ATE72238T1 - Imidazoliumsalze, zwischenprodukte fuer ihre herstellung sowie ihre verwendung. - Google Patents

Imidazoliumsalze, zwischenprodukte fuer ihre herstellung sowie ihre verwendung.

Info

Publication number
ATE72238T1
ATE72238T1 AT84108015T AT84108015T ATE72238T1 AT E72238 T1 ATE72238 T1 AT E72238T1 AT 84108015 T AT84108015 T AT 84108015T AT 84108015 T AT84108015 T AT 84108015T AT E72238 T1 ATE72238 T1 AT E72238T1
Authority
AT
Austria
Prior art keywords
imidazolium salts
preparation
intermediate products
imidazolium
refractoriness
Prior art date
Application number
AT84108015T
Other languages
English (en)
Inventor
Julius Diamond
William Carl Lumma Jr
Thomas Kenneth Morgan Jr
Ronald Andre Wohl
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of ATE72238T1 publication Critical patent/ATE72238T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00Preparation of halogenated hydrocarbons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00Preparation of halogenated hydrocarbons
    • C07C17/26Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/263Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00Preparation of halogenated hydrocarbons
    • C07C17/26Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/263Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
    • C07C17/2632Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions involving an organo-magnesium compound, e.g. Grignard synthesis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00Preparation of halogenated hydrocarbons
    • C07C17/26Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/263Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
    • C07C17/2635Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions involving a phosphorus compound, e.g. Wittig synthesis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01Sulfonic acids
    • C07C309/28Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40Halogenated unsaturated alcohols
    • C07C33/46Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C07C33/48Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts with unsaturation outside the aromatic rings
    • C07C33/483Monocyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40Halogenated unsaturated alcohols
    • C07C33/50Halogenated unsaturated alcohols containing six-membered aromatic rings and other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Gas Separation By Absorption (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT84108015T 1983-07-12 1984-07-09 Imidazoliumsalze, zwischenprodukte fuer ihre herstellung sowie ihre verwendung. ATE72238T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/513,143 US4581370A (en) 1983-07-12 1983-07-12 Antiarrhythmic imidazoliums
EP84108015A EP0131302B1 (de) 1983-07-12 1984-07-09 Imidazoliumsalze, Zwischenprodukte für ihre Herstellung sowie ihre Verwendung

Publications (1)

Publication Number Publication Date
ATE72238T1 true ATE72238T1 (de) 1992-02-15

Family

ID=24042059

Family Applications (1)

Application Number Title Priority Date Filing Date
AT84108015T ATE72238T1 (de) 1983-07-12 1984-07-09 Imidazoliumsalze, zwischenprodukte fuer ihre herstellung sowie ihre verwendung.

Country Status (15)

Country Link
US (2) US4581370A (de)
EP (1) EP0131302B1 (de)
JP (1) JPH08815B2 (de)
AT (1) ATE72238T1 (de)
AU (1) AU582538B2 (de)
CA (1) CA1289563C (de)
DE (1) DE3485488D1 (de)
DK (1) DK339184A (de)
FI (1) FI90232C (de)
GR (1) GR82282B (de)
IE (1) IE59337B1 (de)
IL (1) IL72354A (de)
NO (1) NO168300C (de)
NZ (1) NZ208831A (de)
ZA (1) ZA845410B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0149976A3 (de) * 1983-12-30 1986-12-10 Ciba-Geigy Ag Substituierte Imidazole
US4609670A (en) * 1984-11-13 1986-09-02 Eli Lilly And Company Imidazolium hypoglycemic agents
EP0200947B1 (de) * 1985-04-26 1990-09-12 F. Hoffmann-La Roche Ag 1,3-Disubstituierte Imidazoliumsalze
US4978672A (en) * 1986-03-07 1990-12-18 Ciba-Geigy Corporation Alpha-heterocyclc substituted tolunitriles
US4937250A (en) * 1988-03-07 1990-06-26 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
GB8609331D0 (en) * 1986-04-16 1986-05-21 Pfizer Ltd Anti-arrythmia agents
GB8707120D0 (en) * 1987-03-25 1987-04-29 Pfizer Ltd Antiarrhythmic agents
DE3876006T2 (de) * 1987-04-14 1993-03-25 Glaxo Group Ltd Keton-derivate.
GB8720693D0 (en) * 1987-09-03 1987-10-07 Glaxo Group Ltd Chemical compounds
RU2221788C2 (ru) * 1991-08-14 2004-01-20 Проктер энд Гэмбл Фармасьютикалз Оксоциклические соединения мочевины, фармацевтическая композиция, способ лечения
RU2125568C1 (ru) * 1991-08-14 1999-01-27 Проктер энд Гэмбл Фармасьютикалз, Инк. Соединения циклического уретана или их фармацевтически приемлемые соли, способ лечения людей и других млекопитающих, страдающих сердечной аритмией и/или сердечной фибрилляцией, фармацевтическая композиция для лечения аритмии и фибрилляции
CA2115426C (en) * 1991-08-14 2001-09-11 Stanford Salvatore Pelosi Jr. Novel cyclic ureas useful as antiarrhythmic and antifibrillatory agents
US5635521A (en) * 1991-09-23 1997-06-03 Sandoz Ltd. Imidazolylmethyl-pyridines
IL104125A (en) * 1991-12-18 2000-08-31 Schering Corp Imidazolyl or imidazoylalkyl substituted with a four or five membered nitrogen containing heterocyclic ring and pharmaceutical compositions comprising them
GB9127304D0 (en) * 1991-12-23 1992-02-19 Boots Co Plc Therapeutic agents
US5183813A (en) * 1992-02-19 1993-02-02 Sterling Winthrop Inc. Antiarrhythmic agents
GB9312893D0 (en) * 1993-06-22 1993-08-04 Boots Co Plc Therapeutic agents
US6031109A (en) * 1993-06-22 2000-02-29 Knoll Aktiengesellschaft Phenoxy-, phenylthio-, benzoyl-alkyleneaminoalkylene-imidazole derivatives as therapeutic agents
FR2766178B1 (fr) * 1997-07-16 2000-03-17 Oreal Nouvelles bases d'oxydation cationiques, leur utilisation pour la teinture d'oxydation des fibres keratiniques, compositions tinctoriales et procedes de teinture
FR2766179B1 (fr) * 1997-07-16 2000-03-17 Oreal Nouvelles bases d'oxydation cationiques, leur utilisation pour la teinture d'oxydation des fibres keratiniques, compositions tinctoriales et procedes de teinture
FR2782718B1 (fr) * 1998-09-02 2000-11-10 Oreal Nouveaux composes cationiques, leur utilisation pour la teinture d'oxydation des fibres keratiniques, compositions tinctoriales et procedes de teinture
FR2782719B1 (fr) * 1998-09-02 2000-11-10 Oreal Nouvelles orthophenylenediamines cationiques, leur utilisation pour la teinture d'oxydation des fibres keratiniques, compositions tinctoriales et procedes de teinture
JP4620286B2 (ja) * 2001-06-05 2011-01-26 富士フイルム株式会社 電解質組成物、光電変換素子及び光電気化学電池
US7232821B2 (en) 2002-04-08 2007-06-19 Glaxo Group Limited (2-((2-alkoxy)-phenyl) -cyclopent-1enyl) aromatic carbo and heterocyclic acid and derivatives
GB0225548D0 (en) 2002-11-01 2002-12-11 Glaxo Group Ltd Compounds
JP2008133248A (ja) * 2006-10-24 2008-06-12 Sanyo Chem Ind Ltd イミダゾリウム塩の製造方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2493318A (en) * 1945-07-14 1950-01-03 Lilly Co Eli Imidazolium compounds
FR8357M (de) * 1966-09-08 1971-02-08
SE7600674L (sv) * 1975-02-05 1976-08-06 Rohm & Haas Fungicider
DE2510525C3 (de) * 1975-03-11 1978-03-30 Th. Goldschmidt Ag, 4300 Essen Quartäre 2-Alkylimidazoliumsalze
DK464278A (da) * 1977-10-19 1979-04-20 Wellcome Found Imidazolderivater og salte deraf samt fremgangsmaade og mellemprodukter til deres fremstilling
JPS5479278A (en) * 1977-12-05 1979-06-25 Nippon Soda Co Ltd Imidazolium halide
IT1097314B (it) * 1978-07-26 1985-08-31 Recordati Chem Pharm Derivati dell'imidazolo ad attivita' anticonvulsivante
FR2486079A1 (fr) * 1980-07-07 1982-01-08 Rhone Poulenc Agrochimie Sels quaternaires d'alcoyl-1-imidazolium de l'acide phosphoreux ou ses monoesters, procedes pour les preparer et compositions fongicides les contenant
JPS5838261A (ja) * 1981-08-29 1983-03-05 Kissei Pharmaceut Co Ltd 新規な1,3−二置換イミダゾ−ル誘導体及びその製造方法
JPS5855466A (ja) * 1981-09-28 1983-04-01 Kissei Pharmaceut Co Ltd 新規な1,3−二置換イミダゾ−ル誘導体及びその製造方法
DE3319845A1 (de) * 1983-06-01 1984-12-06 Basf Ag, 6700 Ludwigshafen Arylalkylimidazolium- und -triazoliumsalze, verfahren zu ihrer herstellung und ihre verwendung als mikrozide

Also Published As

Publication number Publication date
EP0131302A3 (en) 1987-06-16
FI90232B (fi) 1993-09-30
IL72354A0 (en) 1984-11-30
FI90232C (fi) 1994-01-10
GR82282B (de) 1984-12-13
IE59337B1 (en) 1994-02-09
US4689341A (en) 1987-08-25
IL72354A (en) 1988-11-30
CA1289563C (en) 1991-09-24
JPS6038366A (ja) 1985-02-27
US4581370A (en) 1986-04-08
NZ208831A (en) 1988-09-29
FI842760A0 (fi) 1984-07-10
JPH08815B2 (ja) 1996-01-10
NO168300C (no) 1992-02-05
AU3054384A (en) 1985-01-17
EP0131302B1 (de) 1992-01-29
FI842760A (fi) 1985-01-13
IE841774L (en) 1985-01-12
DK339184D0 (da) 1984-07-10
AU582538B2 (en) 1989-04-06
NO168300B (no) 1991-10-28
NO842835L (no) 1985-01-14
ZA845410B (en) 1985-02-27
DE3485488D1 (de) 1992-03-12
DK339184A (da) 1985-01-13
EP0131302A2 (de) 1985-01-16

Similar Documents

Publication Publication Date Title
ATE72238T1 (de) Imidazoliumsalze, zwischenprodukte fuer ihre herstellung sowie ihre verwendung.
DE3581699D1 (de) Bis-dimethoxymethyl(trimethoxybenzyl)isochinolinium-salze, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen.
AU1331588A (en) Method for treatment of alcohol abuse
PT77898B (en) Process for the preparation of substituted 4-amino-methylenochromanes and 4-aminomethylenecromenes acting on the blood circulation and application thereof in the preparation of pharmaceutical compositions acting on the blood circulation
AU557590B2 (en) Aroylimidazolones
PL268927A1 (en) Method of obtaining novel derivatives of benzimidazole
FI854926A (fi) Foerfarande foer framstaellning av farmakologiskt aktiva pyrrolobensimidazoler.
ES2051885T3 (es) 4-(1h-imidazol-1-il)-benzamidas sustituidas como agentes antiarritmicos.
IT8547683A0 (it) Procedimento per la preparazione dicomposti 1,3-diossolan-4-metanolici otticamente attivi
NO166863C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 5-substituert-1,2-dihydro-3h-pyrrolo-(1,2-a)-pyrrol-1-carboxylsyrer ut fra deres tilsvarende nitriler.
IT8025159A0 (it) Preparato medicinale ad azione citostatica, nonche' derivati dell'acido isocianurico eprocedimento per la loro preparazione.
ES472847A1 (es) Procedimiento para la preparacion de la 2-bromoergosina y sus sales acidas de adicion
DE69501359D1 (de) Verwendung von Phosphatdiestern zur Behandlung von Erkrankungen der Retina
BG44379A3 (en) Method for preparing of 9- chlor- 1, 5- benzothiazepine derivatives
HUT42770A (en) Process for preparing novel pyrrolo-benzimidazole derivatives, pyrrolo -benzoxazole derivatives and pyrrolo-benzthiazole derivatives and pharmaceutical compositions comprising the same
CA2038025A1 (en) Optically active alkylenedioxybenzene derivatives and their use in therapy
ATE30582T1 (de) Ungesaettigte arylalkylammoniumsalze.
ES554311A0 (es) Un procedimiento para preparar derivados de piridina
NO171499C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 5,6-dihydro-4h-cyklo-penta(b)tiofen-6-karboksylsyre-derivater
NO903585L (no) Fremgangsmaate for fremstilling av terapeutisk aktive 1,3-oksaziner.
EP0118867A3 (de) Substituierte 4,10-Dihydro-10-oxothienobenzodiazepine, Methode zu ihrer Herstellung, Zwischenprodukte und ihre Anwendung als Arzneimittel
NO156866C (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktivt 17s, 17's-bisspartein og akseptable syreaddisjonssalter.
ATE155479T1 (de) Neue cytarabin-derivate, ihre herstellung und verwendung
ATE56360T1 (de) Zusammensetzung zur herstellung eines arzneimittels zur therapeutischen behandlung von hauttrauma.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee
EEFA Change of the company name