ATE62672T1 - Pyrrole-3-carboxylate cardiotonische mittel. - Google Patents

Pyrrole-3-carboxylate cardiotonische mittel.

Info

Publication number
ATE62672T1
ATE62672T1 AT86101397T AT86101397T ATE62672T1 AT E62672 T1 ATE62672 T1 AT E62672T1 AT 86101397 T AT86101397 T AT 86101397T AT 86101397 T AT86101397 T AT 86101397T AT E62672 T1 ATE62672 T1 AT E62672T1
Authority
AT
Austria
Prior art keywords
pyrrole
carboxylate
lower alkyl
hydrogen
cardiotonic agent
Prior art date
Application number
AT86101397T
Other languages
English (en)
Inventor
Richard A Schnettler
J Martin Grisar
Richard C Dage
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Application granted granted Critical
Publication of ATE62672T1 publication Critical patent/ATE62672T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
AT86101397T 1985-02-08 1986-02-04 Pyrrole-3-carboxylate cardiotonische mittel. ATE62672T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/699,607 US4560700A (en) 1985-02-08 1985-02-08 Pyrrole-3-carboxylate cardiotonic agents
EP86101397A EP0190712B1 (de) 1985-02-08 1986-02-04 Pyrrole-3-Carboxylate Cardiotonische Mittel

Publications (1)

Publication Number Publication Date
ATE62672T1 true ATE62672T1 (de) 1991-05-15

Family

ID=24810073

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86101397T ATE62672T1 (de) 1985-02-08 1986-02-04 Pyrrole-3-carboxylate cardiotonische mittel.

Country Status (5)

Country Link
US (1) US4560700A (de)
EP (1) EP0190712B1 (de)
JP (1) JPS61183222A (de)
AT (1) ATE62672T1 (de)
DE (1) DE3678731D1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1339784C (en) * 1988-06-23 1998-03-31 Shinya Inoue Pyrrolecarboxylic acid derivatives
JPH06104658B2 (ja) * 1988-06-23 1994-12-21 三菱化成株式会社 ピロールカルボン酸誘導体
CA2032421A1 (en) * 1989-12-20 1991-06-21 Mitsubishi Chemical Corporation Pyrrolealdehyde derivative
JPH0637390B2 (ja) * 1989-12-21 1994-05-18 三菱化成株式会社 高脂血症治療剤
KR100460414B1 (ko) * 1995-11-02 2005-01-26 다이이찌 산토리 파마 가부시키가이샤 1-치환피롤-3-카르복실산유도체의제조방법
JPH09183765A (ja) * 1995-11-02 1997-07-15 Suntory Ltd １位置換ピロール−３−カルボン酸誘導体の製造法
DE19858352A1 (de) * 1998-12-17 2000-06-21 Basf Ag Verfahren zum Herstellen von 2,4-Dimethyl-3,5-bis-alkoxycarbonyl-pyrrol
ME00415B (me) * 2000-02-15 2011-10-10 Pharmacia & Upjohn Co Llc Pirol supstituisani 2-indol protein kinazni inhibitori
AR042586A1 (es) 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
EP1434774A1 (de) 2001-10-10 2004-07-07 Sugen, Inc. 3-(4-substituierte heterocyclyl)-pyrrol-2-ylmethylidene)-2-indolinone derivate als protein-kinase-inhibitoren

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3328421A (en) * 1964-07-09 1967-06-27 Fujisawa Pharmaceutical Co 3-phenylpyrrole derivatives
NL8004025A (nl) * 1979-08-09 1981-02-11 Hoffmann La Roche Pyrrolidinederivaten en werkwijze voor het bereiden daarvan alsmede geneesmiddel.
US4282242A (en) * 1980-03-07 1981-08-04 Pfizer Inc. Antidiabetic pyrrolecarboxylic acids

Also Published As

Publication number Publication date
EP0190712B1 (de) 1991-04-17
EP0190712A2 (de) 1986-08-13
JPS61183222A (ja) 1986-08-15
US4560700A (en) 1985-12-24
DE3678731D1 (de) 1991-05-23
EP0190712A3 (en) 1988-03-02

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