ATE555096T1 - Heterocyclische verbindungen als viruzide - Google Patents

Heterocyclische verbindungen als viruzide

Info

Publication number
ATE555096T1
ATE555096T1 AT09780611T AT09780611T ATE555096T1 AT E555096 T1 ATE555096 T1 AT E555096T1 AT 09780611 T AT09780611 T AT 09780611T AT 09780611 T AT09780611 T AT 09780611T AT E555096 T1 ATE555096 T1 AT E555096T1
Authority
AT
Austria
Prior art keywords
virucides
heterocyclic compounds
heterocyclic
compounds
Prior art date
Application number
AT09780611T
Other languages
English (en)
Inventor
Kenneth Brameld
David Carter
Elbert Chin
Vicente Fidalgo Javier De
Jim Li
Ryan Schoenfeld
Eric Sjogren
Francisco Talamas
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE555096T1 publication Critical patent/ATE555096T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62Oxygen or sulfur atoms
    • C07D213/63One oxygen atom
    • C07D213/64One oxygen atom attached in position 2 or 6
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT09780611T 2008-07-23 2009-07-15 Heterocyclische verbindungen als viruzide ATE555096T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8284708P 2008-07-23 2008-07-23
US20792509P 2009-02-17 2009-02-17
US17983709P 2009-05-20 2009-05-20
PCT/EP2009/059039 WO2010010017A1 (en) 2008-07-23 2009-07-15 Heterocyclic antiviral compounds

Publications (1)

Publication Number Publication Date
ATE555096T1 true ATE555096T1 (de) 2012-05-15

Family

ID=41057595

Family Applications (1)

Application Number Title Priority Date Filing Date
AT09780611T ATE555096T1 (de) 2008-07-23 2009-07-15 Heterocyclische verbindungen als viruzide

Country Status (18)

Country Link
US (1) US8273773B2 (de)
EP (1) EP2307372B1 (de)
JP (1) JP2011528686A (de)
KR (1) KR20110033291A (de)
CN (1) CN102099335A (de)
AR (1) AR072824A1 (de)
AT (1) ATE555096T1 (de)
AU (1) AU2009273327A1 (de)
BR (1) BRPI0916233A2 (de)
CA (1) CA2730517A1 (de)
CL (1) CL2011000136A1 (de)
ES (1) ES2383273T3 (de)
IL (1) IL209696A0 (de)
MX (1) MX2011000656A (de)
PE (1) PE20110409A1 (de)
TW (1) TW201008922A (de)
WO (1) WO2010010017A1 (de)
ZA (1) ZA201009183B (de)

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KR101552474B1 (ko) 2007-09-17 2015-09-11 애브비 바하마스 리미티드 C형 간염 치료용 우라실 또는 티민 유도체
ES2368879T3 (es) 2007-09-17 2011-11-23 Abbott Laboratories Pirimidinas antiinfecciosas y usos de las mismas.
MX2011002846A (es) * 2008-09-26 2011-04-07 Hoffmann La Roche Derivados de pirina o pirazina para tratar el virus de la hepatitis c.
AU2009309813A1 (en) 2008-10-30 2010-05-06 F. Hoffmann-La Roche Ag Heterocyclic antiviral arylpyridone derivatives
BRPI1016266A2 (pt) * 2009-03-06 2019-09-24 Hoffmann La Roche compostos antivirais heterocíclicos
WO2010111348A1 (en) * 2009-03-24 2010-09-30 Abbott Laboratories Process for preparing antiviral compound
CN105924386A (zh) 2009-03-25 2016-09-07 Abbvie 公司 抗病毒化合物和其用途
WO2010122082A1 (en) * 2009-04-25 2010-10-28 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds
WO2010133528A1 (en) * 2009-05-20 2010-11-25 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds
CA2770195C (en) * 2009-08-07 2015-10-13 Chugai Seiyaku Kabushiki Kaisha Aminopyrazole derivative
CA2768924A1 (en) * 2009-09-21 2011-03-24 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds
JP2013511489A (ja) 2009-11-21 2013-04-04 エフ.ホフマン−ラ ロシュ アーゲー 複素環式抗ウイルス化合物
US9255074B2 (en) 2010-07-16 2016-02-09 Abbvie Inc. Process for preparing antiviral compounds
AU2011278927B2 (en) 2010-07-16 2015-05-21 Abbvie Ireland Unlimited Company Process for preparing antiviral compounds
MX338725B (es) 2010-07-16 2016-04-28 Abbvie Bahamas Ltd Ligando de fosfina para reacciones cataliticas.
US8975443B2 (en) 2010-07-16 2015-03-10 Abbvie Inc. Phosphine ligands for catalytic reactions
JP5620417B2 (ja) * 2011-02-07 2014-11-05 中外製薬株式会社 アミノピラゾール誘導体を含む医薬
NO2686520T3 (de) 2011-06-06 2018-03-17
TW201329025A (zh) 2011-11-01 2013-07-16 Astex Therapeutics Ltd 醫藥化合物
JP6306585B2 (ja) * 2012-07-31 2018-04-04 ダウ グローバル テクノロジーズ エルエルシー オレフィン重合触媒活性化剤を製造する方法
WO2014095555A1 (en) 2012-12-19 2014-06-26 Basf Se New substituted triazoles and imidazoles and their use as fungicides
NZ753904A (en) 2013-06-13 2020-07-31 Akebia Therapeutics Inc Compositions and methods for treating anemia
EP2886118B1 (de) * 2013-07-31 2018-09-05 Chugai Seiyaku Kabushiki Kaisha Pharmazeutisches präparat mit einem aminopyrazolderivat
SG10201913313QA (en) * 2013-12-13 2020-03-30 Vertex Pharma Prodrugs of pyridone amides useful as modulators of sodium channels
EP3581179A1 (de) 2013-12-27 2019-12-18 Chugai Seiyaku Kabushiki Kaisha Mutantes fgfr-gatekeeper-gen und dagegen gerichteter wirkstoff
EP3247355A4 (de) 2015-01-23 2018-06-13 Akebia Therapeutics, Inc. Feste formen von 2-(5-(3-fluorphenyl)-3-hydroxypicolinamido)essigsäure, zusammensetzungen und verwendungen davon
LT3277270T (lt) 2015-04-01 2022-01-10 Akebia Therapeutics, Inc. Kompozicijos ir būdai skirti anemijos gydymui
US10479780B2 (en) 2015-06-17 2019-11-19 Chugai Seiyaku Kabushiki Kaisha Aminopyrazole derivatives
MX2020011845A (es) 2018-05-09 2021-01-15 Akebia Therapeutics Inc Proceso para preparar acido 2-[[5-(3-clorofenil)-3-hidroxipiridina -2-carbonil]amino]acetico.
CN110724091B (zh) * 2019-12-04 2022-03-11 阿里生物新材料(常州)有限公司 一种6-(二氟甲基)-2-羟基吡啶-3-磺酰氯的合成方法
CN112876409A (zh) * 2021-01-20 2021-06-01 都创(上海)医药科技股份有限公司 一种2-(5-溴-6-甲氧基吡啶-2-基)乙腈及其衍生物的合成方法
CN112898200A (zh) * 2021-01-20 2021-06-04 都创(上海)医药科技股份有限公司 5-溴-6-甲氧基吡啶-2-羧酸酯的合成方法

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ES2368879T3 (es) 2007-09-17 2011-11-23 Abbott Laboratories Pirimidinas antiinfecciosas y usos de las mismas.
CN105693626A (zh) 2007-09-17 2016-06-22 艾伯维巴哈马有限公司 治疗丙型肝炎的尿嘧啶或胸腺嘧啶衍生物
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Also Published As

Publication number Publication date
US8273773B2 (en) 2012-09-25
CL2011000136A1 (es) 2011-07-08
AR072824A1 (es) 2010-09-22
TW201008922A (en) 2010-03-01
EP2307372A1 (de) 2011-04-13
US20100021423A1 (en) 2010-01-28
KR20110033291A (ko) 2011-03-30
CN102099335A (zh) 2011-06-15
BRPI0916233A2 (pt) 2018-03-13
CA2730517A1 (en) 2010-01-28
MX2011000656A (es) 2011-02-23
JP2011528686A (ja) 2011-11-24
ES2383273T3 (es) 2012-06-19
AU2009273327A1 (en) 2010-01-28
PE20110409A1 (es) 2011-06-22
ZA201009183B (en) 2013-05-29
EP2307372B1 (de) 2012-04-25
WO2010010017A1 (en) 2010-01-28
IL209696A0 (en) 2011-02-28

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