 Research Corporation Malonato platinum compounds
US4241046A (en) * 1978-11-30 1980-12-23 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4271085A (en) * 1979-06-20 1981-06-02 Engelhard Minerals & Chemicals Corporation Cis-platinum (II) amine lactate complexes
US4284579A (en) * 1979-07-17 1981-08-18 The United States Of America As Represented By The Of The Department Of Health & Human Services (N-Phosphonacetyl-L-aspartato)(1,2-diaminocyclchexane)platinum(II) or alkali metal salt
JPS5622724A (en) * 1979-08-02 1981-03-03 Asahi Chem Ind Co Ltd Pharmaceutical preparation of n4-acylcytosine arabinoside
NL181434C (nl) * 1980-01-03 1987-08-17 Tno Platina(iv)-diamine-complexen, alsmede hun bereiding en toepassing.
NL8101026A (nl) * 1981-03-03 1982-10-01 Tno Platinadiamine-complexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijk platinadiamine-complex voor de behandeling van kanker alsmede aldus verkregen gevormd geneesmiddel.
US4522803A (en) * 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
EP0113508A1 (de) * 1982-11-04 1984-07-18 Inco Research & Development Center, Inc. Hydrophobische Platinverbindungen und ihre Herstellung
US4661516A (en) * 1983-06-20 1987-04-28 Research Corporation Diaminocyclohexane platinum complexes
GR82129B (de) * 1983-06-20 1984-12-13 Research Corp
DE3477788D1 (en) * 1983-08-05 1989-05-24 Yoshinori Kidani Cytostatic platinum complexes
BE898614A (fr) * 1984-01-05 1984-05-02 Abello Quimicos Farma Prod Sa Nouveaux composes de coordination contenant du platine
US4663167A (en) * 1984-04-16 1987-05-05 The Board Of Regents Of The University Of Texas System Composition and method for treatment of disseminated fungal infections in mammals
JPS617283A (ja) * 1984-06-20 1986-01-13 Shionogi & Co Ltd 新規白金錯体および抗悪性腫瘍剤
DE3582961D1 (de) * 1984-06-27 1991-07-04 Johnson Matthey Plc Platinkoordinationsverbindungen.
EP0169645A1 (de) * 1984-06-27 1986-01-29 Johnson Matthey Public Limited Company Platin-Koordinationsverbindungen
CA1270198A (en) * 1984-08-08 1990-06-12 Marcel B. Bally Encapsulation of antineoplastic agents in liposomes
JPS6296A (ja) * 1985-03-06 1987-01-06 Sumitomo Pharmaceut Co Ltd 脂溶性白金（２）錯体
EP0198765A3 (de) * 1985-04-09 1987-10-21 Georgetown University Herstellung von Liposomen
US5059421A (en) * 1985-07-26 1991-10-22 The Liposome Company, Inc. Preparation of targeted liposome systems of a defined size distribution
US4680308A (en) * 1985-12-26 1987-07-14 Andrulis Research Corporation Stable soluble 1,2-diaminocyclohexane platinum complexes
US4923854A (en) * 1986-01-22 1990-05-08 The Liposome Company, Inc. Solubilization of hydrophobic materials using lysophospholipid
US4760157A (en) * 1986-01-31 1988-07-26 American Cyanamid Company (2,2,-bis(aminomethyl)-1,3-propanediol-N,N')platinum complexes
JPS62207283A (ja) * 1986-03-07 1987-09-11 Yoshinori Kitani 新規な白金錯体
US5011959A (en) * 1986-11-17 1991-04-30 The Board Of Regents, The University Of Texas System 1,2-diaminocyclohexane-platinum complexes with antitumor activity
JPH0825869B2 (ja) * 1987-02-09 1996-03-13 株式会社ビタミン研究所 抗腫瘍剤包埋リポソ−ム製剤
US4956459A (en) * 1987-07-17 1990-09-11 Georgetown University Platinum compounds suitable for use as pharmaceuticals
DE3826946C1 (de) * 1988-08-09 1990-03-15 A. Nattermann & Cie Gmbh, 5000 Koeln, De
US4913907A (en) * 1988-08-15 1990-04-03 Cytopharm, Inc. Porphycene anti-cancer agents and treatment methods
US4946954A (en) * 1989-01-17 1990-08-07 Georgetown University Platinum pharmaceutical agents

Also Published As

Publication number Publication date
IL80349A (en) 1991-06-30
WO1987002364A1 (en) 1987-04-23
US5178876A (en) 1993-01-12
FI872646A0 (fi) 1987-06-15
DE3685751T2 (de) 1993-02-04
FI85492C (fi) 1992-04-27
EP0248036A1 (de) 1987-12-09
US5186940A (en) 1993-02-16
DK307787A (da) 1987-08-17
KR870700631A (ko) 1987-12-30
FI872646L (fi) 1987-06-15
FI85492B (fi) 1992-01-15
EP0248036B1 (de) 1992-06-17
DE3685751D1 (de) 1992-07-23
DK307787D0 (da) 1987-06-17
IL80349A0 (en) 1987-01-30
CA1312616C (en) 1993-01-12
KR900003094B1 (ko) 1990-05-07
US5041581A (en) 1991-08-20

Similar Documents

Publication Publication Date Title
ATE77384T1 (de) In liposomen inkorporierte hydrophobe cis-platin- komplexe.
ES8600931A1 (es) Un procedimiento para preparar una solucion acuosa que contiene una sustancia farmaceutica soluble en lipidos
NZ505163A (en) Sustained release medicinal compositions comprising an ionic compound with an opposite charge to the ionic active substance
RU94026288A (ru) Новые соединения как средства подавления полилекарственной резистентности, способы их получения, фармацевтическая композиция, способ лечения
ATE45579T1 (de) Diazabicyclo-(3,3,1)-nonane.
DE3460577D1 (en) Sodium salt of ursodeoxycholic sulphate
LV10949A (lv) Aizvietoti 4-fenil-4piperidinkarboksamidi to iegusanas panemiens farmaceitiska kompozicija
ES8405795A1 (es) Procedimiento para la preparacion de derivados de b-carbolina
DK540585D0 (da) 5-alkyl-1-phenyl-2-piperazinoalkylpyrasolin-3-on-forbindelser, fremgangsmaade til fremstilling heraf og mellemprodukter til brug herved, samt farmaceutiske praeparater indeholdende disse forbindelser
KR920004387A (ko) 진통제 및 피부질환 치료용 국소용 소염제로서의 4-치환된 디하이드로피리도[4,3-d]피리미딘
ATE44028T1 (de) Kronenaether-derivate.
BG38638A3 (bg) Метод за получаване на арилциклобутил-аминопроизводни
FR2416013A1 (fr) Derives d'acide (-)-(cis)-1,2-epoxypropylphosphonique, leur preparation et compositions pharmaceutiques les contenant
DE3374005D1 (en) 1-methyl-5-nitro-imidazoline derivatives and therapeutic compositions which contain them as active principle
ES8401074A1 (es) Sal de n-metil-d-glucamina.
FR2421894A1 (fr) Nouvelles 2,3-dihydro-4h-1-benzopyranne-4-one-o-carbamoyloximes utiles notamment comme inhibiteurs de secretion gastrique
FR2374321A1 (fr) Utilisation de quinoxalinedioxydes pour promouvoir la croissance et ameliorer le rendement alimentaire d'animaux
SE8105340L (sv) Nya 4-karbamoyloxioxazafosforiner samt forfarande for framstellning derav
EP0088413A3 (de) Isoxazolopyrimidinderivate und ihre Herstellung
JPS5767578A (en) N-phthtalidy-5-fluorouracil derivative
FR2414511A1 (fr) Nouveaux 1, 2, 3, 4-tetrahydropyrido(4', 3' : 4,5)thiazolo(3,2-a)benzimidazoles utiles notamment comme anti-inflammatoires et leur procede de preparation
FR2375300A1 (fr) Colorants monoazoiques acides
JPS5414595A (en) Novel antibiotic substance c19-97
ES8704181A1 (es) Un procedimiento para preparar un compuesto de bis (difenilfosfino) alquil -bis-oro-i
JPS56122371A (en) Preparation of 5,8,9,11,12,14,15-heptadeutero-6-oxo- prostaglandin f1alpha

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee