ATE555114T1 - Verfahren zur herstellung von mirtazapin - Google Patents
Verfahren zur herstellung von mirtazapinInfo
- Publication number
- ATE555114T1 ATE555114T1 AT08722032T AT08722032T ATE555114T1 AT E555114 T1 ATE555114 T1 AT E555114T1 AT 08722032 T AT08722032 T AT 08722032T AT 08722032 T AT08722032 T AT 08722032T AT E555114 T1 ATE555114 T1 AT E555114T1
- Authority
- AT
- Austria
- Prior art keywords
- mirtazapine
- phenylpiperazin
- cyclization
- propanol
- pyridine
- Prior art date
Links
- RONZAEMNMFQXRA-UHFFFAOYSA-N mirtazapine Chemical compound C1C2=CC=CN=C2N2CCN(C)CC2C2=CC=CC=C21 RONZAEMNMFQXRA-UHFFFAOYSA-N 0.000 title abstract 6
- 229960001785 mirtazapine Drugs 0.000 title abstract 6
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- PYZPABZGIRHQTA-UHFFFAOYSA-N [2-(4-methyl-2-phenylpiperazin-1-yl)pyridin-3-yl]methanol Chemical compound C1N(C)CCN(C=2C(=CC=CN=2)CO)C1C1=CC=CC=C1 PYZPABZGIRHQTA-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 abstract 2
- 239000011541 reaction mixture Substances 0.000 abstract 2
- 238000007363 ring formation reaction Methods 0.000 abstract 2
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 2
- 238000010790 dilution Methods 0.000 abstract 1
- 239000012895 dilution Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007075573A JP5192707B2 (ja) | 2007-03-22 | 2007-03-22 | ミルタザピンの製造方法 |
| PCT/JP2008/054628 WO2008114691A1 (ja) | 2007-03-22 | 2008-03-13 | ミルタザピンの製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE555114T1 true ATE555114T1 (de) | 2012-05-15 |
Family
ID=39765800
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08722032T ATE555114T1 (de) | 2007-03-22 | 2008-03-13 | Verfahren zur herstellung von mirtazapin |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8173804B2 (de) |
| EP (1) | EP2135870B1 (de) |
| JP (1) | JP5192707B2 (de) |
| KR (1) | KR101418620B1 (de) |
| CN (1) | CN101541798B (de) |
| AT (1) | ATE555114T1 (de) |
| AU (1) | AU2008227637B2 (de) |
| BR (1) | BRPI0805835A2 (de) |
| CA (1) | CA2664286A1 (de) |
| DK (1) | DK2135870T3 (de) |
| ES (1) | ES2386165T3 (de) |
| IL (1) | IL197572A (de) |
| PL (1) | PL2135870T3 (de) |
| PT (1) | PT2135870E (de) |
| WO (1) | WO2008114691A1 (de) |
| ZA (1) | ZA200901559B (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP20211040T1 (hr) | 2015-02-27 | 2021-10-01 | Dechra Limited | Poticanje apetita, upravljanje gubitkom težine, i liječenje anoreksije kod pasa i mačaka |
| JP6452575B2 (ja) * | 2015-08-19 | 2019-01-16 | 株式会社トクヤマ | ミルタザピンの製造方法 |
| JP6571497B2 (ja) * | 2015-11-13 | 2019-09-04 | 株式会社トクヤマ | ミルタザピンの製造方法 |
| JP2017088564A (ja) * | 2015-11-13 | 2017-05-25 | 株式会社トクヤマ | ミルタザピンの製造方法 |
| JP7018840B2 (ja) * | 2018-07-04 | 2022-02-14 | 住友化学株式会社 | フェニルピペラジンピリジンメチルアセテートの製造方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL189199C (nl) | 1975-04-05 | 1993-02-01 | Akzo Nv | Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten. |
| KR20020019902A (ko) | 1999-04-19 | 2002-03-13 | 추후보정 | 피페라진 고리 함유 화합물의 신규한 합성법 및 결정화법 |
| US6545149B2 (en) | 1999-04-19 | 2003-04-08 | Teva Pharmaceutical Industries Ltd. | Synthesis and crystallization of piperazine ring-containing compounds |
| WO2001038329A1 (en) | 1999-11-24 | 2001-05-31 | Sumika Fine Chemicals Co., Ltd. | Anhydrous mirtazapine crystals and process for producing the same |
| US6660730B2 (en) | 2000-11-27 | 2003-12-09 | Sumika Fine Chemicals Co., Ltd. | Anhydrous mirtazapine and process for preparing the same |
| US6434049B1 (en) * | 2000-12-29 | 2002-08-13 | Intel Corporation | Sample and hold voltage reference source |
| UA83666C2 (ru) | 2003-07-10 | 2008-08-11 | Н.В. Органон | Способ получения энантиомерно чистого миртазапина |
-
2007
- 2007-03-22 JP JP2007075573A patent/JP5192707B2/ja not_active Expired - Fee Related
-
2008
- 2008-03-13 CN CN2008800007408A patent/CN101541798B/zh not_active Expired - Fee Related
- 2008-03-13 WO PCT/JP2008/054628 patent/WO2008114691A1/ja not_active Ceased
- 2008-03-13 BR BRPI0805835-0A patent/BRPI0805835A2/pt not_active IP Right Cessation
- 2008-03-13 DK DK08722032.3T patent/DK2135870T3/da active
- 2008-03-13 CA CA002664286A patent/CA2664286A1/en not_active Abandoned
- 2008-03-13 AT AT08722032T patent/ATE555114T1/de active
- 2008-03-13 KR KR1020097006525A patent/KR101418620B1/ko not_active Expired - Fee Related
- 2008-03-13 PL PL08722032T patent/PL2135870T3/pl unknown
- 2008-03-13 EP EP08722032A patent/EP2135870B1/de not_active Not-in-force
- 2008-03-13 US US12/443,662 patent/US8173804B2/en not_active Expired - Fee Related
- 2008-03-13 ES ES08722032T patent/ES2386165T3/es active Active
- 2008-03-13 AU AU2008227637A patent/AU2008227637B2/en not_active Ceased
- 2008-03-13 PT PT08722032T patent/PT2135870E/pt unknown
-
2009
- 2009-03-04 ZA ZA2009/01559A patent/ZA200901559B/en unknown
- 2009-03-12 IL IL197572A patent/IL197572A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2386165T3 (es) | 2012-08-10 |
| DK2135870T3 (da) | 2012-07-16 |
| US20100029934A1 (en) | 2010-02-04 |
| AU2008227637B2 (en) | 2012-02-16 |
| JP5192707B2 (ja) | 2013-05-08 |
| PL2135870T3 (pl) | 2012-07-31 |
| EP2135870B1 (de) | 2012-04-25 |
| BRPI0805835A2 (pt) | 2011-08-30 |
| IL197572A0 (en) | 2009-12-24 |
| EP2135870A1 (de) | 2009-12-23 |
| KR101418620B1 (ko) | 2014-07-14 |
| JP2008231062A (ja) | 2008-10-02 |
| CN101541798B (zh) | 2011-09-14 |
| CA2664286A1 (en) | 2008-09-25 |
| PT2135870E (pt) | 2012-05-11 |
| EP2135870A4 (de) | 2011-06-08 |
| AU2008227637A1 (en) | 2008-09-25 |
| ZA200901559B (en) | 2010-02-24 |
| IL197572A (en) | 2013-03-24 |
| WO2008114691A1 (ja) | 2008-09-25 |
| US8173804B2 (en) | 2012-05-08 |
| CN101541798A (zh) | 2009-09-23 |
| KR20090121270A (ko) | 2009-11-25 |
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