IL63313A - Process for the optical resolution of mixtures of d-and 1-2-(6-methoxy-2-naphthyl)-propionic acids with cinchonidine - Google Patents

Process for the optical resolution of mixtures of d-and 1-2-(6-methoxy-2-naphthyl)-propionic acids with cinchonidine

Info

Publication number
IL63313A
IL63313A IL63313A IL6331381A IL63313A IL 63313 A IL63313 A IL 63313A IL 63313 A IL63313 A IL 63313A IL 6331381 A IL6331381 A IL 6331381A IL 63313 A IL63313 A IL 63313A
Authority
IL
Israel
Prior art keywords
cinchonidine
naphthyl
methoxy
mixtures
optical resolution
Prior art date
Application number
IL63313A
Other languages
English (en)
Other versions
IL63313A0 (en
Original Assignee
Alfa Farmaceutici Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Farmaceutici Spa filed Critical Alfa Farmaceutici Spa
Publication of IL63313A0 publication Critical patent/IL63313A0/xx
Publication of IL63313A publication Critical patent/IL63313A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL63313A 1980-07-30 1981-07-15 Process for the optical resolution of mixtures of d-and 1-2-(6-methoxy-2-naphthyl)-propionic acids with cinchonidine IL63313A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT03492/80A IT1154663B (it) 1980-07-30 1980-07-30 Procedimento per la risoluzione in antipodi ottici di miscele di acidi d- e l-2-(6-metossi-2-naftil)-propionico

Publications (2)

Publication Number Publication Date
IL63313A0 IL63313A0 (en) 1981-10-30
IL63313A true IL63313A (en) 1985-01-31

Family

ID=11108380

Family Applications (1)

Application Number Title Priority Date Filing Date
IL63313A IL63313A (en) 1980-07-30 1981-07-15 Process for the optical resolution of mixtures of d-and 1-2-(6-methoxy-2-naphthyl)-propionic acids with cinchonidine

Country Status (19)

Country Link
US (1) US4399284A (de)
EP (1) EP0044984B1 (de)
JP (2) JPS5764642A (de)
KR (1) KR860001228B1 (de)
AR (1) AR229029A1 (de)
AT (1) ATE6499T1 (de)
CA (1) CA1159833A (de)
DE (1) DE3162513D1 (de)
DK (2) DK337781A (de)
ES (1) ES504398A0 (de)
GR (1) GR74968B (de)
HU (2) HU187975B (de)
IE (1) IE51531B1 (de)
IL (1) IL63313A (de)
IT (1) IT1154663B (de)
NO (2) NO155005C (de)
PT (1) PT73452B (de)
YU (2) YU42576B (de)
ZA (1) ZA814679B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4520203A (en) * 1983-08-16 1985-05-28 American Home Products Corporation Resolution of (±)-1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid using cinchonine
IT1208109B (it) * 1983-11-23 1989-06-06 Alfa Chem Ital Procedimento per la risoluzione ottica di acidi arilpropionici
IT1196197B (it) * 1984-07-23 1988-11-10 Ravizza Spa Procedimento per la risoluzione dell'acido (+)(-) 2-(2'-(p-fluorofenil)--5'-benzossazolil)-propionico
IT1196332B (it) * 1984-11-20 1988-11-16 Secifarma Spa Procedimento per la risoluzione dell'acido (+)-6-metossi-alfa-metil-2-naftalen acetico nei corrispondenti antipodi ottici
IT1196334B (it) * 1984-11-22 1988-11-16 Alfa Chem Ital Processo per la risoluzione ottica di miscugli racemi di acidi alfanaftil-propionici
IT1203605B (it) * 1985-04-18 1989-02-15 Alfa Chem Ital Processo per la risoluzione ottica di miscigli racemi di acidi e naftilpropionici
US6313247B1 (en) 1996-06-05 2001-11-06 Wolfgang Lindner Cinchonan based chiral selectors for separation of stereoisomers
WO2012059797A1 (en) * 2010-11-04 2012-05-10 Lupin Limited Process for synthesis of (s) - pregabalin

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3904682A (en) * 1967-01-13 1975-09-09 Syntex Corp 2-(6{40 -Methoxy-2{40 -naphthyl)acetic acid
US3686183A (en) * 1969-03-24 1972-08-22 Syntex Corp Preparation of optical isomers of arylalkylacetic acids
US3658863A (en) * 1969-09-30 1972-04-25 Syntex Corp 6-methoxy-2-naphthyl copper(i)
US3658858A (en) * 1969-09-30 1972-04-25 Syntex Corp Di-(6-methoxy-2-naphthyl) cadmium
US3683015A (en) * 1970-11-04 1972-08-08 Norman H Dyson Resolution of 2-(6-methoxy-2-naphthyl)propionic
US3988365A (en) * 1973-04-11 1976-10-26 Syntex Corporation Resolution of 2-(6-methoxy-2-napthyl)propionic acid
CH641432A5 (de) * 1978-07-19 1984-02-29 Syntex Pharma Int Verfahren zur aufspaltung von racemischer 6-methoxy-alpha-methyl-2-naphthalinessigsaeure in die optischen antipoden.

Also Published As

Publication number Publication date
ES8207495A1 (es) 1982-10-01
AR229029A1 (es) 1983-05-31
KR830006141A (ko) 1983-09-17
ES504398A0 (es) 1982-10-01
NO155005C (no) 1987-01-28
DE3162513D1 (en) 1984-04-12
ZA814679B (en) 1982-07-28
ATE6499T1 (de) 1984-03-15
JPS6351135B2 (de) 1988-10-13
NO854414L (no) 1982-02-01
EP0044984A1 (de) 1982-02-03
CA1159833A (en) 1984-01-03
HU185941B (en) 1985-04-28
DK255489D0 (da) 1989-05-25
DK255489A (da) 1989-05-25
IE51531B1 (en) 1987-01-07
GR74968B (de) 1984-07-12
KR860001228B1 (ko) 1986-08-30
PT73452B (en) 1982-07-30
YU42576B (en) 1988-10-31
US4399284A (en) 1983-08-16
YU129083A (en) 1984-06-30
JPS5764642A (en) 1982-04-19
NO155005B (no) 1986-10-20
EP0044984B1 (de) 1984-03-07
IL63313A0 (en) 1981-10-30
JPS62174037A (ja) 1987-07-30
HU187975B (en) 1986-03-28
PT73452A (en) 1981-08-01
YU186981A (en) 1984-04-30
IT8003492A0 (it) 1980-07-30
IT1154663B (it) 1987-01-21
NO155806B (no) 1987-02-23
DK337781A (da) 1982-01-31
NO812593L (no) 1982-02-01
IE811724L (en) 1982-01-30

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