ATE6499T1 - Verfahren zur optischen trennung von mischungen aus d- und l-2-(6-methoxy-2-naphthyl)propions[uren, das cinchonidinsalz der d-2-(6- methoxy-2-naphthyl)-propionsaeure und verfahren zu dessen herstellung. - Google Patents

Verfahren zur optischen trennung von mischungen aus d- und l-2-(6-methoxy-2-naphthyl)propions[uren, das cinchonidinsalz der d-2-(6- methoxy-2-naphthyl)-propionsaeure und verfahren zu dessen herstellung.

Info

Publication number
ATE6499T1
ATE6499T1 AT81105355T AT81105355T ATE6499T1 AT E6499 T1 ATE6499 T1 AT E6499T1 AT 81105355 T AT81105355 T AT 81105355T AT 81105355 T AT81105355 T AT 81105355T AT E6499 T1 ATE6499 T1 AT E6499T1
Authority
AT
Austria
Prior art keywords
naphthyl
methoxy
propionic acid
mixtures
production
Prior art date
Application number
AT81105355T
Other languages
English (en)
Inventor
Vincenzo Cannata
Graziono Zagnoni
Original Assignee
Alfa Farmaceutici S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Farmaceutici S.P.A. filed Critical Alfa Farmaceutici S.P.A.
Application granted granted Critical
Publication of ATE6499T1 publication Critical patent/ATE6499T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT81105355T 1980-07-30 1981-07-09 Verfahren zur optischen trennung von mischungen aus d- und l-2-(6-methoxy-2-naphthyl)propions[uren, das cinchonidinsalz der d-2-(6- methoxy-2-naphthyl)-propionsaeure und verfahren zu dessen herstellung. ATE6499T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT03492/80A IT1154663B (it) 1980-07-30 1980-07-30 Procedimento per la risoluzione in antipodi ottici di miscele di acidi d- e l-2-(6-metossi-2-naftil)-propionico
EP81105355A EP0044984B1 (de) 1980-07-30 1981-07-09 Verfahren zur optischen Trennung von Mischungen aus d- und l-2-(6-Methoxy-2-naphthyl)-propionsäuren, das Cinchonidinsalz der d-2-(6-Methoxy-2-naphthyl)-propionsäure und Verfahren zu dessen Herstellung

Publications (1)

Publication Number Publication Date
ATE6499T1 true ATE6499T1 (de) 1984-03-15

Family

ID=11108380

Family Applications (1)

Application Number Title Priority Date Filing Date
AT81105355T ATE6499T1 (de) 1980-07-30 1981-07-09 Verfahren zur optischen trennung von mischungen aus d- und l-2-(6-methoxy-2-naphthyl)propions[uren, das cinchonidinsalz der d-2-(6- methoxy-2-naphthyl)-propionsaeure und verfahren zu dessen herstellung.

Country Status (19)

Country Link
US (1) US4399284A (de)
EP (1) EP0044984B1 (de)
JP (2) JPS5764642A (de)
KR (1) KR860001228B1 (de)
AR (1) AR229029A1 (de)
AT (1) ATE6499T1 (de)
CA (1) CA1159833A (de)
DE (1) DE3162513D1 (de)
DK (2) DK337781A (de)
ES (1) ES504398A0 (de)
GR (1) GR74968B (de)
HU (2) HU185941B (de)
IE (1) IE51531B1 (de)
IL (1) IL63313A (de)
IT (1) IT1154663B (de)
NO (2) NO155005C (de)
PT (1) PT73452B (de)
YU (2) YU42576B (de)
ZA (1) ZA814679B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4520203A (en) * 1983-08-16 1985-05-28 American Home Products Corporation Resolution of (±)-1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid using cinchonine
IT1208109B (it) * 1983-11-23 1989-06-06 Alfa Chem Ital Procedimento per la risoluzione ottica di acidi arilpropionici
IT1196197B (it) * 1984-07-23 1988-11-10 Ravizza Spa Procedimento per la risoluzione dell'acido (+)(-) 2-(2'-(p-fluorofenil)--5'-benzossazolil)-propionico
IT1196332B (it) * 1984-11-20 1988-11-16 Secifarma Spa Procedimento per la risoluzione dell'acido (+)-6-metossi-alfa-metil-2-naftalen acetico nei corrispondenti antipodi ottici
IT1196334B (it) * 1984-11-22 1988-11-16 Alfa Chem Ital Processo per la risoluzione ottica di miscugli racemi di acidi alfanaftil-propionici
IT1203605B (it) * 1985-04-18 1989-02-15 Alfa Chem Ital Processo per la risoluzione ottica di miscigli racemi di acidi e naftilpropionici
US6313247B1 (en) 1996-06-05 2001-11-06 Wolfgang Lindner Cinchonan based chiral selectors for separation of stereoisomers
WO2012059797A1 (en) * 2010-11-04 2012-05-10 Lupin Limited Process for synthesis of (s) - pregabalin

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3904682A (en) * 1967-01-13 1975-09-09 Syntex Corp 2-(6{40 -Methoxy-2{40 -naphthyl)acetic acid
US3686183A (en) * 1969-03-24 1972-08-22 Syntex Corp Preparation of optical isomers of arylalkylacetic acids
US3658863A (en) * 1969-09-30 1972-04-25 Syntex Corp 6-methoxy-2-naphthyl copper(i)
US3658858A (en) * 1969-09-30 1972-04-25 Syntex Corp Di-(6-methoxy-2-naphthyl) cadmium
US3683015A (en) * 1970-11-04 1972-08-08 Norman H Dyson Resolution of 2-(6-methoxy-2-naphthyl)propionic
US3988365A (en) * 1973-04-11 1976-10-26 Syntex Corporation Resolution of 2-(6-methoxy-2-napthyl)propionic acid
CH641432A5 (de) * 1978-07-19 1984-02-29 Syntex Pharma Int Verfahren zur aufspaltung von racemischer 6-methoxy-alpha-methyl-2-naphthalinessigsaeure in die optischen antipoden.

Also Published As

Publication number Publication date
IL63313A (en) 1985-01-31
NO812593L (no) 1982-02-01
IE51531B1 (en) 1987-01-07
CA1159833A (en) 1984-01-03
JPS5764642A (en) 1982-04-19
ES8207495A1 (es) 1982-10-01
IE811724L (en) 1982-01-30
NO854414L (no) 1982-02-01
IT8003492A0 (it) 1980-07-30
YU129083A (en) 1984-06-30
NO155806B (no) 1987-02-23
DK255489D0 (da) 1989-05-25
KR830006141A (ko) 1983-09-17
IT1154663B (it) 1987-01-21
ZA814679B (en) 1982-07-28
DK337781A (da) 1982-01-31
JPS62174037A (ja) 1987-07-30
DE3162513D1 (en) 1984-04-12
GR74968B (de) 1984-07-12
US4399284A (en) 1983-08-16
AR229029A1 (es) 1983-05-31
NO155005C (no) 1987-01-28
YU186981A (en) 1984-04-30
NO155005B (no) 1986-10-20
PT73452A (en) 1981-08-01
PT73452B (en) 1982-07-30
DK255489A (da) 1989-05-25
HU185941B (en) 1985-04-28
ES504398A0 (es) 1982-10-01
EP0044984B1 (de) 1984-03-07
JPS6351135B2 (de) 1988-10-13
KR860001228B1 (ko) 1986-08-30
HU187975B (en) 1986-03-28
YU42576B (en) 1988-10-31
EP0044984A1 (de) 1982-02-03
IL63313A0 (en) 1981-10-30

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee