ATE555790T1 - Kombinationen aus einem vegf-rezeptor-hemmer und einem penetrationsverstärker - Google Patents
Kombinationen aus einem vegf-rezeptor-hemmer und einem penetrationsverstärkerInfo
- Publication number
- ATE555790T1 ATE555790T1 AT06791989T AT06791989T ATE555790T1 AT E555790 T1 ATE555790 T1 AT E555790T1 AT 06791989 T AT06791989 T AT 06791989T AT 06791989 T AT06791989 T AT 06791989T AT E555790 T1 ATE555790 T1 AT E555790T1
- Authority
- AT
- Austria
- Prior art keywords
- combinations
- penetration enhancer
- vegf receptor
- receptor inhibitor
- inhibitor
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0518672A GB0518672D0 (en) | 2005-09-13 | 2005-09-13 | Organic compounds |
| GB0518671A GB0518671D0 (en) | 2005-09-13 | 2005-09-13 | Organic compounds |
| PCT/EP2006/008857 WO2007031265A2 (en) | 2005-09-13 | 2006-09-12 | Combinations comprising a vegf receptor inhibitor and a penetration enhancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE555790T1 true ATE555790T1 (de) | 2012-05-15 |
Family
ID=37663150
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06791989T ATE555790T1 (de) | 2005-09-13 | 2006-09-12 | Kombinationen aus einem vegf-rezeptor-hemmer und einem penetrationsverstärker |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US20080306058A1 (de) |
| EP (1) | EP1945217B1 (de) |
| JP (1) | JP2009507871A (de) |
| KR (1) | KR20080058376A (de) |
| AR (1) | AR056194A1 (de) |
| AT (1) | ATE555790T1 (de) |
| AU (1) | AU2006291526B2 (de) |
| BR (1) | BRPI0615881A2 (de) |
| CA (1) | CA2621399A1 (de) |
| EC (1) | ECSP088259A (de) |
| GT (1) | GT200600411A (de) |
| IL (1) | IL189984A0 (de) |
| MA (1) | MA29788B1 (de) |
| MY (1) | MY145751A (de) |
| NO (1) | NO20081807L (de) |
| NZ (1) | NZ566474A (de) |
| PE (1) | PE20070457A1 (de) |
| RU (1) | RU2424804C2 (de) |
| SA (1) | SA06270315B1 (de) |
| SG (1) | SG165371A1 (de) |
| TN (1) | TNSN08112A1 (de) |
| TW (1) | TWI325321B (de) |
| WO (1) | WO2007031265A2 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0605120D0 (en) | 2006-03-14 | 2006-04-26 | Novartis Ag | Organic Compounds |
| CN101687801B (zh) | 2007-04-17 | 2012-10-03 | 诺瓦提斯公司 | 用作癌症治疗的萘甲酸酰胺的醚 |
| WO2009026408A1 (en) * | 2007-08-22 | 2009-02-26 | Allergan, Inc. | Therapeutic quinoline and naphthalene derivatives |
| JO3265B1 (ar) | 2008-12-09 | 2018-09-16 | Novartis Ag | مثبطات بيريديلوكسى اندولات vegf-r2 واستخدامها لعلاج المرض |
| US20110112121A1 (en) | 2009-07-06 | 2011-05-12 | Joerg Berghausen | Pharmaceutical Compositions and Solid Forms |
| WO2012094451A1 (en) * | 2011-01-06 | 2012-07-12 | Beta Pharma Canada Inc. | Novel ureas for the treatment and prevention of cancer |
| EP2786752B1 (de) * | 2011-12-01 | 2019-06-12 | Teikoku Seiyaku Co., Ltd. | Ropinirolhaltige heftpflaster |
| US10149834B2 (en) | 2011-12-01 | 2018-12-11 | Teikoku Seiyaku Co., Ltd. | Ropinirole-containing adhesive patch |
| CN104334543B (zh) * | 2013-04-09 | 2017-08-25 | 广州慧柏瑞生物医药科技有限公司 | 抗新生血管的化合物、其中间体及其用途 |
| CN106414402A (zh) * | 2013-11-01 | 2017-02-15 | 宇部兴产株式会社 | 丙烯酰(氧基或氨基)五氟硫烷基苯化合物、其药学可接受的盐及其前药 |
| CN104860885B (zh) * | 2014-02-24 | 2017-11-17 | 中国科学院上海药物研究所 | 萘酰胺类化合物、其制备方法和用途 |
| JO3705B1 (ar) * | 2014-11-26 | 2021-01-31 | Bayer Pharma AG | إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية |
| CN107098884A (zh) * | 2016-02-19 | 2017-08-29 | 中国科学院上海药物研究所 | 一类取代的氨基吡啶类化合物及其制备和用途 |
| JP2023515630A (ja) * | 2020-02-28 | 2023-04-13 | 上▲海▼▲潤▼石医▲薬▼科技有限公司 | Ｃｓｆ－１ｒキナーゼ阻害剤の使用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0148748B1 (ko) * | 1988-09-16 | 1998-08-17 | 장 크라메르, 한스 루돌프 하우스 | 사이클로스포린을 함유하는 약학조성물 |
| US5879690A (en) * | 1995-09-07 | 1999-03-09 | Perricone; Nicholas V. | Topical administration of catecholamines and related compounds to subcutaneous muscle tissue using percutaneous penetration enhancers |
| US6355657B1 (en) * | 1998-12-30 | 2002-03-12 | Atrix Laboratories, Inc. | System for percutaneous delivery of opioid analgesics |
| EP1212318B1 (de) * | 1999-08-27 | 2006-01-25 | Boehringer Ingelheim Pharma GmbH & Co.KG | Substituierte indolinone als tyrosinkinase inhibitoren |
| ATE415396T1 (de) * | 2000-09-20 | 2008-12-15 | Ortho Mcneil Pharm Inc | Pyrazine derivate als tyrosin kinase modulatoren |
| ATE399766T1 (de) * | 2000-10-20 | 2008-07-15 | Eisai R&D Man Co Ltd | Stickstoff enthaltende aromatische heterozyklen |
| SI1478358T1 (sl) * | 2002-02-11 | 2013-09-30 | Bayer Healthcare Llc | Sorafenib tozilat za zdravljenje bolezni, značilnih po abnormalni angiogenezi |
| BR0311172A (pt) * | 2002-05-13 | 2005-04-26 | Children S Hospital Los Angele | Tratamento e prevenção de formação de cicatriz anormal em quelóides e outras lesões ou ferimentos internos ou cutâneos |
| PE20040522A1 (es) | 2002-05-29 | 2004-09-28 | Novartis Ag | Derivados de diarilurea dependientes de la cinasa de proteina |
| EP1522540A4 (de) * | 2002-08-30 | 2011-08-10 | Eisai R&D Man Co Ltd | Azaarenderivate |
| WO2004103159A2 (en) * | 2003-05-14 | 2004-12-02 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for modulating endometrium |
| BRPI0414011A (pt) * | 2003-08-29 | 2006-10-24 | Pfizer | naftalencarboxamidas e seus derivados úteis como novos agentes antiangiogênicos |
| WO2005069906A2 (en) * | 2004-01-16 | 2005-08-04 | Yale University | Methods and compositions relating to vascular endothelial growth factor and th2 mediated inflammatory diseases |
| AU2005206571B8 (en) * | 2004-01-23 | 2010-09-02 | Amgen Inc. | Compounds and methods of use |
| EP1568368A1 (de) * | 2004-02-26 | 2005-08-31 | Schering Aktiengesellschaft | Pharmazeutische Kombination enthaltend einen CDK Inhibitoren und einen VEGF Rezeptor Inhibitoren |
| PE20060664A1 (es) * | 2004-09-15 | 2006-08-04 | Novartis Ag | Amidas biciclicas como inhibidores de cinasa |
-
2006
- 2006-09-08 GT GT200600411A patent/GT200600411A/es unknown
- 2006-09-10 SA SA6270315A patent/SA06270315B1/ar unknown
- 2006-09-11 AR ARP060103941A patent/AR056194A1/es not_active Application Discontinuation
- 2006-09-12 SG SG201006609-0A patent/SG165371A1/en unknown
- 2006-09-12 TW TW095133706A patent/TWI325321B/zh not_active IP Right Cessation
- 2006-09-12 RU RU2008114048/15A patent/RU2424804C2/ru not_active IP Right Cessation
- 2006-09-12 KR KR1020087008666A patent/KR20080058376A/ko not_active Application Discontinuation
- 2006-09-12 EP EP06791989A patent/EP1945217B1/de not_active Not-in-force
- 2006-09-12 NZ NZ566474A patent/NZ566474A/en not_active IP Right Cessation
- 2006-09-12 CA CA002621399A patent/CA2621399A1/en not_active Abandoned
- 2006-09-12 AU AU2006291526A patent/AU2006291526B2/en not_active Ceased
- 2006-09-12 AT AT06791989T patent/ATE555790T1/de active
- 2006-09-12 PE PE2006001109A patent/PE20070457A1/es not_active Application Discontinuation
- 2006-09-12 JP JP2008530401A patent/JP2009507871A/ja active Pending
- 2006-09-12 MY MYPI20080558A patent/MY145751A/en unknown
- 2006-09-12 BR BRPI0615881-1A patent/BRPI0615881A2/pt not_active IP Right Cessation
- 2006-09-12 US US12/066,726 patent/US20080306058A1/en not_active Abandoned
- 2006-09-12 WO PCT/EP2006/008857 patent/WO2007031265A2/en active Application Filing
-
2008
- 2008-03-06 IL IL189984A patent/IL189984A0/en unknown
- 2008-03-11 EC EC2008008259A patent/ECSP088259A/es unknown
- 2008-03-12 TN TNP2008000112A patent/TNSN08112A1/en unknown
- 2008-03-17 MA MA30759A patent/MA29788B1/fr unknown
- 2008-04-14 NO NO20081807A patent/NO20081807L/no not_active Application Discontinuation
-
2012
- 2012-03-15 US US13/420,993 patent/US20120172386A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1945217A2 (de) | 2008-07-23 |
| AU2006291526B2 (en) | 2010-07-29 |
| NO20081807L (no) | 2008-05-16 |
| RU2424804C2 (ru) | 2011-07-27 |
| CA2621399A1 (en) | 2007-03-22 |
| MY145751A (en) | 2012-03-30 |
| SG165371A1 (en) | 2010-10-28 |
| TNSN08112A1 (en) | 2009-07-14 |
| AU2006291526A1 (en) | 2007-03-22 |
| WO2007031265A2 (en) | 2007-03-22 |
| IL189984A0 (en) | 2008-11-03 |
| TWI325321B (en) | 2010-06-01 |
| RU2008114048A (ru) | 2009-10-20 |
| PE20070457A1 (es) | 2007-06-06 |
| ECSP088259A (es) | 2008-04-28 |
| NZ566474A (en) | 2011-05-27 |
| JP2009507871A (ja) | 2009-02-26 |
| US20120172386A1 (en) | 2012-07-05 |
| KR20080058376A (ko) | 2008-06-25 |
| SA06270315B1 (ar) | 2010-12-21 |
| TW200744600A (en) | 2007-12-16 |
| MA29788B1 (fr) | 2008-09-01 |
| US20080306058A1 (en) | 2008-12-11 |
| EP1945217B1 (de) | 2012-05-02 |
| BRPI0615881A2 (pt) | 2011-05-31 |
| GT200600411A (es) | 2007-05-21 |
| WO2007031265A3 (en) | 2007-07-12 |
| AR056194A1 (es) | 2007-09-26 |
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