ATE62672T1 - Pyrrole-3-carboxylate cardiotonische mittel. - Google Patents
Pyrrole-3-carboxylate cardiotonische mittel.Info
- Publication number
- ATE62672T1 ATE62672T1 AT86101397T AT86101397T ATE62672T1 AT E62672 T1 ATE62672 T1 AT E62672T1 AT 86101397 T AT86101397 T AT 86101397T AT 86101397 T AT86101397 T AT 86101397T AT E62672 T1 ATE62672 T1 AT E62672T1
- Authority
- AT
- Austria
- Prior art keywords
- pyrrole
- carboxylate
- lower alkyl
- hydrogen
- cardiotonic agent
- Prior art date
Links
- DOYOPBSXEIZLRE-UHFFFAOYSA-N pyrrole-3-carboxylic acid Chemical compound OC(=O)C=1C=CNC=1 DOYOPBSXEIZLRE-UHFFFAOYSA-N 0.000 title abstract 2
- 239000000496 cardiotonic agent Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- -1 nitro, hydroxy, carboxy Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000005344 pyridylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000005301 thienylmethyl group Chemical group [H]C1=C([H])C([H])=C(S1)C([H])([H])* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/699,607 US4560700A (en) | 1985-02-08 | 1985-02-08 | Pyrrole-3-carboxylate cardiotonic agents |
| EP86101397A EP0190712B1 (de) | 1985-02-08 | 1986-02-04 | Pyrrole-3-Carboxylate Cardiotonische Mittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE62672T1 true ATE62672T1 (de) | 1991-05-15 |
Family
ID=24810073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT86101397T ATE62672T1 (de) | 1985-02-08 | 1986-02-04 | Pyrrole-3-carboxylate cardiotonische mittel. |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4560700A (de) |
| EP (1) | EP0190712B1 (de) |
| JP (1) | JPS61183222A (de) |
| AT (1) | ATE62672T1 (de) |
| DE (1) | DE3678731D1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06104658B2 (ja) * | 1988-06-23 | 1994-12-21 | 三菱化成株式会社 | ピロールカルボン酸誘導体 |
| CA1339784C (en) * | 1988-06-23 | 1998-03-31 | Shinya Inoue | Pyrrolecarboxylic acid derivatives |
| CA2032421A1 (en) * | 1989-12-20 | 1991-06-21 | Mitsubishi Chemical Corporation | Pyrrolealdehyde derivative |
| JPH0637390B2 (ja) * | 1989-12-21 | 1994-05-18 | 三菱化成株式会社 | 高脂血症治療剤 |
| KR100460414B1 (ko) * | 1995-11-02 | 2005-01-26 | 다이이찌 산토리 파마 가부시키가이샤 | 1-치환피롤-3-카르복실산유도체의제조방법 |
| DE69630184T2 (de) * | 1995-11-02 | 2004-08-12 | Daiichi Suntory Pharma Co., Ltd. | Verfahren zur Herstellung von 1-substituierten Pyrrol-3-carbonsäure-Derivaten |
| DE19858352A1 (de) * | 1998-12-17 | 2000-06-21 | Basf Ag | Verfahren zum Herstellen von 2,4-Dimethyl-3,5-bis-alkoxycarbonyl-pyrrol |
| HU228979B1 (en) * | 2000-02-15 | 2013-07-29 | Sugen | Pyrrole substituted 2-indolinone protein kinase inhibitors |
| AR042586A1 (es) | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
| WO2003031438A1 (en) | 2001-10-10 | 2003-04-17 | Sugen, Inc. | 3-[4-(substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2-indolinone derivatives as kinase inhibitors |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3328421A (en) * | 1964-07-09 | 1967-06-27 | Fujisawa Pharmaceutical Co | 3-phenylpyrrole derivatives |
| IT1131959B (it) * | 1979-08-09 | 1986-06-25 | Hoffmann La Roche | Derivati pirrolidinici |
| US4282242A (en) * | 1980-03-07 | 1981-08-04 | Pfizer Inc. | Antidiabetic pyrrolecarboxylic acids |
-
1985
- 1985-02-08 US US06/699,607 patent/US4560700A/en not_active Expired - Fee Related
-
1986
- 1986-02-04 DE DE8686101397T patent/DE3678731D1/de not_active Expired - Fee Related
- 1986-02-04 EP EP86101397A patent/EP0190712B1/de not_active Expired - Lifetime
- 1986-02-04 AT AT86101397T patent/ATE62672T1/de active
- 1986-02-06 JP JP61023065A patent/JPS61183222A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE3678731D1 (de) | 1991-05-23 |
| JPS61183222A (ja) | 1986-08-15 |
| US4560700A (en) | 1985-12-24 |
| EP0190712A3 (en) | 1988-03-02 |
| EP0190712B1 (de) | 1991-04-17 |
| EP0190712A2 (de) | 1986-08-13 |
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