ATE70442T1 - Peroral anzuwendende zubereitung eines saeureempfindlichen wirkstoffes. - Google Patents

Peroral anzuwendende zubereitung eines saeureempfindlichen wirkstoffes.

Info

Publication number
ATE70442T1
ATE70442T1 AT89108492T AT89108492T ATE70442T1 AT E70442 T1 ATE70442 T1 AT E70442T1 AT 89108492 T AT89108492 T AT 89108492T AT 89108492 T AT89108492 T AT 89108492T AT E70442 T1 ATE70442 T1 AT E70442T1
Authority
AT
Austria
Prior art keywords
acid
active substance
sensitive active
layer
peroral preparation
Prior art date
Application number
AT89108492T
Other languages
English (en)
Inventor
Yasuharu Saeki
Noritoshi Koyama
Sumio Watanabe
Shigeru Aoki
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Application granted granted Critical
Publication of ATE70442T1 publication Critical patent/ATE70442T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2009Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Detergent Compositions (AREA)
AT89108492T 1988-05-18 1989-05-11 Peroral anzuwendende zubereitung eines saeureempfindlichen wirkstoffes. ATE70442T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP63121233A JPH0768125B2 (ja) 1988-05-18 1988-05-18 酸不安定化合物の内服用製剤
EP89108492A EP0342522B1 (de) 1988-05-18 1989-05-11 Peroral anzuwendende Zubereitung eines säureempfindlichen Wirkstoffes

Publications (1)

Publication Number Publication Date
ATE70442T1 true ATE70442T1 (de) 1992-01-15

Family

ID=14806208

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89108492T ATE70442T1 (de) 1988-05-18 1989-05-11 Peroral anzuwendende zubereitung eines saeureempfindlichen wirkstoffes.

Country Status (14)

Country Link
US (1) US5035899A (de)
EP (1) EP0342522B1 (de)
JP (1) JPH0768125B2 (de)
KR (1) KR910002641B1 (de)
AT (1) ATE70442T1 (de)
CA (1) CA1336958C (de)
DD (1) DD283771A5 (de)
DE (1) DE68900566D1 (de)
DK (1) DK174664B1 (de)
ES (1) ES2051919T3 (de)
FI (1) FI93422C (de)
GR (1) GR3003389T3 (de)
HU (1) HU203200B (de)
NO (1) NO178135C (de)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1246382B (it) * 1990-04-17 1994-11-18 Eurand Int Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon
YU48263B (sh) * 1991-06-17 1997-09-30 Byk Gulden Lomberg Chemische Fabrik Gmbh. Postupak za dobijanje farmaceutskog preparata na bazi pantoprazola
US6764697B1 (en) * 1991-06-27 2004-07-20 Alza Corporation System for delaying drug delivery up to seven hours
DE69327745T2 (de) * 1992-05-29 2000-09-21 Nikken Chemicals Co., Ltd. Tablette zur langsamen Freisetzung von Natriumvalproat
SE9302395D0 (sv) * 1993-07-09 1993-07-09 Ab Astra New pharmaceutical formulation
FI970058L (fi) * 1994-07-08 1997-01-07 Astra Ab Uusi suun kautta annettava farmaseuttinen valmiste, joka sisältää omepratsolin magnesiumsuolaa
ES2094694B1 (es) * 1995-02-01 1997-12-16 Esteve Quimica Sa Nueva formulacion farmaceuticamente estable de un compuesto de bencimidazol y su proceso de obtencion.
SE9500478D0 (sv) * 1995-02-09 1995-02-09 Astra Ab New pharmaceutical formulation and process
US5945124A (en) * 1995-07-05 1999-08-31 Byk Gulden Chemische Fabrik Gmbh Oral pharmaceutical composition with delayed release of active ingredient for pantoprazole
SE512835C2 (sv) * 1996-01-08 2000-05-22 Astrazeneca Ab Doseringsform innehållande en mångfald enheter alla inneslutande syralabil H+K+ATPas-hämmare
JPH09323926A (ja) * 1996-03-15 1997-12-16 Nikken Chem Co Ltd バルプロ酸ナトリウムの徐放性錠剤
US5891474A (en) 1997-01-29 1999-04-06 Poli Industria Chimica, S.P.A. Time-specific controlled release dosage formulations and method of preparing same
US5788987A (en) * 1997-01-29 1998-08-04 Poli Industria Chimica Spa Methods for treating early morning pathologies
GB9710800D0 (en) * 1997-05-23 1997-07-23 Cipla Limited Pharmaceutical composition and method of preparing it
US6296876B1 (en) 1997-10-06 2001-10-02 Isa Odidi Pharmaceutical formulations for acid labile substances
FR2774288B1 (fr) * 1998-01-30 2001-09-07 Ethypharm Sa Microgranules d'omeprazole gastroproteges, procede d'obtention et preparations pharmaceutiques
AU3967399A (en) * 1998-04-30 1999-11-16 Sepracor, Inc. S-rabeprazole compositions and methods
US6174902B1 (en) 1999-04-28 2001-01-16 Sepracor Inc. R-rabeprazole compositions and methods
FR2793688B1 (fr) 1999-05-21 2003-06-13 Ethypharm Lab Prod Ethiques Microgranules gastroproteges, procede d'obtention et preparations pharmaceutiques
SI1187601T1 (sl) 1999-06-07 2005-12-31 Altana Pharma Ag Novi pripravek in dajalna oblika, ki obsega kislinsko labilen inhibitor protonske crpalke
US6245913B1 (en) 1999-06-30 2001-06-12 Wockhardt Europe Limited Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole
ES2168043B1 (es) * 1999-09-13 2003-04-01 Esteve Labor Dr Forma farmaceutica solida oral de liberacion modificada que contiene un compuesto de bencimidazol labil en medio acido.
DE19959419A1 (de) 1999-12-09 2001-06-21 Ratiopharm Gmbh Stabile galenische Zubereitungen umfassend ein Benzimidazol und Verfahren zu ihrer Herstellung
WO2002026210A2 (en) * 2000-09-29 2002-04-04 Geneva Pharmaceuticals Inc. Proton pump inhibitor formulation
JP2002234842A (ja) * 2001-02-09 2002-08-23 Kyowa Yakuhin Kogyo Kk 内服腸溶性製剤
JP5005157B2 (ja) * 2001-03-13 2012-08-22 ペンウェスト ファーマシューティカルズ カンパニー 時間治療(chronotherapeutic)投与形態
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
US20050163846A1 (en) * 2001-11-21 2005-07-28 Eisai Co., Ltd. Preparation composition containing acid-unstable physiologically active compound, and process for producing same
DE10211289A1 (de) * 2002-03-14 2003-09-25 Basf Ag Kombination von Polyvinylacetat von wasserunlöslichen, säureunlöslichen oder alkaliunlöslichen Polymeren zur Hestellung von Filmüberzügen mit sehr kontrollierter Freisetzung und hoher Stabilität
US20030228363A1 (en) * 2002-06-07 2003-12-11 Patel Mahendra R. Stabilized pharmaceutical compositons containing benzimidazole compounds
US20040028737A1 (en) * 2002-08-12 2004-02-12 Kopran Research Laboratories Limited Enteric coated stable oral pharmaceutical composition of acid unstable drug and process for preparing the same
US20040146558A1 (en) * 2003-01-28 2004-07-29 Kyowa Pharmaceutical Co., Ltd. Oral enteric-coated preparation
JP2004231520A (ja) * 2003-01-28 2004-08-19 Nichiko Pharmaceutical Co Ltd 保存安定性及び溶出速度に優れた医薬組成物
CL2004000983A1 (es) 2003-05-08 2005-03-04 Altana Pharma Ag Composicion farmaceutica oral en forma de tableta que comprende a pantoprazol magnetico dihidratado, en donde la forma de tableta esta compuesto por un nucleo, una capa intermedia y una capa exterior; y uso de la composicion farmaceutica en ulceras y
PE20050150A1 (es) 2003-05-08 2005-03-22 Altana Pharma Ag Una forma de dosificacion que contiene (s)-pantoprazol como ingrediente activo
EP2112920B1 (de) 2003-06-26 2018-07-25 Intellipharmaceutics Corp. Protonenpumpeninhibitoren enthaltende kapseln, die verschieden aufgebaute untereinheiten zur verzögerten wirkstofffreisetzung enthalten
RU2375048C2 (ru) * 2003-07-17 2009-12-10 Д-Р Редди'С Лабораторис Инк. Фармацевтическая композиция с набухающим покрытием
US20050147663A1 (en) * 2003-07-17 2005-07-07 Mohan Mailatur S. Method of treatment for improved bioavailability
WO2005025544A1 (en) * 2003-09-11 2005-03-24 Glykon Technologies Group, Llc Enteric delivery of (-)-hydroxycitric acid
WO2005027878A1 (en) * 2003-09-19 2005-03-31 Penwest Pharmaceuticals Co. Delayed released dosage forms
CA2539182A1 (en) * 2003-09-19 2005-03-31 Penwest Pharmaceuticals Co. Chronotherapeutic dosage forms
US20070292498A1 (en) * 2003-11-05 2007-12-20 Warren Hall Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
CA2547398A1 (en) * 2003-11-28 2005-06-09 Ranbaxy Laboratories Limited Oral benzimidazole compositions comprising an active core, an optional separating layer and an enteric coating
WO2005065726A1 (en) * 2003-12-30 2005-07-21 Dr. Reddy's Laboratories Ltd. Pharmaceutical composition
AU2005225283B2 (en) * 2004-03-26 2008-09-18 Eisai R&D Management Co., Ltd. Controlled-release pharmaceutical composition and method for producing the same
CA2561700A1 (en) * 2004-04-16 2005-12-15 Santarus, Inc. Combination of proton pump inhibitor, buffering agent, and prokinetic agent
US8394409B2 (en) 2004-07-01 2013-03-12 Intellipharmaceutics Corp. Controlled extended drug release technology
US20060024362A1 (en) 2004-07-29 2006-02-02 Pawan Seth Composition comprising a benzimidazole and process for its manufacture
US10624858B2 (en) 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
NZ555693A (en) * 2004-12-27 2010-10-29 Eisai R&D Man Co Ltd Matrix type sustained-release preparation containing donepezil
US20060280789A1 (en) * 2004-12-27 2006-12-14 Eisai Research Institute Sustained release formulations
US20070129402A1 (en) * 2004-12-27 2007-06-07 Eisai Research Institute Sustained release formulations
US20060246003A1 (en) * 2004-12-27 2006-11-02 Eisai Co. Ltd. Composition containing anti-dementia drug
US20060160852A1 (en) * 2004-12-27 2006-07-20 Eisai Co. Ltd. Composition containing anti-dementia drug
US20090208575A1 (en) * 2005-01-03 2009-08-20 Lupin Limited Pharmaceutical Composition Of Acid Labile Substances
CN101375534B (zh) * 2005-06-29 2012-03-21 美国亚德诺半导体公司 用于音频设备的改进的充/放电控制电路
EP1930030A1 (de) * 2005-09-29 2008-06-11 Eisai R&D Management Co., Ltd. Puls-präparat mit verbesserten zerfallseigenschaften in vivo
US10064828B1 (en) 2005-12-23 2018-09-04 Intellipharmaceutics Corp. Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems
JP2009523784A (ja) * 2006-01-16 2009-06-25 ジュビラント・オルガノシス・リミテッド 酸不安定化合物の安定な医薬製剤およびその製造方法
US10960077B2 (en) 2006-05-12 2021-03-30 Intellipharmaceutics Corp. Abuse and alcohol resistant drug composition
CA2665226C (en) 2006-10-05 2014-05-13 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations
US20100105738A1 (en) * 2006-10-06 2010-04-29 Mitsuru Mizuno Extended release formulations of a proton pump inhibitor
EP2486910A3 (de) 2006-10-27 2012-08-22 The Curators Of The University Of Missouri Vorrichtung mit mehreren Kammern und Dispenser
CA2704826A1 (en) 2007-11-27 2009-06-04 Ohara Pharmaceutical Co., Ltd. Method for producing granulated preparation
SI22806A (sl) * 2008-06-23 2009-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nove kristalinične oblike natrijevega rabeprazola
CH699302B1 (de) * 2008-08-11 2012-03-15 Mepha Gmbh Orale pharmazeutische Formulierung für Omeprazol, enthaltend eine spezifische Trennschicht.
CA2736547C (en) 2008-09-09 2016-11-01 Pozen Inc. Method for delivering a pharmaceutical composition to patient in need thereof
US20100093747A1 (en) * 2008-10-10 2010-04-15 Erica Brook Goodhew Method of inducing negative chemotaxis
EA201290026A1 (ru) 2009-06-25 2012-07-30 Астразенека Аб Способ лечения пациента, имеющего риск развития язвы, связанной с приемом нестероидных противовоспалительных средств (nsaid)
KR20120093140A (ko) * 2009-06-25 2012-08-22 포젠 인크. 아스피린 치료를 필요로 하는 환자의 치료 방법
CN102805733B (zh) * 2011-06-01 2016-03-09 日东电工株式会社 颗粒制剂及其制造方法
EP2790696A1 (de) 2011-12-16 2014-10-22 Atopix Therapeutics Limited Kombination von crth2-antagonisten und einem protonenpumpenhemmer zur behandlung von eosinophiler ösophagitis
EP2797600A4 (de) 2011-12-28 2015-09-16 Pozen Inc Verbesserte zusammensetzungen und verfahren zur abgabe von omeprazol und acetylsalicylsäure
BR112015020836B1 (pt) * 2013-03-01 2022-09-20 Bpsi Holdings, Llc Revestimentos de filme de liberação retardada que contêm silicato de cálcio e substratos revestidos com os mesmos
JP6344678B2 (ja) * 2013-09-27 2018-06-20 キョーリンリメディオ株式会社 テルミサルタン含有製剤及びその製造方法
EP4598528A1 (de) 2022-10-04 2025-08-13 Arsenil Zabirnyk Hemmung der verkalkung der aortenklappe

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2189698A (en) * 1986-04-30 1987-11-04 Haessle Ab Coated omeprazole tablets
GB2189699A (en) * 1986-04-30 1987-11-04 Haessle Ab Coated acid-labile medicaments
FI90544C (fi) * 1986-11-13 1994-02-25 Eisai Co Ltd Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi

Also Published As

Publication number Publication date
NO891935L (no) 1989-11-20
NO178135C (no) 1996-01-31
NO178135B (no) 1995-10-23
KR910002641B1 (ko) 1991-04-27
CA1336958C (en) 1995-09-12
FI891650L (fi) 1989-11-19
HU203200B (en) 1991-06-28
GR3003389T3 (en) 1993-02-17
US5035899A (en) 1991-07-30
KR890016964A (ko) 1989-12-14
JPH01290628A (ja) 1989-11-22
JPH0768125B2 (ja) 1995-07-26
FI891650A0 (fi) 1989-04-06
DK239189D0 (da) 1989-05-17
NO891935D0 (no) 1989-05-12
HUT51896A (en) 1990-06-28
FI93422B (fi) 1994-12-30
ES2051919T3 (es) 1994-07-01
EP0342522B1 (de) 1991-12-18
EP0342522A1 (de) 1989-11-23
DK174664B1 (da) 2003-08-18
FI93422C (fi) 1995-04-10
DD283771A5 (de) 1990-10-24
DK239189A (da) 1989-11-19
DE68900566D1 (de) 1992-01-30

Similar Documents

Publication Publication Date Title
ATE70442T1 (de) Peroral anzuwendende zubereitung eines saeureempfindlichen wirkstoffes.
FI891163A0 (fi) Kontrollerat frigoerande farmaceutiskt preparat och foerfarande foer framstaellning av detta.
DK462585A (da) Diffusionsovertrukket polydepotpraeparat
DE68928034D1 (de) Protein mit zeitverabreichung
EE9700176A (et) Kuivpulbriinhalaatorites kasutatav pulber, selle valmistamismeetod, selles kasutatavad osakesed ja meetod nende valmistamiseks ning pulbri lisandi kasutamine
ES2151476T3 (es) Formulaciones de farmacos en aerosol.
ATE112961T1 (de) Cimetidin enthaltende arzneimittel.
MX9304975A (es) Una composicion en polvo para inhalacion y procedimiento para preparar la misma.
SE8304143L (sv) Perfluorokemisk emulsion for artificiellt blod
ES2045317T3 (es) Protesis.
DE69623801D1 (de) Wasserlöslicher film
DE69312708D1 (de) Beschichtete teilchen
AU3925389A (en) Transparent emulsion of pyrethroidal insecticide with a surface active agent and polar solvent
IT8621204A0 (it) Substrato e procedimento d'uso. dispositivo di rivestimento di
YU48708B (sh) Nosač obložen sa praškastim farmaceutskim preparatom, postupak za pripremu nosača i postupak za doziranje praškova za inhaliranje
CO4940359A1 (es) Composicion de maquillaje en base acuosa y metodo de preparacion
ATE89720T1 (de) Wasserdisperierbare gemfibrozilhaltige mittel.
DE69014090D1 (de) Wärmehärtendes Überzugsmittel und Herstellung eines pigmentierten Films.
BG104757A (en) Pellets having a core coated with a lipid lowering agent and a polymer
KR900002854A (ko) 기판표면에 얇은 유체막을 코우팅하는 방법과 장치
SE8901788L (sv) Sammansatta belaeggningar paa eldfasta substrat och belaeggningsfoerfarande
JPS5367706A (en) Method of cleaning and cleaning agent
DE69023241D1 (de) Ionophore enthaltende abgabevorrichtung.
MY103634A (en) Pellicle
SE8302034L (sv) Dibens(cd,f)indolderivat, deras framstellning och farmaceutiska kompositioner innehallande dessa

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time